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您的检索式：作者名="WAN Chenyi"
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| 1 | Application of microneedle-based vaccines in biosecurity显示文摘Countries must have strong early warning,detection,and response capabilities in the face of the risks and challenges posed by major infectious diseases and bioterrorism threats.Vaccination is one of the most effective means for countries to maintain biosecurity and respond to bioterrorism attacks.Microneedles are emerging as a potential vaccine delivery method with minimal pain,no bleeding,and the ability to be self-administered,doing away with the need for professional health care workers.This last advantage,particularly if combined with room temperature preservation,could have an important role in improving national biosecurity through large-scale,rapid deployment of a biological vaccine.In this review,we summarized the research status of microneedles,including the types,materials,and production technologies of microneedles.Recent progress regarding microneedles in the field of biosecurity is introduced and challenges in its future application are discussed. | Zhiying Jin Baohua Zhao Wei Wan Yue Li Xuexin Bai Chenyi Hu Jing Wang Yanwei Li Wenwen Xin Lin Kang Hao Yang Jinglin Wang Shan Gao | 2022 | Journal of Biosafety and Biosecurity2022，4，1： | 0 |
| 2 | Efficacy of Heshouwu(Radix Polygoni Multiflori)on gut mircobiota in mice with autoimmune encephalomyelitis显示文摘OBJECTIVE:To learn the mechanisms between gut microbiome and the autoimmunity benefits on Traditional Chinese Medicine(TCM)in central nervous system(CNS),we investigated the neuro-protection effects and gut mircobiota changes of Heshouwu(Radix Polygoni Multiflori)on experimental autoimmune encephalomyelitis(EAE),an animal model of multiple sclerosis(MS).METHODS:Mice were randomly divided into four groups:EAE mice(control phosphate-buffered saline group),50 mg·kg^(-1)·d^(-1)Heshouwu(Radix Polygoni Multiflori)-treated EAE mice,100 mg·kg^(-1)·d^(-1)Heshouwu(Radix Polygoni Multiflori)-treated EAE mice,and 200 mg·kg^(-1)·d^(-1)Heshouwu(Radix Polygoni Multiflori)-treated EAE mice.The spinal cords were stained with hematoxylin and eosin(HE)and luxol fast blue for evaluating inflammatory infiltration and demyelination.The percentages of granulocyte macrophage-colony stimulating factor(GM-CSF)+CD4+,interleukin 17(IL-17)+CD4+,Foxp3 CD4+,and interferon-γ(IFN-γ)+CD4+T cells in the inguinal lymph nodes(LNs)and brain were determined by flow cytometry analysis.16S rRNA gene sequencing was employed to analyze the changes in gut microbiota.RESULTS:We found that Heshouwu(Radix Polygoni Multiflori)alleviated the disease severity and neuropathology of EAE as evaluated by clinical and histopathologyical scores.Heshouwu(Radix Polygoni Multiflori)increased the diversity and abundance of the gut microbiota,and decreased Firmicutes/Bacteroidetes ratio(F/B ratio).Heshouwu(Radix Polygoni Multiflori)also decreased the concentrations of IL-10,and IL-21 and increase the levels of GM-CSF,IL-17A,IL-17F and IL-22 in serum of EAE mice.Moreover,Heshouwu(Radix Polygoni Multiflori)modulated the T cell responses by inhibiting Th17 cells and restoring Treg cells in the small intestine lymphoid tissues and inguinal lymph nodes.Microbiota-depleted mice receiving Heshouwu(Radix Polygoni Multiflori)-treated fecal microbiota transplantation had lower disease severity,neuropathology scores and alleviation of Th17/Treg imbalance compared to ad libitum group.CONCLUSIONS:Our findings suggested that the vital neuro-protection role of Heshouwu(Radix Polygoni Multiflori)(TCM)in immunomodulation effects partly by regulations of gut microbiome. | ZHOU Jun WANG Junhua LI Xiaobing WAN Chenyi LI Fangjun LüYanni CHEN Hao SUN Meiying | 2023 | Journal of Traditional Chinese Medicine2023，43，4： | 0 |
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