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| 1 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis显示文摘 | Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang | 2015 | Cell Research2015，25，8： | 323 |
| 2 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 3 | Sirt1-ROS-TRAF6 Signaling-Induced Pyroptosis Contributes to Early Injury in Ischemic Mice显示文摘Stroke is an acute cerebro-vascular disease with high incidence and poor prognosis,most commonly ischemic in nature.In recent years,increasing attention has been paid to inflammatory reactions as symptoms of a stroke.However,the role of inflammation in stroke and its underlying mechanisms require exploration.In this study,we evaluated the inflammatory reactions induced by acute ischemia and found that pyroptosis occurred after acute ischemia both in vivo and in vitro,as determined by interleukin-1β,apoptosis-associated speck-like protein,and caspase-1.The early inflammation resulted in irreversible ischemic injury,indicating that it deserves thorough investigation.Meanwhile,acute ischemia decreased the Sirtuin 1(Sirtl)protein levels,and increased the TRAF6(TNF receptor associated factor 6)protein and reactive oxygen species(ROS)levels.In further exploration,both Sirtl suppression and TRAF6 activation were found to contribute to this pyroptosis.Reduced Sirtl levels were responsible for the production of ROS and increased TRAF6 protein levels after ischemic exposure.Moreover,N-acetyl-L-cysteine,an ROS scavenger,suppressed the TRAF6 accumulation induced by oxygen-glucose deprivation via suppression of ROS bursts.These phenomena indicate that Sirtl is upstream of ROS,and ROS bursts result in increased TRAF6 levels.Further,the activation of Sirtl during the period of ischemia reduced ischemiainduced injury after 72 h of reperfusion in mice with middle cerebral artery occlusion.In sum,these results indicate that pyroptosis-dependent machinery contributes to the neural injury during acute ischemia via the Sirt1-ROS-TRAF6 signaling pathway.We propose that inflammatory reactions occur soon after oxidative stress and are detrimental to neuronal survival;this provides a promising therapeutic target against ischemic injuries such as a stroke. | Weijie Yan Wei Sun Jiahui Fan Haiqing Wang Song Han Junfa Li Yanling Yin | 2020 | Neuroscience Bulletin2020，36，8： | 9 |
| 4 | Efficient manipulations of circularly polarized terahertz waves with transmissive metasurfaces显示文摘The unrestricted control of circularly polarized(CP)terahertz(THz)waves is important in science and applications,but conventional THz devices suffer from issues of bulky size and low efficiency.Although Pancharatnam-Berry(PB)metasurfaces have shown strong capabilities to control CP waves,transmission-mode PB devices realized in the THz regime are less efficient,limiting their applications in practice.Here,based on Jones matrix analysis,we design a trilayer structure(thickness of ~λ/5)and experimentally demonstrate that the structure can serve as a highly efficient transmissive meta-atom(relative efficiency of ~90%)to build PB metadevices for manipulating CP THz waves.Two ultrathin THz metadevices are fabricated and experimentally characterized with a z-scan THz imaging system.The first device can realize a photonic spin Hall effect with an experimentally demonstrated relative efficiency of ~90%,whereas the second device can generate a high-quality background-free CP Bessel beam with measured longitudinal and transverse field patterns that exhibit the nondiffracting characteristics of a Bessel beam.All the experimental results are in excellent agreement with full-wave simulations.Our results pave the way to freely manipulate CP THz beams,laying a solid basis for future applications such as biomolecular control and THz signal transportation. | Min Jia Zhuo Wang Heting Li Xinke Wang Weijie Luo Shulin Sun Yan Zhang Qiong He Lei Zhou | 2019 | Light(Science & Applications)2019，8，1： | 9 |
| 5 | Activation of Rev-erbα attenuates lipopolysaccharide-induced inflammatory reactions in human endometrial stroma cells via suppressing TLR4-regulated NF-κB activation显示文摘Perturbation of the circadian rhythm damages the biological characteristics of cells and leads to their dysfunction. Rev-erbα, an important gene in the transcription-translation loop of circadian rhythm, is involved in regulating the balance between pro-inflammation and anti-inflammation. The disruption of this balance in human endometrial stroma cells (hESCs) destroys their biological behavior function in maintaining the menstrual cycle and embryonic implantation. Whether pharmacological modulation of Rev-erbα affects the inflammation of hESCs remains unclear. In this study, we treated hESCs with lipopolysaccharide (LPS) and found that LPS treatment increased the mRNA levels of pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-8, IL-18, and TNFα, and the secretion of IL-6. SR9009, a Rev-erbα agonist, significantly alleviated the LPS-induced production of pro-inflammatory cytokines in hESCs. Meanwhile, knockdown of Rev-erbα increased the expressions of IL-1β, IL-6, and IL-8, accompanied by an increased mRNA level of the core clock gene Bmal1. Western blot analysis showed that SR9009 inhibited the expression of toll-like receptor 4 (TLR4) and the activation of NF-κB induced by LPS. All these findings suggested that pharmacological activation of Rev-erbα attenuated the LPS-induced inflammatory response of hESCs by suppressing TLR4-regulated NF-κB activation. This study may provide a strategy for preventing inflammation-related endometrial dysfunction and infertility or recurrent implantation failure. | Weijie Zhao Liyuan Cui Xixi Huang Songcun Wang Dajin Li Liping Li Yan Sun Meirong Du | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 8 |
| 6 | Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis显示文摘Hydrogen has been used to suppress tumor growth with considerable efficacy.Inhalation of hydrogen gas and oral ingestion of hydrogen-rich saline are two common systemic routes of hydrogen administration.We have developed a topical delivery method of hydrogen at targeted sites through the degradation of magnesium-based biomaterials.However,the underlying mechanism of hydrogen’s role in cancer treatment remains ambiguous.Here,we investigate the mechanism of tumor cell apoptosis triggered by the hydrogen released from magnesium-based biomaterials.We find that the localized release of hydrogen increases the expression level of P53 tumor suppressor proteins,as demonstrated by the in vitro RNA sequencing and protein expression analysis.Then,the P53 proteins disrupt the membrane potential of mitochondria,activate autophagy,suppress the reactive oxygen species in cancer cells,and finally result in tumor suppression.The anti-tumor efficacy of magnesium-based biomaterials is further validated in vivo by inserting magnesium wire into the subcutaneous tumor in a mouse.We also discovered that the minimal hydrogen concentration from magnesium wires to trigger substantial tumor apoptosis is 91.2μL/mm^(3)per day,which is much lower than that required for hydrogen inhalation.Taken together,these findings reveal the release of H2 from magnesium-based biomaterial exerts its anti-tumoral activity by activating the P53-mediated lysosome-mitochondria apoptosis signaling pathway,which strengthens the therapeutic potential of this biomaterial as localized anti-tumor treatment. | Rui Zan Hao Wang Weijie Cai Jiahua Ni Berengere J.C.Luthringer-Feyerabend Wenhui Wang Hongzhou Peng Weiping Ji Jun Yan Jiazeng Xia Yang Song Xiaonong Zhang | 2022 | Bioactive Materials2022，7，3： | 3 |
| 7 | Luminescence tuning of Ce^3+,Pr^3+activated(Y,Gd)AGG system by band gap engineering and energy transfer显示文摘Tuning of phosphor luminescence properties,including the emission energy/intensity and thermal stability,is an important way to develop superior luminescent materials for diverse applications.In this work,we discuss the effect of band gap engineering and energy transfer on the luminescence properties of Ce^3+or Pr^3+doped(Y,Gd)AGG systems,and analyze the underlying reasons for their different phenomena.By using VUV-UV excitation spectra and constructing VRBE schemes,the changes of host band structure,5 d excited level energies and emission thermal stability of Ce^3+and Pr^3+with the incorporation of Gd^3+ions were studied.In addition,the energy transfer dynamics was also investigated in terms of the luminescence decay curves.This work demonstrates a way to tune phosphor luminescence properties by combining band gap engineering and energy transfer tailoring and provides an inspiring discussion on the different results of Ce^3+doping on the Ce^3+and Pr^3+emissions. | Yiyi Ou Weijie Zhou Fengkai Ma Chunmeng Liu Rongfu Zhou Fang Su Yan Huang Pieter Dorenbos Hongbin Liang | 2020 | Journal of Rare Earths2020，38，5： | 3 |
| 8 | Technology and engineering application of cross area HVDC interconnection system high-precision simulation modeling based on ADPSS显示文摘In recent years, a large number of high voltage direct current(HVDC) transmission projects have been connected to AC systems. This has started to have an impact on AC/DC hybrid power grids, particularly receiving terminal power grids. An HVDC system is a large-scale power electronic integrated nonlinear system, and it includes a primary system and a control and protection system. Hence, the precision and degree of detail of HVDC systems directly affect the actual effect of simulation. In recent years, in the case of the normal operation and failure of AC power grids, the abnormal fluctuation and even locking of HVDC systems caused by the inappropriate strategies of the control and protection system component have strongly affected power grids. This has significantly affected the safety and stability of receiving power grids and normal operation. In this study, the actual engineering HVDC control logic provided by a manufacturer is analyzed and simulated based on the user defined component library of the ADPSS electromagnetic transient calculation program, and an HVDC control model based on an actual system is established. The accuracy of the DC control custom model based on ADPSS is verified through the simulation of an actual power grid. | Weijie Zheng Jianfeng Yan Xujiang Chen Shuwen Xu Yalou Li | 2018 | Global Energy Interconnection2018，1，5： | 3 |
| 9 | CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance显示文摘 | Gaopeng Li Xiaoli Wu Wenchang Qian Huayong Cai Xinbao Sun Weijie Zhang Sheng Tan Zhengsheng Wu Pengxu Qian Keshuo Ding Xuefei Lu Xiao Zhang Hong Yan Haifeng Song Shouhong Guang Qingfa Wu Peter E Lobie Ge Shan Tao Zhu | 2016 | Cell Research2016，26，6： | 3 |
| 10 | Quantitation of HBV covalently closed circular DNA in micro formalin fixed paraffin-embedded liver tissue using rolling circle amplification in combination with real-time PCR显示文摘 | Yanwei Zhong Jiaqi Han Zhengsheng Zou Shuhong Liu Bo Tang Xiaoqiang Ren Xiaodong Li Yulai Zhao Yan Liu Dongqing Zhou Weijie Li Jingmin Zhao Dongping Xu | 2011 | Clinica Chimica Acta2011，，21： | 2 |
| 11 | Further study on tensor absolute value equations显示文摘In this paper,we consider the tensor absolute value equations(TAVEs),which is a newly introduced problem in the context of multilinear systems.Although the system of the TAVEs is an interesting generalization of matrix absolute value equations(AVEs),the well-developed theory and algorithms for the AVEs are not directly applicable to the TAVEs due to the nonlinearity(or multilinearity)of the problem under consideration.Therefore,we first study the solutions existence of some classes of the TAVEs with the help of degree theory,in addition to showing,by fixed point theory,that the system of the TAVEs has at least one solution under some checkable conditions.Then,we give a bound of solutions of the TAVEs for some special cases.To find a solution to the TAVEs,we employ the generalized Newton method and report some preliminary results. | Chen Ling Weijie Yan Hongjin He Liqun Qi | 2020 | Science China Mathematics2020，63，10： | 2 |
| 12 | The Entire Small Intestine Mediates the Changes in Glucose Homeostasis After Intestinal Surgery in Goto-Kakizaki Rats显示文摘 | Shaozhuang Liu Guangyong Zhang Lei Wang Dong Sun Weijie Chen Zhibo Yan Yu Sun Sanyuan Hu | 2012 | Annals of Surgery2012，，6： | 2 |
| 13 | Analysis and Improvement of SNR in FBG Sensing System显示文摘到噪音比率(SNR ) 的信号的改进有重要意思到察觉到系统的纤维布拉格栅栏(FBG ) 。噪音以及察觉到系统的 FBG 的信号变细的来源被分析。光回来损失(ORL ) 引起的光噪音是在系统的噪音的主要来源,这被发现,并且 coupler 是信号的变细的主要来源。在光纤的元素的 ORL 的原因(例如跳线开关电报,接头和纤维结束) 被介绍。另外,优化纤维的建议光察觉到网络被介绍以便改进 SNR。压制噪音的方法由 FBG 的纤维结束接口引起了,用匹配索引的液体包括,把以在这份报纸提及的方法的纤维辫子弄弯并且劈开是 8 湩敧 ? 楷桴的纤维接口的观点角度吗? | Delong KONG Jun CHANG Peijun GONG Yongning LIU Boning SUN Xiangzhi LIU Pengpeng WANG Zongliang WANG Weijie WANG Yan ZHANG | 2012 | Photonic Sensors2012，2，2： | 2 |
| 14 | Critical role of miR-10b in transforming growth factor-β1-induced epithelial-mesenchymal transition in breast cancer显示文摘 | Han X Yan S Weijie Z | 2014 | Cancer Gene Ther2014，21，2： | 1 |
| 15 | Experimental and Numerical Study of the Effect of Fuel/Air Mixing Modes on NO_(x) and CO Emissions of MILD Combustion in a Boiler Burner显示文摘The Moderate or Intense Low-oxygen Dilution (MILD) combustion is characterized by low emissions,stable combustion and low noise for various kinds of fuel,which has great potential in the industry.The aim of this study is to investigate the effect of fuel/air mixing modes on NO_(x) and CO emissions of MILD combustion in a boiler burner by experiments and numerical simulations.Three types of fuel/air mixing modes (premixing mode,diffusion mode and hybrid mode) have been considered in this study.The realizable k-ε turbulent model and the Eddy Dissipation Concept (EDC) combustion model were used in numerical simulations.In addition to the temperature near the burner head,the calculation results match very well with the axial temperature distribution at the furnace center.The flow pattern under different mixing modes is similar,while the hybrid mode has a higher OH concentration near the diffusive fuel nozzle than the premixing mode,and the corresponding position of the peak OH concentration is closer to the rear half of the furnace.The distribution of temperature is extremely uniform for the premixing mode in the main reactive zone,which is typical for MILD combustion.There is a distinct area where the reaction temperature is higher than 1600 K for the hybrid mode.Moreover,in the main reactive zone,the gas recirculation ratio is high enough to ensure flue gas recirculation,which is beneficial to achieve MILD combustion at local areas.At the location where the axial distance is greater than 0.2 m,the gas recirculation ratio of the premixing mode is larger than that of the hybrid mode,which strengthens the entrainment of hot flue gas into the recirculated gas.The experimental results show that when the thermal intensity is less than 1.67 MW·m^(-3),the NO_(x) emissions are less than 15× 10^(-6)@3.5%O_(2) in near stoichiometric ratio in the premixing mode,and the CO emissions are less than 10× 10^(-6)@3.5%O2 under the same conditions.In the diffusion mode,the NO_(x) emissions are less than 30×10^(-6)@3.5%O_(2).In order to keep NO_(x) and CO emissions low,the hybrid modes with optimized fuel distribution ratio are found under different thermal intensities. | ZHU Ziru XIONG Yan ZHENG Xianglong CHEN Weijie REN Baohe XIAO Yunhan | 2021 | Journal of Thermal Science2021，30，2： | 1 |
| 16 | Co encapsulated N-doped carbon nanotubes as robust catalyst for valorization of levulinic acid in aqueous media显示文摘The construction of an acid resistant catalyst for synthesis of γ-valerolactone from levulinic acid in aqueous media is an important but highly challenging goal.Herein,an efficient Co@NCNT-800(after 800℃ pyrolysis) catalyst was constructed by confining Co in N-doped carbon nano-tubes(NCNT) from low cost materials by a facile strategy.Combined with the characterization results and control experiments,the in situ formed Co and Co-Ox, but not Co-Nx, proved to be the main synergistic active sites of the catalyst.It was also found that Co species are completely isolated within the bamboo-like NCNT,which could protect the metal nanoparticles from agglomeration and leaching in the strong acid reaction system.The γ-valerolactone yield of no less than 99.9% can be obtained under a relatively mild condition,and the catalytic performance has not been significantly reduced within five cycles.Therefore,this work may pave a way for the design of robust non-noble catalyst,and has potential for the production of γ-valerolactone from biomass in large-scale industries. | Xiangjin Kong Weijie Geng Wenxiu Li Lin Liu Xiaoqi Yan Longchen Gong Junhai Liu | 2021 | Journal of Energy Chemistry2021，30，1： | 1 |
| 17 | Cloning and sequence analysis of β-actin gene from Aedes albopictus (Diptera: Culicidae)显示文摘Objective: To obtain the complete β-actin gene from Aedes albopictus. Methods: Total RNA was extracted from C6/36 cells. Degenerate primers were designed based on the β-actin sequences of An. gambiae, Ae. aegypti, Cx. pipiens pallens and D. melanogaster. By RT-PCR, the product was amplified, purified, cloned into the pGT vector and sequenced. The β-actin sequence was aligned and phylogenetically analyzed by the BLAST program and the CLUSTAL W program. Results: A sequence of 1132 bp including an open reading frame of 1131 bp was obtained(GenBank DQ657949). The deduced protein had 376 amino acids. Aligned to SWISS-PROT, it exhibited a high level of identity with β-actins from Anopheles, Drosophila and Culex at the amino acid sequence level. Phylogenetic analysis indicated that Ae. albopictus β-actin was much more homologous with invertebrate β-actin than with vertebrate β-actin. Conclusion: The gene may be used as the internal control in the experiments of Ae. albopictus. | Weijie Wang Xiaobang Hu Donghui Zhang Jianhua Jiao Yan Sun Lei M' Changliang Zhu | 2007 | Journal of Nanjing Medical University2007，21，2： | 1 |
| 18 | Critical role of miR-10b in trans- forming growth factor-betal-induced epithelial-mesenchymal transition in breast cancer显示文摘 | Han X Yan S Weijie Z | 2014 | Cancer Gene Therapy2014，21，2： | 1 |
| 19 | Fabrication and characterization of microcantilever integrated with PZT thin film sensor and actuator 显示文摘 | Weijie Dong Xiaoguang Lu Yan Cui | 2007 | Thin Solid Films2007，515，： | 1 |
| 20 | Critical role of miR-10b in trans{ormiug growth factor-betal-induced epitheKal-mesen- chymal transition in breast cancer显示文摘 | Han X Yan S Weijie Z | 2014 | Cancer Gene Ther2014，21，2： | 1 |
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