|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘 | Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou | 2015 | Cell Research2015，25，2： | 39 |
| 2 | Expression of miR-125b in the new,highly invasive glioma stem cell and progenitor cell line SU3显示文摘MicroRNA (miR)-125b has been shown to play a potential role in the development of glioma stem cells.However,the relationship between miRNA and glioma stem cells is still elusive.This study was designed to elucidate this potential relationship.We established a highly invasive glioma stem cell and progenitor (GSCP) cell line SU3.SU3 cell suspensions were injected into nude mice brains in situ,and the invasiveness of graft tumors was analyzed using hematoxylin and eosin staining as well as immunohistochemistry.Real-time polymerase chain reaction (PCR) was used to measure the expression levels of miR-125b in SU3 and other cells.In vitro,SU3 cells expressed CD133 and nestin as well as differentiation markers glial fibrillary acidic protein (GFAP) and β-tubulin III,which were consistent with the characteristics of glioma stem cells.Scratch assays indicated that the migration ability of SU3 cells was stronger than that of U251 stem cells (U251s).In vivo,SU3 cells invaded into each part of the mouse brain from the caudate nucleus in a diffuse pattern and highly expressed invasive and proliferative cell markers matrix metalloprotease 2 (MMP2),MMP9,and Ki-67.Real-time PCR results revealed that the levels of miR-125b and MMP9 were significantly higher in SU3 and SU2,also a highly invasive GSCP cell line we established before,than in U251s.High expression of miR-125b both in newly established GSCPs,SU3,and long-term cultured GSCPs,SU2 suggests that miR-125b exhibits oncogene-like behavior.This behavior should be considered in further studies of miR-125b in cancer stem cells.Furthermore,MMP9,which plays a role in cancer stem cell invasion,may be a target gene of miR-125b. | Yi Wan Xi-Feng Fei Zhi-Min Wang Dong-Yi Jiang Han-Chun Chen Jian Yang Lei Shi Qiang Huang | 2012 | Chinese Journal of Cancer2012，31，4： | 25 |
| 3 | Atg7 is required for acrosome biogenesis during spermatogenesis in mice显示文摘acrosome 是盖住精子原子核的前面的部分并且在授精的过程起一个必要作用的一个专业化细胞器。位于这个 lysosome 相关的细胞器(LRO ) 的生物的续生说下面的分子的机制大部分仍然是未知的。这里,我们显示出房间特定的 Atg7 大美人老鼠是的那个细菌由于在 acrosome 生物的续生说的一个缺点不肥沃并且显示了类似于人的 globozoospermia 的显型;这个繁殖缺点被 intracytoplasmic 精子注射成功地救。而且,在细菌房间的 Atg7 的弄空没影响细菌房间的开发的早阶段,但是精子发生在以后上演,在 Golgi 期间没有通过到保险丝进一个单个 acrosomal 泡的 proacrosomal 泡分阶段执行,它最后导致了不规则或将近 round-headed 精子。Autophagic 流动在弄空 Atg7 的细菌房间被破坏,最后导致 LC3 变化形式的失败到 Golgi 导出仪器的泡。另外, Atg7 部分调整了另一 globozoospermia 相关的蛋白质,联系 Golgi 的 PDZ 卷和卷卷包含主题的蛋白质(GOPC ) ,在 acrosome 生物的续生说期间。最后,任何一个 autophagy 的注射或进睾丸的 lysosome 禁止者导致了类似的显型到细菌的房间特定的 Atg7 大美人老鼠。总的来说,我们的结果揭开为在 acrosome 的生物的续生说的 Atg7 的一个新角色,并且我们提供证据为 acrosome 支持 autolysosome 起源假设。 | Hongna Wang Haifeng Wan Xixia Li Weixiao Liu Qi Chen Yaqing Wang Lin Yang Hongmei Tang Xiujun Zhang Enkui Duan Xiaoyang Zhao Fei Gao Wei Li | 2014 | Cell Research2014，24，7： | 25 |
| 4 | Nomogram to predict overall survival after gallbladder cancer resection in China显示文摘AIM To integrate clinically significant variables related to prognosis after curative resection for gallbladder carcinoma(GBC) into a predictive nomogram.METHODS One hundred and forty-two GBC patients who underwent curative intent surgical resection at Peking Union Medical College Hospital(PUMCH) were included. This retrospective case study was conducted at PUMCH of the Chinese Academy of Medical Sciences and Peking Union Medical College(CAMS & PUMC) in China from January 1, 2003 to January 1, 2018. The continuous variable carbohydrate antigen 19-9(CA19-9) was converted into a categorical variable(cCA19-9) based on the normal reference range. Stages 0 to IIIA were merged into one category, while the remaining stages were grouped into another category. Pathological grade X(GX) was treated as a missing value. A multivariate Cox proportional hazards model was used to select variables to construct a nomogram. Discrimination and calibration of the nomogram were performed via the concordance index(C-index) and calibration plots. The performance of the nomogram was estimated using the calibration curve. Receiver operating characteristic(ROC) curve analysis and decision curve analysis(DCA) were performed to evaluate the predictive accuracy and net benefit of the nomogram, respectively.RESULTS Of these 142 GBC patients, 55(38.7%) were male, and the median and mean age were 64 and 63.9 years, respectively. Forty-eight(33.8%) patients in this cohort were censored in the survival analysis. The median survival time was 20 months. A series of methods, including the likelihood ratio test and Akaike information criterion(AIC) as well as stepwise, forward, and backward analyses, were used to select the model, and all yielded identical results. Jaundice [hazard ratio(HR) = 2.9; 95% confidence interval(CI): 1.60-5.27], cCA19-9(HR = 3.2; 95%CI: 1.91-5.39), stage(HR = 1.89; 95%CI: 1.16-3.09), and resection(R)(HR = 2.82; 95%CI: 1.54-5.16) were selected as significant predictors and combined into a survival time predictive nomogram(C-index = 0.803; 95%CI: 0.766-0.839). High prediction accuracy(adjusted C-index = 0.797) was further verified via bootstrap validation. The calibration plot demonstrated good performance of the nomogram. ROC curve analysis revealed a high sensitivity and specificity. A high net benefit was proven by DCA.CONCLUSION A nomogram has been constructed to predict the overall survival of GBC patients who underwent radical surgery from a clinical database of GBC at PUMCH. | Yi Bai Zhi-Song Liu Jian-Ping Xiong Wei-Yu Xu Jian-Zhen Lin Jun-Yu Long Fei Miao Han-Chun Huang Xue-Shuai Wan Hai-Tao Zhao | 2018 | World Journal of Gastroenterology2018，24，45： | 25 |
| 5 | Status quo of soil petroleum contamination and evolution of bioremediation显示文摘Along with the rapid development of oil industries internationally,petroleum prospecting and exploitation activities are growing intensively.Especially in China,with the fastest economic growth in the world and shortage of petroleum resources,we are leading the practices of petroleum deep exploitation.Obviously,the risk of damage to the natural environment from these activities is high.Oil contamination in soils and groundwater is becoming a big issue along with pesticide pollution,which makes organic pollution prevention and control (OPPC) much more complex.In this paper,based on recent research on oil-contaminated soil at home and abroad,we make comments on the remediation technologies for polluted soil,emphasizing bioremediation techniques and degradation mechanisms in order to push forward research into bound organic pollution prevention and control (OPPC),especially in China. | Du Weidong Wan Yunyang Zhong Ningning Fei Jiajia ZhangZhihuan Chen Lijun Hao Jiming | 2011 | Petroleum Science2011，8，4： | 19 |
| 6 | Wheel/rail dynamic interaction due to excitation of rail corrugation in high-speed railway显示文摘Characteristics of wheel-rail dynamic interaction due to the rail corrugation in a high-speed railway are analyzed based on the theory of vehicle-track coupled dynamics in this paper.Influences of the corrugation wavelength and depth on the wheel-rail dynamic performance are investigated.The results show that,under the excitation of a measured rail corrugation,the wheel-rail dynamic interaction of high-speed railway is enhanced obviously,and the high-frequency dynamic force between wheel and rail is generated,which has an obvious impact on the vibrations of the wheelset and rail,and little effect on the vibration of the frame and carbody.If the corrugation wavelength is shorter than the sensitive wavelength,the wheel-rail vertical force will increase with the growth of the corrugation wavelength,otherwise,it will decrease.However,the wheel-rail vertical force keeps increasing with the growth of corrugation depth.Furthermore,if the corrugation wavelength is shorter than the sensitive wavelength,the wheel-rail vertical force will increase with the decrease of the running speed,otherwise,it will decrease.It is also found that the critical wavelength of corrugation increases with the growth of the corrugation depth and the running speed,and the critical depth of corrugation is nonlinearly related to the sensitive wavelength. | WANG Kai Yun LIU Peng Fei ZHAI Wan Ming HUANG Chao CHEN Zai Gang GAO JianMin | 2015 | Science China(Technological Sciences)2015，58，2： | 17 |
| 7 | Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells and Schwann cells显示文摘背景最重要的目的在受伤针的绳索移植研究是为 axonal 生长提供有利环境。而且,新接枝的持续发现正在提供新潜在地有趣移植候选人。我们的目的是观察神经干细胞(NSC ) 的合作移植的词法、功能的修理效果, Schwann 装壁板圩(SC ) 并且 poly rats.Methods 的针的绳索损害上的 lactide-co-glycolide 酸(PLGA ) PLGA 的脚手架被制作。NSC 和 SC 是有教养的,与用 5-bromodeoxyuridine 标记的 NSC,并且 NSC/PLGA 或 NSC+SCs/PLGA 的建筑群被构造。36 只 Wistar 老鼠随机被划分成三个组:组织 A (PLGA 的移植) ,组织 B (NSC/PLGA 的移植) 并且组织 C (NSC+SCs/PLGA 的移植) 。正确 hemicord 的 3 公里长度在所有老鼠在显微镜下面被移开。PLGA 或 PLGA-celIs 的建筑群被植入进损害地点。Basso-Beattie-Bresnahan (BBB ) 运动分数,马达和更低的手足潜在的唤起的 somatosensory 被检验听说康复感觉并且在在损害以后的 4 个星期, 8 个星期, 12 个星期和 24 个星期的马达功能。所有恢复针的绳索损害( SCI )纸巾被观察与他染色, immunohistochemistry ,和 transelectronmicroscopy 到在 4 个星期识别移植房间和神经纤维的新生的幸存,迁居和区别, 8 个星期,在到在损害以后的 24 个星期的从 4 个星期的 injury.Results ( 1 )以后的 12 个星期和 24 个星期,移植房间的组的 BBB 运动分数比 non-cell-transplanted 组的那些好,特别组 C ( P 0.05 )。somatosensory 的振幅唤起了潜力(9 月) ,唤起马达的潜力(MEP ) 在组 B 和 C 在损害以后被改进,但是在 4 个星期的 9 月和 MEP 的振幅在损害以后在 12 个星期和 24 个星期是比那低的。与组 B 相比,在组 C 的 9 月和 MEP 的振幅被改进。9 月和 MEP 的振幅没在组 A 在损害以后被改进。(2 ) 他染色表明支架的体积减少了,在支架的房间的数字增加了。成长得最新的 capillaries 能也被看见。染色的 Immunohistochemistry 证明移植 NSC 能幸存并且移居直到 24 个星期和他们能区分进神经原和 oligodendrocytes。改革轴突与 transelectronmicroscopy 在支架房间建筑群被观察。上述表明在在损害,和他们能区分进各种各样的神经房间以后,移植 NSC 能在老鼠的针的绳索熬过并且移居直到 24 个星期的组 C.Conclusions 是更广泛的。cells/PLGA 的合作移植能支持受伤针的绳索的功能的恢复。共同移植的效果 NSC+SCs/PLGA 比独自移植 NSC/PLGA 好。 | CHEN Gang HU Yan-rong WAN Hong XIA Lei LI Jun-hua YANG Fei QU Xue WANG Shen-guo WANG Zhong-cheng | 2010 | Chinese Medical Journal2010，，17： | 16 |
| 8 | Co-transplantation of neural stem cells and Schwann cells within poly (L-lactic-co-glycolic acid) scaffolds facilitates axonal regeneration in hemisected rat spinal cord显示文摘 | XIA Lei WAN Hong HAO Shu-yu LI De-zhi CHEN Gang GAO Chuan-chuan LI Jun-hua YANG Fei WANG Shen-guo LIU Song | 2013 | Chinese Medical Journal2013，，5： | 15 |
| 9 | Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality显示文摘Severe fever with thrombocytopenia syndrome (SFTS),an emerging tick-borne infectious disease caused by a novel phlebovirus (SFTS virus, SFTSV), was listed among the top 10 priority infectious diseases by the World Health Organization due to its high fatality of 12%-50% and possibility of pandemic transmission. Currently, effective anti-SFTSV intervention remains unavailable. Here, by screening a library of FDA-approved drugs, we found that benidipine hydrochloride, a calcium channel blocker (CCB), inhibited SFTSV replication in vitro. Benidipine hydrochloride was revealed to inhibit virus infection through impairing virus internalization and genome replication. Further experiments showed that a broad panel of CCBs, including nifedipine, inhibited SFTSV infection. The anti-SFTSV effect of these two CCBs was further an a lyzed in a humanized mouse model in which CCB treatment resulted in reduced viral load and decreased fatality rate. Importantly, by performing a retrospective clinical investigation on a large cohort of 2087 SFTS patients, we revealed that nifedipine administration enhaneed virus clearance, improved clinical recovery, and remarkably reduced the case fatality rate by >5-fold. These findings are highly valuable for developing potential host-oriented therapeutics for SFTS and other lethal acute viral infections known to be inhibited by CCBs in vitro. | Hao Li Lei-Ke Zhang Shu-Fen Li Shao-Fei Zhang Wei-Wei Wan Yu-Lan Zhang Qi-Lin Xin Ke Dai Yuan-Yuan Hu Zhi-Bo Wang Xiang-Tao Zhu Yu-Jie Fang Ning Cui Pan-He Zhang Chun Yuan Qing-Bin Lu Jie-Ying Bai Fei Deng Geng-Fu Xiao Wei Liu Ke Peng | 2019 | Cell Research2019，29，9： | 15 |
| 10 | Control of Leaf Senescence by an MeOH- Jasmonates Cascade that Is Epigenetically Regulated by OsSRT1 in Rice显示文摘 | ChuanYing Fang Hua Zhang Jian Wan YangYang Wu Kang Li Cheng Jin Wei Chen ShouChuang Wang WenSheng Wang HaiWei Zhang Pan Zhang Fei Zhang LiangHuan Qu Xianqing Liu Dao-Xiu Zhou Jie Luo | 2016 | Molecular Plant2016，9，10： | 14 |
| 11 | Seroepidemiological Investigation of Lyme Disease and Human Granulocytic Anaplasmosis among People Living in Forest Areas of Eight Provinces in China显示文摘Objective Lyme disease and Human granulocytic anaplasmosis are tick‐borne diseases caused by Borrelia burgdorferi and Anaplasma phagocytophilum respectively. We have investigated infection and co-infection of the two diseases in the population of forest areas of eight provinces in China by measuring seroprevalence of antibodies against B. burgdorferi and A. phagocytophilum. Methods Forest areas in 8 provinces were chosen for investigation using whole sampling and questionnaire survey methods. 3 669 serum samples from people in the forest areas were tested for the presence of antibodies by indirect immunofluorescent assay (IFA). Results Seroprevalence against B. burgdorferi was 3% to 15% and against A. phagocytophilum was 2% to 18% in the study sites in the 8 provinces in China. We also found co-infection of B. burgdorferi and A. phagocytophilum in 7 of the 8 provinces (the exception being the Miyun area in Beijing). The seroprevalence for both B. burgdorferi and A. phagocytophilum was significantly higher among people exposed to ticks than among people who were not exposed to ticks. Conclusion We conclude that both pathogens are endemic in the forest areas in the eight provinces, but the prevalence of B. burgdorferi and A. phagocytophilum differs between the provinces. | HAO Qin GENG Zhen HOU Xue Xia TIAN Zhen YANG Xiu Jun JIANG Wei Jia SHI Yan ZHAN Zhi Fei LI Guo Hua YU De Shan WANG Hua Yong XU Jian Guo WAN Kang Lin | 2013 | Biomedical and Environmental Sciences2013，26，3： | 13 |
| 12 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 13 | Screening beneficial bacteriostatic lactic acid bacteria in the intestine and studies of bacteriostatic substances显示文摘Lactic acid bacteria(LAB)are a representative probiotic.As the dominant flora in the human intestinal tract,LAB can regulate the balance of human intestinal flora and improve host health.The purpose of this study was to isolate and screen LAB that are well suited to the intestinal characteristics of the Chinese population,with excellent probiotics and high antibacterial activity.After 16S ribosomal RNA(rRNA)homology and phylogenetic tree analysis,potential probiotics were tested for their antibacterial activity,resistance to artificial gastrointestinal fluid and drugs,surface hydrophobicity,and safety.Three strains of LAB with acid resistance,bile salt resistance,epithelial cell adhesion,and no multidrug resistance were selected:Lactobacillus salivarius,Leuconostoc lactis,and Lactobacillus paracasei.Analysis of the antibacterial active substances in the three strains and their fermentation broths revealed that the main antibacterial substances of L.lactis were organic acids,whereas those of L.salivarius and L.paracasei were organic acids and bacteriocins with broad-spectrum antibacterial activity.These three strains of probiotic LAB with high antibacterial activity were identified as bacterial resources that could potentially be used to develop probiotic preparations for the prevention and treatment of intestinal diseases caused by intestinal pathogens. | Zhijing LIU Cong XU Ran TIAN Wan WANG Jiage MA Liya GU Fei LIU Zhanmei JIANG Juncai HOU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，7： | 10 |
| 14 | Self-nitrogen-doped porous biochar derived from kapok (Ceiba insignis) fibers: Effect of pyrolysis temperature and high electrochemical performance显示文摘Self-nitrogen-doped porous biochar derived from kapok fibers possesses unique structure and excellent electrochemical performance. In this study, one-step pyrolysis method was introduced to prepare porous biochar from kapok fibers, and effect of pyrolysis temperature on structure and electrochemical performance of the porous biochar was investigated. It was found that pyrolysis temperature played an important role in determining microstructure of the biochar. At the pyrolysis temperature of 750℃, the as-prepared biochar(C_(KF)-750) represented a largest specific surface area of 1125.7 m2 g^(-1) and pore volume of 0.7130 m^3 g^(-1), and hence brings C_(KF)-750 a highest specific capacitance of 283 Fg^(-1) at a current density of 1 A g^(-1) in a 6 mol L^(-1) KOH electrolyte. Furthermore, the cycle stability of C_(KF)-750 was wonderful,and the specific capacitance retained almost constant after 10000 cycles. Therefore, the pyrolysis temperature of 750℃ is optimal for the preparation of porous biochar as an outstanding electrode material for supercapacitor. | Jun-Rui Wang Feng Wan Qiu-Feng Lu Fei Chen Qilang Lin | 2018 | Journal of Materials Science & Technology2018，34，10： | 7 |
| 15 | Performance Analysis of NOMA-Based Cooperative Networks with Relay Selection显示文摘Non-orthogonal multiple access(NOMA)technique is an expert on channel differences exploiting.In this paper,a dual-hop NOMA-based cooperative relaying network where a best relay is selected as an active node to accomplish the communication between a source and a destination is discussed.We assume that both decode-and-forward(DF)and amplify-and-forward(AF)protocols are applied to the selected relay.The metrics that ergodic sum-rate and outage probability are investigated,and the closed-form expressions of the latter for DF and AF protocols are derived.Numerical and simulation results are conducted to verify the validity of the theoretical analysis,in which we can see that the NOMA based DF relaying is better than the NOMA based AF relaying and other existing NOMA-based cooperative communication schemes. | Ronglan Huang Dehuan Wan Fei Ji Hua Qing Jie Li Hua Yu Fangjiong Chen | 2020 | China Communications2020，17，11： | 6 |
| 16 | Using approximate dynamic programming for multi-ESM scheduling to track ground moving targets显示文摘This paper researches the adaptive scheduling problem of multiple electronic support measures(multi-ESM) in a ground moving radar targets tracking application. It is a sequential decision-making problem in uncertain environment. For adaptive selection of appropriate ESMs, we generalize an approximate dynamic programming(ADP) framework to the dynamic case. We define the environment model and agent model, respectively. To handle the partially observable challenge, we apply the unsented Kalman filter(UKF) algorithm for belief state estimation. To reduce the computational burden, a simulation-based approach rollout with a redesigned base policy is proposed to approximate the long-term cumulative reward. Meanwhile, Monte Carlo sampling is combined into the rollout to estimate the expectation of the rewards. The experiments indicate that our method outperforms other strategies due to its better performance in larger-scale problems. | WAN Kaifang GAO Xiaoguang LI Bo LI Fei | 2018 | Journal of Systems Engineering and Electronics2018，29，1： | 5 |
| 17 | Recent progress in organic solar cells(PartⅠmaterial science)显示文摘During past several years,the photovoltaic performances of organic solar cells(OSCs)have achieved rapid progress with power conversion efficiencies(PCEs)over 18%,demonstrating a great practical application prospect.The development of material science including conjugated polymer donors,oligomer-like organic molecule donors,fused and nonfused ring acceptors,polymer acceptors,single-component organic solar cells and water/alcohol soluble interface materials are the key research topics in OSC field.Herein,the recent progress of these aspects is systematically summarized.Meanwhile,the current problems and future development are also discussed. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，2： | 5 |
| 18 | Human adenovirus(HAdV)infection in children with acute respiratory tract infections in Guangzhou,China,2010–2021:a molecular epidemiology study显示文摘Background Human adenovirus(HAdV)infection can cause a variety of diseases.It is a major pathogen of pediatric acute respiratory tract infections(ARIs)and can be life-threatening in younger children.We described the epidemiology and subtypes shifting of HAdV among children with ARI in Guangzhou,China.Methods We conducted a retrospective study of 161,079 children diagnosed with acute respiratory illness at the Guangzhou Women and Children’s Medical Center between 2010 and 2021.HAdV specimens were detected by real-time PCR and the hexon gene was used for phylogenetic analysis.Results Before the COVID-19 outbreak in Guangzhou,the annual frequency of adenovirus infection detected during this period ranged from 3.92%to 13.58%,with an epidemic peak every four to fve years.HAdV demonstrated a clear seasonal distribution,with the lowest positivity in March and peaking during summer(July or August)every year.A signifcant increase in HAdV cases was recorded for 2018 and 2019,which coincided with a shift in the dominant HAdV subtype from HAdV-3 to HAdV-7.The latter was associated with a more severe disease compared to HAdV-3.The average mortality proportion for children infected with HAdV from 2016 to 2019 was 0.38%but increased to 20%in severe cases.After COVID-19 emerged,HAdV cases dropped to 2.68%,suggesting that non-pharmaceutical interventions probably reduced the transmission of HAdV in the community.Conclusion Our study provides the foundation for the understanding of the epidemiology of HAdV and its associated risks in children in Southern China. | Yi Chen Tao Lin Chang‑Bing Wang Wan‑Li Liang Guang‑Wan Lian Mark Zanin Sook‑San Wong Xin‑Gui Tian Jia‑Yu Zhong Ying‑Ying Zhang Jia‑Hui Xie Ling‑Ling Zheng Fei‑Yan Chen Run Dang Ming‑Qi Zhao Yi‑Yu Yang Rong Zhou Bing Zhu | 2022 | World Journal of Pediatrics2022，18，8： | 5 |
| 19 | Clinical guidelines of non-alcoholic fatty liver disease: A systematic review显示文摘AIM To perform a systematic review to grade guidelines and present recommendations for clinical management of non-alcoholic fatty liver disease(NAFLD).METHODS A database search was conducted on Pub Med for guidelines published before May 2016, supplemented by reviewing relevant websites. The Appraisal of Guidelines for Research and Evaluation(ARGEE) instrument Ⅱ was a tool designed to appraise the methodological rigor and transparency in which a clinical guideline is developed and it is used internationally. it was used to appraise the quality of guidelines in this study. The inclusion criteria include: clinical NAFLD guidelines for adults, published in English, and released by governmental agencies or key organizations.RESULTS Eleven guidelines were included in this study. Since 2007, guidelines have been released in Asia(3 in China, 1 in South Korea, and 1 in Japan), Europe(1 in italy),America(1 in United States and 1 in Chile) and three international agencies [European associations joint, Asia-Pacific Working Party and World Gastroenterology Organization(WGO)]. Using the ARGEE Ⅱ instrument, we found US 2012 and Europe 2016 had the highest scores, especially in the areas of rigor of development and applicability. Additionally, italy 2010 and Korea 2013 also presented comprehensive content, rigorous procedures and good applicability. And WGO 2014 offered various algorithms for clinical practice. Lastly, a practical algorithm for the clinical management was developed, based on the recommended guidelines.CONCLUSION This is the first systematic review of NAFLD guidelines. it may yield insights for physicians and policy-makers in the development and application of guidelines. | Jin-Zhou Zhu Kelseanna Hollis-Hansen Xing-Yong Wan Su-Juan Fei Xun-Lei Pang Fan-Dong Meng Chao-Hui Yu You-Ming Li | 2016 | World Journal of Gastroenterology2016，22，36： | 5 |
| 20 | Accelerated Learning for Restricted Boltzmann Machine with a Novel Momentum Algorithm显示文摘We investigated two commonly used momentum algorithms, Classical momentum(CM) and Nesterov momentum(NM). We found that, when used in Restricted Boltzmann machine(RBM), they have two main problems: The first one is their performances are not obvious and not as good as expected. The second one is they may lose accelerating ability in the later stage of training process. Aiming at these two problems, we proposed the Weight momentum algorithm and evaluated our approach on four datasets. It has been demonstrated that our methods can achieve better performance under both reconstruction error and classification rate criterions. | GAO Xiaoguang LI Fei WAN Kaifang | 2018 | Chinese Journal of Electronics2018，27，3： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员