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| 1 | Self-monitoring of blood glucose in type 2 diabetic patients in China:current status and influential factors显示文摘 | Yuan Li Guo Xiaohui Xiong Zhenzhen Lou Qingqing Shen Li Zhao Fang Sun Zilin Li Jianwei | 2014 | Chinese Medical Journal2014，，2： | 21 |
| 2 | Estimation Method of State-of-Charge For Lithium-ion Battery Used in Hybrid Electric Vehicles Based on Variable Structure Extended Kalman Filter显示文摘Since the main power source of hybrid electric vehicle(HEV) is supplied by the power battery,the predicted performance of power battery,especially the state-of-charge(SOC) estimation has attracted great attention in the area of HEV.However,the value of SOC estimation could not be greatly precise so that the running performance of HEV is greatly affected.A variable structure extended kalman filter(VSEKF)-based estimation method,which could be used to analyze the SOC of lithium-ion battery in the fixed driving condition,is presented.First,the general lower-order battery equivalent circuit model(GLM),which includes column accumulation model,open circuit voltage model and the SOC output model,is established,and the off-line and online model parameters are calculated with hybrid pulse power characteristics(HPPC) test data.Next,a VSEKF estimation method of SOC,which integrates the ampere-hour(Ah) integration method and the extended Kalman filter(EKF) method,is executed with different adaptive weighting coefficients,which are determined according to the different values of open-circuit voltage obtained in the corresponding charging or discharging processes.According to the experimental analysis,the faster convergence speed and more accurate simulating results could be obtained using the VSEKF method in the running performance of HEV.The error rate of SOC estimation with the VSEKF method is focused in the range of 5% to 10% comparing with the range of 20% to 30% using the EKF method and the Ah integration method.In Summary,the accuracy of the SOC estimation in the lithium-ion battery cell and the pack of lithium-ion battery system,which is obtained utilizing the VSEKF method has been significantly improved comparing with the Ah integration method and the EKF method.The VSEKF method utilizing in the SOC estimation in the lithium-ion pack of HEV can be widely used in practical driving conditions. | SUN Yong MA Zilin TANG Gongyou CHEN Zheng ZHANG Nong | 2016 | Chinese Journal of Mechanical Engineering2016，29，4： | 17 |
| 3 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 4 | Multi-objective parameter optimization for a single-shaft series-parallel plug-in hybrid electric bus using genetic algorithm显示文摘最近,插件混合电的公共汽车(PHEB ) 的单个柄的系列平行 powertrain 为驾驶周期由于它的可改变的操作模式,优秀燃料经济和强壮的适应性成为了最流行的 powertrains 之一。为在开发阶段与单个柄的系列平行 powertrain 设置 PHEB,当选择并且匹配主要部件参数时,不过,它仍然比另外的配置面对更大的挑战。由这个问题激发了,全面多目的优化策略与典型 powertrain 为 PHEB 基于基因算法(GA ) 被开发。就公共汽车线路的重覆性和整齐而言,首先,离线的数据处理和数学统计的方法被采用,到获得一个代表性的开车周期,它能很好反映真实世界的公共汽车线路的一般特征。然后,节俭的优化目的被定义,它是由生产关键部件和精力消费的费用组成,并且与动态优化目的结合了,多客观的优化功能被提出。同时, GA 算法被用来优化参数,为新奇系列平行 powertrain 的最佳的部件联合。最后,有原型的比较被执行沿着驾驶周期验证优化 powertrain 的表演。模拟结果显示建议全面多目的优化策略获得的 powertrain 部件的参数可能得到更好的燃料经济,同时保证 PHEB 的动态性能。与原版相对照,费用在 18% 衰退了。因此,策略将为 PHEB 制造商在参数选择上提供理论指导。 | CHEN Zheng ZHOU LiYan SUN Yong MA ZiLin HAN ZongQi | 2016 | Science China(Technological Sciences)2016，59，8： | 4 |
| 5 | Rejection of insulin therapy among patients with type 2 diabetes in China: reasons and recommendations显示文摘 | Xiong Zhenzhen Yuan Li Guo Xiaohui Lou Qingqing Zhao Fang Shen Li Zhang Mingxia Sun Zilin | 2014 | Chinese Medical Journal2014，，20： | 4 |
| 6 | Super Na^(+)Half/Full Batteries and Ultrafast Na+Diffusion Kinetics of Cobalt-Nickel Selenide from Assembling Co_(0.5)Ni_(0.5)Se_(2)@NC Nanosheets into Cross-Stacked Architecture显示文摘Explorati on of adva need an ode materials for sodium-i on batteries(SIBs)is still a big challe nge due to the large radius of sodium.In this work,the hierarchical architectures assembled from N-doped carbon-coated Co_(0.5)Ni_(0.5)Se_(2)(Co_(0.5)Ni_(0.5)Se_(2)@NC)nanoparticles encapsulated into cross-stacked nano sheets have been successfully prepared from the cobalt-nickel bin ary-metal organic frameworks(CoNi-MOF)by two steps of the solid-state sele nizati on and carb on coating processes.Imports ntly,the resulta nt hierarchical Co0.5Nio:5Se2@NC architecture can achieve a satisfactory electrochemical performance,maintaining a high-rate capacity of 330 mA-h-g^(-1)1 at 3 A·g^(-1) and a stable cyclability of 100 cycles without obvious capacity decay at 0.2 A·g^(-1).The design of distinct superstructure can not only be applied to other electrode materials but also boost the forward development of energy storage systems. | Zhiyong Li Zilin Peng Rui Sun Zhaoxia Qin Xinlong Liu Caihong Wang Haosen Fan Shengjun Lu | 2021 | Chinese Journal of Chemistry2021，39，9： | 3 |
| 7 | Pancreatitis-Associated Protein Inhibits Human Pancreatic Stellate Cell MMP-1 and -2, TIMP-1 and -2 Secretion and RECK Expression显示文摘 | Ling Li Max G. Bachem Shaoxia Zhou Zilin Sun Jinfei Chen Marco Siech Daniel Bimmler Rolf Graf | 2009 | Pancreatology . 2009 (1-2)2009，，1： | 1 |
| 8 | Hexafluoropropylene oxide trimer acid,a perfluorooctanoic acid alternative,induces cardiovascular toxicity in zebrafish embryos显示文摘As an increasingly used alternative to perfluorooctanoic acid(PFOA),hexafluoropropylene oxide trimer acid(HFPO-TA)has been widely detected in global water environments.However,little is known regarding its toxic effects on cardiovascular development.Here,zebrafish embryos were treated with egg water containing 0,60,120,or 240 mg/L HFPO-TA.Results showed that HFPO-TA treatment led to a significant reduction in both larval survival percentage and heart rate.Furthermore,HFPO-TA exposure caused severe pericardial edema and elongation of the sinus venous to bulbus arteriosus distance(SV-BA)in Tg(myl7:GFP)transgenic larvae,disrupting the expression of genes involved in heart development and thus causing abnormal heart looping.Obvious sprouting angiogenesis was observed in the 120 and 240 mg/L exposed Tg(fli:GFP)transgenic larvae.HFPO-TA treatment also impacted the mRNA levels of genes involved in the vascular endothelial growth factor(VEGF)pathway and embryonic vascular development.HFPO-TA exposure significantly decreased erythrocyte number in Tg(gata1:DsRed)transgenic embryos and influenced gene expression associated with the heme metabolism pathway.HFPO-TA also induced oxidative stress and altered the transcriptional levels of genes related to cell cycle and apoptosis,inhibiting cell proliferation while promoting apoptosis.Therefore,HFPO-TA exposure may induce abnormal development of the cardiovascular and hematopoietic systems in zebrafish embryos,suggesting it may not be a suitable or safe alternative for PFOA. | Sujie Sun Li Zhang Xue Li Lu Zang Ling Huang Junquan Zeng Zigang Cao Xinjun Liao Zilin Zhong Huiqiang Lu Jianjun Chen | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
| 9 | Hysteretic behavior of post-tensioned precast segmental CFT double-column piers显示文摘Considering the desirable behavior of concrete filled steel tube(CFT)columns and the complicated behavior of segmental double-column piers under cyclic loads,three post-tensioned precast segmental CFT double-column pier specimens were tested to extend their application in moderate and high seismicity areas.The effects of the number of CFT segments and the steel endplates as energy dissipaters on the seismic behavior of the piers were evaluated.The experimental results show that the segmental piers exhibited stable hysteretic behavior with small residual displacements under cyclic loads.All the tested specimens achieved a drift ratio no less than 13%without significant damage and strength deterioration due to the desirable behavior of CFT columns.Since the deformation of segmental columns was mainly concentrated at the column-footing interfaces,the increase of the segment numbers for each column had no obvious effects on the loading capacity but reduced the initial stiffness of the specimens.The use of steel endplates improved the bearing capacity,stiffness and energy dissipation of segmental piers,but weakened their self-centering capacity.Fiber models were also proposed to simulate the hysteretic behavior of the tested specimens,and the influences of segment numbers and prestress levels on seismic behavior were further studied. | Li Xian Zhang Zilin Zhou Tao Xiao Yu Sun Yushun | 2023 | Earthquake Engineering and Engineering Vibration2023，22，3： | 0 |
| 10 | Energy band engineering via“Bite”defect located on N=8 armchair graphene nanoribbons显示文摘Graphene nanoribbons(GNRs)not only share many superlative properties of graphene but also display an exceptional degree of tunability of their electronic properties.The bandgaps of GNRs depend greatly on their widths,edges,etc.Herein,we report the synthesis path and the physical properties of atomic accuracy staggered narrow N=8 armchair graphene nanoribbons(sn-8AGNR)with alternating'Bite'defects on the opposite side.The intermediate structures in the surface physicochemical reactions from the precursors to the sn-8AGNR are characterized by scanning tunneling microscopy.The electronic properties of the sn-8AGNR are characterized by scanning tunneling spectroscopies and 6//6V mappings.Compared with the perfect N=8 armchair graphene nanoribbons(8AGNR),the sn-8AGNR has a larger bandgap,indicating that the liB\Xen edges can effectively regulate the electronic structures of GNRs. | Shijie Sun Yurou Guan Zhenliang Hao Zilin Ruan Hui Zhang Jianchen Lu Lei Gao Xiaoqing Zuo Jinming Cai | 2022 | Nano Research2022，15，1： | 0 |
| 11 | Mutations in epigenetic regulator KMT2C detected by liquid biopsy are associated with worse survival in prostate cancer patients显示文摘Background:KMT2(lysine methyltransferase)family enzymes are epigenetic regulators that activate gene transcription.KMT2C is mainly involved in enhancer-associated H3K4me1,and is also one of the top mutated genes in cancer(6.6%in pan-cancer).Currently,the clinical significance of KMT2C mutations in prostate cancer is understudied.Methods:We included 221 prostate cancer patients diagnosed between 2014 and 2021 in West China Hospital of Sichuan University with cell-free DNA-based liquid biopsy test results in this study.We investigated the association between KMT2C mutations,other mutations,and pathways.Furthermore,we evaluated the prognostic value of KMT2C mutations,measured by overall survival(OS)and castration resistance-free survival(CRFS).Also,we explored the prognostic value of KMT2C mutations in different patient subgroups.Lastly,we investigated the predictive value of KMT2C mutations in individuals receiving conventional combined anti-androgen blockade(CAB)and abiraterone(ABI)as measured by PSA progression-free survival(PSA-PFS).Results:The KMT2C mutation rate in this cohort is 7.24%(16/221).KMT2C-mutated patients showed worse survival than KMT2C-wild type(WT)patients regarding both CRFS and OS(CRFS:mutated:9.9 vs.WT:22.0 months,p=0.015;OS:mutated:71.9 vs.WT 137.4 months,p=0.012).KMT2C mutations were also an independent risk factor in OS[hazard ratio:3.815(1.461,9.96),p=0.006]in multivariate analyses.Additionally,we explored the association of KMT2C mutations with other genes.This showed that KMT2C mutations were associated with Serine/Threonine-Protein Kinase 11(STK11,p=0.004)and Catenin Beta 1(CTNNB1,p=0.008)mutations.In the CAB treatment,KMT2C-mutated patients had a significantly shorter PSA-PFS compared to KMT2C-WT patients.(PSA-PFS:mutated:9.9 vs.WT:17.6 months,p=0.014).Moreover,KMT2C mutations could effectively predict shorter PSA-PFS in 10 out of 23 subgroups and exhibited a strong trend in the remaining subgroups.Conclusions:KMT2C-mutated patients showed worse survival compared to KMT2C-WT patients in terms of both CRFS and OS,and KMT2C mutations were associated with STK11 and CTNNB1 mutations.Furthermore,KMT2C mutations indicated rapid progression during CAB therapy and could serve as a potential biomarker to predict therapeutic response in prostate cancer. | SHA ZHU NANWEI XU JIAYU LIANG FENGNIAN ZHAO ZILIN WANG YUCHAO NI JINDONG DAI JINGE ZHAO XINGMING ZHANG JUNRU CHEN GUANGXI SUN PENGFEI SHEN HAO ZENG | 2023 | Oncology Research2023，31，4： | 0 |
| 12 | Chiral structures of 6,12-dibromochrysene on Au(111)and Cu(111)surfaces显示文摘Nanoscale low-dimensional chiral architectures are increasingly receiving scientific interest,because of their potential applications in many fields such as chiral recognition,separation and transformation.Using 6,12-dibromochrysene(DBCh),we successfully constructed and characterized the large-area two-dimensional chiral networks on Au(111)and one-dimensional metal-liganded chiral chains on Cu(111)respectively.The reasons and processes of chiral transformation of chiral networks on Au(111)were analyzed.We used scanning tunneling spectroscopy(STS)to analyze the electronic state information of this chiral structure.This work combines scanning tunneling microscopy(STM)with non-contact atomic force microscopy(nc-AFM)techniques to achieve ultra-high-resolution characterization of chiral structures on low-dimensional surfaces,which may be applied to the bond analysis of functional nanofilms.Density functional theory(DFT)was used to simulate the adsorption behavior of the molecular and energy analysis in order to verify the experimental results. | Shijie Sun Baijin Li Boyu Fu Zilin Ruan Hui Zhang Wei Xiong Yong Zhang Gefei Niu Jianchen Lu Xiaoqing Zuo Lei Gao Jinming Cai | 2022 | Chinese Chemical Letters2022，33，12： | 0 |
| 13 | Improving Na^(+)transport kinetics and Na^(+)storage of hierarchical rhenium-nickel sulfide(ReS_(2)@NiS_(2))hollow architecture by assembling layered 2D-3D heterostructures显示文摘Mixed metal sulfides have been widely used as anode material of sodium-ion batteries(SIBs)because of their excellent conductivity and sodium ion storage performance.Herein,ReS_(2)@NiS_(2)heterostructures have been triumphantly designed and prepared through anchoring ReS_(2)nanosheet arrays on the surface of NiS_(2)hollow nanosphere.Specifically,the carbon nanospheres was used as hard template to synthesize NiS_(2)hollow spheres as the substrate and then the ultrathin two-dimensional ReS_(2)nanosheet arrays were uniformly grown on the surface of NiS_(2).The internal hollow property provides sufficient space to relieve the volume expansion,and the outer two-dimensional nanosheet realizes the rapid electron transport and insertion/extraction of Na^(+).Owing to the great improvement of the transport kinetics of Na^(+),NiS_(2)@ReS_(2)heterostructure electrode can achieve a high specific capacity of 400 mAh/g at the high current density of 1 A/g and still maintain a stable cycle stability even after 220 cycles.This hard template method not only paves a new way for the design and construct binary metal sulfide heterostructure electrode materials with outstanding electrochemical performance for Na^(+)batteries but also open up the potential applications of anode materials of SIBs. | Zelin Cai Zilin Peng Xinlong Liu Rui Sun Zhaoxia Qin Haosen Fan Yufei Zhang | 2021 | Chinese Chemical Letters2021，32，11： | 0 |
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