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| 1 | TRANSLUCENT GREEN, an ERF Family Transcription Factor, Controls Water Balance in Arabidopsis by Activating the Expression of Aquaporin Genes显示文摘水是在几乎所有生活有机体的最丰富的分子。Aquaporins 是玩控制房间的水内容的批评 rolesin 的隧道蛋白质。这里,我们报导 AP2/EREBP 家庭抄写 factorin Arabidopsis thaliana 的鉴定,半透明的格林( TG )其在转基因的植物的 overexpression 给了提高的干旱忍耐并且使 leaves.TG 蛋白质成玻璃在原子核是局部性的,在 vitro 绑 DRE 和 GCC 元素,并且在酵母房间充当 transcriptional 使活跃之物。Microarray 分析揭示了 TG,五基因在之中编码 aquaporins 调整的 330 基因的一个总数。短暂表示试金证明 TG 直接绑在 threeaquaporin 基因的倡导者,例如 AtTIP1; 1, AtTIP2; 3,并且 AtPIP2; 2,直接显示那 TG 调整这些基因的表示。而且, AtTIP1 的 overexpression; 1 在转基因的 Arabidopsis 植物导致了使成玻璃的显型,类似于在 TG overexpression 线观察的那些。进野类型的叶子的水注射概括了 vitrifiedleaf 显型,它被从脉管的捆割掉水供应颠倒。一起拿,我们在通过直接激活 aquaporin genes.Key 词的表达式的 Arabidopsis 的数据 supportthat TG 控制水平衡: | Danling Zhu Zhe Wu Guangyu Cao Jigang Li Jia Wei Tomohiko Tsuge Hongya Gua Takashi Aoyama Li-Jia Qu | 2014 | Molecular Plant2014，7，4： | 8 |
| 2 | 天然树脂紫胶的热裂解-气相色谱特性(英文)显示文摘研究了有机碱试剂,氢氧化四甲铵(tetramethylammonium hydroxide TMAH)共存下的反应热裂解气相色谱(Py-GC)应用于天然树脂紫胶的化学组成分析。并在反应Py-GC测得的化学组成的基础上,应用主成分分析(principal component analysis,PCA)对印度和泰国产紫胶进行产地识别分析。 | 王丽丽 Yasuyuki Ishida Hajime Ohtani Shin Tsuge Toshihiro Nakayama | 2003 | 浙江科技学院学报2003，15，B11： | 5 |
| 3 | The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 Protein Forms an SCF Ubiquitin Ligase and Regulates Hypocotyl Elongation显示文摘由 ubiquitin proteasome 系统(不间断电源) 的蛋白质周转的规定是在优核质的主要 posttranslational 机制。UPS,的关键部件之一 COP9 signalosome (CSN ) ,调整 cullinring E3 ubiquitin ligases。在植物, CSN 参予多样的细胞、发展的进程,从到房间周期控制的轻发信号。在这个工作,我们孤立新植物特定的交往 CSN F 盒子蛋白质,我们它给 CFK1 (COP9 交往 F 盒子 KELCH 1 ) 取名。我们证明在 Arabidopsis thaliana, CFK1 是功能的 ubiquitin ligase 建筑群的一个部件。我们也证明那 CFK1 稳定性被 CSN 并且由 proteasome 依赖的解朊作用调整,并且那盏灯在胚轴导致 CFK1 抄本的累积。CFK1 的分析击倒,异种,和 overexpressing 幼苗显示 CFK1 由增加支持胚轴延伸房间尺寸。CSN 层次的减小提高弄空 CFK1 的幼苗的短胚轴显型,当 CSN 活动的完全的损失压制 CFK1-overexpressing 幼苗的长胚轴的显型时。我们建议那 CFK1 (并且它由 CSN 的规定) 细胞的机制的一个新奇部件正在控制胚轴延伸。 | Anna Franciosini Benedetta Lombardi Silvia lafrate Valeria.Pecce Giovanni Mele Leonardo Lupacchini Gianmarco Rinaldi Youichi Kondou Giuliana Gusmaroli Shiori Aki Tomohiko Tsuge Xing-Wang Deng Minami Matsui Paola Vittorioso Paolo Costantin Giovanna Serino | 2013 | Molecular Plant2013，6，5： | 3 |
| 4 | SNAIL1 is essential for female gametogenesis in Arabidopsis thaliana显示文摘Two yeast Brix family members Ssf1 and Ssf2,involved in large ribosomal subunit synthesis, are essential for yeast cell viability and mating efficiency. Their putative homologs exist in the Arabidopsis genome; however, their role in plant development is unknown. Here, we show that Arabidopsis thaliana SNAIL1(At SNAIL1), a protein sharing high sequence identity with yeast Ssf1 and Ssf2, is critical to mitosis progression of female gametophyte development.The snail1 homozygous mutant was nonviable and its heterozygous mutant was semi-sterile with shorter siliques.The mutation in SNAIL1 led to absence of female transmission and reduced male transmission. Further phenotypic analysis showed that the synchronic development of female gametophyte in the snail1 heterozygous mutant was greatly impaired and the snail1 pollen tube growth, in vivo, was also compromised. Furthermore, SNAIL1 was a nucleolarlocalized protein with a putative role in protein synthesis.Our data suggest that SNAIL1 may function in ribosome biogenesis like Ssf1 and Ssf2 and plays an important role during megagametogenesis in Arabidopsis. | Lihong Hao Xiaolin Wei Jiulei Zhu Jiao Shi Jingjing Liu Hongya Gu Tomohiko Tsuge Li-Jia Qu | 2017 | Journal of Integrative Plant Biology2017，59，9： | 3 |
| 5 | Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report显示文摘BACKGROUND Esophageal submucosal hematoma is a rare condition.Although the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant therapy.Serious conditions are rare,with a better prognosis.We present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss syndrome.CASE SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral aneurysm.The patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the surgery.Several hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic shock.Esophageal submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed tomography.In addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)tube.Afterwards,she became hemodynamically stable.On postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric junction.We started oral intake on postoperative day 10.The patient made steady progress,and was discharged on postoperative day 33.CONCLUSION We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome. | Jiro Oba Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita | 2022 | World Journal of Clinical Cases2022，10，27： | 3 |
| 6 | CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1显示文摘CSN1 is a component of the COP9 signalosome(CSN),a conserved protein complex with pleiotropic functions in many organs and cell types.CSN regulates ubiquitinproteasome dependent protein degradation via the deneddylation and the associated deubiquitination activities.In addition,CSN associates with protein kinases and modulates cell signaling,particularly the activator protein 1(AP-1)pathway.We have shown previously that CSN1 suppresses AP-1 transcription activity and inhibits ultraviolet(UV)and serum activation of c-fos expression.Here we show that CSN1 can inhibit phosphorylation of proto-oncogene c-Jun product and repress c-Jun dependent transcription.Further,CSN1 dramatically downregulates ectopic expression of c-Jun N-terminal kinase 1(JNK1)in cultured cells.The decline in JNK1 is not caused by excessive proteolysis or by 3′UTR-dependent mRNA instability,but by CSN1-dependent repression of one or multiple steps in transcriptional and posttranscriptional mechanisms.Thus,in contrast to CSN5/Jab1,which promotes AP-1 activity,CSN1 displays a negative effect on the AP-1 pathway.Finally,we discuss about the dynamic equilibrium of the CSN complexes in regulation of the AP-1 pathway. | Tomohiko Tsuge Suchithra Menon Yingchun Tong Ning Wei | 2011 | Protein & Cell2011，2，5： | 2 |
| 7 | Cloning,sequencing,and characterization of the iturin A operon显示文摘 | Tsuge K Aldyama T Shoda M | 2001 | Journal of Bacteriology2001，183，21： | 1 |
| 8 | Structural and functional complexity of thegenomic region controlling AK-toxin biosynthesis and pathogenicityin the Japanese pear pathotype of Alternaria alternata显示文摘 | TANAKA A TSUGE T | 2000 | Molecu-lar Plant-Microbe Interact2000，13，： | 1 |
| 9 | A bimodal maxwellian distribution as the equilibrium solution of the two-particle regime显示文摘 | Sagara K Tsuge S | 1982 | Physics of Fluids1982，25，11： | 1 |
| 10 | Catalytic asymmetric epoxidation of enones under phase-transfer catalyzed conditions 显示文摘 | Arai S Tsuge H Oku M | 2002 | Tetrahedron2002，58，： | 1 |
| 11 | Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex,and their abundance is differentially affected by the pleiotropic cop/det/fus mutations显示文摘 | Kwok SF Solano R Tsuge T | 1998 | Plant Cell1998，10，11： | 1 |
| 12 | Nucleotide sequence responsible for the synthesis of a truncated coat protein of brome ~nosaic virus strain ATCC66 显示文摘 | MIsE K TSUGE S NAGAO K | 1992 | Journal of General Virology1992，73，： | 1 |
| 13 | Differences inhemagglutination inhibition activity against bovine rotavirus andhen Newcastle disease virus based on the subunits in hen egg whiteovomucin显示文摘 | TSUGE Y SH1MOYAMADA M WATANABE K | 1996 | Biosci Biotechnol Biochem1996，60，9： | 1 |
| 14 | Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3- 4A protease inhibitor显示文摘 | Kamiya N lwao E Hiraga N Tsuge M | 2010 | J Gen Virol2010，91，7： | 1 |
| 15 | Apporoach to the origin of turbulence on the basis of two-point kinetic theory显示文摘 | Tsuge S | 1974 | Physics of Fluids1974，17，1： | 1 |
| 16 | Isolation of a gene essential for biosynthesis of the lipopeptide antibiotics plipastatin B1 and surfactin in Bacillus subtilis YB8显示文摘 | Tsuge K Ano T Shoda M | 1996 | Arch Microbiol1996，165，： | 1 |
| 17 | Structuralfeatures of Newcastle disease virus-and anti-ovomucin antibody-binding glycopeptides from pronase-treated ovomucin 显示文摘 | TSUGE Y SHIMOYAMADA M WATANABE K | 1997 | Journal ofAgricultural and Food Chemistry1997，45，7： | 1 |
| 18 | Antitumor effects of pronase - treated fragments, glycopeptides, from ovomucin in hen egg white in a double grafted tumor sys- tem显示文摘 | Watanabe K Tsuge Y Shimoyamada M | 1998 | J Agrie Food Chem1998，46，8： | 1 |
| 19 | One step assembly of multiple DNA fragments with a designed order and orientation in Bacillus subtilis plasmid 显示文摘 | Tsuge K Matsui K Itaya M | 2003 | Nucleic Acids Research2003，31，21： | 1 |
| 20 | The COP9 Signalosome Inhibits p27 kip1 Degradation and Impedes G1-S Phase Progression via Deneddylation of SCF Cul1显示文摘 | Xiaoming Yang Suchithra Menon Karin Lykke-Andersen Tomohiko Tsuge Di Xiao Xiping Wang Roberto J. Rodriguez-Suarez Hui Zhang Ning Wei | 2002 | Current Biology2002，，8： | 1 |
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