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| 1 | Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers显示文摘High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors. | Dongqing Lin Wenhua Zhang Hang Yin Haixia Hu Yang Li He Zhang Le Wang Xinmiao Xie Hongkai Hu Yongxia Yan Haifeng Ling Jin'an Liu Yue Qian Lei Tang Yongxia Wang Chaoyang Dong Linghai Xie Hao Zhang Shasha Wang Ying Wei Xuefeng Guo Dan Lu Wei Huang | 2022 | Research2022，，2： | 3 |
| 2 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 3 | An anthocyanin- rich extract from black rice enhances atheresclerotic plaque stabilization in apolipoprotein E-deficient mice显示文摘 | Xiaodong Xia Wenhua Ling Jing Ma et ol | 2006 | The journal of nutrition2006，136，8： | 1 |
| 4 | Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF- α-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation显示文摘 | GUO Honghui LING Wenhua WANG Qing | 2008 | Bio- chemical Pharmacology2008，75，6： | 1 |
| 5 | Supplementation of the black rice outer layer fraction to rabbits decreases atherosclerotic plaque formation and increases antioxidant status显示文摘 | Ling Wenhua Wang Linlin Ma Jing | 2002 | J Nutr2002，132，1： | 1 |
| 6 | Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1显示文摘 | Honghui Guo Min Xia Tangbin Zou Wenhua Ling Ruimin Zhong Weiguo Zhang | 2012 | The Journal of Nutritional Biochemistry2012，，4： | 1 |
| 7 | Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial显示文摘Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary central nervous system lymphoma(PCNSL).Methods:A prospective,single-center phase II clinical trial was conducted.Patients with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were studied.The R-FPD regimen consisted of rituximab(375 mg/m2 i.v.on D0),fotemustine(100 mg/m2 i.v.on D1),pemetrexed(600 mg/m2 i.v.on D1),and dexamethasone(40 mg i.v.on D1-5).Patients 60 years or younger who showed a complete response(CR)were treated with 23.4 Gy of WBRT after the end of chemotherapy;those older than 60 years with CR were treated with a wait-and-see approach;and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy+local tumor field irradiation up to 45 Gy,regardless of age.Results:A total of 30 patients were included.After 2 cycles,the objective response rate(ORR)was 96.5%(28/29,1 CR,27 PR,0 SD,and 1 PD).After 4 cycles,the ORR was 73.1%(19/26,11 CR,8 PR,4 SD,and 3 PD).After WBRT,the ORR was 90.9%(10/11,7 CR,3 PR,and 1 SD).The grade III and IV toxicity responses were mainly leukopenia(20.0%),thrombocytopenia(23.3%),and anemia(10.0%).Conclusions:Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes,providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL. | Jingjing Wu Fenghua Gao Wenhua Wang Xudong Zhang Meng Dong Lei Zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan Jiaqian Yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming Zhang Mingzhi Zhang | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 8 | Supplementation of diets with black rice pigment fiaction attenuates atherosclerotic plaque forma tion in apolipoprotein E-deficient mice显示文摘 | XIA Min LING Wenhua MA Jing | 2004 | J Nutrl2004，134，9： | 1 |
| 9 | Commentary:Can FXR serve as a potential target for COVID-19 prevention?显示文摘A research article has been accepted by Nature very recently entitled:FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.This is a multiple-author study by 80 scientists from 40 different research units in UK,Germany,Greece,USA,Austria,Sweden,and Norway,with Teresa Brevini as the 1st author and one of the senior authors^(1).The pre-print of this study was posted online back to June 7,2021(bioRxiv). | Juan Pang Jia Nuo Feng Wenhua Ling Tianru Jin | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 10 | Supplementation of dietswith the black rice pigment fraction attenuates atherosclerotic plaqueformation in apolipoprotein e deficient mice显示文摘 | XIA Min LING Wenhua MA Jin | 2003 | J Nutr2003，133，3： | 1 |
| 11 | An anthocyanin-rich extractfrom black rice enhances atherosclerotic plaque stabilization inapolipoprotein E-deficient mice显示文摘 | XIA Min LING Wenhua MA Jin | 2006 | J Nutr2006，136，8： | 1 |
| 12 | Cyanidin 3 - Glucoside Protects 3T3 - L1 Adipocytes Against H2O2 - or TNF - a - induced Insulin Resistance by Inhibitingc - Jun NH2 - terminal Kinase Activation 显示文摘 | Guo Honghui Ling Wenhua Wang Qing | 2008 | Biochemical Pharmacology2008，75，： | 1 |
| 13 | Effect of Anthocyanin-Rich Extract from Black Rice (Oryza sativa L. indica) on Hyperlipidemia and Insulin Resistance in Fructose-Fed Rats显示文摘 | HONGHUI GUO WENHUA LING QING WANG CHI LIU YAN HU MIN XIA XIANG FENG XIAODONG XIA | 2007 | Plant Foods for Human Nutrition2007，，1： | 1 |
| 14 | Anthocyanin attenuates CD40- mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation 显示文摘 | Xia Min Ling Wenhua Zhu Huilian | 2009 | Atherosclerosis2009，202，1： | 1 |
| 15 | The activation and dynamics of cytokine expression by CD4 + T cells and AIDS progression in HIV-1-infected Chinese individuals显示文摘 | Yan Li Wenhua Ling Huifang Xu Ming Wang Changyou Wu | 2012 | Microbial Pathogenesis (-)2012，，5： | 1 |
| 16 | Supplementation of diets with the black rice pigment fraction attenuates atherosclerotic plaque formation in apolipoprotein e deficient mit, e显示文摘 | XIA Min LING Wenhua MA Jin | 2003 | J Nutr2003，133，3： | 1 |
| 17 | An anthocyanin-rich extract from black rice enhances atherosclerotic plaque stabilization in apolipoprotein E-deficient mice显示文摘 | XIA Min LING Wenhua MA Jin | 2006 | J Nutr2006，136，8： | 1 |
| 18 | Effects of different β-D- glycosidases on bound aroma compounds in muscat grape determined by HS-SPME and GC-MS显示文摘 | KANG Wenhua XU Yan Q1N Ling | 2010 | Journal of the Institute of Brewing2010，116，1： | 1 |
| 19 | Red and black rice decrease atherosclerotic plaque formation and increase antioxidant status in rabbits显示文摘 | LING Wenhua CHENG Qixuan Ma Jing | 2001 | Journal of Nutrition2001，131，5： | 1 |
| 20 | Gut microbiota,inflammation,and molecular signatures of host response to infection显示文摘Gut microbial dysbiosis has been linked to many noncommunicable diseases.However,little is known about specific gut microbiota composition and its correlated metabolites associated with molecular signatures underlying host response to infection.Here,we describe the construction of a proteomic risk score based on 20 blood proteomic biomarkers,which have recently been identified as molecular signatures predicting the progression of the COVID-19.We demonstrate that in our cohort of 990 healthy individuals without infection,this proteomic risk score is positively associated with proinflammatory cytokines mainly among older,but not younger,individuals.We further discover that a core set of gut microbiota can accurately predict the above proteomic biomarkers among 301 individuals using a machine learning model and that these gut microbiota features are highly correlated with proinflammatory cytokines in another independent set of 366 individuals.Fecal metabolomics analysis suggests potential amino acid-related pathways linking gut microbiota to host metabolism and inflammation.Overall,our multi-omics analyses suggest that gut microbiota composition and function are closely related to inflammation and molecular signatures of host response to infection among healthy individuals.These results may provide novel insights into the cross-talk between gut microbiota and host immune system. | Wanglong Gou Yuanqing Fu Liang Yue Geng-Dong Chen Xue Cai Menglei Shuai Fengzhe Xu Xiao Yi Hao Chen Yi Zhu Mian-Li Xiao Zengliang Jiang Zelei Miao Congmei Xiao Bo Shen Xiaomai Wu Haihong Zhao Wenhua Ling Jun Wang Yu-Ming Chen Tiannan Guo Ju-Sheng Zheng | 2021 | Journal of Genetics and Genomics2021，48，9： | 1 |
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