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| 1 | Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy显示文摘Photodynamic therapy(PDT),as one of the noninvasive clinical cancer phototherapies,suffers from the key drawback associated with hypoxia at the tumor microenvironment(TME),which plays an important role in protecting tumor cells from damage caused by common treatments.High concentration of hydrogen peroxide(H2O2),one of the hallmarks of TME,has been recognized as a double-edged sword,posing both challenges,and opportunities for cancer therapy.The promising perspectives,strategies,and approaches for enhanced tumor therapies,including PDT,have been developed based on the fast advances in H2O2-enabled theranostic nanomedicine.In this review,we outline the latest advances in H2O2-responsive materials,including organic and inorganic materials for enhanced PDT.Finally,the challenges and opportunities for further research on H2O2-responsive anticancer agents are envisioned. | Nan Yang Wanyue Xiao Xuejiao Song Wenjun Wang Xiaochen Dong | 2020 | Nano-Micro Letters2020，12，1： | 11 |
| 2 | Novel resonant pressure sensor based on piezoresistive detection and symmetrical in-plane mode vibration显示文摘In this paper,a novel resonant pressure sensor is developed based on electrostatic excitation and piezoresistive detection.The measured pressure applied to the diaphragm will cause the resonant frequency shift of the resonator.The working mode stress–frequency theory of a double-ended tuning fork with an enhanced coupling beam is proposed,which is compatible with the simulation and experiment.A unique piezoresistive detection method based on small axially deformed beams with a resonant status is proposed,and other adjacent mode outputs are easily shielded.According to the structure design,high-vacuum wafer-level packaging with different doping in the anodic bonding interface is fabricated to ensure the high quality of the resonator.The pressure sensor chip is fabricated by dry/wet etching,high-temperature silicon bonding,ion implantation,and wafer-level anodic bonding.The results show that the fabricated sensor has a measuring sensitivity of~19 Hz/kPa and a nonlinearity of 0.02%full scale in the pressure range of 0–200 kPa at a full temperature range of−40 to 80°C.The sensor also shows a good quality factor>25,000,which demonstrates the good vacuum performance.Thus,the feasibility of the design is a commendable solution for high-accuracy pressure measurements. | Xiangguang Han Qi Mao Libo Zhao Xuejiao Li Li Wang Ping Yang Dejiang Lu Yonglu Wang Xin Yan Songli Wang Nan Zhu Zhuangde Jiang | 2020 | Microsystems & Nanoengineering2020，6，1： | 4 |
| 3 | Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury显示文摘Spinal cord injury(SCI)involves diverse injury responses in different cell types in a temporally and spatially specific manner.Here,using single-cell transcriptomic analyses combined with classic anatomical,behavioral,electrophysiological analyses,we report,with single-cell resolution,temporal molecular and cellular changes in crush-injured adult mouse spinal cord.Data revealed pathological changes of 12 different major cell types,three of which infiltrated into the spinal cord at distinct times post-injury.We discovered novel microglia and astrocyte subtypes in the uninjured spinal cord,and their dynamic conversions into additional stage-specific subtypes/states.Most dynamic changes occur at 3-days post-injury and by day-14 the second wave of microglial activation emerged,accompanied with changes in various cell types including neurons,indicative of the second round of attacks.By day-38,major cell types are still substantially deviated from uninjured states,demonstrating prolonged alterations.This study provides a comprehensive mapping of cellular/molecular pathological changes along the temporal axis after SCI,which may facilitate the development of novel therapeutic strategies,including those targeting microglia. | Chen Li Zhourui Wu Liqiang Zhou Jingliang Shao Xiao Hu Wei Xu Yilong Ren Xingfei Zhu Weihong Ge Kunshan Zhang Jiping Liu Runzhi Huang Jing Yu Dandan Luo Xuejiao Yang Wenmin Zhu Rongrong Zhu Changhong Zheng Yi Eve Sun Liming Cheng | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 4 |
| 4 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 5 | Generating Giant Membrane Vesicles from Live Cells with Preserved Cellular Properties显示文摘Biomimetic giant membrane vesicles,with size and lipid compositions comparable to cells,have been recognized as an attractive experimental alternative to living systems.Due to the similarity of their membrane structure to that of body cells,cell-derived giant plasma membrane vesicles have been used as a membrane model for studying lipid/protein behavior of plasma membranes.However,further application of biomimetic giant membrane vesicles has been hampered by the side-efects of chemical vesiculants and the utilization of osmotic bufer.We herein develop a facile strategy to derive giant membrane vesicles(GMVs)from mammalian cells in biofriendly medium with high yields.Tese GMVs preserve membrane properties and adaptability for surface modifcation and encapsulation of exogenous molecules,which would facilitate their potential biological applications.Moreover,by loading GMVs with therapeutic drugs,GMVs could be employed for drug transport to tumor cells,which represents another step forward in the biomedical application of giant membrane vesicles.Tis study highlights biocompatible GMVs with biomimicking membrane surface properties and adaptability as an ideal platform for drug delivery strategies with potential clinical applications. | Qiaoling Liu Cheng Bi Jiangling Li Xuejiao Liu Ruizi Peng Cheng Jin Yang Sun Yifan Lyu Hui Liu Huijing Wang Can Luo Weihong Tan | 2019 | Research2019，，1： | 2 |
| 6 | Ametryn degradation by aqueous chlorine: Kinetics and reaction influences显示文摘 | Bin Xu Nai-yun Gao Hefa Cheng Chen-yan Hu Sheng-ji Xia Xiao-feng Sun Xuejiao Wang Shaogui Yang | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 7 | Self-anti-angiogenesis nanoparticles enhance anti-metastatic-tumor efficacy of chemotherapeutics显示文摘Beyond traditional endothelium-dependent vessel(EDV),vascular mimicry(VM)is another critical tumor angiogenesis that further forms in many malignant metastatic tumors.However,the existing anti-angiogenesis combined chemotherapeutics strategies are only efficient for the treatment of EDV-based subcutaneous tumors,but remain a great challenge for the treatment of in situ malignant metastatic tumor associated with EDV and VM.Here,we demonstrate a self-assembled nanoparticle(VE-DDP-Pro)featuring self-anti-EDV and-VM capacity enables to significantly enhance the treatment efficacy of cisplatin(DDP)against the growth and metastasis of ovarian cancer.The VE-DDP-Pro is constructed by patching DDP loaded cRGD-folate-heparin nanoparticles(VE)onto the surface of protamine(Pro)nanoparticle.We demonstrated the self-anti-angiogenesis capacity of VE-DDP-Pro was attributed to VE,which could significantly inhibit the formation of EDV and VM by regulating signaling pathway of MMP-2/VEGF,AKT/mTOR/MMP-2/Laminin and AKT/mTOR/EMT,facilitating chemotherapeutics to effectively suppress the development and metastasis of ovarian cancer.Thus,combing with the chemotherapeutics effectiveness of DDP,the VE-DDP-Pro can significantly enhance treatment efficacy and prolong median survival of mice with metastatic ovarian cancer.We believe our self-assembled nanoparticles integrating the anti-EDV and anti-VM capacity provide a new preclinical sight to enhance the efficacy of chemotherapeutics for the treatment malignant metastasis tumor. | Jiamao Luo Xinxian Zhong Yingming Peng Chenyuan Hao Xiaomei Liang Yulu Yang Xiubo Shi Xuncai Chen Xiao Yi iaoxuan Li Jianhua Wu Jinheng Li Qian Xiao Chentian Wu b Ruojing Lu b Yao Pan Xuejiao Wang Jun-Bing Fan Yifeng Wang Ying Wang | 2022 | Bioactive Materials2022，7，7： | 1 |
| 8 | A new multi-feature approach to object-oriented change detection based on thzzy classification显示文摘 | Du Xuejiao Zhang Chao Yang Jianyu | 2012 | Intelligent Automation and Soft Computing2012，，： | 1 |
| 9 | Effects of Juvenile Hormone and Precocene on the Reproduction of Brachionus calyciflorus显示文摘 | Linlan Lv Qichen Jiang Xuejiao Chen1 Jiaxin Yang | 2012 | International Review of Hydrobiology2012，，5： | 1 |
| 10 | Fast quantitative detection of cocaine inbeverages using nanoextractive electrospray ionization tandem mass spectrometry显示文摘 | Hu Bin Peng Xuejiao Yang Shuiping | 2010 | J Am Sco Mass Spectrom2010，21，2： | 1 |
| 11 | In-situ photoisomerization of azobenzene to inhibit ion-migration for stable high-efficiency perovskite solar cells显示文摘Ion migration is a notorious problem in perovskite solar cells(PSCs)that severely mutilates device performance.Herein,a strategy to inhibit ion migration in situ is developed by using photoisomerization of azobenzene(AZO)to immobilize cations in the lattice.During the nucleation process,the photoisomerized cis-AZO reacts with FA^(+),MA^(+)and Pb2+cations in the perovskite precursor by synergistic cation-πinteraction and Lewis base coordination,leading to heterogeneous nucleation to produce uniform perovskite film.Meanwhile,it accelerates conversion of intermediate yellowδ-phase to desired black aphase of FAPb I3for improved crystallinity with well-passivated grain surface.Consequently,defect density is effectively reduced for the perovskite film to demonstrate suppressed carrier recombination and enhanced carrier extraction.Subsequently,the solar cell efficiency is elevated from 21.29%to 23.58%with negligible J-V hysteresis.Long-term stability is also improved,with the bare device without any encapsulation retaining 84%of its initial efficiency after aging 744 hours in ambient. | Xuejiao Zuo Yiyang He Hongyu Ji Yong Li Xiuying Yang Binxun Yu Tao Wang Zhike Liu Wenliang Huang Jing Gou Ningyi Yuan Jianning Ding Shengzhong Frank Liu | 2022 | Journal of Energy Chemistry2022，31，10： | 1 |
| 12 | pH-sensitive poly(glutamic acid) grafted mesoporous silica nanoparticles for drug delivery显示文摘 | Jin Zheng Xuejiao Tian Yangfei Sun Daru Lu Wuli Yang | 2013 | International Journal of Pharmaceutics (-)2013，，1： | 1 |
| 13 | Geological,Fluid Inclusion,H-O-S-Pb Isotope Constraints on the Genesis of the Erdaogou Gold Deposit,Liaoning Province显示文摘The Erdaogou gold deposit is located in the conjuncture of North China Carton and Xingmeng orogenic belt.The ore-forming process of Erdaogou gold deposit is divided into three stages(ⅠtoⅢ),which are quartz-pyrite stage(stage I),quartz-polymetallic sulfide stage(stage II)and quartz-calcite stage(stage III).Two types of fluid inclusions is distinguished in the ore-forming stage,i.e.,aqueous type(W-type)and aqueous-carbonic type(C-type)inclusions.From the stageⅠtoⅢ,the homogenization temperature of fluid inclusions are respectively 334-395,214-364 and 172-272℃,with salinities of 7.72 wt.%-11.23 wt.%NaCl equiv.,0.20 wt.%-23.18 wt.%NaCl equiv.,and 0.35 wt.%to 5.25 wt.%NaCl equiv.The ore-forming fluids of the Erdaogou deposit have the characteristics of medium-low temperatures,moderate salinities and low densities.And the fluids belong to the CO,-H2O-NaCl system.The values ofδ34SV-CDT in sulphide samples at different stages(stages I to III)are between-2.2‰ to 2.3‰,indicating sulfur source from magma volatiles or subvolcanic rock leaching.The lead isotopes suggest that ore-forming metals may be derived from a mixture of lower crust and mantle materials.Oxygen and hydrogen isotope data at Erdaogou indicate that magmatic fluid and meteoric water may both be involved in the hydrothermal system.Based on the geological characteris-tics,fluid inclusion results,stable and radiogenic isotope results of Erdaogou gold deposit,we believe that the temperature decrease,fluid boiling are the key factors leading to the ore precipitation and the genetic type of Erdaogou gold deposit is low-sulfidation epithermal deposit. | Fan Yang Xuejiao Pang Bin Li Jingsheng Chen Jilong Han Miao Liu zhongzhu Yang Yan Wang Yi Shi | 2021 | Journal of Earth Science2021，32，1： | 1 |
| 14 | New Discovery of the Devonian Orthoclase Granite of Nenjiang–Heihe Structural belt, China and its Zircon U-Pb Data显示文摘Objective The Nenjiang–Heihe structural belt is located in the eastern Xing’anling Mongolian Orogenic Belt between the Songnen block and Xiang’an block.This structural belt has long been the focus of geological scholars(Miao Laicheng et al.,2003;Liang Chenyue et al.,2011;Li Chao et al.,2017),which has complex geological condition, | YANG Fan NA Fuchao ZHANG Guangyu WANG Yan FU Junyu SUN Wei CHEN Jingsheng LI Bin LIU Miao PANG Xuejiao SHI Yi SHI Lu | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 0 |
| 15 | Characterization of Skin Symbiotic Bacteria of Sympatric Amphibians in Southeastern China显示文摘The fungal infection called chytridiomycosis,caused by Batrachochytrium dendrobatidis(Bd),has given rise to dramatic declines or extinctions of many amphibian species around the world;however,in Asia,this disease has shown a low zoospore load or scant mortality.One potential reason for this may be that certain unique community structures of amphibian skin symbiosis contribute to the outcome of the disease;nevertheless,we know very little about the microbiota in this region. In this study,we used skin swabs of five sympatric amphibian species that have various habitat preferences in Lishui,Zhejiang Province,a place in southeastern China,to explore the skin bacterial communities by using 16 S rRNA amplicon sequencing.We detected a total of 1020 OTUs,belonging to 17 phyla,among which Proteobacteria,Firmicutes,Actinobacteria and Bacteroidetes dominated all five host species.Enterobacteriaceae and Exiguobacteraceae and the genera Escherichia and Exiguobacterium belonging to these two families were identified as the most abundant taxa on our focal species.The alpha diversity was significantly lower on the terrestrial species,and also the highly enriched Proteobacteria was found on the terrestrial species,Rana zhenhaiensis,whereas Actinobacteria,Bacteroidetes,Cyanobacteria and Firmicutes were more abundant on aquatic species than on the terrestrial species.Our results suggest that both host species and habitat sites are important factors driving skin microbial diversity and composition and that amphibians in China may harbour unique skin bacterial communities.This study helps elucidate amphibian skin microbial ecology,and with further efforts,the specific mechanism of the interaction between Bd and host amphibians in China could be elucidated. | Xuejiao YANG Xianglei HOU Li WEI Yu LI Mingshuo QIN Tianjian SONG Yiming LI | 2020 | Asian Herpetological Research2020，11，4： | 0 |
| 16 | The Origin and Preservation of Suspended Barites near the 90°E Ridge in the Northeastern Indian Ocean显示文摘Suspended particulate barite crystals were detected in the water columns at four different stations near the 90°E ridge in the Indian Ocean.Four distinct morphological types of marine barites were distinguished:euhedral-subhedral crystals,oval or round crystals,rhombic crystals,and irregular crystals.The barite crystals in the study area are typically fine,with a dominant size of 1–3μm.The vertical distribution of barites is significantly affected by the formation and sedimentation processes.Barites begin to appear at a depth of 30 m and are formed primarily from the surface to the depth of 2000m with a concentration peak at the depth of 200m,where particles are coarser than those in the other layers.The barites begin to settle and dissolve once formed in the water column,resulting in finer barite particles and lower particle concentrations.The formation of barite crystals is related to biological processes associated with the decomposition of barium-rich skeletons in the microenvironment of decaying organic matter that is affected by the primary productivity and dissolved oxygen content in the water column.The dissolving process of barite crystals showed similar variation with the concentration of dissolved barium in ocean water,and the substitution of strontium for barite in crystals promotes the selective dissolution of barite and exerts an important impact on its morphology.It is approximately 33%of barites in the amount and 22%in the concentration to settle to the bottom of the water column compared to that observed in the main barite formation zone. | BU Xuejiao LIU Ming DING Yi YANG Yadi HUANG Mu SUN Xiaoxia FAN Dejiang YANG Zuosheng | 2023 | Journal of Ocean University of China2023，22，1： | 0 |
| 17 | Empirical Analysis of Agricultural Cultural Resources Value Evaluation under DEA Model显示文摘Agricultural culture is a productive activity about education and management.It aims at high efficiency and high quality,uses technology as its means,and takes nature as its carrier.Agricultural cultural resources are the product of the rapid development of modern economy.It promotes the development of the national economy and profoundly affects people's production and life.DEA model,also known as data envelope analysis method,is an algorithm that uses multiple data decision units for input and output training to obtain the final model.This article explains the concept and basic characteristics of agricultural culture.Through questionnaire surveys and expert interviews,we collected development data,screened human,material,and financial data,and calculated information on economic and social resources.On this basis,this paper establishes the evaluation index of agricultural culture based on DEA model.Then,through empirical analysis from a specific perspective,it can be concluded that increasing human,material and financial input can achieve economic and social benefits.Generally speaking,cultural investment can promote the development of the industry.The research results of this paper laid a theoretical foundation for the development of agricultural culture,and put forward a development model focusing on technology development,improving investment efficiency,and investing in material resources. | Wei Liang Yang Ni Tingyi Li Xuejiao Lin Soo-Jin Chung | 2020 | Computers, Materials & Continua2020，，11： | 0 |
| 18 | BSA stabilized photothermal-fenton reactor with cisplatin for chemo/chemodynamic cascade oncotherapy显示文摘Cisplatin(CDDP)-based chemotherapy is substantially limited in the clinic due to its high postoperative recurrence rate.Synergy therapy has been proven as a potent approach to minimize recurrence and achieve enhanced treatment effects.Herein,chemotherapy drug CDDP is assembled with the photothermal-Fenton agent of bovine serum albumin(BSA)stabilized gallic acid-functionalized iron nanoparticles(GA-Fe NPs)to achieve chemo/chemodynamic synergistic cascade oncotherapy.The Pt-GA-Fe NPs can be utilized to generate H_(2)O_(2) via the activation of nicotinamide adenine dinucleotide phosphate(NADPH)oxidases(NOXs)in the tumor microenvironment(TME),which would then greatly boost H2O2-depending chemodynamic therapy(CDT).The generated cytotoxic reactive oxygen species(hydroxyl radicals,·OH)and the depletion of glutathione(GSH)would further promote CDDP-induced DNA damage.Moreover,benefiting from the absorption in the near-infrared(NIR)region,Pt-GA-Fe NPs exhibit excellent photothermal conversion efficiency(η=45.5%)and allow photoacoustic imaging(PAI)guided photothermal therapy(PTT).In vitro and in vivo experiments show that synergy therapy can effectively kill cancer cells and successfully cure cancer without systemic toxicity.The work highlights a new type of therapeutic agent based on CDDP with the ability of H_(2)O_(2) self-generation,thermal responsiveness,and enhanced CDT effects for applications in cancer therapy. | Nan Yang Tian Zhang Changyu Cao Genxiang Mao Jinjun Shao Xuejiao Song Wenjun Wang Xiaozhou Mou Xiaochen Dong | 2022 | Nano Research2022，15，3： | 0 |
| 19 | Cerium-based nanoparticles for cancer photodynamic therapy显示文摘Metal-and metal-oxide-based nanoparticles have been widely exploited in cancer photodynamic therapy(PDT).Among these materials,cerium-based nanoparticles have drawn extensive attention due to their superior biosafety and distinctive physicochemical properties,especially the reversible transition between the valence states of Ce(Ⅲ)and Ce(Ⅳ).In this review,the recent advances in the use of cerium-based nanoparticles as novel photosensitizers for cancer PDT are discussed,and the activation mechanisms for electron transfer to generate singlet oxygen are presented.In addition,the types of cerium-based nanoparticles used for PDT of cancer are summarized.Finally,the challenges and prospects of clinical translations of cerium-based nanoparticles are briefly addressed. | Hui Li Min Wei Xinyi Lv Yanling Hu Jinjun Shao Xuejiao Song Dongliang Yang Wenjun Wang Buhong Li Xiaochen Dong | 2022 | Journal of Innovative Optical Health Sciences2022，15，6： | 0 |
| 20 | Microstructural Transformation and Precipitation of an Ultra-high Strength Steel under Continuous Cooling显示文摘We investigated phase transition and precipitation of ultra-high strength steel(UHSS)in a new 'short process' with controlled rolling and controlled cooling.Thermalexpansion test combined with metallographic observation was used to research the continuous cooling transformation(CCT)curve.Moreover,the microstructuraltransformation and precipitation law was revealed by morphologicalobservation and alloying elements by electron probe micro-analyzer(EPMA).Transmission electron microscopy(TEM)was utilized to analyze the composition and grain orientation of microstructure.The study showed that the measured criticaltransformation temperatures of Ac1 and Ac3 were 746 and 868 ℃,respectively.The CCT curve indicated that the undercooled austenite was transformed into proeutectoid ferrite and bainite with HV 520 in a broad range of cooling rate 0.1^(-1) ℃·s^(-1).When subjected to a cooling rate of 1 ℃·s^(-1),the undercooled austenite was divided into small-sized blocks by formed martensite.With further increase of cooling rate,micro-hardness increased dramatically,the microstructure of specimen was mainly lathe bainite(LB),granular bainite(GB),lath martensite(LM)and residualaustenite.By diffraction test analysis,it was identified that there was K-S orientation relationship between martensite and austenite for {110}_α//{111}_γ,{111}_α//{101}_γ.EPMA clearly showed that carbon diffused adequately due to staying for a long time at high temperature with a lower cooling rate of 2 ℃·s-1.Phase transition drive force was lower and the residualaustenite existed in the block form of Martensite austenite island(M-A).With the increase of cooling rate to 10 ℃·s^(-1),the block residualaustenite reduced,the carbon content of residualaustenite increased and α phase around the residualaustenite formed into a low carbon bainite form. | 陈永利 ZHAO Yang ZHOU Xuejiao HUANG Jianguo | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，2： | 0 |
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