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| 1 | Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death显示文摘混合的系 kinase 像域的蛋白质(MLKL ) 被识别受体交往下游地工作蛋白质 3 (RIP3 ) 在肿瘤坏死 factor-α(TNF ) 导致了坏死(也叫的 necroptosis ) 。然而, MLKL 怎么工作调停 necroptosis 是未知的。由在 MLKL 大美人房间的 MLKL 功能的宪法,我们证明 MLKL 的 N 终点在 necroptosis 为它的功能被要求。在对待 TNF 的房间的 MLKL 的 oligomerization 为 necroptosis 是必要的,当人工地由使用荷尔蒙绑定领域一起强迫 MLKL (HBD*) 扳机 necroptosis。尤其是,一起强迫 N 终端领域(ND ) 然而并非 MLKL 的 C 终端 kinase 领域引起 necroptosis。进一步的删除分析证明 four-α MLKL (1-130 氨基酸) 的螺旋捆是足够的触发 necroptosis。两 HBD*调停并且 MLKL (ND ) 或 MLKL 的导致 TNF 的建筑群是到血浆膜的类脂化合物椽子的这些建筑群的 tetramers,和 translocation 先于房间死亡。homo-oligomerization 为 MLKL translocation 被要求,为血浆膜地点的信号顺序位于第一和第二 α 的连接; MLKL 的 -helices。MLKL 或 MLKL (ND ) 的血浆膜 translocation 导致钠流入,并且从房间文化媒介的钠的弄空禁止 necroptosis。上述所有现象没在 apoptosis 被看见。因此, MLKL oligomerization 导致 MLKL 的 translocation 到血浆膜,和血浆膜的类脂化合物椽子由自己或经由到增加的另外的蛋白质的 MLKL 复杂行为任何一个钠流入,增加渗透的压力,最后导致膜破裂。 | Xin Chen Wenjuan Li Junming Ren Deli Huang Wan-ting He Yunlong Song Chao Yang Wanyun Li Xinru Zheng PengdaChen Jiahuai Han | 2014 | Cell Research2014，24，1： | 67 |
| 2 | Effects of elevated CO_2 on the nutrient compositions and enzymes activities of Nilaparvata lugens nymphs fed on rice plants显示文摘Elevated CO 2 may reduce the tolerance of Nilaparvata lugen (N. lugens) to adverse environmental factors through the biological and physiological degeneration of N. lugens. In an artificial climate box, under 375 and 750 μL L 1 CO 2 levels, the rice stems nutrient content, the nutrient content and enzyme activities of N. lugens nymph fed on rice seedlings exposed to ambient and elevated CO 2 were studied. The results showed that rice stems had significantly higher protein and total amino acid levels under ambient than elevated CO 2 levels. Nymphs had significantly higher protein levels in the ambient CO 2 treatment, while their glucose levels were significantly lower under ambient CO 2 conditions. Significantly higher trypsin activity was observed in nymphs grown in elevated CO 2 . Significantly lower activities of the protective enzymes total superoxide dismutase and catalase were observed in the nymphs under ambient CO 2 . Meanwhile, the activity of the detoxification enzyme glutathione S-transferase was significantly higher in the ambient CO 2 treatment. Measuring how energy and resources were allocated to enzymes in N. lugens nymphs under elevated CO 2 conditions can provide a more meaningful evaluation of their metabolic tolerances to adverse climatic conditions. | ZENG YunYun HUANG WenKun SU Li WU Gang ZHUANG Jing ZHAO WanYun HUA HongXia LI JunSheng XIAO NengWen XIONG-YanFei | 2012 | Science China(Life Sciences)2012，55，10： | 7 |
| 3 | Quantitative Analysis of Relationship Between Pore Structure and Compressive Strength of Foamed Concrete显示文摘The effect of dry density,water-cement ratio,the addition of fly ash,and sand content on the porosity and pore distribution of foamed concrete is investigated.Digital microscopy and Image J software are employed to examine the landscape of pores with different sizes.Based on the Balshin empirical formula,a mathematical model is established to quantitatively predict the relationship between the pore structures and the compressive strength of foamed concrete.The results well demonstrate that there is a significant correlation between the modified formula and empirical parameters. | Geng Fei Yin Wanyun Xie Jianguang Liu Shoucheng Li Haoran Gui Jingneng | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，3： | 2 |
| 4 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 5 | Novel U-shape gold nanoparticles modified optical fiberfor localized plasmon res- onance chemical sensing 显示文摘 | Chen Chien-hsing Tsao Tzu-chien Li Wanyun | 2010 | Microsyst Technol2010，16，： | 1 |
| 6 | Highly Efficient Bulky a-Diimine Palladium Complexes for Suzuki-Miyaura Cross-Coupling Reaction显示文摘A series of bulky 9,10-dihydro-9,10-ethanoanthracene-11,12-diimine methyl palladium chloride complexes (C1 --C6) with different steric and electronic substituent have been applied in Suzuki-Miyaura cross-coupling reactionsThe influence of these substituents was investigated by comparing the catalytic performance of the complexes in thecross-coupling reactions and it can be found that the complex with bulky and electron-donating substituent is facili-tated for the cross-coupling reaction of aryl halides with arylboronic acids under ambient atmosphere. The most ac-tive complex shows a wide substrate scope in excellent yields using very low catalyst concentration of 0.01 mol%. | Ping Huo Jingbo Li Wanyun Liu Guangquan Mei | 2017 | Chinese Journal of Chemistry2017，35，3： | 1 |
| 7 | Exploring HONO formation and its role in driving secondary pollutants formation during winter in the North China Plain显示文摘Daytime HONO photolysis is an important source of atmospheric hydroxyl radicals(OH).Knowledge of HONO formation chemistry under typical haze conditions,however,is still limited.In the Multiphase chemistry experiment in Fogs and Aerosols in the North China Plain in 2018,we investigated the wintertime HONO formation and its atmospheric implications at a rural site Gucheng.Three different episodes based on atmospheric aerosol loading levels were classified:clean periods(CPs),moderately polluted periods(MPPs)and severely polluted periods(SPPs).Correlation analysis revealed that HONO formation via heteroge.neous conversion of NO_(2)was more efficient on aerosol surfaces than on ground,highlighting the important role of aerosols in promoting HONO formation.Daytime HONO budget analysis indicated a large missing source(with an average production rate of 0.66±0.26,0.97±0.47 and 1.45±0.55 ppbV/hr for CPs,MPPs and SPPs,respectively),which strongly correlated with photo-enhanced reactions(NO_(2)heterogeneous reaction and particulate nitrate photolysis).Average OH formation derived from HONO photolysis reached up to(0.92±0.71),(1.75±1.26)and(1.82±1.47)ppbV/hr in CPs,MPPs and SPPs respectively,much higher than that from O3 photolysis(i.e.,(0.004±0.004),(0.006±0.007)and(0.0035±0.0034)ppbV/hr).Such high OH production rates could markedly regulate the atmospheric oxidation capacity and hence promote the formation of secondary aerosols and pollutants. | Shaobin Zhang Guo Li Nan Ma Yao He Shaowen Zhu Xihao Pan Wenlin Dong Yanyan Zhang Qingwei Luo Jeannine Ditas Uwe Kuhn Yuxuan Zhang Bin Yuan Zelong Wang Peng Cheng Juan Hong Jiangchuan Tao Wanyun Xu Ye Kuang Qiaoqiao Wang Yele Sun Guangsheng Zhou Yafang Cheng Hang Su | 2023 | Journal of Environmental Sciences2023，，10： | 0 |
| 8 | Themis suppresses the effector function of CD8^(+)T cells in acute viral infection显示文摘CD8^(+)T cells play a central role in antiviral immune responses.Upon infection,naive CD8^(+)T cells differentiate into effector cells to eliminate virus-infected cells,and some of these effector cells further differentiate into memory cells to provide long-term protection after infection is resolved.Although extensively investigated,the underlying mechanisms of CD+T-cell differentiation remain incompletely understood.Themis is a T-cell-specific protein that plays critical roles in T-cell development.Recent studies using Themis T-cell conditional knockout mice also demonstrated that Themis is required to promote mature CD8^(+)T-cell homeostasis,cytokine responsiveness,and antibacterial responses.In this study,we used LCMV Armstrong infection as a probe to explore the role of Themis in viral infection.We found that preexisting CD8^(+)T-cell homeostasis defects and cytokine hyporesponsiveness do not impair viral clearance in Themis T-cell conditional knockout mice.Further analyses showed that in the primary immune response,Themis deficiency promoted the differentiation of CD8^(+)effector cells and increased their TNF and IFNy production.Moreover,Themis deficiency impaired memory precursor cell(MPEC)differentiation but promoted short-lived effector cell(SLEC)differentiation.Themis deficiency also enhanced effector cytokine production in memory CD8^(+)T cells while impairing central memory CD8^(+)T-cell formation.Mechanistically,we found that Themis mediates PD-1 expression and its signaling in effector CD8^(+)T cells,which explains the elevated cytokine production in these cells when Themis is disrupted. | Jian Tang Xian Jia Jian Li Junchen Dong Jiayu Wang Wanyun Li Yuzhen Zhu Yanyan Hu Bowen Hou Chunjie Lin Yu Cong Tong Ren Changsheng Yan Hongying Yang Qian Lai Haiping Zheng Yuzhou Bao Namrata Gautam Hong-Rui Wang Bing Xu Xiao Lei Chen Qing Li Nicholas R.J.Gascoigne Guo Fu | 2023 | Cellular & Molecular Immunology2023，20，5： | 0 |
| 9 | Effect of Zhi Tang Shu on Blood System in Rats显示文摘 | YANG Wanyun SHU Sijie ZHENG Xi LUO Xinmao SHU Hui LI Rong | 2005 | 美国中华健康卫生杂志2005，8，4： | 0 |
| 10 | GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling显示文摘The high mortality rate associated with gastric cancer(GC)has resulted in an urgent need to identify novel therapeutic targets for GC.This study aimed to investigate whether GAIP interacting protein,C terminus 1(GIPC1)represents a therapeutic target and its regulating mechanism in GC.GIPC1 expression was elevated in GC tissues,liver metastasis tissues,and lymph node metastases.GIPC1 knockdown or GIPC1 blocking peptide blocked the platelet-derived growth factor receptor(PDGFR)/PI3K/AKT signaling pathway,and inhibited the proliferation and migration of GC cells.Conversely,GIPC1 overexpression markedly activated the PDGFR/PI3K/AKT signaling pathway,and promoted GC cell proliferation and migration.Furthermore,platelet-derived growth factor subunit BB(PDGF-BB)cytokines and the AKT inhibitor attenuated the effect of differential GIPC1 expression.Moreover,GIPC1 silencing decreased tumor growth and migration in BALB/c nude mice,while GIPC1 overexpression had contrasting effects.Taken together,our findings suggest that GIPC1 functions as an oncogene in GC and plays a central role in regulating cell proliferation and migration via the PDGFR/PI3K/AKT signaling pathway. | TINGTING LI WEI ZHONG LIU YANG ZHIYU ZHAO LI WANG CONG LIU WANYUN LI HAIYAN LV SHENGYU WANG JIANGHUA YAN TING WU GANG SONG FANGHONG LUO | 2024 | Oncology Research2024，32，2： | 0 |
| 11 | Effects of maternal aging on localizations and expression levels of DNA methyltransferases and chromosome architecture in in-vivo matured mouse oocytes显示文摘This paper investigated the age-related changes in the expression patterns of maintenance methyltransferase (DNMT1) and de novo methyltransferases (DNMT3a, 3b, 3L) and the chromosome architecture in in-vivo matured mouse oocytes using two-photon laser-scanning microscope. Our results showed that (1) DNMT1 and DNMT3a, 3b, 3L in the oocytes of pubertal mice were located in the cortical region of oocyte cytoplasm. In aging groups, DNMT1 was also located in the cortical region. However, DNMT3a, 3b, 3L had a relatively wider distribution in the oocyte cytoplasm and appeared near the chromosomes. These differences between pubertal and aging groups suggested that aging might affect DNA methylation; (2) the expression of DNMT1, and DNMT3a, 3b in aging groups increased significantly compared to pubertal groups, while, the expression of DNMT3L decreased. These results might be explained by the compensation mechanism among DNMTs, which might be impervious to aging; (3) aging caused increased errors in the distribution and three-dimensional morphology of chromosomes, including the increased total volume and surface area, the high ratio of height to diameter of a circular cylinder enclosing the chromosomes (H/D). Our work provided morphological information for the studies of age-related decline in oocyte qualities. | TIAN Ning ZHANG Lu L DanYu ZHENG JingGao MA WanYun LI Ying | 2013 | Chinese Science Bulletin2013，58，26： | 0 |
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