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| 1 | The relationship between concentration of growth hormone in serum and microangiopathy in patients with diabetes mellitus.显示文摘Therelationshipbetwenconcentrationofgrowthhormoneinserumandmicroangiopathyinpatientswithdiabetesmelitus.ChenMingsheng,YuWenbi... | Chen Mingsheng, Yu Wenbin, Hu Shaowen, et al. Clinical Laboratovy, Xijing Hospital, Xi’an 710032, China. | 1998 | Chinese Medical Journal1998，，1： | 9 |
| 2 | Machine learning for detecting mesial temporal lobe epilepsy by structural and functional neuroimaging显示文摘Mesial temporal lobe epilepsy(mTLE),the most common type of focal epilepsy,is associated with functional and structural brain alterations.Machine learning(ML)techniques have been successfully used in discriminating mTLE from healthy controls.However,either functional or structural neuroimaging data are mostly used separately as input,and the opportunity to combine both has not been exploited yet.We conducted a multimodal ML study based on functional and structural neuroimaging measures.We enrolled 37 patients with left mTLE,37 patients with right mTLE,and 74 healthy controls and trained a support vector ML model to distinguish them by using each measure and the combinations of the measures.For each single measure,we obtained a mean accuracy of 74%and 69%for discriminating left mTLE and right mTLE from controls,respectively,and 64%when all patients were combined.We achieved an accuracy of 78%by integrating functional data and 79%by integrating structural data for left mTLE,and the highest accuracy of 84%was obtained when all functional and structural measures were combined.These findings suggest that combining multimodal measures within a single model is a promising direction for improving the classification of individual patients with mTLE. | Baiwan Zhou Dongmei An Fenglai Xiao Running Niu Wenbin Li Wei Li Xin Tong Graham J Kemp Dong Zhou Qiyong Gong Du Lei | 2020 | Frontiers of Medicine2020，14，5： | 2 |
| 3 | Peer effects and school dropout in rural China显示文摘 | Qiang Li Wenbin Zang Lian An | 2013 | China Economic Review2013，，： | 1 |
| 4 | 显示文摘 | He Ying Sang Wenbin Wang Jun'an | 2005 | Mater Chem Phys2005，94，： | 1 |
| 5 | 显示文摘 | He Ying Sang Wenbin Wang Jun'an | 2005 | Mater Chem Phys2005，94，： | 1 |
| 6 | Dimensionality Re- duction by Combining Category Information and Latent Semantic Index for Text Categorization 显示文摘 | Wenbin Zheng Lixin An Zhanyi Xu | 2013 | Journal of In- formation & Computational Science2013，10，8： | 1 |
| 7 | Application of single-cell RNA sequencing in head and neck squamous cell carcinoma显示文摘Single-cell RNA sequencing has been broadly applied to head and neck squamous cell carcinoma(HNSCC) for characterizing the heterogeneity and genomic mutations of HNSCC benefiting from the advantage of single-cell resolution. We summarized most of the current studies and aimed to explore their research methods and ideas, as well as how to transform them into clinical applications. Through single-cell RNA sequencing, we found the differences in tumor cells’ expression programs and differentiation tracks. The studies of immune microenvironment allowed us to distinguish immune cell subpopulations, the extensive expression of immune checkpoints, and the complex crosstalk network between immune cells and non-immune cells. For cancerassociated fibroblasts(CAFs), single-cell RNA sequencing had made an irreplaceable contribution to the exploration of their differentiation status, specific CAFs markers, and the interaction with tumor cells and immune cells. In addition, we demonstrated in detail how single-cell RNA sequencing explored the HNSCC epithelial-tomesenchymal transition(EMT) model and the mechanism of drug resistance, as well as its clinical value. | Zhaohong An Wan Liu Wenbin Li Minghui Wei Changming An | 2023 | Chinese Journal of Cancer Research2023，35，4： | 0 |
| 8 | Adjoint Method for an Inverse Problem of CCPF Model显示文摘The problem for determining the exchange rate function of 2D CCPF model by measurements on the partial boundary is considered and solved as one PDE-constraint optimization problem. The optimal variant is the minimum of a cost functional that quantifies the difference between the measurements and the exact solutions. Gradientbased algorithm is used to solve this optimization problem. At each step, the derivative of the cost functional with respect to the exchange rate function is calculated and only one forward solution and one adjoint solution are needed. One method based on the adjoint equation is developed and implemented. Numerical examples show the efficiency of the adjoint method. | Zhenhua CHEN Kaiqi AN Yuan LIU Wenbin CHEN | 2014 | Chinese Annals of Mathematics,Series B2014，35，3： | 0 |
| 9 | DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination显示文摘Fanconi anemia(FA),an X-linked genetic or autosomal recessive disease,exhibits complicated pathogenesis.Previously,we detected the mutated Dynein Axonemal Heavy Chain 2(DNAH2)gene in 2 FA cases.Herein,we further investigated the potential association between DNAH2 and the homologous recombination repair pathway of FA.The assays of homologous recombination repair,mitomycin C(MMC)sensitivity,immunofluorescence,and ubiquitination modification were performed in U2OS and DR-U2OS cell lines.In MMC-treated U2OS cells,the downregulation of the DNAH2 gene increased the sensitivity of cells to DNA inter-strand crosslinks.We also observed the reduced enrichment of FANCD2 protein to DNA damage sites.Furthermore,the ubiquitination modification level of FANCD2 was influenced by the deficiency of DNAH2.Thus,our results suggest that DNAH2 may modulate the cell homologous recombination repair partially by increasing the ubiquitination and the enrichment to DNA damage sites of FANCD2.DNAH2 may act as a novel co-pathogenic gene of FA patients. | Lixian Chang Xingjie Gao Yuxia Wang Chunmin Huang Min Gao Xiaomin Wang Chao Liu Wenqi Wu Wenbin An Yang Wan Aoli Zhang Yingchi Zhang Weiping Yuan Xiaofan Zhu | 2021 | Blood Science2021，3，3： | 0 |
| 10 | Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model显示文摘Multiple system atrophy(MSA)is a rare,fatal neurodegenerative disease characterized by the accumulation of misfolded asynuclein(asyn)in glial cells,leading to the formation of glial cytoplasmic inclusions(GCl).We previous found that glial fatty acidbinding protein 7(FABP7)played a crucial role in alpha-synuclein(aSyn)aggregation and toxicity in oligodendrocytes,inhibition of FABP7 by a specific inhibitor MF 6 reduced aSyn aggregation and enhanced cell viability in cultured cell lines and mouse oligodendrocyte progenitor cells.In this study we investigated whether MF 6 ameliorated aSyn-associated pathological processes in PLP-haSyn transgenic mice(PLP-aSyn mice),a wildly used MSA mouse model with overexpressing aSyn in oligodendroglia under the proteolipid protein(PLP)promoter.PLP-aSyn mice were orally administered MF6(0.1,1 mg·kg^(-1)·d^(-1))for 32 days starting from the age of 6 months.We showed that oral administration of MF 6 significantly improved motor function assessed in a pole test,and reduced aSyn aggregation levels in both cerebellum and basal ganglia of PLP-aSyn mice.Moreover,MF 6 administration decreased oxidative stress and inflammation levels,and improved myelin levels and Purkinje neuron morphology in the cerebellum.By using mouse brain tissue slices and aSyn aggregates-treated KG-1C cells,we demonstrated that MF 6 reduced aSyn propagation to Purkinje neurons and oligodendrocytes through regulating endocytosis.Overall,these results suggest that MF 6 improves cerebellar functions in MSA by inhibiting asyn aggregation and propagation.We conclude that MF 6 is a promising compound that warrants further development for the treatment of MSA. | An Cheng Wenbin Jia David I.Finkelstein Nadia Stefanova Haoyang Wang Takuya Sasaki Ichiro Kawahata Kohji Fukunaga | 2024 | Acta Pharmacologica Sinica2024，45，1： | 0 |
| 11 | Solid-state-reaction fabrication and properties of a high-doping Nd:YAG transparent laser ceramic显示文摘High-quality neodymium-doped yttrium aluminum garnet(Nd:YAG)transparent ceramic(4.0 mole percent)was fabricated by a solid-state reaction method and vacuum sintering.The microstructure,optical transmittance,spectral properties and laser performance were investigated.The average grain size of the sample is about 10 mm.The transmittance of a 2.8-mm thick sample reaches 79.5%at the laser wavelength of 1064 nm.The highest absorption peak is centered at 807 nm and the absorption coefficient is 13.9 cm^(-1).The absorption coefficient at the laser wavelength is 0.2 cm^(-1).The main emission peak is at 1064 nm and the fluorescence lifetime is 102 ms.A laser diode(808 nm)whose maximum output is about 1000 mW was used as a pump source and an endpumped laser experiment was performed.The 1064 nm-CW-laser output was obtained and the threshold is 733 mW.With 998 mW of maximum absorbed pump power,a laser output of 17 mW is obtained with a slope efficiency of 6.1%. | Jiang LI Yusong WU Yubai PAN Wenbin LIU Liqiong AN Shiwei WANG Jingkun GUO | 2008 | Frontiers of Chemical Science and Engineering2008，2，3： | 0 |
| 12 | Expert consensus on prevention and cardiopulmonary resuscitation for cardiac arrest in COVID-19显示文摘Background:Cardiopulmonary resuscitation(CPR)strategies in COVID-19 patients differ from those in patients suffering from cardiogenic cardiac arrest.During CPR,both healthcare and non-healthcare workers who provide resuscitation are at risk of infection.The Working Group for Expert Consensus on Prevention and Cardiopulmonary Resuscitation for Cardiac Arrest in COVID-19 has developed this Chinese Expert Consensus to guide clinical practice of CPR in COVID-19 patients.Main recommendations:1)A medical team should be assigned to evaluate severe and critical COVID-19 for early monitoring of cardiac-arrest warning signs.2)Psychological counseling and treatment are highly recommended,since sympathetic and vagal abnormalities induced by psychological stress from the COVID-19 pandemic can induce cardiac arrest.3)Healthcare workers should wear personal protective equipment(PPE).4)Mouth-to-mouth ventilation should be avoided on patients suspected of having or diagnosed with COVID-19.5)Hands-only chest compression and mechanical chest compression are recommended.6)Tracheal-intubation procedures should be optimized and tracheal-intubation strategies should be implemented early.7)CPR should be provided for 20-30 min.8)Various factors should be taken into consideration such as the interests of patients and family members,ethics,transmission risks,and laws and regulations governing infectious disease control.Changes in management:The following changes or modifications to CPR strategy in COVID-19 patients are proposed:1)Healthcare workers should wear PPE.2)Hands-only chest compression and mechanical chest compression can be implemented to reduce or avoid the spread of viruses by aerosols.3)Both the benefits to patients and the risk of infection should be considered.4)Hhealthcare workers should be fully aware of and trained in CPR strategies and procedures specifically for patients with COVID-19. | Wei Song Jie Wei Xiangdong Jian Deren Wang Yanhong Ouyang Yuanshui Liu Xianjin Du Ying Chen Yingqi Zhang Heping Xu Shuming Xianyu Qiong Ning Xiang Li Xiaotong Han Feng Zhan Tao Yu Wenteng Chen Jun Zhang Wenwei Cai Sheng’ang Zhou Shengyang Yi Yu Cao Xiaobei Chen Shunjiang Xu Zong’an Liang Duohu Wu Fen Ai Zhong Wang Qingyi Meng Yuhong Mi Sisen Zhang Rongjia Yang Shouchun Yan Wenbin Han Yong Lin Chuanyun Qian Wenwu Zhang Yan Xiong Jun Lv Baochi Liu Yan Cao Xiaojun He Xuelian Sun Yufang Cao Tian’en Zhou | 2021 | Asian Pacific Journal of Tropical Medicine2021，14，6： | 0 |
| 13 | CRACK INITIATION POINT DETERMINATION AND DYNAMIC FRACTURE TOUGHNESS FOR CHARPY PRE-CRACKED SPECIMEN显示文摘The method to detect the crack initiation point of Charpy pre-cracked specimen under dy-namie loading was studied using strain gauge.The load-time curve and nominal strain-timecurve at the crack tip for impact testing specinens may be shnultaneously measured bytwin-channel oscilloscope with high speed sampling and diskette storing.Based on the dynam-ic finite element simulation of impact response of Charpy specimen,the measuring method ofdynamic fracture toughness was analysed and some problems in previous dynamic fracturetoughness measurement were discussed. | LIN Junshan YAN Wenbin TU Mingjing Xi’an Jiaotong University,Xi’an,China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，5： | 0 |
| 14 | Research on Multi-Blockchain Electronic Archives Sharing Model显示文摘The purpose of introducing blockchain into electronic archives sharing and utilization is to break the information barrier between electronic archives sharing departments by relying on technologies such as smart contract and asymmetric encryption.Aiming at the problem of dynamic permission management in common access control methods,a new access control method based on smart contract under blockchain is proposed,which improves the intelligence level under blockchain technology.Firstly,the Internet attribute access control model based on smart contract is established.For the dynamic access of heterogeneous devices,the management contract,permission judgment contract and access control contract are designed;Secondly,the access object credit evaluation algorithm based on particle swarm optimization radial basis function(PSO-RBF)neural network is used to dynamically generate the access node credit threshold combined with the access policy,so as to realize the intelligent access right management method.Finally,combined with the abovemodels and algorithms,the workflow of electronic archives sharing and utilization model of multi blockchain is constructed.The experimental results show that the timeconsuming of the process increases linearly with the number of continuous access to electronic archives blocks,and the secure access control of sharing and utilization is feasible,secure and effective. | Fang Yu Wenbin Bi Ning Cao Jun Luo Diantang An Liqiang Ding Russell Higgs | 2023 | Computers, Materials & Continua2023，76，9： | 0 |
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