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| 1 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 2 | Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells for severe aplastic anemia: Successful engraftment and mild GVHD显示文摘 | Yamei Wu Yongbin Cao Xiaohong Li Lixin Xu Zhihong Wang Pei Liu Pei Yan Zhouyang Liu Jing Wang Shuang Jiang Xiaoxiong Wu Chunji Gao Wanming Da Zhongchao Han | 2014 | Stem Cell Research2014，，1： | 3 |
| 3 | Down-regulation of lipocalin 2 suppresses the growth of human lung adenocarcinoma through oxidative stress involving Nrf2/HO-1 signaling显示文摘Lipocalin 2 (LCN2 ) ,作为嗜中性的联系 gelatinase 的 lipocalin (NGAL ) 知道的多功能的能分泌的蛋白质,在许多癌症被表示。然而,很少在肺腺癌的发展对 NGAL 的生物功能被知道。在现在的学习,我们首先发现那 NGAL 表情在人的肺腺癌纸巾是起来调整的。另外, NGAL 表示的弄空减少了房间增长和导致的房间 apoptosis 的能力。而且与 N-acetylcysteine 的增加,反应的氧种类(ROS ) 的 scavenger, NGAL 弄空是足够的由通过原子因素的抑制产生 ROS 引起肺腺癌细胞的 apoptosis,这被发现 E2 相关的因素 2/heme oxygenase-1 抗氧化剂小径。最后,人的肺腺癌的生长上的 NGAL 下面规定的效果在 BALB/c 裸体老鼠被决定。这些调查结果证明 NGAL 可以是为有肺腺癌的病人的一个潜在的治疗目标。 | Baoquan Song Hairui Zhang Lei Jiang Ying Chi Jianjian Tian Wenjing Du Bentong Yu Zhongchao Han | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 2 |
| 4 | Endothelial progenitor cell therapy in atherosclerosis: A double-edged sword?显示文摘 | Pengxia Liu Bin Zhou Dongsheng Gu Lei Zhang Zhongchao Han | 2008 | Ageing Research Reviews2008，，2： | 1 |
| 5 | Pathogenesis and management for chronic idiopathic thrombocytopenic purpura:An update显示文摘 | Renchi Yang Zhongchao Han | 2000 | Int J Hematol2000，，1： | 1 |
| 6 | Pathogenesis and Management for Chronic Idiopathic Thrombocytopenic Purpura: An Update显示文摘 | HAN Zhongchao | 1999 | Int J Hematol1999，，： | 1 |
| 7 | Expression and purification of recombinant human hemangiopoietin in Escherichia coli显示文摘Objective:To express the soluble recombinant hemangiopoietin protein in E.coli BL21(DE3).Methods:Using human fetal live cDNA as a template,a partial cDNA fragment of HAPO coding N-terminal region was subcloned into plasmids pTrc99,pQE60 and pET32c to construct different recombinant prokaryotic expression systems.After selecting,the soluble rhHAPO fusion protein was expressed stably in E.coli BL21(DE3) by vector pET32c-HAPO and further isolated by nickelnitrilotriacetic acid(NTA) affinity chromatography.After cleavage with enterokinase,the rhHAPO protein was applied to Fast Flow SP sepharose column.Results:The rhHAPO protein had a purity of more than 95% and a good bioactivity based on the cell adhesion assay in ECV304 cells.Conclusion:We have established a protein engineering system to produce rhHAPO which may provide the possibility for clinical application. | Ren Qian Ma Fengxia Chen Zhong Lu Shihong Han Zhibo Liu Yongjun Xu Bin Zhang Xiangyu Han Zhongchao | 2008 | Journal of Medical Colleges of PLA(China)2008，23，3： | 0 |
| 8 | PERFORMANCE AND MICROSTRUCTURE OF SUPERHARD Si_3N_4 FILM BY HIGH POWER CO_2 LASER CVD显示文摘A superhard α-Si3N4 film,deposited on metal substrate,was produced by laser chemicalvapor deposition adopting a kW-level high power CO2 laser.Most films are composedof fine Si3N4 partieles.They join the metal substrate in strong bond.The films havesuper hardness,excellent resistance to wear and corrosion,etc.Their thickness may becontrolled within 5-30 μm. | FENG Zhongchao GUO Liang LIANG Yong HAN Jian HOU Wanliang NING Xiaoguang Institute of Metal Research,Academia Sinica,Shenyang,China Associate Professor,Institute of Metal Research,Academia Sinica,Shenyang 110015,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，7： | 0 |
| 9 | 白血病骨髓微环境中GATA-1、GATA-2和GATA-3基因表达模式(英文)显示文摘Objective: The aim of the study was to investigate the expression pattern of hematopoietic transcription factor GATA-1, -2 and -3 genes in leukemic bone marrow (BM) microenvironment [including bone marrow stromal cells (BMSCs) and BM hematopoietic cells]. Methods: Mononuclear cells were isolated from BM of patients with acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), or acute lymphoblastic leukemia (ALL). Adherent cells (BMSCs) and nonadherent cells (BM hematopoietic cells) were collected after long-term culture in vitro. The semi-quantitative expression levels of GATA genes in the BMSCs or BM hematopoietic cells from patients with leukemia were analyzed by using RT-PCR-ELISA and compared with normal controls. Results: The expression level of GATA-1 gene in the BMSCs from CML group was significantly lower than that of the normal controls. The expression level of GATA-3 gene in the BMSCs from ALL was higher than that of the normal controls, but that from CML was lower than the normal controls. Dominant expression of GATA-3 gene was found in the normal BM hematopoietic cells. The dominant expression of GATA-2 gene was found in the normal BMSCs and the BMSCs from CML, whereas the dominant expression of GATA-3 gene was detected in the BMSCs from AML. Conclusion: GATA-1, -2 and -3 genes might play a role in hematopoiesis regulation in leukemia, and the changes of expression pattern of GATA genes might influence the hematopoiesis in BM microenvironment and relate to the pathogenesis and development of leukemia. | Xiuli Wu Yangqiu Li Kanger Zhu Zhen Wang Shaohua Chen Lijian Yang Zhongchao Han | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，9： | 0 |
| 10 | Embryonic stem cell-derived extracellular vesicles rejuvenate senescent cells and antagonize aging in mice显示文摘Aging is a degenerative process that leads to tissue dysfunction and death.Embryonic stem cells(ESCs)have great therapeutic potential for age-related diseases due to their capacity for self-renewal and plasticity.However,the use of ESCs in clinical treatment is limited by immune rejection,tumourigenicity and ethical issues.ESC-derived extracellular vesicles(EVs)may provide therapeutic effects that are comparable to those of ESCs while avoiding unwanted effects.Here,we fully evaluate the role of ESC-EVs in rejuvenation in vitro and in vivo.Using RNA sequencing(RNA-Seq)and microRNA sequencing(miRNA-Seq)screening,we found that miR-15b-5p and miR-290a-5p were highly enriched in ESC-EVs,and induced rejuvenation by silencing the Ccn2-mediated AKT/mTOR pathway.These results demonstrate that miR-15b-5p and miR-290a-5p function as potent activators of rejuvenation mediated by ESC-EVs.The rejuvenating effect of ESC-EVs was further investigated in vivo by injection into aged mice.The results showed that ESC-EVs successfully ameliorated the pathological age-related phenotypes and rescued the transcriptome profile of aged mice.Our findings demonstrate that ESC-EVs treatment can rejuvenate senescence both in vitro and in vivo and suggest the therapeutic potential of ESC-EVs as a novel cell-free alternative to ESCs for age-related diseases. | Lu Yu Hang Wen Chang Liu Chen Wang Huaxin Yu Kaiyue Zhang Qingsheng Han Yue Liu Zhongchao Han Zongjin Li Na Liu | 2023 | Bioactive Materials2023，，11： | 0 |
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