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| 1 | Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma显示文摘AIM: To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma (HCC)eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria.METHODS: Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were: (1) histological assessment of tumor grade by means of percutaneous biopsies; (2) determination of AFP mRNA status in the blood; (3) patient's eligibility for radical therapies.RESULTS: At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery (resection or liver transplantation) was performed in 29 patients,while 21 had percutaneous ablation procedures. After a median follow-up of 28 mo, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables (AFP mRNA, HCC grade and gross vascular invasion) resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile (AFP mRNA negative and well-differentiated tumor without gross vascular invasion) as independent survival variables.CONCLUSION: The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies. | Umberto Cillo Alessandro Vitale Filippo Navaglia Daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus Vito De Pascale Mario Plebani Davide Francesco D'Amico | 2005 | World Journal of Gastroenterology2005，11，44： | 12 |
| 2 | De novo autoimmune hepatitis in liver transplant: State-of-the-art review显示文摘In the two past decades, a number of communications, case-control studies, and retrospective reports have appeared in the literature with concerns about the development of a complex set of clinical, laboratory and histological characteristics of a liver graft dysfunction that is compatible with autoimmune hepatitis. The de novo prefix was added to distinguish this entity from a pre-transplant primary autoimmune hepatitis, but the globally accepted criteria for the diagnosis of autoimmune hepatitis have been adopted in the diagnostic algorithm. Indeed, de novo autoimmune hepatitis is characterized by the typical liver necroinflammation that is rich in plasma cells, the presence of interface hepatitis and the consequent laboratory findings of elevations in liver enzymes, increases in serum gamma globulin and the appearance of nonorgan specific auto-antibodies. Still, the overall features of de novo autoimmune hepatitis appear not to be attributable to a univocal patho-physiological pathway because they can develop in the patients who have undergone liver transplantation due to different etiologies. Specifically, in subjects with hepatitis C virus recurrence, an interferon-containing antiviral treatment has been indicated as a potential inception of immune system derangement. Herein, we attempt to review the currently available knowledge about de novo liver autoimmunity and its clinical management. | Ranka Vukotic Giovanni Vitale Antonia D'Errico-Grigioni Luigi Muratori Pietro Andreone | 2016 | World Journal of Gastroenterology2016，22，10： | 4 |
| 3 | Prospective validation of the Barcelona Clinic Liver Cancer staging system显示文摘 | Umberto Cillo Alessandro Vitale Francesco Grigoletto Fabio Farinati Alberto Brolese Giacomo Zanus Daniele Neri Patrizia Boccagni Nela Srsen Francesco D’Amico Francesco Antonio Ciarleglio Alessio Bridda Davide Francesco D’Amico | 2006 | Journal of Hepatology2006，，4： | 2 |
| 4 | Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress显示文摘 | Vitale M Di Matola T D'Ascoli F | 2000 | Endocrinology2000，141，2： | 1 |
| 5 | Large dinurnal fluctuations in intraocular pressure are an in- dependent risk factor in patients with glaucoma显示文摘 | Asrani S Zeimer R Wilensky J Gieser D Vitale S IAndenmuth K | 2000 | J Glauco- ma2000，9，2： | 1 |
| 6 | Iodide excess induces apoptosis in thyroid cells through a p53-independ- ent mechanism involving oxidative stress 显示文摘 | Vitale M Di Matola T D'Ascoli F | 2000 | Endocrinol- ogy2000，141，2： | 1 |
| 7 | Venous thromboembo- lism and lung cancer: a review显示文摘 | Vitale C D'Amato M Calabrb P | 2015 | Muhidiscip Respir Med2015，10，1： | 1 |
| 8 | Identification of a TGF-beta responsive element in the human elastin promoter显示文摘 | Margio V Volpin D Vitale G | 1994 | Biochem Biophys Res Commun1994，99，2： | 1 |
| 9 | Levosimendan pre-treat- ment improves outcomes in patients undergoing coronary artery bypass graft surgery显示文摘 | Tritapepe L De Santis V Vitale D | 2009 | Br J Anaesth2009，102，2： | 1 |
| 10 | Effect of gonadotropin - releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells显示文摘 | Vitale AM Abramovich D Peluffo MC | 2006 | Fertil Steril2006，85，4： | 1 |
| 11 | Neurological manifestations of Whipple disease 显示文摘 | Vital D Gerard A Rousset H | 2002 | Rev Neurol2002，158，： | 1 |
| 12 | Muhiorgan failure is an adaptive, endocrine- mediated metabolic response to overwhelming systemic in- flammation显示文摘 | Singer M De Santis V Vitale D | 2001 | Lancet2001，361，： | 1 |
| 13 | Management of uterine leiomyomas in pregnancy:review of literature显示文摘 | Vitale SG Tropea A Rossetti D | | 0，，03： | 1 |
| 14 | Film conden- sation in inclined tubes with noncondensable gases: An experimental study on the local heat transfer coefficient 显示文摘 | Caruso G Vitale Di Maio D Naviglio A | 2013 | International Communications in Heat and Mass Transfer2013，45，： | 1 |
| 15 | Bone marrow-derived mesenchymal cell dift~rentiation toward myogenic lineages: facts and perspectives显示文摘 | Galli D Vitale M Vaccarezza M | 2014 | Biomed Res lnt2014，，76： | 1 |
| 16 | Aliasing effects mitigation by optimized sampling grids and impact on image acquisition chains 显示文摘 | VITALLI R BELLO U D ARMBRUSTER P | 2002 | IEEE2002，，： | 1 |
| 17 | Muhiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelm- ing systemic inflammation 显示文摘 | Singer M De Santis V Vitale D | 2004 | Lancet2004，364，9433： | 1 |
| 18 | Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress显示文摘 | Vitale M Di Matola T D'Ascoli F | 2000 | Endocrinology2000，141，2： | 1 |
| 19 | Purification and partial character- ization of a peroxidase from plant cell cultures of cassia didymo- botrya and biotransformation studies显示文摘 | Vitall A Botta B Monache G D | 1998 | Biochemical Journal1998，331，2： | 1 |
| 20 | Selective Cyclooxygenase-1 inhibition by P6 and gastrotoxicity: preliminary investigation显示文摘 | Perrone M G Lofrumento D D Vitale P | 2015 | Pharmacology2015，95，12： | 1 |
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