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| 1 | Severe scrub typhus infection: Clinical features, diagnostic challenges and management显示文摘Scrub typhus infection is an important cause of acute undifferentiated fever in South East Asia. The clinical picture is characterized by sudden onset fever with chills and non-specific symptoms that include headache, myalgia, sweating and vomiting. The presence of an eschar, in about half the patients with proven scrub typhus infection and usually seen in the axilla, groin or inguinal region, is characteristic of scrub typhus. Common laboratory findings are elevated liver transaminases, thrombocytopenia and leukocytosis. About a third of patients admitted to hospital with scrub typhus infection have evidence of organ dysfunction that may include respiratory failure, circulatory shock, mild renal or hepatic dysfunction, central nervous system involvement or hematological abnormalities. Since the symptoms and signs are non-specific and resemble other tropical infections like malaria, enteric fever, dengue or leptospirosis, appropriate laboratory tests are necessary to confirm diagnosis. Serological assays are the mainstay of diagnosis as they are easy to perform; the reference test is the indirect immunofluorescence assay(IFA) for the detection of Ig M antibodies. However in clinical practice, the enzyme-linked immuno-sorbent assay is done due to the ease of performing this test and a good sensitivity and sensitivity when compared with the IFA. Paired samples, obtained at least two weeks apart, demonstrating a ≥ 4 fold rise in titre, is necessary for confirmation of serologic diagnosis. The mainstay of treatment is the tetracycline group of antibiotics or chloramphenicol although macrolides are used alternatively. In mild cases, recovery is complete. In severe cases with multi-organ failure, mortality may be as high as 24%. | John Victor Peter Thomas I Sudarsan John Anthony J Prakash George M Varghese | 2015 | World Journal of Critical Care Medicine2015，4，3： | 13 |
| 2 | Vanishing bile duct syndrome in human immunodeficiency virus: Nevirapine hepatotoxicity revisited显示文摘Vanishing bile duct syndrome (VBDS) refers to a group of disorders characterized by prolonged cholestasis as a result of destruction and disappearance ofintrahepatic bile ducts. Multiple etiologies have been indentifi ed including infections, neoplastic disorders, autoimmune conditions and drugs. The natural history of this condition is variable and may involve resolution of cholestasis or progression with irreversible damage. VBDS is extremely rare in human immunodeficiency virus (HIV)-infected patients and anti-retroviral therapy has never been implicated as a cause. We encountered a young pregnant female with HIV and VBDS secondary to anti-retroviral therapy. Here, we report her clinical course and outcome. | Rajan Kochar Moises I Nevah Frank J Lukens Michael B Fallon Victor I Machicao | 2010 | World Journal of Gastroenterology2010，16，26： | 6 |
| 3 | The rendezvous technique for the treatment of choledocholithiasis显示文摘 | Mari M. Calvo Luis Bujanda I?aki Heras José L. Cabriada Antonio Bernal Victor Orive José Miguelez | 2001 | Gastrointestinal Endoscopy2001，，4： | 2 |
| 4 | Mental health in the post-COVID-19 era:challenges and the way forward显示文摘The COVID-19 pandemic has posed a serious threat to global mental health.Multiple lines of evidence suggest that there is a varying yet considerable increase in mental health issues among the general population and vulnerable groups.12 The aftermath is obscure and speculative from a social,economic,individual and public mental health perspective.Recently published studies support the existence of an emotional epidemic curve,describing a high probability of an increase in the burden of mental health issues in the post-pandemic era.34 Furthermore,previous major public health emergencies showed that more than half of the population devel-oped mental health problems and required mental health intervention.45 There is,therefore,an urgent need to reorganise existing mental health services to address the current unmet needs for mental health and to prepare for future challenges in the postpandemic era in terms of prevention and management. | Ramyadarshni Vadivel Sheikh Shoib Sarah El Halabi Samer El Hayek LamiaàEssam Drita Gashi Bytyçi Ruta Karaliuniene Andre Luiz Schuh Teixeira Sachin Nagendrappa Rodrigo Ramalho Ramdas Ransing Victor Pereira-Sanchez Chonnakarn Jatchavala Frances Nkechi Adiukwu Ganesh Kudva Kundadak | 2021 | General Psychiatry2021，34，1： | 2 |
| 5 | A surface plasmon resonance array biosensor based on spectroscopic imaging显示文摘 | Michael J O Brien I I Victor H Perez-Luna Brueck S R J | 2001 | Biosensors Bioelectronics2001，16，： | 1 |
| 6 | Design, the Future and the Hu- man Spirit显示文摘 | I Victor Margolin | 2007 | Design Issues2007，23，3： | 1 |
| 7 | Stability of Ag nanoparticles dispersed in amphiphilic organic matrix显示文摘 | Elena I S Vera V K Victor V K | 2004 | Journal of Crystal Growth2004，21，： | 1 |
| 8 | Laccase eatalysed oxidation of syringic acid: Calorimetric determination of kinetic parameters 显示文摘 | NATALIA V VICTOR I RAJNI H K | 2012 | Enzyme and Microbial Technology2012，，50： | 1 |
| 9 | TIS7 regulation of the beta-catenin/Tcf-4 target gene osteopontin(OPN)is histone deacetylase-dependent显示文摘 | Victor I Kurzbauer R Brosch G | | 0，，48： | 1 |
| 10 | Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ显示文摘 | Jedeszko C Victor BC Podgorski I | | 0，，23： | 1 |
| 11 | Environmentally-Friendly Physico Chemical Rapid Ultrasonicrecycling of Fumed Silica- filled Poly (dimethyl siloxane) Vulcanizate 显示文摘 | Shim S E Victor V Y Isayeva I | 2004 | Green Che mistry2004，，6： | 1 |
| 12 | Diagnostic value of cervical discography in management of cervical discogenic pain secondary to whiplash Injuries and its predictive value for cervical fusion显示文摘 | Victor W Isaac I Faisel M | 2005 | Am J Phys Med Rehabil2005，84，1： | 1 |
| 13 | Comparison between magnetic resonance cholangiopancreatography and ERCP for evaluation of the pancreatic duct显示文摘 | Mari M Calvo Luis Bujanda Angel Calderón I?aki Heras José L Cabriada Antonio Bernal Victor Orive Elena Astigarraga | 2002 | The American Journal of Gastroenterology2002，，2： | 1 |
| 14 | Fluorescence studies of the calcium binding to whiting (Gadus merlangus) parvalbumin显示文摘 | Permyakov E A Victor I Yarmolenko V V | | 0，，01： | 1 |
| 15 | Added value of Virtual Touch IQ shear wave elastography in the ul- trasound assessment of breast lesions显示文摘 | Victor I Laura Maria C Ariane D | 2014 | Eur J Radi- oi2014，83，5： | 1 |
| 16 | Effect of UV irradiation on enzymatic activities and physicochemical properties of apple juices from different varieties显示文摘 | Victor F Jordi P Albert I | 2011 | LWT-Food Science and Technology2011，44，： | 1 |
| 17 | Enhanced expression of vascular endothelial growth factor in pulmonary arteries of smokers and patients with moderate chronic obstructive pulmonary disease显示文摘 | Santos S Victor I Peinado VI | 2003 | Am J Respir Crit Care Med2003，167，9： | 1 |
| 18 | Three-dimensional partial zona dissection for preimplantation genetic diagnosis and assisted hatching显示文摘 | Jeanine C Victor I Georg W | 1999 | Fertil Steril1999，71，： | 1 |
| 19 | Consumer - based Brand Equity: Development and Validation of a Measurement Instrument 显示文摘 | Vazquez R Rio D Belen A Victor I | 2002 | Journal of Marketing Management2002，18，2： | 1 |
| 20 | Tairus hydrothermal synthetic sapphires doped with nickel and chromium 显示文摘 | Victor G Rudolf I Sergey M | 1997 | Gems & Gemology1997，33，3： | 1 |
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