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| 1 | Total mesorectal excision with or without preoperative chemoradiotherapy for resectable mid/low rectal cancer: a long-term analysis of a prospective, single-center, randomized trial显示文摘Background:The preliminary results of our phase II randomized trial reported comparable functional sphincter pres-ervation rates and short-term survival outcomes between patients undergoing total mesorectal excision(TME)with or without preoperative concurrent chemoradiotherapy(CCRT).We now report the long-term results after a median follow-up of 71 months.Methods:Between March 23,2008 and August 2,2012,192 patients with T3-T4 or node-positive,resectable,mid/low rectal adenocarcinoma were randomly assigned to receive TME with or without preoperative CCRT.The following endpoints were assessed:cumulative rates of local recurrence and distant metastasis,disease-free survival(DFS),and overall survival(OS).Results:The data of 184 eligible patients were analyzed:94 patients in the TME group and 90 patients in the CCRT+TME group.In the whole cohort,the 5-year DFS and OS rates were 84.8%and 85.1%,respectively.The 5-year DFS rates were 85.2%in the CCRT+TME group and 84.3%in the TME group(P=0.969),and the 5-year OS rates were 83.5%in the CCRT+TME group and 86.5%in the TME group(P=0.719).The 5-year cumulative rates of local recur-rence were 6.3%and 5.0%(P=0.681),and the 5-year cumulative rates of distant metastasis were 15.0%and 15.7%(P=0.881)in the CCRT+TME and TME groups,respectively.No significant improvements in 5-year DFS and OS were observed with CCRT by subgroup analyses.Conclusions:Both treatment strategies yielded similar long-term outcomes.A selective policy towards preoperative CCRT is thus recommended for rectal cancer patients if high-quality TME surgery and enhanced chemotherapy can be performed. | Fulong Wang Wenhua Fan Jianhong Peng Zhenhai Lu Zhizhong Pan Liren Li Yuanhong Gao Hui Li Gong Chen Xiaojun Wu Peirong Ding Zhifan Zeng Desen Wan | 2018 | Cancer Communications2018，38，1： | 6 |
| 2 | 中国慢性病的挑战与应对显示文摘中国在短短几十年内,完成了从传染病向慢性病的流行病学模式转变,转变速度远远高于其他许多国家。而行为模式的转变,包括膳食习惯变化、体力活动减少、高水平的男性吸烟率等危险因素是中国疾病模式快速转变的重要原因。其结果是,这些本可避免的慢性病的发病率和死亡率快速上升。引发了医疗卫生服务费用显著上升。目前,中国有1.77亿高血压患者,有3.03亿烟民(占世界烟民的1/3),并有5.3亿人遭受被动吸烟危害。 | Gonghuan Yang Lingzhi Kong Wenhua Zhao Xia Wan Yi Zhai Lincoln C Chen Jeffrey P Koplan | 2008 | 世界临床医学2008，2，6： | 5 |
| 3 | An Ecologically Oriented Operation Strategy for a Multi-Reservoir System: A Case Study of the Middle and Lower Han River Basin, China显示文摘水库群的建设和调度改变了河流的自然流态,对河流生态系统造成了不利影响。本文提出了一种面向生态的水库群调度策略,将河流内不同生态功能所需的生态流量整合到水库群联合调度中,以实现生态流量需求和人类用水需求之间的均衡。该策略耦合了常规优化调度方案和一系列实时生态调度方案。在人类用水需求与生态流量需求冲突较小的时段,水库群调度在保障河流最小流量的前提下采用常规优化调度方案,最大限度地提高人类用水效益。在水库引发的水文改变对河流关键生态功能产生严重影响的时期,水库群调度采用实时生态调度方案,调整下泄流量,从而满足河流生态流量需求。该策略被应用于位于中国汉江中下游流域的一个大型水库群中。模拟调度结果表明,实时生态调度方案保证了河流关键生态功能的生态流量需求,其对人类用水效益的不利影响可通过常规优化调度方案得到部分补偿。本文提出的面向生态的水库群调度策略丰富了考虑生态流量需求的水库群联合调度的理论应用。 | Hao Wang Xiaohui Lei Denghua Yan Xu Wang Shuyue Wu Zhengjie Yin Wenhua Wan | 2018 | Engineering2018，4，5： | 3 |
| 4 | 对可切除的中/低位直肠癌是/否进行术前放化疗的全直肠系膜切除术研究:一项前瞻性、单中心、随机试验的长期分析显示文摘背景与目的我们的Ⅱ期随机试验的初步研究结果显示,对进行全直肠系膜切除术(total mesorectal excision,TME)的患者是/否进行术前同步放化疗(concurrent chemoradiotherapy,CCRT),二者的功能性括约肌保留率和短期生存结局相近。在经过中位71个月的随访后,现报告这一长期试验的结果。方法在2008年3月23日至2012年8月2日期间,192例患有T3–T4或淋巴结阳性、可切除的中/低直肠腺癌患者被随机分为接受或不接受术前CCRT组,之后均进行TME。评估以下终点:局部复发和远处转移的累积率、无病生存(disease?free survival,DFS)和总生存(overall survival,OS)。结果对入组的184例患者资料进行分析,其中TME组有94例,CCRT+TME组有90例。在整个队列中,5年DFS和OS率分别为84.8%和85.1%。CCRT+TME组的5年DFS率为85.2%,TME组为84.3%(P=0.969);CCRT+TME组的5年OS率为83.5%,TME组为86.5%(P=0.719)。在CCRT+TME和TME组中,局部复发的5年累积率分别为6.3%和5.0%(P=0.681),远处转移的5年累积率分别为15.0%和15.7%(P=0.881)。通过亚组分析,接受CCRT未观察到5年DFS和OS的显著改善。结论两种治疗方案的长期结局相近。因此,如果可以进行高质量的TME手术和强化化疗,建议选择性地对直肠癌患者进行术前CCRT。 | Fulong Wang Wenhua Fan Jianhong Peng Zhenhai Lu Zhizhong Pan Liren Li Yuanhong Gao Hui Li Gong Chen Xiaojun Wu Peirong Ding Zhifan Zeng Desen Wan | 2019 | 癌症2019，38，5： | 2 |
| 5 | Segmentation of Planar Curves into Straight-Line Segments and Elliptical Arcs 显示文摘 | Wenhua Wan Jose' A Ventura | 1997 | Graphical Models and Image Processing1997，59，6： | 1 |
| 6 | Segmentation of planar curves into straight-line segments and elliptical arcs 显示文摘 | Wenhua Wan Jose AVentura | 1997 | Graphical Models and Image Processing1997，59，6： | 1 |
| 7 | Identification of an H6N6 swine influenza virus in southern China显示文摘 | Guihong Zhang Weili Kong Wenbao Qi Li-Ping Long Zongxi Cao Liangzong Huang Haitao Qi Nan Cao Wenhua Wang Furong Zhao Zhangyong Ning Ming Liao Xiu-Feng Wan | 2011 | Infection Genetics and Evolution2011，，5： | 1 |
| 8 | Angular dependent NEXAFS study of the molecular orientation of PTCDA multilayers on Au (111) surface显示文摘The molecular orientation of perylene-3,4,9,10-tetracarboxylic acid dianhydride (PTCDA) multilayers adsorbed on Au (111) surface has been investigated using angular dependent O K-edge near edge X-ray absorption fine structure (NEXAFS) spectroscopy. The significant angular dependence of important resonant structures (π* and σ*) reveals that PTCDA molecules adopt an ordered geometry on the substrate surface. The average tilt angle of the PTCDA molecular planes is 27°±10° from the Au (111) surface. | CAO Liang ZHANG WenHua HAN YuYan CHEN TieXin ZHENG ZhiYuan WAN Li XU FaQiang IBRAHIM Kurash QIAN HaiJie WANG JiaOu | 2011 | Chinese Science Bulletin2011，56，33： | 1 |
| 9 | Accurate matching of two-dimensional shapes using the minimal tolerance zone error显示文摘 | Jose A. Ventura Wenhua Wan | 1997 | Image and Vision Computing1997，，12： | 1 |
| 10 | Effectiveness of Fuling(Poria) and its extracts against spleen deficiency in rats via tonifying spleen显示文摘OBJECTIVE:To observe and explore the effect of Fuling(Poria) in alleviating the spleen deficiency symptom pattern(SDSP).METHODS:We established an animal model of SDS in Sprague-Dawley(SD) rats by treating them with deficiency-inducing factors,including irregular feeding and tail clamping.Mice were administered Fuling(Poria) and its extracts(raw/cooked powder,aqueous/alcohol extract) by gavage once a day for 21 d.The body weight,rectal temperature,and spleen and thymus organ coefficients were calculated.The levels of motilin(MTL),gastrin(GAS),aquaporin 2(AQP2),interleukin 2(IL-2),IL-4,and 5-hydroxytryptamine(5-HT) in the serum and the level of AQP2 in the kidneys were evaluated by enzyme-linked immunosorbent assay.RESULTS:Fuling(Poria) and its extracts did not change the body weight,rectal temperature,and organ coefficients of the spleen and thymus.However,it reduced the levels of MTL and GAS and increased the levels of IL-2 and AQP2.In addition,the levels of IL-4 and 5-HT showed no significant alteration.CONCLUSIONS:These results suggested the crucial function of Fuling(Poria) in SDSP,especially promoting digestive function and water metabolism. | FENG Min JIA Ziming WAN Ming FAN Bolin TANG Xiaoqiao CHENG Wenhua SUN Fanzhong | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 0 |
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