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| 1 | Paracrine and endocrine actions of bone——the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts显示文摘The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone cells, namely osteoblasts, osteocytes,and osteoclasts exert regulation on osteoblastogenesis, osteclastogenesis, and angiogenesis in a paracrine manner. Osteoblasts secrete a range of different molecules including RANKL/OPG, M-CSF, SEMA3A, WNT5A, and WNT16 that regulate osteoclastogenesis. Osteoblasts also produce VEGFA that stimulates osteoblastogenesis and angiogenesis. Osteocytes produce sclerostin(SOST) that inhibits osteoblast differentiation and promotes osteoclast differentiation. Osteoclasts secrete factors including BMP6, CTHRC1, EFNB2, S1P, WNT10B, SEMA4D, and CT-1 that act on osteoblasts and osteocytes, and thereby influencea A osteogenesis. Osteoclast precursors produce the angiogenic factor PDGF-BB to promote the formation of Type H vessels, which then stimulate osteoblastogenesis. Besides, the evidences over the past decades show that at least three hormones or 'osteokines'from bone cells have endocrine functions. FGF23 is produced by osteoblasts and osteocytes and can regulate phosphate metabolism. Osteocalcin(OCN) secreted by osteoblasts regulates systemic glucose and energy metabolism, reproduction, and cognition. Lipocalin-2(LCN2) is secreted by osteoblasts and can influence energy metabolism by suppressing appetite in the brain.We review the recent progresses in the paracrine and endocrine functions of the secretory proteins of osteoblasts, osteocytes, and osteoclasts, revealing connections of the skeleton with other tissues and providing added insights into the pathogenesis of degenerative diseases affecting multiple organs and the drug discovery process. | Yujiao Han Xiuling You Wenhui Xing Zhong Zhang Weiguo Zou | 2018 | Bone Research2018，6，2： | 52 |
| 2 | A High-Density SNP Genotyping Array for Rice Biology and Molecular Breeding显示文摘一个高密度的单个核苷酸多型性(SNP ) 数组为遗传学者和分子的 breeders.With 是极其重要的 genomic 的巨大的数量的累积重新定序为精确 SNP 察觉的数据和可得到的技术,设计高密度、高质量的米饭 SNP 数组是可能的。这里,我们报导一个高密度的 riceSNP 数组和它的实用程序的开发。SNP 探针被屏蔽超过 10 设计从变化和一个数组说出 RiceSNP50 的 801 米饭的 re-sequencingdata 提取的 000 000 SNP loci 在 Illumina Infinium 站台上被生产。数组 contained51 478 个均匀地分布式的标记,其 68% 个在遗传因子的区域以内。有 parent/F1 relationshipswere 的几百米饭植物过去常为精确 SNP 打电话产生一个高质量的簇文件。应用程序测试证明这穿有的 highgenotyping 精确性,并且能被用于不同目的。例如,有好分辨率的精英米饭变化 wasclustered 的一个核心集合。染色体宽的协会研究(GWAS ) 分析正确地识别了描绘的 QTL.Further,这个数组成功地为变化确认和特点基因渗入被使用。作为一个精确 high-throughputgenotyping 工具, RiceSNP50 将在两功能的 genomics 学习和分子的 breeding.Key 词起一个重要作用: | Haodong Chen Weibo Xie Hang He Huihui Yu Wei Chen Jing Li Renbo Yu Yue Yao Wenhui Zhang Yuqing He Xiaoyan Tang Fasong Zhou Xing Wang Deng Qifa Zhang | 2014 | Molecular Plant2014，7，3： | 38 |
| 3 | Progress of Air Pollution Control in China and Its Challenges and Opportunities in the Ecological Civilization Era显示文摘China’s past economic growth has substantially relied on fossil fuels,causing serious air pollution issues.Decoupling economic growth and pollution has become the focus in developing ecological civilization in China.We have analyzed the three-decade progress of air pollution controls in China,highlighting a strategic transformation from emission control toward air quality management.Emission control of sulfur dioxide(SO2)resolved the deteriorating acid rain issue in China in 2007.Since 2013,control actions on multiple precursors and sectors have targeted the reduction of the concentration of fine particulate matter(PM2.5),marking a transition to an air-quality-oriented strategy.Increasing ozone(O3)pollution further requires O3 and PM2.5 integrated control strategies with an emphasis on their complex photochemical interactions.Fundamental improvement of air quality in China,as a key indicator for the success of ecological civilization construction,demands the deep de-carbonization of China’s energy system as well as more synergistic pathways to address air pollution and global climate change simultaneously. | Xi Lu Shaojun Zhang Jia Xing Yunjie Wang Wenhui Chen Dian Ding Ye Wu Shuxiao Wang Lei Duan Jiming Hao | 2020 | Engineering2020，6，12： | 24 |
| 4 | Identification of immunoreactive proteins of Brucella melitensis by immunoproteomics显示文摘Infection with Brucella causes brucellosis, a chronic disease in humans, which induces abortion and sterility in livestock. Among the different Brucella species, Brucella melitensis is considered the most virulent and is the predominant species associated with outbreaks in China. To date, no safe human vaccine is available against Brucella infection. The currently used live vaccines against Brucella in livestock induce antibodies that interfere with the diagnosis of field infection in vaccinated animals, which is harmful to eradication programs. However, there is as yet no complete profile of immunogenic proteins of B. melitensis. Towards the development of a safer, equally efficacious, and field infection-distinguishable vaccine, we used immunoproteomics to identify novel candidate immunogenic proteins from B. melitensis M5. Eighty-eight immunoreactive protein spots from B. melitensis M5 were identified by Western blotting and were assigned to sixty-one proteins by mass spectrometry, including many new immunoreactive proteins such as elongation factor G, F0F1 ATP synthase subunit beta, and OMP1. These provide many candidate immunoreactive proteins for vaccine development. | ZHAO ZhongPeng YAN Fang JI WenHui LUO DeYan LIU Xin XING Li DUAN YueQiang YANG PengHui SHI XiuMin LI Zhong WANG XiLiang | 2011 | Science China(Life Sciences)2011，54，9： | 12 |
| 5 | High-resolution crustal structure of the Yinchuan basin revealed by deep seismic reflection profiling:implications for deep processes of basin显示文摘The Yinchuan basin, located on the western margin of the Ordos block, has the characteristics of an active continental rift. A NW-striking deep seismic reflection profile across the center of Yinchuan basin precisely revealed the fine structure of the crust. The images showed that the crust in the Yinchuan basin was characterized by vertical stratifications along a detachment located at a two-way travel time(TWT) of 8.0 s.The most outstanding feature of this seismic profile was the almost flat Mohorovicˇic′ discontinuity(Moho) and a high-reflection zone in the lower crust. This sub-horizontal Moho conflicts with the general assumption of an uplifted Moho under sedimentary basins and continental rifts, and may indicate the action of different processes at depth during the evolution of sedimentary basins or rifts.We present a possible interpretation of these deep processes and the sub-horizontal Moho. The high-reflection zone, which consists of sheets of high-density, mantlederived materials, may have compensated for crustal thinning in the Yinchuan basin, leading to the formation of a sub-horizontal Moho. These high-density materials may have been emplaced by underplating with mantlesourced magma. | Xing fuHuang Shaoying Feng Rui Gao Wenhui Li | 2016 | Earthquake Science2016，29，2： | 8 |
| 6 | Bi_(2)O_(2)Se/BP van der Waals heterojunction for high performance broadband photodetector显示文摘Broadband photodetector has wide applications in the field of remote sensing,health monitoring and medical imaging.Two-dimensional(2D)materials with narrow bandgaps have shown enormous potential in broadband photodetection.However,the device performance is often restricted by the high dark currents.Herein,we demonstrate a high performance broadband photodetector by constructing Bi_(2)O_(2) Se/BP van der Waals heterojunction.The device exhibits a p-n diode behavior with a current rectification ratio of~20.Benifited from the low dark current of the heterojunction and the effective carrier separation,the device achieves the responsivity(R)of~500 A/W,~4.3 A/W and~2.3 A/W at 700 nm,1310 nm and 1550 nm,respectively.The specific detectivity(D^(*))is up to~2.8×10^(11) Jones(700 nm),~2.4×10^(9) Jones(1310 nm)and~1.3×10^(9) Jones(1550 nm).Moreover,the response time is~9 ms,which is more than 20 times faster than that of individual BP(~190 ms)and Bi_(2)O_(2)Se(~180 ms)devices. | Xing LIU Wenhui WANG Fang YANG Shaopeng FENG Zhenliang HU Junpeng LU Zhenhua NI | 2021 | Science China(Information Sciences)2021，64，4： | 2 |
| 7 | Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers显示文摘 | Jian Shu Chen Wu Yetao Wu Zhiyuan Li Sida Shao Wenhui Zhao Xing Tang Huan Yang Lijun Shen Xiaohan Zuo Weifeng Yang Yan Shi Xiaochun Chi Hongquan Zhang Ge Gao Youmin Shu Kehu Yuan Weiwu He Chao Tang Yang Zhao Hongkui Deng | 2013 | Cell2013，，5： | 1 |
| 8 | Population transcriptomics reveals a potentially positive role of expression diversity in adaptation显示文摘While it is widely accepted that genetic diversity determines the potential of adaptation,the role that gene expression variation plays in adaptation remains poorly known.Here we show that gene expression diversity could have played a positive role in the adaptation of Miscanthus lutarioriparius.RNA-seq was conducted for 80 individuals of the species,with half planted in the energy crop domestication site and the other half planted in the control site near native habitats.A leaf reference transcriptome consisting of 18,503 high-quality transcripts was obtained using a pipeline developed for de novo assembling with population RNA-seq data.The population structure and genetic diversity of M.lutarioriparius were estimated based on 30,609 genic single nucleotide polymorphisms.Population expression(Ep) and expression diversity(Ed)were defined to measure the average level and the magnitude of variation of a gene expression in the population,respectively.It was found that expression diversity increased while genetic Resediversity decreased after the species was transplanted from the native habitats to the harsh domestication site,especially for genes involved in abiotic stress resistance,histone methylation,and biomass synthesis under water limitation.The increased expression diversity could have enriched phenotypic variation directly subject to selections in the new environment. | Qin Xu Shilai Xing Caiyun Zhu Wei Liu Yangyang Fan Qian Wang Zhihong Song Wenhui Yang Fan Luo Fei Shang Lifang Kang Wenli Chen Juan Yan Jianqiang Li Tao Sang | 2015 | Journal of Integrative Plant Biology2015，57，3： | 1 |
| 9 | 6 - 18 Operation Status of On-line Ion Sources in 2012显示文摘 | FengYucheng Lu Wang Li Jinyu Zhang Wenhui Ma Hongyi Ma Baohua Wang Hui Li Jiaqing Lin Shuhao Cao Yun Sha Shan W u Qi Guo Junwei Fang Xing Yang Yao Li Xixia Zhang Hengjuan Zhao Huanyu Zhang Xuezhen Sun Liangting Zhao Hongwei | 2012 | IMP & HIRFL Annual Report2012，，1： | 1 |
| 10 | Re- mediation of soil co-contaminated with petroleum and heavy metals by the integration of electrokinetics and biostimulation 显示文摘 | DONG Zhiyong HUANG Wenhui XING Dingfeng | 2013 | Journal of Hazardous Materials2013，260，9： | 1 |
| 11 | Target-activated and ratiometric photochromic probe for “double-check” detection of toxic thiols in live cells显示文摘Photochromic molecules can achieve reversible isomerization upon alternate light irradiations, which offers a great opportunity to improve the precision of analytes detection and imaging in complicated biological environments. Previous reported photochromic probe exhibited only mono-color switching and an initially fluorescence-ON state that may cause high background signal and impose an adverse impact on the desired sensing precision. To overcome this set-back, we developed a novel photochromic probe with an analyte-activation mode for ratiometric sensing of toxic thiols in both real water samples and live cells. The dynamic dual-fluorescence signal is released only after the fast and selective cleavage of the 2,4-dinitrophenyl sulfonate by the targeted thiophenol derivatives. Consequently, a 'double-check' with synchronized dual-fluorescence blinking for analyte detection is successfully employed upon alternate light triggers with rapid response(k=7.2×10^(-2) s^(-1)), high sensitivity(LOD=6.1 nM) as well as selectivity of thiophenol derivatives over other common thiol species(e.g., GSH, Cys and Hcy). The photochromic probe was successfully introduced to the fast and on-site detection of highly toxic thiophenols in real waste water samples. Moreover, by using confocal laser-scanning microscopy(CLSM) and flow cytometric analysis, the potential applications of this ratiometric photochromic probe for trace toxic thiol sensing in live cells are examined. | Youxin Fu Xing Zhang Feng Cao Wenhui Wang Guangren Qian Junji Zhang | 2019 | Science China Chemistry2019，62，9： | 0 |
| 12 | 6-15 Status Report of On-line Ion Sources in 2015显示文摘In 2015, the service time of the two on-line ion sources of HIRFL-CSR accelerator facility, SECRAL and LECR3, is 3 335.5 and 3 168.5 h, respectively, amouting to 6 504 h. Except 26Mg7+, which was required by the accelerator but failed to be produced due the oxidation of the material, 20 kinds of ion beams have been delivered successfull.The failure time is 49 h this year, mainly attributed to the breakdown of the cryostat system. | Feng Yucheng Lu Wang Zhang Wenhui Ma Hongyi Yang Yao Fang Xing Guo Junwei Ma Baohua Wang Hui Qian Cheng Zhang Junjie Li Jibo Jin Qianyu sheng Sifan Liu Pengyan Li Xixia Zhao Huanyu Zhang Xuezhen Sun Liangting | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 13 | Histones of Neutrophil Extracellular Traps Induce CD11b Expression in Brain Pericytes Via Dectin-1 after Traumatic Brain Injury显示文摘The brain pericyte is a unique and indispensable part of the blood-brain barrier(BBB),and contributes to several pathological processes in traumatic brain injury(TBI).However,the cellular and molecular mechanisms by which pericytes are regulated in the damaged brain are largely unknown.Here,we show that the formation of neutrophil extracellular traps(NETs)induces the appearance of CD11b^(+)pericytes after TBI.These CD11b^(+)pericyte subsets are characterized by increased permeability and pro-inflammatory profiles compared to CD11b-pericytes.Moreover,histones from NETs by Dectin-1 facilitate CD11b induction in brain pericytes in PKC-c-Jun dependent manner,resulting in neuroinflammation and BBB dysfunction after TBI.These data indicate that neutrophil-NET-pericyte and histone-Dectin-1-CD11b are possible mechanisms for the activation and dysfunction of pericytes.Targeting NETs formation and Dectin-1 are promising means of treating TBI. | Yang-Wuyue Liu Jingyu Zhang Wanda Bi Mi Zhou Jiabo Li Tiantian Xiong Nan Yang Li Zhao Xing Chen Yuanguo Zhou Wenhui He Teng Yang Hao Wang Lunshan Xu Shuang-Shuang Dai | 2022 | Neuroscience Bulletin2022，38，10： | 0 |
| 14 | Controllable n-type doping in WSe_(2)monolayer via construction of anion vacancies显示文摘The successful applications of two-dimensional(2 D)transition metal dichalcogenides highly rely on rational regulation of their electronic properties.The nondestructive and controllable doping strategy is of great importance to implement 2 D materials in electronic devices.Herein,we propose a straightforward and effective method to realize controllable n-type doping in WSe_(2)monolayer by electron beam irradiation.Electrical measurements and photoluminescence(PL)spectra verify the strong n-doping in electron beam-treated WSe_(2)monolayers.The n-type doping arises from the generation of Se vacancies and the doping degree is precisely controlled by irradiation fluences.Due to the n-dopinginduced narrowing of the Schottky barrier,the current of back-gated monolayer WSe_(2)is enhanced by an order of magnitude and a$8?increase in the electron filed-effect mobility is observed.Remarkably,it is a moderate method without significant reduction in electrical performance and severe damage to lattice structures even under ultra-high doses of irradiation. | Mengchen Wang Wenhui Wang Yong Zhang Xing Liu Lei Gao Xiaoxue Jing Zhenliang Hu Junpeng Lu Zhenhua Ni | 2021 | Chinese Chemical Letters2021，32，10： | 0 |
| 15 | 6-42 Status Report of On-line Ion Sources in 2014显示文摘In 2014, the service time of the two on-line ion sources of HIRFL-CSR accelerator facility, SECRAL and LECR3is 3 594 and 3 457.2 h, respectively, amouting to 7051.2 h. 17 kinds of ion beams have been delivered successfull.The failure time is shrinked down to 8 h in this year, which is the lowest among these years. Table 1 summarizesthe main information about the ion beams delievered by the two ion sources. Fig. 1 shows the comparison of theion beam delivering time for HIRFL-CSR accelerator facitily from the three ion sources, LECR3, SECRAL andLAPECR1 since 2007. | Feng Yucheng Lu Wang Zhang Wenhui Ma Hongyi Yang Yao Fang Xing Guo Junwei Ma Baohua Wang Hui Qian Cheng Zhang Junjie Lin Shuhao Li Jibo Li Xixia Zhang Hengjuan Zhang Xuezhen Sun Liangting | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 16 | Analysis on Double-difference Earthquake Location and the Seismicity Pattern of the Yangjiang Earthquake Sequences显示文摘The locations of about 400 earthquakes in Yangjiang,Guangdong Province are determined using the double-difference earthquake location algorithm(DDA).The seismicity pattern becomes concentrated from discrete grids.The rupture characteristics of the Yangjiang earthquake sequence show a conjugated distribution in NW and NE directions.The major distribution trends NE and dips NE with an angle of 30° and a length of 30km,and the minor distribution trends NW and dips SE with an angle of 30° and a length of 20km.The focal depth is 5km~15km.The distribution of the Enping earthquake sequence,which is not far from Yangjiang,is NW-trending.The relationship between hypocenter distribution and geological structure is discussed. | Kang Ying Yang Xuan Huang Wenhui Chen Xing Chen Guimei Lin Wei Wu Huadeng | 2008 | Earthquake Research in China2008，22，1： | 0 |
| 17 | 2018年在线离子源运行报告显示文摘HIRFL accelerator facility has been operated with two ion sources as its pre-injectors,which are LECR3 and SECRAL-II.In 2018,there were 19 kinds of ion beams delivered successfully,and the service time of the two sources are 4594.5 and 2231 h respectively,amounting to 6825.5 h in total,in which SECRAL and LECR3 provided 4 and 1 kinds of metallic ion beams respectively,and the total service time for the metallic ones is 2322 h,accounting for 34%of the total service time.Table 1 summarizes the main information about the ion beams delivered by the two ion sources. | Feng Yucheng Zhang Wenhui Ma Hongyi Fang Xing Guo Junwei Huang Wei Jia Zehua Jin Qianyu Li Jiaqing Li Jibo Li Libin Li Lixuan Lu Yuting Qian Cheng Shen Zhen Wang Guicai Wang Hui Yang Yao Zhai Yuhan Zhang Junjie Zhang Sheng Zhang Xuezhen Sun Liangting | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 18 | Identification and validation of a major gene for kernel length at the P1 locus in Triticum polonicum显示文摘Kernel size, one of the traits that determine wheat yield, is controlled by multiple quantitative trait loci.Polish wheat(Triticum polonicum) has elongated and plump kernel and is a valuable material for breeding high-yielding wheat cultivars. However, genes or loci determining kernel length(KL) in Polish wheat are unknown. We identified and validated a major KL gene, KL-PW, at the P1 locus in Polish wheat. KL-PW is VRT-A2, which encodes a MIKC-type MADS-box protein(MADS55). An insertion/deletion mutation in intron 1 of VRT-A2;led to an alternatively spliced transcript, VRT-A2;. Quantitative PCR analysis showed that VRT-A2;was more highly expressed in developing seeds than was VRT-A2 Ailanmai.Brassinosteroid(BR) sensitivity experiment and the expression of BR-related genes indicated that VRTA2;functions as a positive regulator of BR responses. VRT-A2;significantly increased KL of wheat.These findings not only reveal the molecular basis of KL-PW in controlling KL, but also provide a valuable genetic resource for increasing kernel size in wheat. | Songyue Chai Qin Yao Rui Liu Wenhui Xiang Xue Xiao Xing Fan Jian Zeng Lina Sha Houyang Kang Haiqin Zhang Dan Long Dandan Wu Yonghong Zhou Yi Wang | 2022 | The Crop Journal2022，10，2： | 0 |
| 19 | Operational Report of On-line Ion Sources in 2019显示文摘In 2019,the service time of the two on-line ion sources,LECR3 and SECRAL,is 3642.5 and 3617 h respectively,amounting to 7259.5 h.There are 19 kinds of ion beams delivered to the accelerator successfully. | Feng Yucheng Zhang Wenhui Ma Hongyi Ma Jindou Fang Xing Guo Junwei Jia Zehua Jin Qianyu Li Jiaqing Li Jibo Li Libin Li Lixuan Lu Yuting Qian Cheng Shen Zhen Wang Guicai Wang Hui Yang Yao Zhai Yuhan Zhang Junjie Zhang Xuezhen Sun Liangting | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 20 | Beam Commissioning and Operation of LEAF in 2019显示文摘Beam commissioning with several ion species,such as H2^(+),He^(+),N^(2+).Kr^(13+).Xe^(20+) and so on,was implemented in 2019.The layout of LEAF is shown in Fig.1.The transmission efficiency of the RFQ is higher than 97%with beam intensity at the level of one-hundred microampere. | Yang Yao Zhai Yuhan Guo Yuhui Jing Long Lu Wang Ma Hongyi Zhang Wenhui Sun Liepeng Xu Xianbo Shi Longbo Xing Chaochao Yang Lei He Tao Fang Xing Gao Zheng Chang Jianjun Liu Xiaojun Jin Xiaofeng Sun Liangting He Yuan Zhao Hongwei | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
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