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| 1 | Structure-based Comparative Analysis and Prediction of N-linked Glycosylation Sites in Evolutionarily Distant Eukaryotes显示文摘The asparagine-X-serine/threonine (NXS/T) motif, where X is any amino acid except proline, is the consensus motif for N-linked glycosylation. Significant numbers of high-resolution crystal structures of glycosylated proteins allow us to carry out structural analysis of the N-linked glycosylation sites (NGS). Our analysis shows that there is enough structural information from diverse glycoproteins to allow the development of rules which can be used to predict NGS. A Python-based tool was developed to investigate asparagines implicated in N-glycosylation in five species: Homo sapiens, Mus musculus, Drosophila melanogaster, Arabidopsis thaliana and Saccharomyces cerevisiae. Our analysis shows that 78% of all asparagines of NXS/T motif involved in N-glycosylation are localized in the loop/turn conformation in the human proteome. Similar distribution was revealed for all the other species examined. Comparative analysis of the occurrence of NXS/T motifs not known to be glycosylated and their reverse sequence (S/TXN) shows a similar distribution across the secondary structural elements, indicating that the NXS/T motif in itself is not biologically relevant. Based on our analysis, we have defined rules to determine NGS. Using machine learning methods based on these rules we can predict with 93% accuracy if a particular site will be glycosylated. If structural information is not available the tool uses structural prediction results resulting in 74% accuracy. The tool was used to identify glycosylation sites in 108 human proteins with structures and 2247 proteins without structures that have acquired NXS/T site/s due to non-synonymous variation. The tool, Structure Feature Analysis Tool (SFAT), is freely available to the public at http://hive.biochemistry.gwu.edu/tools/sfat. | Phuc Vinh Nguyen Lam Radoslav Goldman Konstantinos Karagiannis Tejas Narsule Vahan Simonyan Valerii Soika Raja Mazumder | 2013 | Genomics, Proteomics & Bioinformatics2013，11，2： | 8 |
| 2 | Data-driven Optimal Control Strategy for Virtual Synchronous Generator via Deep Reinforcement Learning Approach显示文摘This paper aims at developing a data-driven optimal control strategy for virtual synchronous generator (VSG) in the scenario where no expert knowledge or requirement for system model is available. Firstly, the optimal and adaptive control problem for VSG is transformed into a reinforcement learning task. Specifically, the control variables, i.e., virtual inertia and damping factor, are defined as the actions. Meanwhile, the active power output, angular frequency and its derivative are considered as the observations. Moreover, the reward mechanism is designed based on three preset characteristic functions to quantify the control targets: ① maintaining the deviation of angular frequency within special limits;② preserving well-damped oscillations for both the angular frequency and active power output;③ obtaining slow frequency drop in the transient process. Next, to maximize the cumulative rewards, a decentralized deep policy gradient algorithm, which features model-free and faster convergence, is developed and employed to find the optimal control policy. With this effort, a data-driven adaptive VSG controller can be obtained. By using the proposed controller, the inverter-based distributed generator can adaptively adjust its control variables based on current observations to fulfill the expected targets in model-free fashion. Finally, simulation results validate the feasibility and effectiveness of the proposed approach. | Yushuai Li Wei Gao Weihang Yan Shuo Huang Rui Wang Vahan Gevorgian David Wenzhong Gao | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，4： | 2 |
| 3 | Exploring the limits of complexity: A survey of empirical studies on graph visualisation显示文摘For decades,researchers in information visualisation and graph drawing have focused on developing techniques for the layout and display of very large and complex networks.Experiments involving human participants have also explored the readability of different styles of layout and representations for such networks.In both bodies of literature,networks are frequently referred to as being‘large’or‘complex’,yet these terms are relative.From a human-centred,experiment point-of-view,what constitutes‘large’(for example)depends on several factors,such as data complexity,visual complexity,and the technology used.In this paper,we survey the literature on human-centred experiments to understand how,in practice,different features and characteristics of node–link diagrams affect visual complexity. | Vahan Yoghourdjian Daniel Archambault Stephan Diehl Tim Dwyer Karsten Klein Helen C.Purchase Hsiang-Yun Wu | 2018 | Visual Informatics2018，2，4： | 2 |
| 4 | Transition zone studies of vegetable fiber-cement paste composites显示文摘 | Holmer Savastano Jr Vahan Agopyan | | 0，，21： | 1 |
| 5 | Plant fibre reinforced cement components for roofing显示文摘 | HOLMER SAVASTANO JR VAHAN AGOPYAN ADRIANA M | 1999 | Construction and Building Materials1999，13，8： | 1 |
| 6 | Integrated high-concentration PV Near-term alternative for low-cost large-scale solar electric power显示文摘 | Vahan Garboushian Dave Roubideaux Sewang Yoon | 1997 | Solar Energy Materials and Solar Cells1997，47，14： | 1 |
| 7 | Plant fibre reinforced cement components for roofing显示文摘 | Holmer Savastano Jr Vahan Agopyan | | 0，，： | 1 |
| 8 | Plant fibre re- inforced cement components for roofing显示文摘 | HOLMER S J VAHAN A U ADRIANA M N | 1999 | Construction and Building Materials1999，13，8： | 1 |
| 9 | Transition zone studies of vegetable fiber-cement paste composites显示文摘 | Holmer Savastano Jr Vahan Agopyan | | 0，，21： | 1 |
| 10 | Plant fibre reinforced cement components for roofing显示文摘 | Holmer Savastano Jr Vahan Agopyan | | 0，，： | 1 |
| 11 | Comparison of Endothelial Cell Loss and Surgically Induced Astigmatism following Conventional Extracapsular Cataract Surgery, Manual Small-Incision Surgery and Phacoemulsification显示文摘 | Ronnie George Pankaj Rupauliha A. V. Sripriya P. S. Rajesh P. Vishnu Vahan Smita Praveen | 2005 | Ophthalmic Epidemiology2005，，5： | 1 |
| 12 | Plant fibre reinforced cement components for roofing显示文摘 | Holmer Savastano Jr Vahan Agopyan Adriana M Nolasco | 1999 | Construction and Building Materials1999，13，8： | 1 |
| 13 | Subtotal esophagectomy with extended 2-field lymph node dissection for thoracic esophageal cancer显示文摘 | Ivan Stilidi Michail Davydov Vahan Bokhyan | 2003 | European journal of Cardio-tho-racic Surgery2003，23，： | 1 |
| 14 | Optical design considerations for high-concentration photovoltaics显示文摘 | VAHAN G ROBERT G | 2006 | SPIE2006，6339，63： | 1 |
| 15 | Plant fibre reinforced cement components for roofing 显示文摘 | Holmer Savastano Jr Vahan Agopyan Adriana M | 1999 | Construction and Building Materials1999，，13： | 1 |
| 16 | Effect of pH on citrinin and red pigments production by Monascus purpureus CCT3802显示文摘 | SANDRA FERNANDA BILBAO OROZCO BEATRIZ VAHAN KILIKIAN | 2008 | World J Microbiol Biotechnol2008，24，： | 1 |
| 17 | SNVDis:A Proteome-wide Analysis Service for Evaluating nsSNVs in Protein Functional Sites and Pathways显示文摘Amino acid changes due to non-synonymous variation are included as annotations for individual proteins in UniProtKB/Swiss-Prot and RefSeq which present biological data in a protein-or gene-centric fashion. Unfortunately, proteome-wide analysis of non-synonymous singlenucleotide variations (nsSNVs) is not easy to perform because information on nsSNVs and functionally important sites are not well integrated both within and between databases and their search engines. We have developed SNVDis that allows evaluation of proteome-wide nsSNV distribution in functional sites, domains and pathways. More specifically, we have integrated human-specific data from major variation databases (UniProtKB, dbSNP and COSMIC), comprehensive sequence feature annotation from UniProtKB, Pfam, RefSeq, Conserved Domain Database (CDD) and pathway information from Protein ANalysis THrough Evolutionary Relationships (PANTHER) and mapped all of them in a uniform and comprehensive way to the human reference proteome provided by UniProtKB/Swiss-Prot. Integrated information of active sites, pathways, binding sites, domains, which are extracted from a number of different sources, provides a detailed overview of how nsSNVs are distributed over the human proteome and pathways and how they intersect with functional sites of proteins. Additionally, it is possible to find out whether there is an over-or under-representation of nsSNVs in specific domains, pathways or user-defined protein lists. The underlying datasets are updated once every 3 months. SNVDis is freely available at http://hive.biochemistry.gwu.edu/tool/snvdis. | Konstantinos Karagiannis Vahan Simonyan Raja Mazumder | 2013 | Genomics, Proteomics & Bioinformatics2013，11，2： | 1 |
| 18 | Transition zone studies of vegetable fiber-cement paste composites 显示文摘 | Holmer SavastanoJr Vahan Agopyan | 1999 | Cement and Concrete Composites1999，，21： | 1 |
| 19 | Comparison of endothelial cell loss and surgically induced astigmatism following conventional extracapsular cataract surgery, manual small-incision surgery and phacoemulsification显示文摘 | George R Rupauliha P Sripriya AV Rajesh PS Vahan PV Praveen S | 2005 | Ophthalmic Epidemiol2005，12，5： | 1 |
| 20 | Optical design considerations for high-concentration photovoltaics显示文摘 | Vahan G Robert G | | 0，，： | 1 |
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