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| 1 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 2 | Multipal positive solutions to second order Neumann boundary value probtems显示文摘 | Sun Jianping Li Wantong | 2003 | Applied Mathematics and Computation2003，146，1： | 1 |
| 3 | Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin αVβ3显示文摘 | Yunling Li Li Sun Hong Xu Zhengyu Fan Wantong Yao Wei Guo Jia Rao Xiliang Zha | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 1 |
| 4 | Positive solution for system of nonlinear first - order PBVPs on time scales 显示文摘 | Sun Jianping Li Wantong | 2005 | Non- linear Anal2005，62，： | 1 |
| 5 | Three positive solutions for a nonlinear three-point boundary value problems显示文摘 | Sun Jianping Li Wantong Zhao Yahong | 2003 | J Math Anal Appl2003，288，： | 1 |
| 6 | Existence of positive solutions to semipositone Dirichlet BVPs on time scales 显示文摘 | Sun Jianping Li Wantong | 2007 | Dy- nammics Systems Applications2007，16，： | 1 |
| 7 | Positive solution for System of Nonlinear First-order PBVPs on Time scales显示文摘 | Sun jianping Li wantong | | 0，，62： | 1 |
| 8 | Multiple positive solutions of a discrete difference system显示文摘 | Sun Jianping Li Wantong | 2003 | Appl Math & Comput2003，143，23： | 1 |
| 9 | Multiple positive solutions to second-order Neumann boundary value problems 显示文摘 | SUN Jianping LI Wantong | 2003 | Applied Math- ematics and Computation2003，146，： | 1 |
| 10 | Multiple positive solutions to second order Neumann boundary value problems显示文摘 | Sun Jianping and Li Wantong | 2003 | Applied Mathematics and Computation2003，，146： | 1 |
| 11 | Multiple positive solutions to second order Neumann boundaey value problem 显示文摘 | Sun Jianping and Li Wantong | 2003 | Applied Mathematics and Computation2003，146，： | 1 |
| 12 | Positive solutions of BVPs for third-order nonlinear difference systems显示文摘 | Li Wantong Sun Jianping | 2004 | Com- puters Math Applic2004，47，4： | 1 |
| 13 | Multiple positive solutions to second-order Neumann boundary value problems显示文摘 | Sun Jianping Li Wantong | 2003 | Appl Math Comput2003，146，： | 1 |
| 14 | Multiple positive solutions to second order Neumann boundary vaiue problem显示文摘 | Sun Jianping Li Wantong | 2003 | Applied Mathematics and Computation2003，146，： | 1 |
| 15 | Existence of Positive Solutions to Semipositone Dirichlet BVPs on Time Scales显示文摘 | SUN Jianping LI Wantong | 2007 | Dynammics Systems Applications2007，16，： | 1 |
| 16 | Multipal positive solutions to second order Neumann boundary value problem显示文摘 | Sun Jianping Li Wantong | 2003 | Applied Mathematics and Computation2003，246，： | 1 |
| 17 | Three positive solutions for second-order Neumann boundary value problem显示文摘 | Jianping Sun Wantong Li Suisun Cheng | 2004 | Applied Mathematics Letters2004，17，： | 1 |
| 18 | Positive solutions for system of nonlinear first-order PBVPs on time scales显示文摘 | SUN Jianping LI Wantong | 2005 | Nonlinear Analysis2005，62，： | 1 |
| 19 | Research on intelligent judgment method of natural gas hydrate drilling risk显示文摘There are many emergency risks in the process of natural gas hydrate(NGH)drilling.In order to ensure the safe and efficient exploitation of NGH,it is urgent to establish an intelligent judgment method for the risks in the process of NGH drilling.In this paper,the response relationship between monitoring parameters and risk categories of NGH while drilling is established.Based on fuzzy analytic hierarchy process(FAHP),the comprehensive weights of 10 risk monitoring parameters are obtained,including gas production,wellbore instability,hydrate ice barrier,drill string fracture,sticking,bit balling,drilling tool piercement,gas seepage,seabed subsidence and seabed landslide.Besides,the comprehensive judgment weight matrix is constructed,and the reasonable fluctuation range of monitoring parameters is formed.Thus,the intelligent judgment method of NGH drilling risk is established.The intelligent judgment and alarm of NGH drilling risks can be realized quickly and accurately by this method,namely,it can monitor the risks in the process of operation and guarantee the construction safety of NGH drilling. | Haitao Li Zhaolong Ge Na Wei Wantong Sun Yao Zhang Jin Xue Lin Jiang Jun Pei Bing Liao Hongliang Cao Ruixu Zhang Shuangli Li Qixia Lu Jinyan Luo | 2021 | Petroleum2021，7，4： | 1 |
| 20 | Multipal Positive Solutions to Second Order Neumann Boundary Value Problems显示文摘 | Wantong Li | 2003 | Applied Mathematics and Computation2003，146，： | 1 |
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