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| 1 | Relative humidity reconstruction for northwestern China's Altay Mountains using tree-ring δ^(18)O显示文摘Relative humidity is an important factor in water and water vapor feedback cycles.In this study,we established a 222-year annual tree-ring δ^(18)O chronology for Siberian larch(Larix sibirica Ldb.)from the Altay Mountains in northwestern China.Climate response analyses revealed that the relative humidity was the primary factor limiting tree-ring δ^(18)O fractionation.Based on our analysis,tree-ring δ^(18)O can be used to reconstruct the July–August relative humidity based on both a reasonable mechanism of tree-ring δ^(18)O fractionation and a statistically significant regression model.We used this model to reconstruct variations in the July–August relative humidity,and the model explained 47.4% of the total variation in the measured relative humidity data from 1961 to 2011.The relative humidity in the study area increased from 1900 to the 1990s and decreased thereafter.Two regime-shift dry periods were detected during the study period(one from 1817 to 1830 and the other from 2004 to 2011). | Guobao Xu Xiaohong Liu Dahe Qin Tuo Chen Wenzhi Wang Guoju Wu Weizhen Sun Wenling An Xiaomin Zeng | 2014 | Chinese Science Bulletin2014，59，2： | 14 |
| 2 | Recent change of the ice core accumulation rates on the Qinghai-Tibetan Plateau显示文摘Three ice cores recovered from the Himalayas (i.e. the East Rongbuk Glacier and the Far East Rongbuk Glacier at Mt. Qomolangma (Everest), and the Dasuopu Glacier at Xixiabangma) show a sharp decline in the accumulation rates since the 1950s, which is consistent with the precipitation fluctuation over India and the low northern latitude zone (5°-35癗). Correspondingly, an increasing trend is observed for the ice core accumulations from the central and northern Qinghai-Tibetan Plateau (i.e. the Xiao Dongkemadi Glacier in the central Tanggula Mountains, the Guliya Ice Cap in the western Kunlun Mountains, and the Dunde Ice Cap in the Qilian Mountains) since the 1950s, which is consistent with the precipitation fluctuation over the middle-high northern latitude zone (35°-70°N). However, the variation magnitude of the high-elevation ice core accumulations is more significant than that of precipitation at the low-eleva- tion places, suggesting its extra sensitivity of high-elevation areas to climatic change. | Shugui Hou Dahe Qin Tandong Yao Dongqi Zhang Tuo Chen | 2002 | Chinese Science Bulletin2002，47，20： | 10 |
| 3 | Climatic significance of the stable carbon isotope composition of tree-ring cellulose:Comparison of Chinese hemlock (Tsuga chinensis Pritz) and alpine pine (Pinus densata Mast) in a temperate-moist region of China显示文摘In the reconstruction of past climate using stable carbon isotope composition (δ13C) in tree ring,the responses of the stable carbon composition (δ13C) of multiple tree species to environmental factors must be known detailedly. This study presented two δ13C series in annual tree rings for Chinese hem-lock (Tsuga chinensis Pritz) and alpine pine (Pinus densata Mast),and investigated the relationships between climatic parameters and stable carbon discrimination (△13C) series,and evaluated the poten-tial of climatic reconstruction using △13C in both species,in a temperate-moist region of Chuanxi Pla-teau,China. The raw δ13C series of the two species was inconsistent,which may be a result of different responses caused by tree's inherent physiological differences. After removing the low-frequency ef-fects of CO2 concentration,the high-frequency (year-to-year) inter-series correlation of △13C was strong,indicating that △13C of the two tree species were controlled by common environmental conditions. The △13C series of the species were most significantly correlated with temperature and moisture stress,but in different periods and intensity between the species. During the physiological year,the impacts of temperature and moisture stress on △13C occur earlier for Chinese hemlock (previous December to February for moisture stress and February to April for temperature,respectively) than for alpine pine (March to May for moisture stress and April to July for temperature,respectively). In addition,in temperate-moist regions,the control on △13C of single climatic parameter was not strongly dominant and the op-timal multiple regressions functions just explained the 38.5% variance of the total. Therefore,there is limited potential for using δ13C alone to identify clear,reliable climatic signals from two species. | LIU XiaoHong SHAO XueMei WANG LiLi ZHAO LiangJu WU Pu CHEN Tuo QIN DaHe REN JiaWen | 2007 | Science China Earth Sciences2007，50，7： | 10 |
| 4 | Climatic significance of stable carbon isotope in tree rings of Abies spectabibis in southeastern Tibet显示文摘The annually cross-dated stable carbon isotope of tree-ring a-cellulose of Abies spectabibis collected from the southeastern Tibetan Plateau is used to examine its rela-tionship with climatic parameters. The residual D13C series in treerings is constructed after removing the effects of age trend and rising CO2. We found a close relationship between D13C in tree rings and the relative humidity of September—November of the previous year measured at the nearby Ny-ingchi Meteorological Station, albeit a strong 搇agged effect? Thus we developed a transfer function to reconstruct the autumn relative humidity for the Nyingchi region, which explained 37.9% of the total variance (p < 0.001). Our results suggest a high frequency and moderate amplitude variance of the relative humidity before 1800, and the variance re-versed afterwards. | LIU Xiaohong Qin Dahe SHAO Xuemei CHEN Tuo REN Jiawen | 2003 | Chinese Science Bulletin2003，48，18： | 8 |
| 5 | 过表达CXCR4的骨髓间充质干细胞通过增强的肠道归巢能力抑制小鼠肠炎相关肿瘤的形成显示文摘背景:骨髓来源间充质干细胞(MSC)用于炎症性肠病(IBD)及IBD相关肠癌的治疗潜力已受到越来越多的关注。然而,MSC究竟是抵制还是促进肿瘤形成仍然存在争议。基质细胞衍生因子1(SDF-1)/C-X-C趋化因子受体4(CXCR4)在MSC归巢过程具有非常关键的作用。本研究旨在评估过表达CXCR4的MSC在IBD瘤变过程中的作用。方法:应用携带CXCR4或绿色荧光蛋白(GFP)的慢病毒载体转染MSC。通过细胞趋化实验和侵袭实验检测CXCR4表达情况。采用偶氮甲烷和葡聚糖硫酸钠(DSS)制作小鼠结肠炎成瘤模型。将实验小鼠分为3组,分别注射磷酸盐缓冲液(PBS)、MSC-GFP或MSC-CXCR4。结果:与MSC-GFP组小鼠相比,MSC-CXCR4小鼠体重下降程度减少,结肠相对更长,肿瘤数量更少,肿瘤负荷减轻;此外,结肠组织中促炎细胞因子表达和STAT3磷酸化水平均下调。结论:过表达CXCR4的MSC表现出抑瘤功能,其机制可能是CXCR4促进MSC向炎性肠组织的归巢。 | Xiao-Bin Zheng Xiao-Wen He Long-Juan Zhang Hua-Bo Qin Xu-Tao Lin Xuan-Hui Liu Chi Zhou Hua-Shan Liu Tuo Hu Hai-Chun Cheng Xiao-Sheng He Xian-Rui Wu Yu-Feng Chen Jia Ke Xiao-Jian Wu Ping Lan | 2019 | Gastroenterology Report2019，7，2： | 2 |
| 6 | Early activated hepatic stellate cell-derived molecules reverse acute hepatic injury显示文摘AIM: To test whether hepatic stellate cells(HSCs) at different activation stages play different roles in acetaminophen(APAP)-induced acute liver injury(ALI).METHODS: HSCs were isolated from mouse liver and cultured in vitro.Morphological changes of initiation HSCs [HSCs(5d)] and perpetuation HSCs [HSCs(p3)] were observed by immunofluorescence and transmission electron microscopy.The protective effects of HSCderived molecules, cell lysates and HSC-conditioned medium(HSC-CM) were tested in vivo by survival and histopathological analyses.Liver injury was determined by measuring aminotransferase levels in the serum and by histologic examination of tissue sections under a light microscope.Additionally, to determine the molecular mediators of the observed protective effects of initiation HSCs, we examined HSC-CM using a highdensity protein array.RESULTS: HSCs(5d) and HSCs(p3) had different morphological and phenotypic traits.HSCs(5d) presented a star-shaped appearance with expressing α-SMA at non-uniform levels between cells.However, HSCs(p3) evolved into myofibroblast-like cells without lipid droplets and expressed a uniform and higher level of α-SMA.HSC-CM(5d), but not HSC-CM(p3), provided a significant survival benefit and showed a dramatic reduction of hepatocellular necrosis and panlobular leukocyte infiltrates in mice exposed to APAP.However, this protective effect was abrogated at higher cell masses, indicating a therapeutic window of effectiveness.Furthermore, the protein array screenrevealed that HSC-CM(5d) was composed of many chemokines and growth factors that correlated with inflammatory inhibition and therapeutic activity.When compared with HSC-CM(p3), higher levels of monocyte chemoattractant protein-1, macrophage inflammatory protein-1γ, hepatocyte growth factor, interleukin-10, and matrix metalloproteinase-2, but lower levels of stem cell factor and Fas-Ligand were observed in HSCCM(5d).CONCLUSION: These data indicated that initiation HSCs and perpetuation HSCs were different in morphology and protein expression, and provided the first experimental evidence of the potential medical value of initiation HSC-derived molecules in the treatment of ALI. | Wen-Ju Chang Lu-Jun Song Tuo Yi Kun-Tang Shen Hong-Shan Wang Xiao-Dong Gao Min Li Jian-Min Xu Wei-Xin Niu Xin-Yu Qin | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 7 | NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia - reoxygenation显示文摘 | Jian Xiong Chen Heng Zeng Qin Hui Tuo | 2007 | Heart Circ Physiol2007，292，4： | 1 |
| 8 | Application and verification of simultaneous determination of cellulose δ^(13)C and δ^(18)O in Picea shrenkiana tree rings from northwestern China using the high-temperature pyrolysis method显示文摘Stable isotopes in tree-ring cellulose provide important data in ecological,archaeological,and paleoenvironmental researches,thereby,the demand for stable isotope analyses is increasing rapidly.Simultaneous measurement of cellulose δ^(13)C and δ^(18)O values from tree rings would reduce the cost of isotopic commodities and improve the analytical efficiency compared with conventional separate measurement.In this study,we compared the δ^(13)C and δ^(18)O values of tree-ringα-cellulose from Tianshan spruce(Picea schrenkiana)in an arid site in the drainage basin of the Urumqi River in Xinjiang of northwestern China based on separate and simultaneous measurements,using the combustion method(at1050°C)and the high-temperature pyrolysis method(at 1350°C and 1400°C).We verified the results of simultaneous measurement using the outputs from separate measurement and found that both methods(separate and simultaneous)produced similar δ^(13)C values.The two-point calibrated method improved the results(range and variation)of δ^(13)C and δ^(18)O values.The mean values,standard deviations,and trends of the tree-ring δ^(13)C obtained by the combustion method were similar to those by the pyrolysis method followed by two-point calibration.The simultaneously measured δ^(18)O from the pyrolysis method at 1400°C had a nearly constant offset with that the pyrolysis method at 1350°C due to isotopic-dependence on the reaction temperature.However,they showed similar variations in the time series.The climate responses inferred from simultaneously and separately measured δ^(13)C and δ^(18)O did not differ between the two methods.The tree-ring δ^(13)C and δ^(18)O values were negatively correlated with standardized precipitation evapotranspiration index from May to August.In addition,the δ^(18)O was significantly correlated with temperature(positive),precipitation(negative),and relative humidity(negative)from May to August.The tree-ring δ^(13)C and δ^(18)O values determined simultaneously through the high-temperature pyrolysis method could produce acceptable and reliable stable isotope series.The simultaneous isotopic measurement can greatly reduce the cost and time requirement compared with the separate isotopic measurement.These results are consistent with the previous studies at humid sites,suggesting that the simultaneous determination of δ^(13)C and δ^(18)O in tree-ringα-cellulose can be used in wide regions. | XU Guobao LIU Xiaohong SUN Weizhen CHEN Tuo ZHANG Xuanwen ZENG Xiaomin WU Guoju WANG Wenzhi QIN Dahe | 2018 | Journal of Arid Land2018，10，6： | 1 |
| 9 | Effects and underlying mechanisms of curcumin on the proliferation of vascular smooth muscle cells induced by Chol:MbetaCD显示文摘 | Qin L Yang YB Tuo QH | 2009 | Biochem Biophys Res Commun2009，379，2： | 1 |
| 10 | Effects and underlying mecha- nisms of cureumin on the proliferation of vascular smooth mus- cle cells induced by Chol: MbetaCD 显示文摘 | Qin L Yang YB Tuo QH | 2009 | Biochem Biophys Res Commun2009，379，2： | 1 |
| 11 | Effects and underlying mechanisms of curcumin on the proliferation of vascular smooth muscle cells induced by Chol: MhetaCD显示文摘 | Qin L Yang YB Tuo QH | 2009 | Bio- chem Biophys Res Commun2009，379，2： | 1 |
| 12 | Effects and underlying mech- anisms of curcumin on the proliferation of vascular smooth muscle cells induced by Chol: MbetaCD 显示文摘 | Qin L Yang Y Tuo Q | 2009 | Biochem Biophys Res Commun2009，379，2： | 1 |
| 13 | Computing the Determinant of a Matrix with Polynomial Entries by Approximation显示文摘与 univariate 和 multivariate 多项式条目计算一个矩阵的决定因素在地的科学计算并且设计经常产生。这份报纸建议一个有效算法用混合符号、数字的计算与多项式条目计算一个矩阵的决定因素。算法为解决 Vandermonde 系统与错误控制依靠牛顿插值方法。作者也介绍度矩阵为尺寸减小与多项式条目,和度同形方法在一个矩阵估计变量的度。而且,方法的并行化自然地产生。 | QIN Xiaolin SUN Zhi LENG Tuo FENG Yong | 2018 | Journal of Systems Science & Complexity2018，31，2： | 0 |
| 14 | Red list assessments of Chinese higher plants显示文摘Based on the two most recent assessments of Chinese higher plants in 2013 and 2020,of 34,450 and 39,330 species,respectively,we analysed the threatened status of Chinese higher plants.In 2020,around 4,088(10.39%)of the assessed species in China are threatened,2,875(7.31%)Near Threatened,27,593(70.16%)not currently threatened and categorised as Least Concern and 4,752(12.08%)categorised as Data Deficient.While in 2013,3,767(10.93%)of the assessed higher plants in China are threatened,2,723(7.90%)Near Threatened,24,296(70.53%)Least Concern and 3,612(10.48%)Data Deficient.Estimates of the Red List Index in the two years show different patterns when using different weighting methods with the equal steps weighting method showing a slight decrease(0.91675-0.91495)and the extinction risk weighting method showing a slight increase(0.98792-0.98797).We inferred that China's threatened plant species were likely/relatively effectively protected.However,attention should also be given to the non-threatened species in the future as an additional strategy for their conservation,to maintain their non-threatened status. | Liping Li Haining Qin Eimear Nic Lughadha Yaomin Zheng Huawei Wan Jack Plummer Melanie-Jayne R.Howes Huiyuan Liu Yangming Jiang Tuo Wang Huihui Zhao Zhanfeng Shen Huiping Huang | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 15 | Tribological characteristics of dimpled surfaces filled with dopamine-modified MoS_(2)显示文摘To improve the tribological characteristics of dimples on the surface of 45 steel,the dimples were filled with MoS_(2)and MoS_(2)modified by dopamine(MoS_(2)@DA),and ball-disk friction and wear tests were conducted.Specifically,the dimple filling gap,abrasion depth,and surface cross-sectional area of 45 steel were measured.The wear morphology of the friction ball and exfoliation of MoS_(2)in the dimples and the bending characteristics of the specimens were studied.The surface friction coefficient of MoS_(2)@DA-filled specimen was 17.9%lower than MoS_(2)-filled specimen,and the dimple filling gap was 70.1%lower,the surface abrasion depth was 5.8%lower,and the abrasion cross-sectional area was 17.7%smaller.Moreover,the bending strength of the MoS_(2)@DA specimen was 3.27 times greater than that of the MoS_(2)specimen,and the exfoliation of MoS_(2)was slowed by filling with the MoS_(2)@DA.Finally,the tribological characteristics were also superior for the specimens prepared with MoS_(2)@DA. | Tuo Qin Aibing Yu Shuo Zhao Kefan Li Shaochun Qi Jiawang Ye | 2023 | Biosurface and Biotribology2023，9，4： | 0 |
| 16 | Single-nucleus RNA sequencing reveals heterogeneity among multiple white adipose tissue depots显示文摘Regardless of its anatomical site,adipose tissue shares a common energy-storage role but exhibits distinctive properties.Exploring the cellular and molecular heterogeneity of white adipose tissue(WAT)is crucial for comprehending its function and properties.However,existing single-nucleus RNA sequencing(snRNA-seq)studies of adipose tissue heterogeneity have examined only one or two depots.In this study,we employed snRNA-seq to test five representative depots including inguinal,epididymal,mesenteric,perirenal,and pericardial adipose tissues in mice under physiological conditions.By analyzing the contents of main cell catego-ries and gene profiles of various depots,we identified their distinctive physiological properties.Immune cells and fibro-adipogenic progenitor cells(FAPs)showed dramatic differences among WAT depots,while adipocytes seemed to be conserved.The heightened presence of regulatory macrophages and B cells in pericardial adipose tissues implied their potential contribution to the preservation of coronary vascular function.Moreover,the selective aggregation of pericytes within mesenteric adipose tissue was likely associated with the maintenance of intestinal barrier homeostasis.Using a combination of RNA sequencing and snRNA-seq analysis,the major subpopulations of FAPs derived from these depots determined the site characteristics of FAPs to a certain extent.Our work estab-lishes a systematic and reliable foundation for investigating the heterogeneity of WAT depots and elucidating the unique roles these depots play in coordinating the function of adjacent organs. | Limin Xie Wanyu Hu Haowei Zhang Yujin Ding Qin Zeng Xiyan Liao Dandan Wang Wanqin Xie Hannah Xiaoyan Hui Tuo Deng | 2023 | Life Metabolism2023，2，6： | 0 |
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