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| 1 | Genome-wide Association Analyses Reveal the Genetic Basis of Stigma Exsertion in Rice显示文摘耻辱 exsertion,交配系统的米饭的一个关键决定因素,极大地在米饭贡献杂种优势的申请。尽管与耻辱 exsertion 联系的一些量的特点 loci 是印射或克隆的罚款,内在的基因建筑学仍然保持不清楚。我们用在 Oryza sativa 的 533 多样的就职描绘的 650 万 SNP 在耻辱 exsertion 和相关花的特点上执行了染色体宽的协会研究。我们识别了显著地与耻辱 exsertion 和相关特点,其三与三主要谷物尺寸基因 GS3, GW5,和 GW2 co 局部性被联系的 23 genomic loci。进一步的分析显示这三基因由控制小穗状花小穗和耻辱的尺寸和形状影响了耻辱 exsertion。GS3 和 GW5 的联合大部分定义耻辱 exsertion 和相关特点的层次。这二基因的选择在 O 的 subpopulations 之中导致了花的特点的特定的分布。sativa。低耻辱 exsertion 联合 gw5GS3 在栽培米饭变化的一半存在;因此,介绍 GW5gs3 联合进男无菌的线具有为改进混合米饭的种子生产的高潜力。 | Hao Zhou Pingbo Li WeiboXie Saddam Hussain Yibo Li Duo Xia Hu Zhao Shengyuan Sun Junxiao Chen Hong Ye Jun Hou Da Zhao Guanjun Gao Qinglu Zhang Gongwei Wang Xingming Lian Jinghua Xiao Sibin Yu Xianghua Li Yuqing He | 2017 | Molecular Plant2017，10，4： | 15 |
| 2 | Human organoids in basic research and clinical applications显示文摘Organoids are three-dimensional(3D)miniature structures cultured in vitro produced from either human pluripotent stem cells(hPSCs)or adult stem cells(AdSCs)derived from healthy individuals or patients that recapitulate the cellular heterogeneity,structure,and functions of human organs.The advent of human 3D organoid systems is now possible to allow remarkably detailed observation of stem cell morphogens,maintenance and differentiation resemble primary tissues,enhancing the potential to study both human physiology and developmental stage.As they are similar to their original organs and carry human genetic information,organoids derived from patient hold great promise for biomedical research and preclinical drug testing and is currently used for personalized,regenerative medicine,gene repair and transplantation therapy.In recent decades,researchers have succeeded in generating various types of organoids mimicking in vivo organs.Herein,we provide an update on current in vitro differentiation technologies of brain,retinal,kidney,liver,lung,gastrointestinal,cardiac,vascularized and multi-lineage organoids,discuss the differences between PSC-and AdSC-derived organoids,summarize the potential applications of stem cell-derived organoids systems in the laboratory and clinic,and outline the current challenges for the application of organoids,which would deepen the understanding of mechanisms of human development and enhance further utility of organoids in basic research and clinical studies. | Xiao-Yan Tang Shanshan Wu Da Wang Chu Chu Yuan Hong Mengdan Tao Hao Hu Min Xu Xing Guo Yan Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 10 |
| 3 | Mycoplasma pneumoniae Macrolide Resistance and MLVA Typing in Children in Beijing,China,in 2016:Is It Relevant?显示文摘Objective The aim of this study is to investigate the macrolide resistance rate and molecular type with multiple-locus variable-number tandem-repeat analysis(MLVA)of Mycoplasma pneumoniae of Beijing in 2016 in pediatric patients.Methods Real-time quantitative polymerase chain reaction(PCR)was used to identify M.pneumoniae,and MLVA was performed.The domain V of the 23 S rRNA was sequenced to detect macrolide-resistant point mutations.We also investigated the activities of antibiotics against M.pneumoniae isolates in vitro.Results The PCR detection rate of M.pneumoniae in children in Beijing was 40%,and the macrolide resistance rate was 66%.The A2063 G mutation in the 23 S rRNA V region is the dominant mutation(137/146,93.84%),whereas the A2064 G mutation is rare(9/146,6.16%).Seventy-three samples were typed successfully by MLVA typing,including 86.3%(63/73)were MLVA type 4-5-7-2,and 13.7%(10/73)were MLVA type 3-5-6-2.No other types were found.No strains were resistant to levofloxacin or tetracycline.Conclusion In 2016,a specific decrease in the macrolide resistance rate occurred in Beijing.The detection rate and macrolide resistance rate of outpatients are lower than those of inpatients.The A2063 G mutants M.pneumoniae have high levels of resistance to erythromycin and azithromycin.The primary MLVA type is 4-5-7-2,followed by 3-5-6-2.No other MLVA types were detected.No strains resistant to tetracycline or levofloxacin were found in vitro. | DOU Hai Wei TIAN Xiu Jun XIN De Li WEI Ran ZHOU Wei WANG Hong QIN Xuan Guang SHAO Jun Yan XU Bao Ping GE Li Xia SHI Da Wei | 2020 | Biomedical and Environmental Sciences2020，33，12： | 9 |
| 4 | H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak显示文摘AIM To investigate the protective efficacy ofH2 strain attenuated live hepatitis A vaccines(H2-strain vaccines)in hepatitis A(HA)outbreaks.METHODS With the permission of theirparents,5551 pre-school and grade 1-3 primaryschool children were inoculated with 1 dose(106.5TCID50)of H2-strain vaccines in anonrandomized,controlled trial conducted inFucheng County,Hebei Province in May 1997.Another 6485 children in the same grades andcompatible in gender and age were enrolled ascontrols.Epidemiological and serological surveywas conducted to evaluate the protectiveefficacy of the vaccines.ELISA was used todetect serum IgM anti-HAV.RESULTS HA outbreak started in early May1998,peaked in the middle of the same month,and lasted about 80 days.Overall 302 HA caseswere found,192(53.58%)were 5-9 years old.One vaccinee and 25 control cases were found tohave hepatitis A,which account for 0.28%(1/356)and 5.92%(25/422)of all vaccinees andcontrols in the 14 villages,respectively.The protective efficacy of vaccines was 95.27%(95% Cl:85.83%-104.72%).In subjects testedfor anti-HAV IgM from 13 villages,1(0.40%)overt and 11(4.06%)asymptomatic HAV caseswere found in 271 vaccinees,but 21(6.69%)ofovert and asymptomatic ones were found in 314controls.CONCLUSION H2 strain vaccines were excellent in preventing overt hepatitis A, but not so effective in preventing asymptomatic hepatitis A virus infection. A booster dose might be needed to get permanent reliable immunity. | Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu | 2000 | World Journal of Gastroenterology2000，6，6： | 7 |
| 5 | Catalytic Dechlorination of Chlorobenzene in Water by Pd/Fe System显示文摘Chlorobenzene was dechlorinated by Pd/Fe bimetallic system in water through catalytic reduction. The dechlorination rate increases with increase of bulk loading of Pd due to the increase of both the surface loading of the Pd and the total surface area. For conditions with 0.005% Pd/Fe, 45% dechlorination efficiency was achieved within 5 h. The dechlorinated reaction is believed to take place on the bimetal surface in a pseudo-first-order reaction, with the rate constant being 0.0043 min-1. | Xin Hua XU*, Hong Yi ZHOU, Da Hui WANG Department of Environmental Engineering, Zhejiang University, Hangzhou 310027 | 2003 | Chinese Chemical Letters2003，14，7： | 6 |
| 6 | Regulatory effects of electro-acupuncture at Zusanfi on ir-SP content in rat pituitary gland and peripheral blood and their immunity显示文摘INTRODUCTIONIt has been reported in many studies that electro-acupuncture(EA)can positively regulate erythrocyticimmunity and T-lymphocytic subgroups.Nevertheless,its mechanism remains to be explored.In thepresent study,a multi-group,multi-stepped and multi-indexed observation was conducted on the effects of EA | Wei Gao Yu Xin Huang Hong Chen Da Yong Song Qin Li Wang Department of Gastroenterology Medical Affair Office,Tangdu Hospital,4th Military Medical University,Xi’an 710038,Shanxi Province,China Department of Gastroenterology,Chinese PLA General Hospital of Guangzhou Command Area,Guangzhou 510210,Guangdong Province,China | 2000 | World Journal of Gastroenterology2000，6，4： | 5 |
| 7 | Higher sea surface temperature in the northern South China Sea during the natural warm periods of late Holocene than recent decades显示文摘The large-scale syntheses of global mean temperatures in IPCC fourth report suggested that the Northern Hemisphere temperature in the second half of the 20th century was likely the highest in at least the past1,300 years and the 1990s was likely the warmest decade.However,this remains debated and the controversy is centered on whether temperatures during the recent half century were higher than those during the Medieval Climate Anomaly(MCA,AD 800–1300)and the Roman Warm Period(RWP,BC 200–AD 400),the most recent two natural warm periods of the late Holocene.Here the high resolution sea surface temperatures(SSTs)of two time windows around AD 990(±40)and AD 50(±40),which located in the MCA and RWP respectively,were reconstructed by the Sr/Ca ratio and d18O of Tradacna gigas shells from the northern South China Sea.The results suggested that the mean SSTs around AD 990(±40)and AD 50(±40)were 28.1°C and 28.7°C,0.8°C and 1.4°C higher than that during AD 1994–2005,respectively.These records,together with the tree ring,lake sediment and literature records from the eastern China and northwest China,imply that the temperatures in recent decades do not seem to exceed the natural changes in MCA,at least in eastern Asia from northwest China to northern SCS. | Hong Yan Liguang Sun Da Shao Yuhong Wang Gangjian Wei | 2014 | Chinese Science Bulletin2014，59，31： | 4 |
| 8 | Catalytic dechlorination of chlorobenzene in water by Pd/Fe bimetallic system显示文摘Catalytic reductive dechlorination of monochlorobenzene(MCB) was carried out in the palladium/iron system. With low Pd loading(0 005%), 45% dechlorination efficiency was achieved within 5 h. Pd as catalyst accelerated the reductive dechlorination reaction. Dechlorination mechanism and kinetics were discussed. The reaction took place on the bimetal surface in a pseudo first order reaction, with the rate constant being 0 0071 min -1 ( K SA =8 0×10 -3 L/(m 2·h). The reduction product for MCB was benzene. | ZHOU Hong yi 1,2* , XU Xin hua 1, WANG Da hui 1 (1 Department of Environmental Engineering, Zhejiang University, Hangzhou 310027, China. 2 College of Biological & Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China) | 2003 | Journal of Environmental Sciences2003，15，5： | 4 |
| 9 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 10 | Defective T wave combined with incomplete right bundle branch block: a new electrocardiographic index for diagnosing atrial septal defect显示文摘 | WANG Mu-xuan WU Gui-fu GU Jing-li LI Li LU Kun YANG Da CHEN Long ZHANG Xi LUO Fu-tian Andrew D. Michaels MA Hong | 2012 | Chinese Medical Journal2012，，6： | 4 |
| 11 | A novel linear microprobe array for the fabrication of neural microelectrodes显示文摘A novel linear microprobe array(LMPA)has been developed by a conventional microfabrication method from silicon.The LMPA leverages the properties of conventional microwire with additional features of naturally formed regular spacing.With the help of periodic microprobe arrays and double-side V-grooves fabricated in advance between each pair of the two microprobes’rear ends,the number of microprobe units for assembly in one array can be flexibly chosen by cleavage fracture from the LMPA.The fabrication method was demonstrated and the prototype device was assessed by electrochemical impedance spectroscopy(EIS)and in vivo test.The SNR of the spikes recorded was 6. | ZHAO Shan Shan PEI Wei Hua ZHAO Hui WANG Yi Jun CHEN San Yuan CHEN Yuan Fang ZHANG He GUO Dong Mei GUI Qiang CHEN Hong Da | 2015 | Science China(Technological Sciences)2015，58，2： | 3 |
| 12 | Hepatic encephalopathy complicated with hyponatremia and acid-base disturbance and its prognosis显示文摘Objective:To improve the diagnosis and therapeutic effect of occurrence and development of hyponatremia and disorder of acid-base balance among patients with hepatic encephalopathy(HE) by elucidating the regularity and mechanism,as well as its influence on prognosis.Methods:327 HE patients admitted to our hospital from January 1990 to June 2010 were enrolled.Meanwhile 316 patients hospitalized in the medical department of the same hospital were chosen as the control group.Patients in both groups were given the same methods to measure arterial blood gas parameters(pH value,PaCO2,[HCO3-],TCO2,BE and SaO2),blood biochemistry([Na+],[K+],[Cl-]),liver function,kidney function and blood glucose,serum sodium,and thereupon tocalculate the anion gap(AG) and the potential [HCO3-],and acid-base balance disorder.Results:Among the 327 HE patients,hyponatremia was found in 188 cases(57.4%),of whom 132 patients died(70.2%).While among the 316 patients in control group,68 presented with hyponatremia(21.5%),and 19 died(27.9%).The incidence and mortality were significantly different between the two groups(P<0.001).All the 327 patients presented with different degrees of acid-base balance disorder and 178 died(54.4%),in whom 164(50.2%) belonged to simple acid-base balance disorder and 74(45.1%) died,136(41.6%) were dual acid-base balance disorder and 80(58.8%) died,27(8.2%) were triple acid-base disturbance and 24(88.9%) died.Whereas in the control group only 83 patients(26.2%) were recognized as simple and dual acid-base balance disorder,and 18(21.7%) died.There was higher incidence of acid-base balance disorder and mortality rate in HE group than control one(P<0.001).Conclusion:Hyponatremia is valuable to judge HE patients' prognosis.The key parameters in the judgment and evaluation on acid-base balance disorder among HE patients are the change of pH values and serum electrolyte values.When pH value ≤ 7.30 or > 7.55,it generally suggests a poor prognosis. | Ren Chengshan Wang Lei Zhao Xiaoyan Yang Shiming Zhang Yanqi Wang Xiwen Bo Jianying Zhang Pengbin Guo Hong Ling Xianlong Li Yihui Da Siping Xie Xia Ren Wei Li Chunhua Qian Guisheng | 2012 | Journal of Medical Colleges of PLA(China)2012，27，3： | 3 |
| 13 | Transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site显示文摘hepatocellular 癌压制或 1 (HCCS1 ) 基因被在肝癌症的从杂合现象(17p13.3 ) 的损失的一个占优势的区域的两位置的克隆并且由为在大规模 transfection 试金影响房间增长的基因的功能的屏蔽识别。它的过去在在房间文化的房间增长和在裸体鼠标的肿瘤生长的抑制的表达式结果。理解它的抄写规定,倡导者建筑学详细被把了。抄写的主要开始被对 C 残余的教材扩展印射, ATG 在上游的 177 核苷酸上哄骗。由在短暂 transfection 试金估计最小的倡导者(到 +148 区域的 -60 )的一套扫描连接器的异种的倡导者活动,我们发现 +1 到 40 区域是的+对 HCCS1 基因抄写批评,为抄写因素 NF-kappaB (到 +7 的 -21 和到 +26 的 +40 )的包含的有约束力的地点, p53 (到 +9 的 +29 )和 et (到 +20 的 +4 和到 +39 的 +23 )。生物化学、分子的分析表明 ETS 抄写因素 ETS-2 和 Elf-1 在 situ 绑在二个 et 地点并且显著地作出贡献到抄写结盟 HCCS1 基因的活跃状态,当时 NF-kappaB , p53 和 ETS 家庭( ETS-1 和 NERF2 )的二个另外的成员看起来起很少作用。我们的观察提供卓见进 HCCS1 抄写规定的机械学的方面。房间研究(2006 ) 16:780-796。做 i:10.1038/sj .cr.7310092;出版联机 2006 年 9 月 5 日。 | Jing De Zhu Qi Fei Peng Wang Fei Lan Da Qin Mao Hong Yu Zhang Xue Biao Yao | 2006 | Cell Research2006，16，9： | 3 |
| 14 | Effects of IκBα and its mutants on NF-κB and p53 signaling pathways显示文摘AIM: To study the effects of IκBα and its mutants (IκBαM, IκBα243N, IκBαM244C) on NF-κB, p53 and their downstream target genes. The relationship of NF- κB, p53, and IκBα was further discussed.METHODS: pECFP-IκBα, pECFP-IκBαM (amino acides 1-317, Ser32, 36A), pECFP-IκBα243N (amino acides 1-243), pECFP-IκBα244C (amino acides 244-317), pEYFP-p65 and pp53-DsRed were constructed and transfected to ASTC-α-1 cells. Cells were transfected with pECFP-C1 as a control. 30 h after the transfection, location patterns of NF-κB, p53 and IκBα (IκBαM, IκBα243N, IκBα244C) were observed by a laser scanning microscope (LSM510/ConfoCor2, Zeiss). RNA extraction and reverse transcription were performed in cells transfected or co-transfected with different plasmids. Effects of IκBα and its mutants on the transprition level of NF-κB, NF-κB downstream target gene TNF-α, p53 and p53 downstream target gene Bax were observed by real time QT-PCR. In all experiments β-actin was reference. Results are expressed as the target/reference ratio of the sample divided by the target/reference ratio of the control. Different transfected cells were incubated with CCK-8 for 2 h in the incubator. Then the absorbance at 450 nm was measured by using a microplate reader. RESULTS: Cells that were transfected with p53- DsRed revealed a predominant nuclear localization. YFP-p65 mainly existed in the cytoplasm. Cells were transfected with CFP-IκBα, CFP-IκBαM, and CFP- IκBα243N respectively and revealed a predominant cytosolic localization. However, cells transfected of CFP- IκBα244C revealed a predominant nuclear localization. The mRNA levels of p65, TNF-α, p53 and Bax in CFP-IκBα transfected cells did not change significantly, while in YFP-p65/CFP-IκBα co-transfected cells, IκBα decreased the transcription of p65 downstream gene TNF-α (2.24 ± 0.503) compared with the YFP-p65/ CFP-C1 co-transfected cells (5.08 ± 0.891) (P < 0.05). Phosphorylation defective IκBα (IκBαM) decreased the transcription levels of all the four genes compared with the control (P < 0.05). The N terminus of IκBα (IκBα243N) increased the transcription of NF-κB (1.84 ± 0.176) and TNF-α (1.51 ± 0.203) a little bit. However, the C terminus of IκBα (IκBα244C) increased the transcription of NF-κB, TNF-α, p53 and Bax significantly (8.29 ± 1.662, 14.16 ± 2.121, 10.2 ± 0.621, 3.72 ± 0.346) (P < 0.05). The CCK-8 experiment also showed that IκBα244C and p53 synergistically mediate apoptosis. CONCLUSIONS: IκBα and its mutants (IκBαM, IκBα243N, IκBαM244C) have different effects on NF- κB and p53 signaling pathways, according to their different structures. IκBαM bounds with NF-κB and p53 in cytoplasm steadily, and inhibits both of the two signaling pathways. p53 and IκBα244C may be co-factor in inducing apoptosis. The C terminal of IκBα enhanced cell death, which suggests that it may be a pro-apoptotic protein existed in cells. | Xian Li Da Xing Ju Wang De-Bin Zhu Lan Zhang Xiao-Jia Chen Fen-Yong Sun An Hong | 2006 | World Journal of Gastroenterology2006，12，41： | 3 |
| 15 | Photo-promoted carbonylation of chloroalkanes with carbon monoxide by non-precious metal catalysts显示文摘The photo-promoted carbonylation of chloroalkanes with carbon monoxide was carried out under ambient conditions with copper and cadmium salts catalysts. The results indicated that the corresponding esters were produced with three salt catalysts, i.e. CuBr2, CuCl2 and CdI2. Among these catalysts, CdI2 was the most efficient in terms of ester yield and selectivity, particularly, 60% yield and 75% selectivity in the carbonylation of chlorocyclohexane were achieved. Furthermore, the yield and selectivity of the ester can be improved greatly by adding tri-n-butylamine in the CuBr2 and CuCl2 catalyst systems. On the other hand, the carbonylation did not proceed with single CdCl2, however, the catalytic activity of CdCl2 was increased greatly with NaIá2H2O as additive. As a result, we suggest that iodide ion plays an important role in the catalyst system of the cadmium salts. | Hong Wei Wang Ying Ping Jia Da Bin Gao Jing Mei Yin Guang-Yun-Zhou Shen Min Li | 2007 | Chinese Chemical Letters2007，18，7： | 3 |
| 16 | Application of phase-field method in rechargeable batteries显示文摘Rechargeable batteries have a profound impact on our daily life so that it is urgent to capture the physical and chemical fundamentals affecting the operation and lifetime.The phase-field method is a powerful computational approach to describe and predict the evolution of mesoscale microstructures,which can help to understand the dynamic behavior of the material systems.In this review,we briefly introduce the theoretical framework of the phase-field model and its application in electrochemical systems,summarize the existing phase-field simulations in rechargeable batteries,and provide improvement,development,and problems to be considered of the future phase-field simulation in rechargeable batteries. | Qiao Wang Geng Zhang Yajie Li Zijian Hong Da Wang Siqi Shi | 2020 | npj Computational Materials2020，，1： | 3 |
| 17 | Curcumin Inhibits Proliferation and Induces Apoptosis of Human Colorectal Cancer Cells by Activating the Mitochondria Apoptotic Pathway显示文摘 | Li‐da Guo Xue‐jie Chen Yu‐hong Hu Zhi‐jun Yu Duo Wang Jing‐ze Liu | 2012 | Phytother. Res2012，，3： | 2 |
| 18 | Genomic analyses reveal distinct genetic architectures and selective pressures in Chinese donkeys显示文摘Donkey(Equus asinus)is an important livestock animal in China because of its draft and medicinal value.After a long period of natural and artificial selection,the variety and phenotype of donkeys have become abundant.We clarified the genetic and demographic characteristics of Chinese domestic donkeys and the selection pressures by analyzing 78 whole genomes from 12 breeds.According to population structure,most Chinese domestic donkeys showed a dominant ancestral type.However,the Chinese donkeys still represented a significant geographical distribution trend.In the selective sweep,gene annotation,functional enrichment,and differential expression analyses between large and small donkey groups,we identified selective signals,including NCAPG and LCORL,which are related to rapid growth and large body size.Our findings elucidate the evolutionary history and formation of different donkey breeds and provide theoretical insights into the genetic mechanism underlying breed characteristics and molecular breeding programs of donkey clades. | Jiafei Shen Jie Yu Xuelei Da Mei Li Gang Wang Ningbo Chen Hong Chen Chuzhao Lei Ruihua Dang | 2021 | Journal of Genetics and Genomics2021，48，8： | 2 |
| 19 | Hepatitis B virus X protein sensitizes cells to starvation‐induced autophagy via up‐regulation of beclin 1 expression显示文摘 | Hong Tang Liang Da Yi Mao Ying Li Dong Li Zhenhua Xu Feng Li Yifei Wang Pierre Tiollais Tsaiping Li Mujun Zhao | 2008 | Hepatology2008，，1： | 2 |
| 20 | Optimization and temperature effects on sandwich betavoltaic microbattery显示文摘The design scheme of a sandwich-structure betavoltaic microbattery based on silicon using63Ni is presented in this paper.This structure differs from a monolayer energy conversion unit.The optimization of various physical parameters and the effects of temperature on the microbattery were studied through MCNP.For the proposed optimization design,P-type silicon was used as the substrate for the betavoltaic microbattery.Based on the proposed theory,a sandwich microbattery with a shallow junction was fabricated.The temperature dependence of the device was also measured.The open-circuit voltaic(Voc)temperature dependence of the optimized sandwich betavoltaic microbattery was linear.However,the Voc of the betavoltaic microbattery with a high-resistance substrate exponentially decreased over the range of room temperature in the experiment and simulation.In addition,the sandwich betavoltaic microbattery offered higher power than the monolayer betavoltaic one.The results of this paper provide a significant technical reference for optimizing the design and studying temperature effects on betavoltaics of the same type. | LIU YunPeng TANG XiaoBin XU ZhiHeng HONG Liang WANG Peng CHEN Da | 2014 | Science China(Technological Sciences)2014，57，1： | 2 |
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