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| 1 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 2 | A durable 4-1BB-based CD19 CAR-T cell for treatment of relapsed or refractory non-Hodgkin lymphoma显示文摘Objective:Previous studies reported that 4-1BB-based CD19 chimeric antigen receptor(CAR)-T cells were more beneficial for the clinical outcomes than CD28-based CAR-T cells,especially the lower incidence rate of severe adverse events.However,the median progression-free survival(mPFS)of 4-1BB-based product Kymriah was shorter than that of CD28-based Yescarta(2.9 months vs.5.9 months),suggesting that Kymriah was limited in the long-term efficacy.Thus,a safe and durable 4-1BB-based CD19 CAR-T needs to be developed.Methods:We designed a CD19-targeted CAR-T(named as IM19)which consisted of an FMC63 scFv,4-1BB and CD3ζintracellular domain and was manufactured into a memory T-enriched formulation.A phase I/II clinical trial was launched to evaluate the clinical outcomes of IM19 in relapsed or refractory(r/r)B cell non-Hodgkin lymphoma(B-NHL).Dose-escalation investigation(at a dose of 5×10^(5)/kg,1×10^(6)/kg and 3×106/kg)was performed in 22 r/r B-NHL patients.All patients received a single infusion of IM19 after 3-day conditional regimen.Results:At month 3,the overall response rate(ORR)was 59.1%,the complete response rate(CRR)was 50.0%.The mPFS was 6 months and the 1-year overall survival rate was 77.8%.Cytokine release syndrome(CRS)occurred in 13 patients(59.1%),with 54.5%of grade 1−2 CRS.Only one patient(4.5%)experienced grade 3 CRS and grade 3 neurotoxicity.Conclusions:These results demonstrated the safety and durable efficacy of a 4-1BB-based CD19 CAR-T,IM19,which is promising for further development and clinical investigation. | Zhitao Ying Ting He Shanzhao Jin Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Weiping Liu Lijuan Deng Yanping Ding Xuelian Hu Bing Bu Xin’an Lu Yuqin Song Jun Zhu | 2022 | Chinese Journal of Cancer Research2022，34，1： | 2 |
| 3 | Finite element multigrid method for multi-term time fractional advection diffusion equations显示文摘In this paper,a class of multi-term time fractional advection diffusion equations(MTFADEs)is considered.By finite difference method in temporal direction and finite element method in spatial direction,two fully discrete schemes of MTFADEs with different definitions on multi-term time fractional derivative are obtained.The stability and convergence of these numerical schemes are discussed.Next,a V-cycle multigrid method is proposed to solve the resulting linear systems.The convergence of the multigrid method is investigated.Finally,some numerical examples are given for verification of our theoretical analysis. | Weiping Bu Xiangtao Liu Yifa Tang Jiye Yang | 2015 | International Journal of Modeling, Simulation, and Scientific Computing2015，6，1： | 1 |
| 4 | A fast finite difference/finite element method for the two-dimensional distributed-order time-space fractional reaction-diffusion equation显示文摘In this work,we develop a finite difference/finite element method for the two-dimensional distributed-order time-space fractional reaction-diffusion equation(2D-DOTSFRDE)with low regularity solution at the initial time.A fast evaluation of the distributedorder time fractional derivative based on graded time mesh is obtained by substituting the weak singular kernel for the sum-of-exponentials.The stability and convergence of the developed semi-discrete scheme to 2D-DOTSFRDE are discussed.For the spatial approximation,the finite element method is employed.The convergence of the corresponding fully discrete scheme is investigated.Finally,some numerical tests are given to verify the obtained theoretical results and to demonstrate the effectiveness of the method. | Yaping Zhang Jiliang Cao Weiping Bu Aiguo Xiao | 2020 | International Journal of Modeling, Simulation, and Scientific Computing2020，11，2： | 0 |
| 5 | Statistical analysis of mechanical properties of biological soft tissue under quasi-static mechanical loading显示文摘The mechanical properties of biological soft tissues are inextricably linked to the field of health care,and their mechanical properties can be important indicators for diagnosing and detecting diseases;they can also be used to analyze the causes of organ diseases from a pathological point of view and thus guide the deployment of medical solutions.As an effective method to characterize the mechanical properties of materials,mechanical loading experiments have been successfully applied to the mechanical properties of materials,including tension,compression,pure shear,and so on.Under quasi-static loading,when the material is a biological soft tissue material between a solid and an ideal fluid,its viscoelastic properties strongly respond to the force stimulus,and the stress-strain-time in the elastic phase will have obvious disturbance characteristics.Therefore,the existing statistical methods are often difficult to quantitatively describe the mechanical properties of materials.Therefore,this study proposes an Interval Capture Point based on the principle of integration.The experimental data based on this method can characterize its nonlinear mechanical properties well,especially when the loading speed is extremely low and the soft materials show strong disturbance characteristics.The proposed method can still accurately characterize the hyperelastic and viscoelastic properties of the mechanical properties of biological soft tissues under quasi-static loading. | Wei Kang Yu Zhang Weiping Bu Yanpeng Zhao Lizhen Wang Songyang Liu | 2023 | Medicine in Novel Technology and Devices2023，，1： | 0 |
| 6 | Finite element methods for fractional diffusion equations显示文摘Due to the successful applications in engineering,physics,biology,finance,etc.,there has been substantial interest in fractional diffusion equations over the past few decades,and literatures on developing and analyzing efficient and accurate numerical methods for reliably simulating such equations are vast and fast growing.This paper gives a concise overview on finite element methods for these equations,which are divided into time fractional,space fractional and time-space fractional diffusion equations.Besides,we also involve some relevant topics on the regularity theory,the well-posedness,and the fast algorithm. | Yue Zhao Chen Shen Min Qu Weiping Bu Yifa Tang | 2020 | International Journal of Modeling, Simulation, and Scientific Computing2020，11，4： | 0 |
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