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| 1 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 2 | The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation显示文摘Interleukin(IL)17-producing T helper(Th17)cells play critical roles in the clearance of extracellular bacteria and fungi as well as the pathogenesis of various autoimmune diseases,such as multiple sclerosis,psoriasis,and ulcerative colitis.Although a global transcriptional regulatory network of Th17 cell differentiation has been mapped recently,the participation of epigenetic modifications in the differentiation process has yet to be elucidated.We demonstrated here that histone H3 lysine-27(H3K27)demethylation,predominantly mediated by the H3K27 demethylase Jmjd3,crucially regulated Th17 cell differentiation.Activation of naı¨ve CD41 T cells immediately induced high expression of Jmjd3.Genetic depletion of Jmjd3 in CD41 T cells specifically impaired Th17 cell differentiation both in vitro and in vivo.Ectopic expression of Jmjd3 largely rescued the impaired differentiation of Th17 cells in vitro in Jmjd3-deficientCD41 T cells.Importantly,Jmjd3-deficient mice were resistant to the induction of experimental autoimmune encephalomyelitis(EAE).Furthermore,inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppressed Th17 cell differentiation in vitro.At the molecular level,Jmjd3 directly bound to and reduced the level of H3K27 trimethylation(me3)at the genomic sites ofRorc,which encodes the masterTh17 transcription factorRorgt,and Th17 cytokine genes such as Il17,Il17f,and Il22.Therefore,our studies established acritical role of Jmjd3-mediatedH3K27demethylation inTh17 cell differentiation andsuggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses. | Zhi Liu Wei Cao Longxia Xu Xi Chen Yu Zhan Qian Yang Sanhong Liu Pengfei Chen Yuhang Jiang Xiaohua Sun Yu Tao Yiming Hu Cuifeng Li Qi Wang Ying Wang Charlie Degui Chen Yufang Shi Xiaoren Zhang | 2015 | Journal of Molecular Cell Biology2015，7，6： | 6 |
| 3 | The ChinaMAP reference panel for the accurate genotypeimputation in Chinese populations显示文摘Dear Editor,The genotype imputation is an efficient and pivotal approach to estimate the unobserved genotypes in the genomic data from the single nucleotide polymorphism(SNP)genotyping arrays or whole-genome sequencing(WGS).The fine mapping of variants in the genome-wide association study(GWAS)could be critically improved by the imputation with an optimal reference panel based on the population-specific haplotypes. | Lin Li Peide Huang Xiaohui Sun Siyu Wang Min Xu Sha Liu Zhimin Feng Qing Zhang Xiaoji Wang Xiaole Zheng Mengyao Dai Yufang Bi Guang Ning Yanan Cao Weiqing Wang | 2021 | Cell Research2021，31，12： | 2 |
| 4 | High-loading Co-doped NiO nanosheets on carbon-welded carbon nanotube framework enabling rapid charge kinetic for enhanced supercapacitor performance显示文摘Developing high power and energy supercapacitors(SCs)is a long-pursued goal for the application in transportation and energy storage station.Herein,a rationally-designed Co-doped nickel oxide nanosheets@carbon-welded carbon nanotube foam(Co-doped NiO@WCNTF)as freestanding electrode is successfully prepared for high power and energy SCs.The WCNTF framework with high specific surface area provides three dimensional highly conductive network for fast charge transport and ensures high loading of active materials(9.2 mg/cm2).Moreover,porous Co-doped NiO nanosheets uniformly anchored on the WCNTF framework enable rapid charge kinetics due to the high intrinsic conductivity of Co-doped Ni O nanosheets and their good contact with conductive WCNTF substrate.As a result,the unique integrated electrode with 3D architecture exhibits an ultrahigh specific capacitance of 11.45 F/cm2 at 5 mA/cm2,outstanding rate capability(11.45 F/cm2 at 5 mA/cm2 and a capacitance retention of 86.2%at 30 mA/cm2)and good cycling stability,suggesting great potential for high performance supercapacitor. | Hao Xu Yufang Cao Yong Li Pei Cao Dandan Liu Yongyi Zhang Qing wen Li | 2020 | Journal of Energy Chemistry2020，29，11： | 2 |
| 5 | Genome-wide identification of quantitative trait loci for important plant and flower traits in petunia using a high-density linkage map and an interspecific recombinant inbred population derived from Petunia integrifolia and P.axillaris显示文摘Petunia is a very important flower in the global floriculture industry and has played a critical role as a model in plant genetic studies.Owing to limited genetic variability in commercial germplasm,development of novel petunia phenotypes and new varieties has become increasingly difficult.To enrich petunia germplasm and facilitate genetic improvement,it is important to explore genetic variation in progenitor species that may contain highly valuable genes/alleles.In this study,an interspecific recombinant inbred population(168 recombinant inbreds)derived from Petunia integrifolia×P.axillaris were phenotyped for days to anthesis(DTA),flower count(Flower_C),flower diameter(Flower_D),flower length(Flower_L),plant height(Plant_H),plant spread(Plant_S),and plant size(Plant_Z)in 2014 and 2015.Transgressive segregation was observed for all traits in both years.The broad-sense heritability on a 2-year basis varied from 0.38(Flower_C)to 0.82(Flower_L).Ten QTL were consistently identified in both years and by two mapping strategies[multiple QTL mapping(MQM)in MapQTL and inclusive composite interval mapping(ICIM)in IciMapping].Major QTL explained up to 30.2,35.5,and 47.1%of the total phenotypic variation for Plant_S,Flower_L,and Flower_D,respectively.These findings should be of significant values for introgression of desirable genes from wild petunias into commercial varieties and future genetic improvement of this important flower. | Zhe Cao Yufang Guo Qian Yang Yanhong He Mohammed I.Fetouh Ryan M.Warner Zhanao Deng | 2019 | Horticulture Research2019，6，1： | 1 |
| 6 | Fast Zn^(2+)mobility enabled by sucrose modified Zn^(2+)solvation structure for dendrite-free aqueous zinc battery显示文摘Aqueous zinc battery has been regarded as one of the most promising energy storage systems due to its low cost and environmental benignity.However,the safety concern on Zn anodes caused by uncontrolled Zn dendrite growth in aqueous electrolyte hinders their application.Herein,sucrose with multi-hydroxyl groups has been introduced into aqueous electrolyte to modify Zn^(2+)solvation environment and create a protection layer on Zn anode,thus effectively retarding the growth of zinc dendrites.Atomistic simulations and experiments confirm that sucrose molecules can enter into the solvation sheath of Zn^(2+),and the as-formed unique solvation structure enhances the mobility of Zn^(2+).Such fast Zn^(2+)kinetics in sucrose-modified electrolyte can successfully suppress the dendrite growth.With this sucrose-modified aqueous electrolyte,Zn/Zn symmetric cells present more stable cycle performance than those using pure aqueous electrolyte;Zn/C cells also deliver an impressive higher energy density of 129.7 Wh·kg^(−1)and improved stability,suggesting a great potential application of sucrose-modified electrolytes for future Zn batteries. | Yufang Cao Xiaohui Tang Linge Li Haifeng Tu Yuzhen Hu Yingying Yu Shuang Cheng Hongzhen Lin Liwen Zhang Jiangtao Di Yongyi Zhang Meinan Liu | 2023 | Nano Research2023，16，3： | 0 |
| 7 | Coupled modeling of rainfall-induced floods and sediment transport at the catchment scale显示文摘Rainfall-induced floods may trigger intense sediment transport on erodible catchments, especially on the Loess Plateau in China, which in turn modifies the floods. However, the role of sediment transport in modifying floods has to date remained poorly understood. Concurrently, traditional hydrodynamic models for rainfall-induced floods typically ignore sediment transport, which may lead to inaccurate results for highly erodible catchments. Here, a two-dimensional(2 D) coupled shallow water hydro-sedimentmorphodynamic(SHSM) model, based on the Finite Volume Method on unstructured meshes and parallel computing, is proposed and applied to simulate rainfall-induced floods in the Zhidan catchment on the Loess Plateau, Shaanxi Province, China. For six historical floods of return periods up to 2 years, the numerical results compare well with observations of discharge hydrographs at the catchment outlet. The computed runoff-sediment yield relation is quantitatively reasonable as compared with other catchments under similar geographical conditions. It is revealed that neglecting sediment transport leads to underestimation of peak discharge of the flood by 14%-45%, whilst its effect on the timing of the peak discharge varies for different flood events. For 18 design floods with return periods of 10-500 years, sediment transport may lead to higher peak discharge by around 9%-15%. The temporal pattern of concentrated rainfall in a short period may lead to a larger exponent value of the power function for the runoff-sediment yield relation. The current finding leads us to propose that incorporating sediment transport in rainfallinduced flood modeling is warranted. The SHSM model is applicable to flood and sediment modeling at the catchment scale in support of risk management and water and soil management. | Ronglan Huang Yufang Ni Zhixian Cao | 2022 | International Journal of Sediment Research2022，37，6： | 0 |
| 8 | G Pair Included Fermion Dynamical Symmetry Model for Medium and Heavy Mass Nuclei显示文摘A new description of the hexadecapole degree of freedom in the medium and heavy mass region in the framework of the fermion dynamical symmetry model w proposed.In this lcttert the k-active case is discussed in dctailj in which the pairing and multipole operators generate Spio group.The energy spectra are derived for two limiting cases.The re3ult3 show that these limits and those in the s,d,g IBM have one to one correspondence when N\(=N boson number in the s.d.g IBM)≤Ω_(1)/5. | PAN Feng CAO Yufang PAN Zhenyong | 1991 | Chinese Physics Letters1991，8，1： | 0 |
| 9 | Small-molecule anti-COVID-19 drugs and a focus on China's homegrown mindeudesivir(WV116)显示文摘The coronavirus disease 2019(COVID-19)pandemic has stimulated tremendous efforts to develop therapeutic agents that target severe acute respiratory syndrome coronavirus 2 to control viral infection.So far,a few small-molecule antiviral drugs,including nirmatrelvir-ritonavir(Paxlovid),remdesivir,and molnupiravir have been marketed for the treatment of COVID-19.Nirmatrelvir-ritonavir has been recommended by the World Health Organization as an early treatment for outpatients with mild-to-moderate COVID-19.However,the existing treatment options have limitations,and effective treatment strategies that are cost-effective and convenient for tackling COVID-19 are still needed.To date,four domestically developed oral anti-COVID-19 drugs have been granted conditional market approval in China.These drugs include azvudine,simnotrelvir-ritonavir(Xiannuoxin),leritrelvir,and mindeudesivir(VV11).Preclinical and clinical studies have explored the efficacy and tolerability of mindeudesivir and supported its early use in mild-to-moderate COVID-19 cases at high risk for progression.In this review,we discuss the most recent findings regarding the pharmacological mechanism and therapeutic effects focusing on mindeudesivir and other small-molecule antiviral agents for COVID-19.These findings will expand our understanding and highlight the potential widespread application of China's homegrown anti-COVID-19 drugs. | Qiuyu Cao Yi Ding Yu Xu Mian Li Ruizhi Zheng Zhujun Cao Weiqing Wang Yufang Bi Guang Ning Yiping Xu Ren Zhao | 2023 | Frontiers of Medicine2023，17，6： | 0 |
| 10 | NO adsorption study on the distribution of Ni^(2+) ions on the various micro-environments of carriers显示文摘The decrease of the electron density in the d orbits of Ni2+ ions, resulting from the disturbance of micro-environments in which Ni2+ ions are located, makes the frequency of adsorbed NO shift higher. The shift degree is determined mainly by the property of the microenvi-ronments. When Ni2+ ions are located on SII , SII·(SI·) sites of Y zeolite or on the surface | NIU Guoxing, HUANG Yao, CAO Zhisong, HUANG Yufang and LI QuanzhiDepartment of Chemistry , Fudan University , Shanghai 200433 , China Department of Material Science , Fudan University , Shanghai 200433 , China | 1999 | Chinese Science Bulletin1999，44，21： | 0 |
| 11 | Expert consensus on prevention and cardiopulmonary resuscitation for cardiac arrest in COVID-19显示文摘Background:Cardiopulmonary resuscitation(CPR)strategies in COVID-19 patients differ from those in patients suffering from cardiogenic cardiac arrest.During CPR,both healthcare and non-healthcare workers who provide resuscitation are at risk of infection.The Working Group for Expert Consensus on Prevention and Cardiopulmonary Resuscitation for Cardiac Arrest in COVID-19 has developed this Chinese Expert Consensus to guide clinical practice of CPR in COVID-19 patients.Main recommendations:1)A medical team should be assigned to evaluate severe and critical COVID-19 for early monitoring of cardiac-arrest warning signs.2)Psychological counseling and treatment are highly recommended,since sympathetic and vagal abnormalities induced by psychological stress from the COVID-19 pandemic can induce cardiac arrest.3)Healthcare workers should wear personal protective equipment(PPE).4)Mouth-to-mouth ventilation should be avoided on patients suspected of having or diagnosed with COVID-19.5)Hands-only chest compression and mechanical chest compression are recommended.6)Tracheal-intubation procedures should be optimized and tracheal-intubation strategies should be implemented early.7)CPR should be provided for 20-30 min.8)Various factors should be taken into consideration such as the interests of patients and family members,ethics,transmission risks,and laws and regulations governing infectious disease control.Changes in management:The following changes or modifications to CPR strategy in COVID-19 patients are proposed:1)Healthcare workers should wear PPE.2)Hands-only chest compression and mechanical chest compression can be implemented to reduce or avoid the spread of viruses by aerosols.3)Both the benefits to patients and the risk of infection should be considered.4)Hhealthcare workers should be fully aware of and trained in CPR strategies and procedures specifically for patients with COVID-19. | Wei Song Jie Wei Xiangdong Jian Deren Wang Yanhong Ouyang Yuanshui Liu Xianjin Du Ying Chen Yingqi Zhang Heping Xu Shuming Xianyu Qiong Ning Xiang Li Xiaotong Han Feng Zhan Tao Yu Wenteng Chen Jun Zhang Wenwei Cai Sheng’ang Zhou Shengyang Yi Yu Cao Xiaobei Chen Shunjiang Xu Zong’an Liang Duohu Wu Fen Ai Zhong Wang Qingyi Meng Yuhong Mi Sisen Zhang Rongjia Yang Shouchun Yan Wenbin Han Yong Lin Chuanyun Qian Wenwu Zhang Yan Xiong Jun Lv Baochi Liu Yan Cao Xiaojun He Xuelian Sun Yufang Cao Tian’en Zhou | 2021 | Asian Pacific Journal of Tropical Medicine2021，14，6： | 0 |
| 12 | New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohort study显示文摘A new definition of metabolic dysfunction-associated fatty liver disease(MAFLD)has recently been proposed.We aim to examine the associations of MAFLD,particularly its discordance from non-alcoholic fatty liver disease(NAFLD),with the progression of elevated brachial-ankle pulse wave velocity(baPWV)and albuminuria in a community-based study sample in Shanghai,China.After 4.3 years of follow-up,778 participants developed elevated baPWV and 499 developed albuminuria.In comparison with the non-MAFLD group,the multivariable adjusted odds ratio(OR)of MAFLD group for new-onset elevated baPWV was 1.25(95%confidence interval(CI)1.01–1.55)and 1.35(95%CI 1.07–1.70)for albuminuria.Participants without NAFLD but diagnosed according to MAFLD definition were associated with higher risk of incident albuminuria(OR 1.77;95%CI 1.07–2.94).Patients with MAFLD with high value of hepamet fibrosis score or poor-controlled diabetes had higher risk of elevated baPWV or albuminuria.In conclusion,MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body mass index,waist circumference,and hip circumference.Individuals without NAFLD but diagnosed as MAFLD had high risk of albuminuria,supporting that MAFLD criteria would be practical for the evaluation of long-term risk of subclinical atherosclerosis among fatty liver patients. | Jialu Wang Shanshan Liu Qiuyu Cao Shujing Wu Jingya Niu Ruizhi Zheng Lizhan Bie Zhuojun Xin Yuanyue Zhu Shuangyuan Wang Hong Lin Tiange Wang Min Xu Jieli Lu Yuhong Chen Yiping Xu Weiqing Wang Guang Ning Yu Xu Mian Li Yufang Bi Zhiyun Zhao | 2022 | Frontiers of Medicine2022，16，5： | 0 |
| 13 | Structural evolution of carbon aerogel microspheres by thermal treatment for high–power supercapacitors显示文摘In this work, a series of carbon aerogel microspheres(CAMs) with tailored pore structures were successfully prepared via a sol-gel method and subsequent heat-treatment at various temperatures from 600 to 1600 ℃. The effects of heat-treatment temperature(HTT) on the CAM microstructure were systematically investigated by physical and chemical characterization. The electrical conductivity increased by up to 250 S/cm and mesopores with high electrolyte accessibility developed in the CAM with increasing HTT. However, the specific surface area(SSA) decreased for HTTs from 1000 to 1600 ℃. The results show that these two factors should be finely balanced for further applications in high power supercapacitors.The CAMs carbonized at 1000 ℃ had the highest SSA(1454 m^2/g), large mesoporous content(20%) and favorable conductivity(71 S/cm). They delivered a high energy density of 38.4 Wh/kg at a power density of 0.17 kW/kg. They retained an energy density of 25.5 Wh/kg even at a high power density of 10.2 kW/kg,and a good rate capability of 84% after 10,000 cycles. This performance is superior to, or at least comparable to, those of most reported carbon materials. | Feng Li Lijing Xie Guohua Sun Fangyuan Su Qingqiang Kong Yufang Cao Xiangyun Guo Chengmeng Chen | 2018 | Journal of Energy Chemistry2018，27，2： | 0 |
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