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| 1 | Selective catalytic reduction of NO by C_2H_2 over Ce-Al_2O_3 catalyst with rate-determining step of NO oxidation显示文摘Ce-Al2O3 catalysts prepared by co-precipitation are investigated both in NO oxidation by O2 and in selective catalytic reduction of NO by C2H2(C 2 H 2-SCR).It is found that C2H2-SCR is initiated and controlled by NO oxidation to NO 2 over Al2O3.Ce loading on Al2O3 is almost inactive for NO oxidation below 350 C,since NO2 strongly adsorbs on cerium oxide,leading to the active sites being blocked,which was characterized by temperature-programmed desorption of NO and NO 2 and Fourier transform infrared spectroscopy after NO+O 2 coadsorption over the samples.However,in the case of C2H2-SCR,Ce loading on Al 2 O 3 significantly improves the reaction by accelerating the NO oxidation step in the temperature range of 250-450 C,since the nitrate species produced by NO 2 adsorption is an active intermediate required by C2H 2-SCR. | Suhua Yan Xinping Wang Wenchen Wang Zequn Liu Jiahao Niu | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 6 |
| 2 | Research on the Characteristics of Hot Deformation in BT20 Titanium alloy and Its Optimum Spinning Temperature Range显示文摘Hot compression tests were conducted on a Gleeble-1500 simulator to investigate the hot deformation behavior of BT20 Ti alloy (Ti-6Al-2Zr-1Mo-1V) in the temperature range from 550 to 1000℃ at constant strain rate in the range of 0.01~1 s-1, and then the optimum spinning temperature range was determined. Moreover, tube spinning experiments were executed to verify the reasonability of the optimum temperature range. The results show that the flow stress declines gradually with increasing deformation temperature and decreasing strain rate. In α+β phase region the dynamic recrystallization is the main softening mechanism and in β phase region the hot deformation softening is controlled by dynamic recovery. In α+βphase region with reducing strain rate dynamic recrystallization is fully developed. The optimum temperature of hot spinning is 850~900℃ and that of warm spinning is 600~650℃.Meanwhile, at the temperature above 600℃ tubular workpieces of BT20 Ti alloy have been spun without surface cracks and microstructure inhomogeneity, which proves that the optimum spinning temperature range obtained through hot compression experiments is reasonable. | Wenchen XU+, Debin SHAN, Yan LU and Chunfeng LISchool of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China | 2005 | Journal of Materials Science & Technology2005，21，6： | 2 |
| 3 | Autophagosome activity in macrophage for atherosclerotic plaques in ApoE^-/-mice enhanced by Tiaozhi Tongmai Granules显示文摘Objective:Atherosclerosis is the fundamental pathophysiologic component of cardiovascular disease,and Tiaozhi Tongmai Granules show great efficiency in the treatment of the disease.However,the mechanism of Tiaozhi Tongmai Granules is still unclear.In this study,we have combined experiments with network pharmacology to explore the antiatherosclerosis mechanism of Tiaozhi Tongmai Granules.Method:120 male ApoE/mice were randomly divided into three groups:the model group,Chinese herb group and Atorvastatin group.The model group,Atorvastatin group and Chinese herb group were fed with a high-fat diet,a high-fat diet plus atorvastatin(5.1 mg/kg/d)and a high-fat diet plus Tiaozhi Tongmai Granules(16.5 g/kg/d)for 16 weeks,respectively.Atherogenesis was identified by H&E staining.The colocalization of neutral lipid stain BODIPY and microtubule-associated protein 1 light chain 3(LC3)and the colocalization of BODIPY and lysosomal-associated membrane protein 1(LAMP1)within ApoE/mice aortic plaques were tested using fluorescence confocal microscopy and the Pearson’s coefficients were calculated.To further explore the anti-atherosclerosis mechanism of Tiaozhi Tongmai Granules,the network pharmacology was used to construct the herb-compound-target network.Results:The size of the aortic lipid plaque in the Chinese herb group and Atorvastatin group were smaller compared with the model group on the 16th week.Compared with the model group on the 16th week,the BODIPY and LC3 colocalization rate,the BODIPY and LAMP1 colocalization rate of the Chinese herb group and Atorvastatin group all presented significant increase in the aortic plaque(P<.001),showing that Tiaozhi Tongmai Granules could enhance autophagosome activity in the macrophage.In the herb-compound-target network,17 active compounds and 27 targets were obtained through literature searching and using LHRI&DAVID Bioinformatics.It was found that 23 targets were correlated with the macrophage.Some of them participated in macrophage inflammatory response,and the other targets could promote/inhibit phagocytosis of the macrophage.It was hypothesized that the active compounds of Tiaozhi Tongmai Granules were acting on these targets and having y the biological effects.Conclusions:In the progression stage of atherosclerosis,Tiaozhi Tongmai Granules can still make the macrophage have higher autophagosome activity,and play a role of anti-atherogenesis. | Chenglong Zheng Qing Sun Lu Zhang Shuwen Guo Min Zheng Yan Tang Jiangong Wu Jiani Wu Wenchen Liu Zhaoduo Su Xi Chen | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，3： | 2 |
| 4 | Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b显示文摘The mechanisms underlying spatial and temporal control of cortical neurogenesis of the brain are largely elusive.Long non-coding RNAs(lncRNAs)have emerged as essential cell fate regulators.Here we found LncKdm2b(also known as Kancr),a lncRNA divergently transcribed from a bidirectional promoter of Kdm2b,is transiently expressed during early differentiation of cortical projection neurons.Interestingly,Kdm2b’s transcription is positively regulated in cis by LncKdm2b,which has intrinsic-activating function and facilitates a permissive chromatin environment at the Kdm2b’s promoter by associating with hnRNPAB.Lineage tracing experiments and phenotypic analyses indicated LncKdm2b and Kdm2b are crucial in proper differentiation and migration of cortical projection neurons.These observations unveiled a lncRNA-dependent machinery in regulating cortical neuronal differentiation. | Wei Li Wenchen Shen Bo Zhang Kuan Tian Yamu Li Lili Mu Zhiyuan Luo Xiaoling Zhong Xudong Wu Ying Liu Yan Zhou | 2020 | Protein & Cell2020，11，3： | 2 |
| 5 | NUMB enhances Notch signaling by repressing ubiquitination of NOTCH1 intracellular domain显示文摘The release and nuclear translocation of the intracellular domain of Notch receptor(NICD)is the prerequisite for Notch signaling-mediated transcriptional activation.NICD is subjected to various posttranslational modifications including ubiquitination.Here,we surprisingly found that NUMB proteins stabilize the intracellular domain of NOTCH1 receptor(N1ICD)by regulating the ubiquitin–proteasome machinery,which is independent of NUMB’s role in modulating endocytosis.BAP1,a deubiquitinating enzyme(DUB),was further identified as a positive N1ICD regulator,and NUMB facilitates the association between N1ICD and BAP1 to stabilize N1ICD.Intriguingly,BAP1 stabilizes N1ICD independent of its DUB activity but relying on the BRCA1-inhibiting function.BAP1 strengthens Notch signaling and maintains stem-like properties of cortical neural progenitor cells.Thus,NUMB enhances Notch signaling by regulating the ubiquitinating activity of the BAP1–BRCA1 complex. | Zhiyuan Luo Lili Mu Yue Zheng Wenchen Shen Jiali Li Lichao Xu Bo Zhong Ying Liu Yan Zhou | 2020 | Journal of Molecular Cell Biology2020，12，5： | 2 |
| 6 | Study on precision forging technology for a complex-shaped light alloy forging 显示文摘 | Shan Debin Xu Wenchen Lv Yan | 2004 | Journal of Materials Processing Technology2004，151，13： | 1 |
| 7 | Effects of hot deformation parameters on flow stress and establishment of constitutive relationship system of BT20 titaniun alloy 显示文摘 | XU Wenchen SHAN Debin LU Yan | 2005 | Transactions of Nonferrous Metal Society of China2005，15，2： | 1 |
| 8 | Hot spinning of cylindrical workpieces of TA15 titanium alloy显示文摘In order to form large-diameter thin-wall cylindrical workpieces of TA15 titanium alloy,tube hot spinning experiments of the alloy were conducted on a CNC hot spinning machine.The causes of some forming defects occuring in hot spinning,such as crack,pileup,bulge and corrugation,were analyzed and the corresponding measures were put forward to avoid spinning defects,based on which a proper process scheme of hot spinning of TA15 alloy was obtained and the large-diameter and thin-walled cylindrical workpieces were formed with good quality.The results show that spinning temperature has distinct influence on forming quality of spun workpieces.The range of spinning temperature determines the spinnability of titanium alloy and the ununiformity of temperature distribution near the deformation zone leads to the formation of bulge.The reasonable heating method is that the deforming region is heated to the optimum temperature range of 600-700 ℃,the deformed region is heated continuously and a certain length of undeformed region is preheated.With the thickness-to-diameter ratio(t/D) of spun workpiece reducing to certain value(t/D<1%),surface bulge and corrugation is rather easier to come into being,which could be controlled through restraining diameter growth and employing smaller reduction rate and lower temperature in the optimum spinning temperature range. | XU Wenchen,SHAN Debin,YANG Guoping,CHEN Yu,LU Yan,and KANG Dachang School of Materials Science and Engineering,Harbin Institute of Technology,Harbin 150001,China | 2007 | Rare Metals2007，26，S1： | 1 |
| 9 | Does consciousness overflow cognitive access?Novel insights from the new phenomenon of attribute amnesia显示文摘The moment we open our eyes,we experience a rich and detailed visual world,but the amount of information available to report is rather limited.This dissociation relates to a major debate regarding the nature of visual consciousness.The overflow argument suggests that our conscious experience is quite rich and far beyond what can be reported,standing in sharp contrast to the nooverflow argument that visual consciousness is severely impoverished and limited to what can be reported.In this paper,we systematically reviewed existing evidence in favor of the overflow argument,including studies of several variations of the iconic memory paradigm and the divided attention paradigm,as well as studies of neural correlates of consciousness.Simultaneously,we expounded some critical objections and alternative interpretations to such evidence,as well as some opposing evidence.Finally,we introduced a series of our recent studies based on a striking phenomenon of attribute amnesia,which we believe could provide new insight into the overflow view of visual consciousness. | Yingtao Fu Wenchen Yan Mowei Shen Hui Chen | 2021 | Science China(Life Sciences)2021，64，6： | 0 |
| 10 | Transcriptome Analysis Identifies SenZfp536,a Sense LncRNA that Suppresses Self-renewal of Cortical Neural Progenitors显示文摘Long non-coding RNAs(lncRNAs)regulate transcription to control development and homeostasis in a variety of tissues and organs.However,their roles in the development of the cerebral cortex have not been well elucidated.Here,a bioinformatics pipeline was applied to delineate the dynamic expression and potential cis-regulating effects of mouse lncRNAs using transcriptome data from 8 embryonic time points and sub-regions of the developing cerebral cortex.We further characterized a sense lncRNA,SenZfp536,which is transcribed downstream of and partially overlaps with the protein-coding gene Zfp536.Both SenZfp536 and Zfp536 were predominantly expressed in the proliferative zone of the developing cortex.Zfp536 was cis-regulated by SenZfp536,which facilitates looping between the promoter of Zfp536 and the genomic region that transcribes SenZfp536.Surprisingly,knocking down or activating the expression of SenZfp536 increased or compromised the proliferation of cortical neural progenitor cells(NPCs),respectively.Finally,overexpressing Zfp536 in cortical NPCs reversed the enhanced proliferation of cortical NPCs caused by SenZfp536 knockdown.The study deepens our understanding of how lncRNAs regulate the propagation of cortical NPCs through cis-regulatory mechanisms. | Kuan Tian Andi Wang Junbao Wang Wei Li Wenchen Shen Yamu Li Zhiyuan Luo Ying Liu Yan Zhou | 2021 | Neuroscience Bulletin2021，37，2： | 0 |
| 11 | Predicting the severity of traffic accidents on mountain freeways with dynamic traffic and weather data显示文摘Traffic accident severity prediction is essential for dynamic traffic safety management.To explore the factors influencing the severity of traffic accidents on mountain freeways and to predict the severity of traffic accidents,four models based on machine learning algorithms are constructed using support vector machine(SVM),decision tree classifier(DTC),Ada_SVM and Ada_DTC.In addition,random forest(RF)is used to calculate the importance degree of variables and the accident severity influences with high importance levels form the RF dataset.The results show that rainfall intensity,collision type,number of vehicles involved in the accident and toad section type are important variables influencing accident severity.The RF feature selection method improves the classification performance of four machine leaming algorithms,resulting in a 9.3%,5.5%,7.2% and 3.6% improvement in prediction accuracy for SVM,DTC,Ada_SVM and Ada_DTC,respectively.The combination of the Ada_SVM integrated algorithm and RF feature selection method has the best prediction performance,and it achieves 78.9% and 88.4% prediction precision and accuracy,respectively. | Juan Li Fengxiang Guo Yanning Zhou Wenchen Yang Dingan Ni | 2023 | Transportation Safety and Environment2023，5，4： | 0 |
| 12 | 基因组和转录组测序整合分析揭示混合型肝癌的不同分子亚型显示文摘文章简介原发性肝癌每年造成全球约70万病人死亡且过半死亡病例来自中国,其致死率在所有癌种中高居第二。肝癌主要分为3种类型:肝细胞癌(约80%)、肝内胆管癌(约15%)和混合型肝癌(约5%)。混合型肝癌兼具肝细胞癌和胆管细胞癌两种成分,是预后最差的一种肝癌。 | 薛瑞栋 陈璐 张冲 藤田征志 Ruoyan Li Shu-Mei Yan Choon Kiat Ong Xiwen Liao Qiang Gao Shota Sasagawa Yanmeng Li Jincheng Wang Hua Guo Qi-Tao Huang Qian Zhong Jing Tan Lisha Qi Wenchen Gong Zhixian Hong Meng Li Jingmin Zhao Tao Peng Yinying Lu Kiat Hon Tony Lim Arnoud Boot Atushi Ono Kazuaki Chayama Zemin Zhang Steve George Rozen Bin Tean Teh Xin Wei Wang Hidewaki Nakagawa 曾木圣 白凡 张宁 | 2020 | 科学新闻2020，，2： | 0 |
| 13 | Fibroblasts weaken the anti-tumor effect of gefitinib on co-cultured non-small cell lung cancer cells显示文摘 | Yong Xiao Wang Peiqin Jiang Tao Yu Wenchen Shang Yan Han Yiping Zhang Pingping Li Qiang | 2014 | Chinese Medical Journal2014，，11： | 0 |
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