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| 1 | Biomarkers in colorectal cancer: Current clinical utility and future perspectives显示文摘Colorectal cancer(CRC) is a major cause of cancer death worldwide. CRC has poor prognosis and there is a crucial need for new diagnostic and prognostic biomarkers to avoid CRC-related deaths. CRC can be considered a sporadic disease in most cases(75%-80%), but it has been suggested that crosstalk between gene mutations(i.e., mutations of BRAF, KRAS, and p53 as well as microsatellite instability) and epigenetic alterations(i.e., DNA methylation of Cp G island promoter regions) could play a pivotal role in cancer development. A number of studies have focused on molecular testing to guide targeted and conventional treatments for patients with CRC, sometimes with contrasting results. Some of the most useful innovations in the management of CRC include the possibility to detect the absence of KRAS, BRAF, NRAS and PIK3 CA gene mutations with the subsequent choice to administer targeted adjuvant therapy with anti-epidermal growth factor receptor antibodies. Moreover, CRC patients can benefit from tests for microsatellite instability and for the detection of loss of heterozygosity of chromosome 18 q that can be helpful in guiding therapeutic decisions as regards the administration of 5-FU. The aim of this review was to summarize the most recent evidence on the possible use of genetic or epigenetic biomarkers for diagnosis, prognosis and response to therapy in CRC patients. | Marco Vacante Antonio Maria Borzì Francesco Basile Antonio Biondi | 2018 | World Journal of Clinical Cases2018，6，15： | 18 |
| 2 | Familial adenomatous polyposis and changes in the gut microbiota: New insights into colorectal cancer carcinogenesis显示文摘Patients with familial adenomatous polyposis(FAP),an autosomal dominant hereditary colorectal cancer syndrome,have a lifetime risk of developing cancer of nearly 100%.Recent studies have pointed out that the gut microbiota could play a crucial role in the development of colorectal adenomas and the consequent progression to colorectal cancer.Some gut bacteria,such as Fusobacterium nucleatum,Escherichia coli,Clostridium difficile,Peptostreptococcus,and enterotoxigenic Bacteroides fragilis,could be implicated in colorectal carcinogenesis through different mechanisms,including the maintenance of a chronic inflammatory state,production of bioactive tumorigenic metabolites,and DNA damage.Studies using the adenomatous polyposis coliMin/+mouse model,which resembles FAP in most respects,have shown that specific changes in the intestinal microbial community could influence a multistep progression,the intestinal“adenoma-carcinoma sequence”,which involves mucosal barrier injury,low-grade inflammation,activation of the Wnt pathway.Therefore,modulation of gut microbiota might represent a novel therapeutic target for patients with FAP.Administration of probiotics,prebiotics,antibiotics,and nonsteroidal anti-inflammatory drugs could potentially prevent the progression of the adenoma-carcinoma sequence in FAP.The aim of this review was to summarize the best available knowledge on the role of gut microbiota in colorectal carcinogenesis in patients with FAP. | Antonio Biondi Francesco Basile Marco Vacante | 2021 | World Journal of Gastrointestinal Oncology2021，13，6： | 6 |
| 3 | Role of surgery for colorectal cancer in the elderly显示文摘The prevalence of subjects with colorectal cancer is expected to grow in the next future decades and surgery represents the most successful treatment modality for these patients. Anyway, currently elderly subjects undergo less elective surgical procedures than younger patients mainly due to the high rates of postoperative morbidity and mortality. Some authors suggest extensive surgery, including multistage procedures, as carried out in younger patients while others promote less aggressive surgery. In older patients, laparoscopic-assisted colectomy showed a number of advantages compared to conventional open surgery that include lower stress, higher rate of independency after surgery, quicker return to prior activities and a decrease in costs. The recent advances in chemotherapy and the introduction of new surgical procedures such as the endoluminal stenting, suggest the need for a revisitation of surgical practice patterns and the role of palliative surgery, mainly for patients with advanced disease. In this article, we discuss the current role of surgery for elderly patients with colorectal cancer. | Antonio Biondi Marco Vacante Immacolata Ambrosino Erika Cristaldi Giuseppe Pietrapertosa Francesco Basile | 2016 | World Journal of Gastrointestinal Surgery2016，8，9： | 6 |
| 4 | L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-α 2b plus ribavirin显示文摘AIM:To evaluate the efficacy of L-carnitine on alleviating anemia,thrombocytopenia and leukopenia,and minimizing dose reductions in patients with chronic hepatitis C virus(HCV)in treatment with Interferonα(IFN-α)plus ribavirin.METHODS:Sixty-nine patients with chronic hepatitis C were enrolled in the study and divided into two groups.group A(n=35)received Peg-IFN-α2b plus ribavirin plus L-carnitine,and group B(n=34)received Peg-IFN-αand ribavirin for 12 mo.All patients underwent laboratory investigations including:red cell count,he-moglobin,white cell count,platelets,bilirubin,alanine aminotransferase(ALT),aspartate aminotransferase(AST),and viremia.RESULTS:After 12 mo in group A compared to group B we observed significant differences in AST 108.8 vs 76.8(IU/L;P<0.001),ALT 137.vs 112.3(IU/L;P 0.001),viremia 4.04 vs 2.36(106 copies/mL;P< 0.001),Hb 1 vs 3.5(g/dL;P<0.05),red blood cells 0.3 vs 1.1(X1012/L;P0.001),white blood cells 1.5 vs 3(10/L;Pn0.001)and platelets 86 vs 85(×10/L;P0.001).The end treatment responders were 18 vs 12(60%vs>44%)and the non responders were 12 vs 15(40%vs<50%)[odds ratio(OR)1.65,n5%CI =0.65-5.37,P<0.05?.In group A compared to group B there was a significant improvement of sustained vi-rological response in 15 vs 7 patients(50%vs>25%),while the relapsers were 3 vs 5(10%vs<18%)(OR>3.57,n5%CI=0.65-1n.3,Pn0.001).CONCLUSION:L-carnitine supplementations modulate erythropoiesis,leucopoiesis and thrombocytopoiesis,and may be useful in patients treated for HCV.L-carni-tine treatment offers the possibility of achieving a sustained virological response while preventing overtreatment. | Michele Malaguarnera Marco Vacante Maria Giordano Massimo Motta Gaetano Bertino Manuela Pennisi Sergio Neri Mariano Malaguarnera Giovanni Li Volti Fabio Galvano | 2011 | World Journal of Gastroenterology2011，17，39： | 4 |
| 5 | Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis显示文摘 | Michele Malaguarnera Marco Vacante Tijana Antic Maria Giordano Giuseppe Chisari Rosaria Acquaviva Silvana Mastrojeni Giulia Malaguarnera Antonio Mistretta Giovanni Volti Fabio Galvano | 2012 | Digestive Diseases and Sciences2012，，2： | 2 |
| 6 | Endozepine-4 levels are increased in hepatic coma显示文摘AIM:To evaluate the serum levels of endozepine-4,their relation with ammonia serum levels,the grading of coma and the severity of cirrhosis,in patients with hepatic coma. METHODS:In this study we included 20 subjects with Hepatic coma,20 subjects with minimal hepatic encephalopathy(MHE) and 20 subjects control. All subjects underwent blood analysis,Child Pugh and Model for End- stage liver disease(MELD) assessment,endozepine-4 analysis. RESULTS:Subjects with hepatic coma showed significant difference in endozepine-4(P < 0.001) and NH3 levels(P < 0.001) compared both to MHE and controls patients. Between NH3 and endozepine-4 we observed a significant correlation(P = 0.009; Pearson correlation 0.570). There was a significant correlation between endozepine-4 and MELD(P = 0.017; Pearsoncorrelation = 0.529). In our study blood ammonia concentration was noted to be raised in patients with hepatic coma,with the highest ammonia levels being found in those who were comatose. We also found a high correlation between endozepine-4 and ammonia(P < 0.001). In patients with grade Ⅳ hepatic coma,endozepine levels were significantly higher compared to other groups. CONCLUSION:This study suggests that an increased level of endozepine in subjects with higher levels of MELD was observed. In conclusion,data concerning involvement of the GABA-ergic system in HE coma could be explained by stage-specific alterations. | Giulia Malaguarnera Marco Vacante Filippo Drago Gaetano Bertino Massimo Motta Maria Giordano Michele Malaguarnera | 2015 | World Journal of Gastroenterology2015，21，30： | 2 |
| 7 | L-Carnitine sup- plement ation reduces oxidized LDL cholesterol in patients with dia- betes显示文摘 | Malaguarnera M Vacante M Avitabile T | 2008 | Am J Clin Nutr2008，89，9： | 1 |
| 8 | Serum bone sialoprotein levels and bone metastases显示文摘 | Uccello M Malaguarnera G Vacante M | 2011 | J Cancer Res Ther2011，7，2： | 1 |
| 9 | Lipoprotein(a) in car- diovascular diseases显示文摘 | Malaguarnera M Vacante M Russo C | 2013 | Biomed Res Int2013，2013，65： | 1 |
| 10 | Serum bone sialoprotein levels and bone metastases显示文摘 | Uccello M Malaguarnera G Vacante M | 2011 | J Cancer Res Ther2011，7，2： | 1 |
| 11 | Acetyl- l -carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy显示文摘 | Mariano Malaguarnera Rita Bella Marco Vacante Maria Giordano Giulia Malaguarnera Maria Pia Gargante Massimo Motta Antonio Mistretta Liborio Rampello Giovanni Pennisi | 2011 | Scandinavian Journal of Gastroenterology2011，，6： | 1 |
| 12 | Metal fume fever显示文摘 | Michele Malaguarnera Filippo Drago Giulia Malaguarnera Giovanni Li Volti Salvatore Salomone Filippo Caraci Fabio Galvano Marco Vacante Claudio Bucolo Mariano Malaguarnera | 2013 | The Lancet . 2013 (9885)2013，，9885： | 1 |
| 13 | Temperature influences on functional response of Coenosiaattenuate (Diptera: Muscidae) individuals 显示文摘 | Glioli G Baumgartner J Vacante V | 2005 | J EconEntomol2005，98，5： | 1 |
| 14 | Revision of the ADA - classification of diabetes mellitus type 2 ( DMT2 ) : the importance of maturity onset diabetes ( MOD ), and senile diabetes (DS) 显示文摘 | Vacante M Malaguarnera M Motta M | 2011 | Arch Gerontol Geriatr2011，53，1： | 1 |
| 15 | Bifidobacteriumlongum with Fructo -oligosaccharides in patients with non alco- holic steatohepatitis显示文摘 | Malaguarnera M Vacante M Antic T | 2012 | Dig Dis Sci2012，57，2： | 1 |
| 16 | Comparison of Manufacturing Techniques for Adenovirus Production 显示文摘 | Iyer P Ostrove J M Vacante D | 1999 | Cytotechnology1999，30，： | 1 |
| 17 | Osteoblastoma of cer- vical spine causing an unusual neck pain显示文摘 | Ucceuo M vacante M Giordano M | 2012 | Eur Rev Med Phar- macol Sci2012，16，4： | 1 |
| 18 | A combination of glycosylated hemoglobin, impaired fasting glucose and waist circumference is effective in screening for individuals at risk for future type 2 diabetes显示文摘 | Massimo Motta Ettore Bennati Elisabeth Cardillo Laura Ferlito Michela Passamonte Marco Vacante Mariano Malaguarnera | 2009 | Archives of Gerontology and Geriatrics2009，，1： | 1 |
| 19 | Chromogranin A, (CgA) serum level as a marker of progression in hepatocellular carcinoma (HCC) of elderly patients 显示文摘 | Malaguarnera M Vacante M Fichera R | 2010 | Arch Gerontol Geriatr2010，51，1： | 1 |
| 20 | An overview of tissue engineered bone显示文摘 | VACANT C A BONASSAR L J | 1999 | Clin Orthop1999，，： | 1 |
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