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		题名	作者	年代	出处	被引量
	1	Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis.	Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács	2007	World Journal of Gastroenterology2007，13，33：	5
	2	Therapeutic effect of interleukin-12 on mouse haemangiosarcomas is not associated with an increased anti-tumor cytotoxic T-lymphocyte activity 显示文摘	Vizler C Rosato A Calderazzo F	1998	Br J Cancer1998，77，4：	1
	3	Melanoma cell-deri- ved exosomes alter macrophage and dendritic cell functions in vitro 显示文摘	MARTON A VIZLER C KUSZ E	2012	Immunol Lett2012，148，1：	1
	4	Identification of mo- lecular determinants of tumor sensitivity and resistance to anticancer drugs 显示文摘	Quintieri L Fantin M Vizler C	2007	Adv Exp Med Biol2007，593，：	1
	5	Pathophysiological effects of human TNF-alpha-producing tumor xenografts in immunosuppressed mice显示文摘	Nagy T Janossy T Vizler C	1999	APMIS1999，107，10：	1
	6	Melanoma cell-derived exosomes alter macrophage and dendritic cell functions in vitro显示文摘	Annamaria Marton Csaba Vizler Erzsebet Kusz Viktoria Temesfoi Zsuzsa Szathmary Krisztina Nagy Zsolt Szegletes Gyorgy Varo Laszlo Siklos Robert L. Katona Vilmos Tubak O.M. Zack Howard Erno Duda Janos Minarovits Katalin Nagy Krisztina Buzas	2012	Immunology Letters2012，，：	1
	7	Systemic adminis- tration of agonist peptide blocks the progression of spontaneous CDS-mediated autoimmune diabetes in transgenic mice withoutbystanderdamage 显示文摘	Bercovici N Heurtier A Vizler C	2000	J Immunol2000，165，1：	1
	8	Melanoma cell-derived exosomes alter macrophage and dendritic cell functions in vitro显示文摘	Annamaria Marton Csaba Vizler Erzsebet Kusz Viktoria Temesfoi Zsuzsa Szathmary Krisztina Nagy Zsolt Szegletes Gyorgy Varo Laszlo Siklos Robert L. Katona Vilmos Tubak O.M. Zack Howard Erno Duda Janos Minarovits Katalin Nagy Krisztina Buzas	2012	Immunology Letters2012，，1：	1
	9	Restoration of Motor Function through Delayed Intraspinal Delivery of Human IL-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury显示文摘Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment of an injured spinal cord and promote neuroprotection and functional recovery is a great challenge.Nucleoside-modified messenger RNA(mRNA)has become a promising new modality that can be utilized for the safe and efficient delivery of therapeutic proteins.Here,we used lipid nanoparticle(LNP)-encapsulated human interleukin-10(hIL-10)-encoding nucleoside-modified mRNA to induce neuroprotection and functional recovery following rat spinal cord contusion injury.Intralesional administration of hIL-10 mRNA-LNP to rats led to a remarkable reduction of the microglia/macrophage reaction in the injured spinal segment and induced significant functional recovery compared to controls.Furthermore,hIL-10 mRNA treatment induced increased expression in tissue inhibitor of matrix metalloproteinase 1 and ciliary neurotrophic factor levels in the affected spinal segment indicating a time-delayed secondary effect of IL-105 d after injection.Our results suggest that treatment with nucleoside-modified mRNAs encoding neuroprotective factors is an effective strategy for spinal cord injury repair.	LászlóGál Tamás Bellák Annamária Marton Zoltán Fekécs Drew Weissman Dénes Török Rachana Biju Csaba Vizler Rebeka Kristóf Mitchell B.Beattie Paulo J.C.Lin Norbert Pardi Antal Nógrádi Krisztián Pajer	2023	Research2023，，4：	0

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