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| 1 | Extracellular vesicles in the diagnosis and treatment of central nervous system diseases显示文摘Extracellular vesicles,including exosomes and microvesicles,play a fundamental role in the activity of the nervous system,participating in signal transmission between neurons and providing the interaction of central nervous system with all body systems.In many neurodegenerative diseases,neurons pack toxic substances into vesicles and release them into the extracellular space,which leads to the spread of misfolded neurotoxic proteins.The contents of neuron-derived extracellular vesicles may indicate pathological changes in the central nervous system,and the analysis of extracellular vesicle molecular content contributes to the development of non-invasive methods for the diagnosis of many central nervous system diseases.Extracellular vesicles of neuronal origin can be isolated from various biological fluids due to their ability to cross the blood-brain barrier.Today,the diagnostic potential of almost all toxic proteins involved in nervous system disease pathogenesis,specificallyα-synuclein,tau protein,superoxide dismutase 1,FUS,leucine-rich repeat kinase 2,as well as some synaptic proteins,has been well evidenced.Special attention is paid to extracellular RNAs mostly associated with extracellular vesicles,which are important in the onset and development of many neurodegenerative diseases.Depending on parental cell type,extracellular vesicles may have different therapeutic properties,including neuroprotective,regenerative,and anti-inflammatory.Due to nano size,biosafety,ability to cross the blood-brain barrier,possibility of targeted delivery and the lack of an immune response,extracellular vesicles are a promising vehicle for the delivery of therapeutic substances for the treatment of neurodegenerative diseases and drug delivery to the brain.This review describes modern approaches of diagnosis and treatment of central nervous system diseases using extracellular vesicles. | Alisa A.Shaimardanova Valeriya V.Solovyeva Daria S.Chulpanova Victoria James Kristina V.Kitaeva Albert A.Rizvanov | 2020 | Neural Regeneration Research2020，15，4： | 7 |
| 2 | The evolution of integrative medical education: the influence of the University of Arizona Center for Integrative Medicine显示文摘The University of Arizona Center for Integrative Medicine(Az CIM) was founded in 1994 with a primary focus of educating physicians in integrative medicine(IM). Twenty years later, IM has become an internationally recognized movement in medicine. With 40% of United States' medical schools having membership in the Academic Consortium for Integrative Medicine and Health it is foreseeable that all medical students and residents will soon receive training in the principles and practices of IM. The Az CIM has the broadest range and depth of IM educational programs and has had a major infl uence on integrative medical education in the United States. This review describes the fellowship, residency and medical student programs at Az CIM as well as other signifi cant national drivers of IM education; it also points out the challenges faced in developing IM initiatives. The fi eld of IM has matured with new national board certifi cation in IM requiring fellowship training. Allied health professional IM educational courses, as well as integrative health coaching, assure that all members of the health care team can receive training. This review describes the evolution of IM education and will be helpful to academic centers, health care institutions, and countries seeking to introduce IM initiatives. | Victoria Maizes Randy Horwitz Patricia Lebensohn Hilary McClafferty James Dalen Andrew Weil | 2015 | Journal of Integrative Medicine2015，13，6： | 5 |
| 3 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 4 | Gabapentin does not improve multimodal analgesia outcomes for total knee arthroplasty: a randomized controlled trial显示文摘 | James E. Paul Manyat Nantha-Aree Norman Buckley Ji Cheng Lehana Thabane Antonella Tidy Justin DeBeer Mitchell Winemaker David Wismer Dinshaw Punthakee Victoria Avram | 2013 | Canadian Journal of Anesthesia/Journal canadien d’anesthésie2013，，5： | 1 |
| 5 | Anthropogenic ocean acidification over the twenty-first century and its impact on calcifying organisms显示文摘 | JAMES C O VICTORIA J F OLIVIER A | 2005 | Nature2005，437，： | 1 |
| 6 | Gpx4 protects mitochondrial ATP generation against oxidative damage显示文摘 | Hanyu Liang Holly Van Remmen Victoria Frohlich James Lechleiter Arlan Richardson Qitao Ran | 2007 | Biochemical and Biophysical Research Communications2007，，4： | 1 |
| 7 | Distinct patterns of E - cadherin CpG island methylation in papillary ,follicular, hurthles cell, and poorly differentiated human thyroid carcinoma 显示文摘 | Jeremy GR Victoria EG James GH | 1998 | Cancer Res1998，58，： | 1 |
| 8 | Early-Life Sodium Exposure Unmasks Susceptibility to Stroke in Hyperlipidemic, Hypertensive Heterozygous Tg25 Rats Transgenic for Human Cholesteryl Ester Transfer Protein显示文摘 | Julius L. Decano Jason C. Viereck Ann C. McKee James A. Hamilton Nelson Ruiz-Opazo Victoria L.M. Herrera | 2009 | Circulation2009，，11： | 1 |
| 9 | Incidence of Additional Primary Cancers in Patients with Invasive Intraductal Papillary Mucinous Neoplasms and Sporadic Pancreatic Adenocarcinomas显示文摘 | Taylor S. Riall Victoria M. Stager William H. Nealon Courtney M. Townsend Yong-fang Kuo James S. Goodwin Jean L. Freeman | 2007 | Journal of the American College of Surgeons2007，，5： | 1 |
| 10 | Anthropogenic ocean acidification over the twenty-first century and its impact on calcifying organisms显示文摘 | James C Orr Victoria J Fabry Olivier Aumont | 2005 | Nature2005，437，： | 1 |
| 11 | Extended-Field-of-View Three-Dimensional Transesophageal Echocardiography Using Image-Based X-Ray Probe Tracking显示文摘 | R. James Housden YingLiang Ma Aruna Arujuna Niels Nijhof Pascal Cathier Geert Gijsbers Roland Bullens Jaswinder Gill C. Aldo Rinaldi Victoria Parish Kawal S. Rhode | 2013 | Ultrasound in Medicine & Biology2013，，6： | 1 |
| 12 | Perfusion-CT Assessment of Infarct Core and Penumbra: Receiver Operating Characteristic Curve Analysis in 130 Patients Suspected of Acute Hemispheric Stroke显示文摘 | Max Wintermark Adam E. Flanders Birgitta Velthuis Reto Meuli Maarten van Leeuwen Dorit Goldsher Carissa Pineda Joaquin Serena Irene van der Schaaf Annet Waaijer James Anderson Gary Nesbit Igal Gabriely Victoria Medina Ana Quiles Scott Pohlman Marcel Quist | 2006 | Stroke2006，，4： | 1 |
| 13 | Five-year Analysis of Operative Mortality and Neonatal Outcomes in Congenital Heart Disease显示文摘 | James R. Padley Andrew D. Cole Victoria E. Pye Richard B. Chard Ian A. Nicholson Stephen Jacobe David Baines Nadia Badawi Karen Walker Gabbie Scarfe Karen Leclair Gary F. Sholler David S. Winlaw | 2011 | Heart, Lung and Circulation2011，，7： | 1 |
| 14 | Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission显示文摘 | Christina Chu Jean Boyer Daniel Schullery Phyllis Gimotty Victoria Gamerman James Bender Bruce Levine George Coukos Stephen Rubin Mark Morgan Robert Vonderheide Carl June | 2012 | Cancer Immunology, Immunotherapy2012，，5： | 1 |
| 15 | Effect of 5'-regulatory region polymorphism on paraoxonase gene (PON) expression显示文摘 | Victoria H Rachel L James B | 2001 | Am J Hum Genet2001，68，： | 1 |
| 16 | Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models显示文摘 | Taylor James G Cheuk Adam T Tsang Patricia S Chung Joon-Yong Song Young K Desai Krupa Yu Yanlin Chen Qing-Rong Shah Kushal Youngblood Victoria Fang Jun Kim Su Young Yeung Choh Helman Lee J Mendoza Arnulfo Ngo Vu Staudt Louis M Wei Jun S | 2009 | Journal of Clinical Investigation2009，，11： | 1 |
| 17 | Interaction between climatic, environmental, and demographic factors on cholera outbreaks in Kenya显示文摘Background:Cholera remains an important public health concern in developing countries including Kenya where 11,769 cases and 274 deaths were reported in 2009 according to the World Health Organization(WHO).This ecological study investigates the impact of various climatic,environmental,and demographic variables on the spatial distribution of cholera cases in Kenya.Methods:District-level data was gathered from Kenya’s Division of Disease Surveillance and Response,the Meteorological Department,and the National Bureau of Statistics.The data included the entire population of Kenya from 1999 to 2009.Results:Multivariate analyses showed that districts had an increased risk of cholera outbreaks when a greater proportion of the population lived more than five kilometers from a health facility(RR:1.025 per 1%increase;95%CI:1.010,1.039),bordered a body of water(RR:5.5;95%CI:2.472,12.404),experienced increased rainfall from October to December(RR:1.003 per 1 mm increase;95%CI:1.001,1.005),and experienced decreased rainfall from April to June(RR:0.996 per 1 mm increase;95%CI:0.992,0.999).There was no detectable association between cholera and population density,poverty,availability of piped water,waste disposal methods,rainfall from January to March,or rainfall from July to September.Conclusion:Bordering a large body of water,lack of health facilities nearby,and changes in rainfall were significantly associated with an increased risk of cholera in Kenya. | James D Stoltzfus Jane Y Carter Muge Akpinar-Elci Martin Matu Victoria Kimotho Mark J Giganti Daniel Langat Omur Cinar Elci | 2014 | Infectious Diseases of Poverty2014，3，1： | 1 |
| 18 | Polymorphisms in the glutathione S-transferase mu cluster are associatedwith tumour progression and patient outcome in colorectal cancer显示文摘 | Sarah Holley Ramesh Rajagopal Paul Hoban Mark Deakin Adeshina Fawole James Elder Jackie Elder Victoria Smith Richard Strange Anthony Fryer | 2006 | International Journal of Oncology2006，，1： | 1 |
| 19 | ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma显示文摘 | Victoria Sanz-Moreno Cedric Gaggioli Maggie Yeo Jean Albrengues Fredrik Wallberg Amaya Viros Steven Hooper Richard Mitter Chloé C. Féral Martin Cook James Larkin Richard Marais Guerrino Meneguzzi Erik Sahai Chris J. Marshall | 2011 | Cancer Cell2011，，2： | 1 |
| 20 | Symptom Control and Quality of Life in LUX-Lung 3: A Phase III Study of Afatinib or Cisplatin/Pemetrexed in Patients With Advanced Lung Adenocarcinoma With EGFR Mutations显示文摘 | James Chih-Hsin Yang Vera Hirsh Martin Schuler Nobuyuki Yamamoto Kenneth J. O’Byrne Tony S.K. Mok Victoria Zazulina Mehdi Shahidi Juliane Lungershausen Dan Massey Michael Palmer Lecia V. Sequist | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
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