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| 1 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 2 | Palaeoproterozoic Khondalite Belt in the western North China Craton: New evidence from SHRIMP dating and Hf isotope composition of zircons from metamorphic rocks in the Bayan Ul-Helan Mountains area显示文摘Zircom U-Pb age and Hf isotope analyses were made on gneissic granite and garnet-mica two-feldspar gneiss from the Helanshan Group in the Bayan Ul-Helan Mountains area, the western block of the North China Craton (NCC). Zircons from the gneissic granite commonly show core-mantle-rim structures, with magmatic core, metamorphic mantle and rim having ages of 2323±20 Ma, 1923±28 Ma and 1856±12 Ma, respectively. The core, mantle and rim show similar Hf isotope compositions, with single-stage depleted mantle model ages (TDM1) of 2455 to 2655 Ma (19 analyses). Most of the detrital zircons from the garnet-mica two-feldspar paragneiss have a concentrated U-Pb age distribution, with a weighted mean 207Pb/206Pb age of 1978±17 Ma. A few detrital zircons are older (2871 to 2469 Ma). The age for metamorphic overgrown rim was not determined because of strong Pb loss due to their high U content. The zircons show large variation in Hf isotope composition, with TDM1 ages of 1999 to 3047 Ma. In com- bination with previous studies, the main conclusions are as follows: (1) protolith of the khondalite se- ries in the Helanshan Group formed during Palaeoproterozoic rather than the Archaean as previously considered; (2) The results lend support to the contention that there is a huge Palaeoproterozoic Khondalite (metasedimentary) Belt between the Yinshan Mountains Block and the Ordos Block in the Western Block of NCC; (3) The widely-distributed bodies of early Palaeoproterozoic orthogneisses in the Khondalite Belt might be one of the important sources for detritus material in the khondalite series; (4) Collision between the Yinshan Block, the Ordos Block and the Eastern Block occurred in the same tectonothermal event of late Palaeoproterozoic, resulting in the final assembly of the NCC. | DONG ChunYan LIU DunYi LI JunJian WAN YuSheng ZHOU HongYing LI ChengDong YANG YueHeng XIE LieWen | 2007 | Chinese Science Bulletin2007，52，21： | 52 |
| 3 | Efficacy of cattle encephalon glycoside and ignotin in patients with acute cerebral infarction: a randomized, double-blind, parallel-group, placebo-controlled study显示文摘Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve injuries.However,there is still a need for high-level clinical evidence from large samples to support the use of CEGI.We therefore carried out a prospective,multicenter,randomized,double-blind,parallel-group,placebo-controlled study in which we recruited 319 patients with acute cerebral infarction from 16 centers in China from October 2013 to May 2016.The patients were randomized at a 3:1 ratio into CEGI(n=239;155 male,84 female;61.2±9.2 years old)and placebo(n=80;46 male,34 female;63.2±8.28 years old)groups.All patients were given standard care once daily for 14 days,including a 200 mg aspirin enteric-coated tablet and 20 mg atorvastatin calcium,both taken orally,and intravenous infusion of 250–500 mL 0.9%sodium chloride containing 40 mg sodium tanshinone IIA sulfonate.Based on conventional treatment,patients in the CEGI and placebo groups were given 12 mL CEGI or 12 mL sterile water,respectively,in an intravenous drip of 250 mL 0.9%sodium chloride(2 mL/min)once daily for 14 days.According to baseline National Institutes of Health Stroke Scale scores,patients in the two groups were divided into mild and moderate subgroups.Based on the modified Rankin Scale results,the rate of patients with good outcomes in the CEGI group was higher than that in the placebo group,and the rate of disability in the CEGI group was lower than that in the placebo group on day 90 after treatment.In the CEGI group,neurological deficits were decreased on days 14 and 90 after treatment,as measured by the National Institutes of Health Stroke Scale and the Barthel Index.Subgroup analysis revealed that CEGI led to more significant improvements in moderate stroke patients.No drug-related adverse events occurred in the CEGI or placebo groups.In conclusion,CEGI may be a safe and effective treatment for acute cerebral infarction patients,especially for moderate stroke patients.This study was approved by the Ethical Committee of Peking University Third Hospital,China(approval No.2013-068-2)on May 20,2013,and registered in the Chinese Clinical Trial Registry(registration No.ChiCTR1800017937). | Hui Zhang Chuan-Ling Li Feng Wan Su-Juan Wang Xiu-E Wei Yan-Lei Hao Hui-Lin Leng Jia-Min Li Zhong-Rui Yan Bao-Jun Wang Ren-Shi Xu Ting-Min Yu Li-Chun Zhou Dong-Sheng Fan | 2020 | Neural Regeneration Research2020，15，7： | 54 |
| 4 | Chinese expert consensus on cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal malignancies显示文摘Locoregional spread of abdominopelvic malignant tumors frequently results in peritoneal carcinomatosis(PC). The prognosis of PC patients treated by conventional systemic chemotherapy is poor, with a median survival of < 6 mo. However, over the past three decades, an integrated treatment strategy of cytoreductive surgery(CRS) + hyperthermic intraperitoneal chemotherapy(HIPEC) has been developed by the pioneering oncologists, with proved efficacy and safety in selected patients. Supported by several lines of clinical evidence from phases Ⅰ, Ⅱ and Ⅲ clinical trials, CRS + HIPEC has been regarded as the standard treatment for selected patients with PC in many established cancer centers worldwide. In China, an expert consensus on CRS + HIPEC has been reached by the leading surgical and medical oncologists, under the framework of the China Anti-Cancer Association. This expert consensus has summarized the progress in PC clinical studies and systematically evaluated the CRS + HIPEC procedures in China as well as across the world, so as to lay the foundation for formulating PC treatment guidelines specific to the national conditions of China. | Yan Li Yun-Feng Zhou Han Liang Hua-Qing Wang Ji-Hui Hao Zheng-Gang Zhu De-Seng Wan Lun-Xiu Qin Shu-Zhong Cui Jia-Fu Ji Hui-Mian Xu Shao-Zhong Wei Hong-Bin Xu Tao Suo Shu-Jun Yang Cong-Hua Xie Xiao-Jun Yang Guo-Liang Yang | 2016 | World Journal of Gastroenterology2016，22，30： | 58 |
| 5 | SHRIMP zircon U-Pb dating for subduction-related gran-itic rocks in the northern part of east Junggar, Xinjiang显示文摘SHRIMP U-Pb zircon dating on the Xileketehalasu granodiorite porphyry and Kalasayi monodiorite porphyry that intrude middle Devonian Beitashan Formation at the north part of east Junggar region shows that they were formed at 381±6 Ma and 376±10 Ma respectively. They are interpreted as subduction-related granitic rocks, which is the first report that the isotopic ages for the granitic rocks range from 350 to 390 Ma. Another determined age for the Kalasayi monodiorite porphyry is 408±9 Ma, representing the age of underlain Lower Devonian volcanic rocks. Thus, the U-Pb dates suggest that the northeastward subduction of Junggar ocean from southwest occurred at 408 to 376 Ma (the real inter- val may be larger). Because the ore-bearing porphyry intruded following the formation of the volcanic rocks of middle Devonian Beitashan Formation, their tec- tonic setting is similar to the Andes Mountains that hosts world-class porphyry copper deposits, and the researched area could be regarded as a potential area for prospecting large porphyry copper deposits. | ZHANG Zhaochong YAN Shenghao CHEN Bailin ZHOU Gang HE Yongkang CHAI Fengmei HE Lixin WAN Yusheng | 2006 | Chinese Science Bulletin2006，51，8： | 43 |
| 6 | Validity of Asthma Control Test in Chinese patients显示文摘在中国,背景到目前为止在那里有不是有效或容易的过程定义气喘的控制。这研究估计中国 patients.Methods 的气喘控制测试的有效性三张问询表(气喘控制测试,气喘控制问询表和 30 第二气喘测试) 越过中国从 10 所教学医院予 305 个气喘病人被以。呼吸量测定法也被使用。气喘专家在第一秒根据病人的症状,药和强迫的吐气的体积评估了气喘的控制。病人被划分成 noncontrolled 组并且根据专家的 rating.Reliability,实验有效性和屏蔽精确性控制了组为气喘控制测试分数被进行。屏蔽精确性在 3 张问询表之中被比较。病人的自我等级和专家正在评价也是 5 条款气喘控制测试的内部一致性可靠性是的 compared.Results 0.854。测试和专家正在评估的在气喘控制之间的关联系数是 0.729,它比另外的仪器高。在一些在预言的百分比不同的病人之间区别的气喘控制测试分数在第一秒强迫了吐气的体积(F=26.06, P0.0001 ) ,专家气喘控制的等级(F=88.24, P0.0001 ) 并且气喘控制问询表分数(F=250.57, P0.0001 ) 。气喘控制测试没在正确地分类的百分比与气喘控制问询表显示出重要差别,当百分比正确地分类由时气喘控制测试比 30 第二气喘测试高得多。病人的自我等级与对专家的评价一样(t=0.65, P=0.516 ) 气喘控制测试是的 .Conclusion 为在中国估计气喘控制的一个有效、适用的方法。 | ZHOU Xin DING Feng-ming LIN Jiang-tao YIN Kai-sheng CHEN Ping HE Quan-ying SHEN Hua-hao WAN Huan-ying LIU Chun-tao LI Jing WANG Chang-zheng | 2007 | Chinese Medical Journal2007，，12： | 46 |
| 7 | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘 | Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou | 2015 | Cell Research2015，25，2： | 39 |
| 8 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 9 | Formation ages and source regions of the Palaeoproterozoic Gaofan, Hutuo and Dongjiao groups in the Wutai and Dongjiao areas of the North China Craton from SHRIMP U-Pb dating of detrital zircons: Resolution of debates over their stratigraphic relationships显示文摘这份报纸在北方中国 Craton 的 Wutai 和 Dongjiao 区域报导 Gaofan, Hutuo 和 Dongjiao 组的元沉积的岩石的由岩屑形成的锆石年龄分布。由岩屑形成的锆石一从 Gaofan 组的 quartzite 主要是在年龄的 2.5 Ga,与大约 2.7 Ga 并且更旧。A 石英岩从 Hutuo 组的基础集团企业的卵石在到 Gaofan 组的 quartzite 的由岩屑形成的锆石年龄分发是类似的。为从 Dongjiao 组的 meta-feldspar-quartz 沙岩,由岩屑形成的锆石的年龄主要在 2.5 Ga 被集中。比 2.6 Ga 旧的锆石都没被识别,但是在年龄与一些是 1.84 Ga 和 2.22.0 Ga。与更早的研究结合了,下列结论能被得出:(1 ) Gaofan 组是在年龄的早 Palaeoproterozoic 并且对迟了的 Neoarchaean Wutai 花岗石绿岩岩层年轻得多、无关,它 unconformably 躺它。因此, Gaofan 组是在诺思中国 Craton 的最旧的 Palaeoproterozoic 元沉积的单位之一。(2 ) Hutuo 组在一个大陆人地下室上在中间的 Palaeoproterozoic (2.14-2.09 Ga ) 被扔,在早 Palaeoproterozoic Gaofan 组后面。(3 ) Dongjiao 组在 1.84 Ga 以后被形成,并且可能属于 Changcheng 系统的更低的部分。(4 ) 从所有三个组的由岩屑形成的锆石显示出 2.5 Ga 的一座明显的年龄山峰,从在北方中国 Craton 在太古代的结束在强烈 tectono-magma-thermal 事件形成的火的岩石被采购。 | WAN YuSheng MIAO PeiSheng LIU DunYi YANG ChongHui WANG Wei WANG HuiChu WANG ZheJiu DONG ChunYan DU LiLin ZHOU HongYing | 2010 | Chinese Science Bulletin2010，55，13： | 32 |
| 10 | Huangqi Guizhi Wuwu Decoction for treating diabetic peripheral neuropathy:a meta-analysis of 16 randomized controlled trials显示文摘OBJECTIVE:This meta-analysis was performed to systematically assess the efficacy and safety of the Chinese herbal medicine Huangqi Guizhi Wuwu Decoction(HGWWD) for treating diabetic peripheral neuropathy.DATA SOURCES:Six electronic databases,including the Cochrane Library,MEDLINE database,Chinese Biomedical Database,Chinese National Knowledge Infrastructure Database,Chinese Science and Technique Journals Database,and the Wanfang Database,were search ed on the internet for randomized controlled trials published up until 1 December 2015.The search terms included 'Chinese herbal medicine','diabetic peripheral neuropathy' and 'randomized controlled trials' in Chinese and in English.DATA SELECTION:We included randomized controlled trials using HGWWD/modified HGWWD for the treatment group,without restriction for the control group.We assessed literature quality in accordance with the Cochrane Review Handbook.A random or a fixed effects model was used to analyze outcomes using Rev Man 5.2 software.OUTCOME MEASURES:The primary outcomes were changes in symptoms and nerve conduction velocities.The secondary outcomeswere fasting blood glucose and hemorheological indexes.RESULTS:Sixteen randomized controlled trials,with a total of 1,173 patients,were included.Meta-analysis revealed that the efficacy of HGWWD for diabetic peripheral neuropathy was significantly superior compared with the control treatment(i.e.,control group)(risk ratio = 0.36,95% confidence interval(CI):0.29–0.46,Z =8.33,P < 0.00001) Compared with the control group,there was an increase in median motor nerve conduction velocity(mean difference(MD) = 3.46,95%CI:1.88–5.04,Z = 4.30,P < 0.01) and median sensory nerve conduction velocity(MD = 3.30,95%CI:2.04–4.56,Z = 5.14,P < 0.01).There was also an increase in peroneal motor nerve conduction velocity(MD = 3.22,95%CI:2.45–3.98,Z = 8.21,P < 0.01) and peroneal sensory nerve conduction velocity(MD = 3.05,95%CI:2.01–4.09,Z = 5.75,P < 0.01) in the treatment groups.No significant difference in fasting blood glucose was found between the treatment groups and the control groups(MD =-0.12,95%CI:-0.42–0.19,Z = 0.76,P = 0.45).Plasma viscosity was significantly decreased after treatment(MD =-0.11,95%CI:-0.21 to-0.02,Z = 2.30,P = 0.02).No significant difference in fibrinogen was detectable(MD =-0.53,95%CI:-1.28–0.22,Z = 1.38,P = 0.17).Four trials reported that treatment groups experienced no adverse reactions.Adverse events were not mentioned in the other 12 trials.No trial reported the incidence of complications,quality of life outcomes,or health economics.CONCLUSION:HGWWD treatment improves diabetic neurologic symptoms and ameliorates nerve conduction velocities.Our study suggests that HGWWD may have significant therapeutic efficacy for the treatment of diabetic peripheral neuropathy.However,the methodological quality of the randomized controlled trials was generally low.Larger and better-designed randomized controlled trials are required to more reliably assess the clinical effectiveness of HGWWD. | Bing Pang Tian-yu Zhao Lin-hua Zhao Fang Wan Ru Ye Qiang Zhou Feng Tian Xiao-lin Tong | 2016 | Neural Regeneration Research2016，11，8： | 32 |
| 11 | SHRIMP U-Pb dating for a K-bentonite bed in the Tieling Formation,North China显示文摘A SHRIMP U-Pb zircon age of 1437±21 Ma was obtained for a recently discovered K-bentonite bed in the Tieling Formation,situated northeast of Beijing at the boundary between Liaoning and Hebei provinces,on the northern margin of the North China Craton(NCC).The SHRIMP U-Pb age places Tieling Formation near the end of the Calymmian Period of the early Mesoproterozoic Era.In addition,a SHRIMP U-Pb zircon date of 1372±18 Ma was acquired for K-bentonite beds in the overlying,dark-shale-dominated Xiamaling Formation from the same location northeast of Beijing.This date assigns a similar Mid-Mesoproterozoic(Ectasian Period) age for the Xiamaling Formation,as have previously determined dates from other sections northwest of Beijing.These dates indicate that the Tieling and Xiamaling formations,as well as the related succession in the eastern part of the Yanshan Mountains,represented by the well-known Meso-to Neoproterozoic standard section in Jixian,can be correlated well with sections northwest of Beijing in the western part of the Yanshan Mountains.In other words,the boundary between the Calymmian and Ectasian periods in the northern parts of the NCC is marked by the unconformity between the Tieling and Xiamaling formations in the northern NCC.This boundary was previously ascribed to the 'Qinyu Orogeny' and thought to be of Grenville age.In this regard,the conventional 'Qinyu Orogeny' should now be regarded as a short-lived regional uplift during Early Mesoproterozoic time,rather than a result from the Grenvillian assembly of the NCC to the Rodinia Supercontinent(~1.0 Ga). | SU WenBo LI HuaiKun HUFF W D ETTENSOHN F R ZHANG ShiHong ZHOU HongYing WAN YuSheng | 2010 | Chinese Science Bulletin2010，55，29： | 30 |
| 12 | Effect of scanning strategy on grain structure and crystallographic texture of Inconel 718 processed by selective laser melting显示文摘Two types of scanning strategies were adopted to study the effect of scanning strategy on grain structure and crystallographic texture of selective laser melted(SLM) Inconel 718. The results show that bidirectional scanning without and with a 90?-rotation for every layer produced the bimodal grain structure and the directional columnar grain structure, respectively. Controlling the heat flux direction between the successive layers via scanning strategy enabled the formation of such different grain structures. Furthermore, when the 90?-rotation was applied, the competitive grain growth mechanism became more pronounced and the strong cube texture developed. | H.Y. Wan Z.J. Zhou C.P. Li G.F. Chen G.P. Zhang | 2018 | Journal of Materials Science & Technology2018，34，10： | 22 |
| 13 | Efficient production of omega-3 fatty acid desaturase (sFat-1)-transgenic pigs by somatic cell nuclear transfer显示文摘Omega-3(ω-3) fatty acid desaturase transgenic pigs may improve carcass fatty acid composition. The use of transgenic pigs is also an excellent large animal model for studying the role of ω-3 fatty acids in the prevention and treatment of coronary heart disease and cancer. Transgenic pigs carrying synthesized fatty acid desaturase-1 gene (sFat-1) from Caenorhabditis briggsae by somatic cell nuclear transfer (SCNT) were produced for the first time in China. Porcine fetal fibroblast cells were transfected with a sFat-1 expression cassette by the liposome-mediated method. Transgenic embryos were reconstructed by nuclear transfer of positive cells into enucleated in vitro matured oocytes. A total of 1889 reconstructed embryos were transferred into 10 naturally cycling gilts. Nine early pregnancies were established, 7 of which went to term. Twenty-one piglets were born. The cloning efficiency was 1.1% (born piglets/transferred embryos). The integration of the sFat-1 gene was confirmed in 15 live cloned piglets by PCR and Southern blot except for 2 piglets. Expression of the sFat-1 gene in 12 of 13 piglets was detected with RT-PCR. The data demonstrates that an efficient system for sFat-1 transgenic cloned pigs was developed, which led to the successful production of piglets expressing the sFat-1 gene. | PAN DengKe1, ZHANG Li1, ZHOU YanRong2, FENG Chong1, LONG Chuan1, LIU Xiao1, WAN Rong3, ZHANG Jian3, LIN AiXing3, DONG EnQiu4, WANG ShuChen4, XU HouGang4 & CHEN HongXing2 1 Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China 2 Beijing Institute of Biotechnology, Beijing 100071, China 3 China Agricultural University, Beijing 100193, China 4 Yutian Breeding Swine Farms, Yutian 064104, China | 2010 | Science China(Life Sciences)2010，53，4： | 21 |
| 14 | Donor-derived infections among Chinese donation after cardiac death liver recipients显示文摘AIM To investigate blood cultures of deceased donors and report the confirmed transmission of bacterial infection from donors to liver recipients.METHODS We retrospectively studied the results of blood cultures among our donation after cardiac death(DCD) donors and calculated the donor-derived bacterial infection rates among liver recipients. Study participants underwent liver transplantation between January 1, 2010 and February 1, 2017. The study involved a total of 67 recipients of liver grafts from 67 DCD donors. We extracted the data of donors' and patients' characteristics, culture results and clinical outcomes, especially the post-transplant complications in liver recipients, from electronic medical records. We analyzed the characteristics of the donors and the corresponding liver recipients with emphasis put on donor-derived infections.RESULTS Head trauma was the most common origin of death among our 67 DCD donors(46.3%). Blood taken prior to the procurement operation was cultured for 53 of the donors, with 17 episodes of bloodstream infections developing from 13 donors. The predominant organism isolated from the blood of donors was Gram-positive bacteria(70.6%). Only three(4.5%) of 67 liver recipients developed confirmed donor-derived bacterial infections,with two isolates of multidrug-resistant Klebsiella pneumoniae and one isolate of multidrug-resistant Enterobacter aerogenes. The liver recipients with donorderived infections showed relation to higher crude mortality and graft loss rates(33.3% each) within 3 mo post transplantation, as compared to those without donor-derived infections(9.4% and 4.7%, respectively). All three liver recipients received appropriate antimicrobial therapy.CONCLUSION Liver recipients have high occurrence of donor-derived infections. The liver recipients with donor-derived multidrug-resistant Enterobacteriaceae infections can have good outcome if appropriate antimicrobial therapy is given. | Qi-Fa Ye Wei Zhou Qi-Quan Wan | 2017 | World Journal of Gastroenterology2017，23，31： | 18 |
| 15 | Primary dolostone formation related to mantle-originated exhalative hydrothermal activities,Permian Yuejingou section,Santanghu area, Xinjiang,NW China显示文摘The Permian Lucaogou Formation is an important hydrocarbon source rock in the Junggar, Turpan, and Santanghu basins in Xinjiang, NW China. For the first time, dolostones associated with mantle-originated exhalative hydrothermal fluid flows are discovered in Yuejingou section in the Santanghu Basin area. They include dolomicrite, doloarenite, and a small amount of dolorudite, and are finely (0.05-0.15 cm thick) interlaminated with lime micrite and dolomicritic analcime laminites. Alkali feldspar and analcime grains are common in doloarenite and are interpreted as having been derived from analcime phonolites and peralkaline magmatic rocks. These magmatic fragments were brought up from subsurface by hydrothermal fluid flow and had experienced exhalative brecciation, transport, and deposition on the lake floor. The matrix consists dominantly of dolomite and ankerite smaller than 0.01 mm. The dolostones can be subdivided into four types on the basis of mineral composition and content. The detrital analcime and alkaline feldspar grains and tuff lithics are interpreted as intraclasts, which were deposited in an under-filled starved lake basin. The δ18OPDB values of dolostones are -5‰ to -21.1‰, and -11.9‰ on average; the 87Sr/86Sr ratios of dolostones are 0.70457 to 0.706194, and 0.705005 on average. These values, in combination with evidence of multi-episodes of peralkaline extrusion, suggest a mantle origin of the hydrothermal fluids, which may have promoted primary dolomite formation. The fluid from the upper mantle caused serpentinization of ultramafic rocks that intruded into the lower crust to obtain Mg2+ and Fe2+, and injected the ions into the lake water as the Mg and Fe sources for dolomite and ankerite. Hydro- thermal fluids associated with peralkaline magmatic rocks also provided Ca2+, Mg2+, Fe2+, and CO32-. Explosive breccias formed and dolostones were convoluted near the vent of hydrothermal fluid exhalation, whereas laminated dolostones formed farther away from the vent. The dolostones are primary dolomite deposition in an intracontinental rift basin and associated with mantle-originated hydrothermal fluids. They provide an insight into the origin of dolomite formation in the geologic history and clues to understand the sedimentary environments and tectonic conditions in northern Xinjiang during the late Paleozoic. | LIU YiQun JIAO Xin LI Hong YUAN MingSheng YANG Wan ZHOU XiaoHu LIANG Hao ZHOU DingWu ZHENG ChaoYang SUN Qin WANG ShuangShuang | 2012 | Science China Earth Sciences2012，55，2： | 17 |
| 16 | Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke显示文摘Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic stroke.Microglial activation and polarization,and the inflammatory response mediated by these cells play important roles in the development,progression and outcome of brain injury after ischemic stroke.Currently,there is no effective strategy for treating ischemic stroke in clinical practice.Therefore,it is clinically important to study the role and regulation of microglia in stroke.In this review,we discuss the involvement of microglia in the neuroinflammatory process in ischemic stroke,with the aim of providing a better understanding of the relationship between ischemic stroke and microglia. | Wan Zhang Tian Tian Shao-Xin Gong Wen-Qian Huang Qin-Yi Zhou Ai-Ping Wang Ying Tian | 2021 | Neural Regeneration Research2021，16，1： | 17 |
| 17 | Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients显示文摘AIM: To investigate Fusobacterium nucleatum(F. nucleatum) abundance in colorectal cancer(CRC) tissues and its association with CRC invasiveness in Chinese patients.METHODS: The resected cancer and adjacent normal tissues(10 cm beyond cancer margins) from 101 consecutive patients with CRC were collected. Fluorescent quantitative polymerase chain reaction(FQ-PCR) was applied to detect F. nucleatum in CRC and normal tissues. The difference of F. nucleatum abundance between cancer and normal tissues and the relationship of F. nucleatum abundance with clinical variables were evaluated. Fluorescence in situ hybridization(FISH) analysis was performed on 22 CRC tissues with the highest F. nucleatum abundance by FQ-PCR testing to confirm FQ-PCR results.RESULTS: The median abundance of F. nucleatum in CRC tissues [0.242(0.178-0.276)] was significantly higher than that in normal controls [0.050(0.023-0.067)](P < 0.001). F. nucleatum was over-represented in 88/101(87.1%) CRC samples. The abundance of F. nucleatum determined by 2^(-ΔCT) was significantly greater in tumor samples [0.242(0.178, 0.276)] than in normal controls [0.050(0.023, 0.067)](P < 0.001). The frequency of patients with lymph node metastases was higher in the over-abundance group [52/88(59.1%)] than in the under-abundance group [0/13(0%)](P < 0.005). No significant association of F. nucleatum with other clinico-pathological variables was observed(P > 0.05). FISH analysis also found more F. nucleatum in CRC than in normal tissues(median number 6, 25^(th) 3, 75^(th) 10 vs 2, 25^(th) 1, 75^(th) 5)(P < 0.01).CONCLUSION: F. nucleatum was enriched in CRC tissues and associated with CRC development and metastasis. | Yu-Yuan Li Quan-Xing Ge Jie Cao Yong-Jian Zhou Yan-Lei Du Bo Shen Yu-Jui Yvonne Wan Yu-Qiang Nie | 2016 | World Journal of Gastroenterology2016，22，11： | 17 |
| 18 | Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways显示文摘Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation. Saponins from Panax japonicus are the most abundant and bioactive members in rhizomes of Panax japonicus, and show anti-inflammatory activity. However, it is not known whether saponin from Panax japonicus has an anti-inflammatory effect in the aging brain, and likewise its underlying mechanisms. Sprague-Dawley rats were divided into control groups(3-, 9-, 15-, and 24-month-old groups) and saponins from Panax japonicus-treated groups. Saponins from Panax japonicus-treated groups were orally administrated saponins from Panax japonicus at three doses of 10, 30, and 60 mg/kg once daily for 6 months until the rats were 24 months old. Immunohistochemical staining and western blot assay results demonstrated that many microglia were activated in 24-month-old rats compared with 3-and 9-month-old rats. Expression of interleukin-1β, tumor necrosis factor-α, cyclooxygenase-2, and inducible nitric oxide synthase increased. Each dose of saponins from Panax japonicus visibly suppressed microglial activation in the aging rat brain, and inhibited expression levels of the above factors. Each dose of saponins from Panax japonicus markedly diminished levels of nuclear factor kappa B, IκBα, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38. These results confirm that saponins from Panax japonicus can mitigate neuroinflammation in the aging rat brain by inhibition of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways. | Li-li Deng Ding Yuan Zhi-yong Zhou Jing-zhi Wan Chang-cheng Zhang Chao-qi Liu Yao-yan Dun Hai-xia Zhao Bo Zhao Yuan-jian Yang Ting Wang | 2017 | Neural Regeneration Research2017，12，11： | 17 |
| 19 | Formation age and tectonic environment of the Gantaohe Group,North China Craton:Geology,geochemistry,SHRIMP zircon geochronology and Hf-Nd isotopic systematics显示文摘The Gantaohe Group is an important early Precambrian unit in the Trans-North China Orogen,North China Craton,and is mainly composed of greenschist-facies metabasalt,meta-sandstone and dolomitic marble.We report whole-rock geochemical compositions and SHRIMP zircon ages as well as LA-ICP-MS Hf-in-zircon isotopeic analyses for metabasalts from the Gantaohe Group.SHRIMP dating yielded a weighted mean 207Pb/206Pb age of 2087±16 Ma(MSWD=1.3) for magmatic zircons,but there are also abundant ca.2.5 Ga inherited zircon xenocrysts.The magmatic zircons shows a large Hf(t) variation in Hf(t) from 7.17 to +0.45,suggesting an isotopically highly heterogeneous source for the metabasalt.Chemically all samples show no distinct Zr or Hf anomalies,and some samples show no Nd or Ta anomalies in a primitive mantle-normalized trace element variation diagram,and their whole-rock Nd(t) values range from 4.0 to 0.8.We suggest that the basalt is formed by partial melting of a depleted mantle source,followed by significant crustal contamination.Field observations,the presence of abundant inherited zircon,as well as isotope and trace elements geochemistry support formation of the Gantaohe Group on top of a continental basement.These data and the regional geology lead us to conclude that the Trans-North China Orogen constituted an intracontinental rift during the Paleoproterozoic that was connected to the Eastern Block since the end of the Archean. | XIE HangQiang LIU DunYi YIN XiaoYan ZHOU HongYing YANG ChongHui DU LiLin WAN YuSheng | 2012 | Chinese Science Bulletin2012，57，36： | 16 |
| 20 | OsVPS9A Functions Cooperatively with OsRAB5A to Regulate Post-Golgi Dense Vesicle-Mediated Storage Protein Trafficking to the Protein Storage Vacuole in Rice Endosperm Cells显示文摘在米饭内乳房间, glutelins 作为 proglutelins 在不平的 endoplasmic 蜂窝胃上被综合并且被排序到称为蛋白质身体 II (PBII ) 的 theprotein 存储液泡(PSV ) ,在他们被变换成成熟形式的地方。稠密的泡(DV ) 调停了在大米种子的 proglutelins 的 trafficking 被建议了,但是这个过程的 post-Golgi 控制是 largelyunknown。DV 是否能与 PSV 直接熔化,是争论的另一件事。在这研究,我们建议规章的 mechanismunderlying 调停 DV, post-Golgi proglutelin trafficking 到 PBII (PSV ) 。gpa2, OsVPS9A 的 loss-of-function 异种,编码 OsRAB5A 的 GEF,积累了 uncleaved proglutelins。Proglutelins 对到沿着在 DV 形式的房间墙的 apoplast 的 paramural bodiesand 指向 mis,它在 PBII 尺寸导致了伴随物减小。Previouslyreported gpa1,在 OsRab5a 变异,有类似的显型,当时两倍异种加重了的 gpa1gpa2 条件。另外, OsVPS9A 在 vitro 并且在 vivo 与 OsRAB5A 交往了。我们断定 OsVPS9A 和 OsRAB5A 可以一起工作并且在调停 DV 的 post-Golgi proglutelintrafficking 起一个规章的作用到 PBII (PSV ) 。DV 可能直接熔化到 PBII (PSV ) 交付货物的证据也是 presented.Key 词: | Feng Liu Yulong Ren Yihua Wang Cheng Peng Kunneng Zhou Jia Lv Xiuping Guo Xin Zhang Jianmin wan Yiqun Bao | 2013 | Molecular Plant2013，6，6： | 16 |
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