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| 1 | 物理疗法刮痧干预竞技举重训练的实验研究显示文摘以优秀举重运动员为实验对象,采用具有资质的刮痧师和合理标准化的刮拭技术干预举重训练恢复。结果显示:传统刮痧疗法可提高竞技举重训练效果,降低主观质量感,避免焦虑等心理,提高心率变异性调节交感和副交感神经功能,降低肌酸激酶水平并提高刺激球蛋白含量,提升免疫功能。分析刮痧疗法优势病种治疗范围与竞技训练肌肉疲劳现象的趋同性,说明传统刮痧疗法可促进竞技举重运动员恢复,提升训练成绩。 | 王兴泽 陈佩杰 于杰 WICHAI Eungpinichpong | 2018 | 上海体育学院学报2018，42，3： | 12 |
| 2 | Effect of scraping therapy on weightlifting ability显示文摘OBJECTIVE:To verify the effects of scraping therapy on the weightlifting ability by measuring the subjective sensation,and changes of biomarkers.METHODS:Five students,who have been trained for 3 years in a sport school in China were participated in this study.A course of scraping therapy was applied to intervene during the normal 7-week of weightlifting training programme.The ability of weightlifting,the scale of rating perceived exertion and serum biochemical markers were measured before and after the intervention.RESULTS:Scraping therapy caused a significant increase in weightlifting ability(P<0.05).The level of rating perceived exertion remained stable with the increase in the training volume.Immuno-globulinA was significantly increased(P<0.05),and creatine kinase and blood urea nitrogen were significantly decreased(P<0.05).No significant changes were observed in white blood cell,neutrophil,and testosterone.CONCLUSION:Scraping therapy may facilitate weightlifting ability mainly by decreasing weight sensation and improving serum biochemical parameters. | Xingze Wang Wichai Eungpinichpong Jinsheng Yang Uraiwan Chatchawan Saowanee Nakmareong Yingying Wang Xinyan Gao | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 11 |
| 3 | Guasha improves the rating of perceived exertion scale score and reduces heart rate variability in male weightlifters:a randomized controlled trial显示文摘OBJECTIVE: To evaluate the effects of Guasha therapy on the rating of perceived exertion(RPE) scale score, and heart rate variability(HRV).METHODS: A randomized controlled trial of Guasha(skin scraping) was compared with a sham scraping group and control group. Sixteen sessions within an 8-week period were completed. Sixty-five male weightlifters who had undergone normal weightlifting training for a mean of 5 years before study commencement were recruited. The RPEscale score of 'snatch', 'clean and jerk' maneuvers(85% of one-repetition maximum), and HRV were measured before and after the intervention.RESULTS: The RPE scale score for snatch, clean and jerk were reduced significantly after intervention in the Guasha group and sham group. However, there was a significant difference in the low frequency(LF) domain and LF/high frequency(HF) ratio(P <0.05): the LF domain decreased, and the LF/HF ratio decreased.CONCLUSION: Guasha could be used to reduce the RPE scale score, and increase the response to HRV.Guasha could be considered as an alternative to some types of recovery from sports training. | Wang Xingze Chen Peijie Huang Xingyu Wang Yingying Yang Jinsheng Wichai Eungpinichpong Yang Yuming Uraiwan Chatchawan | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 4 |
| 4 | Screening of SLC25A13 mutation in the Thai population显示文摘AIM:To determine the prevalence of SLC25A13 mutations in the Thai population.METHODS:A total of 1537 subjects representing the Thai population were screened for a novel pathologic allele p.Met1?(c.2T>C)and six previously known common SLC25A13 mutations:[Ⅰ](c.851_854delGTAT),[Ⅱ](g.IVS11+1G>A),[Ⅲ](c.1638_1660dup),[Ⅳ](p.S225X),[Ⅴ](IVS13+1G>A),and[XIX](g.IVS16ins3kb)using a newly developed TaqMan and established HybProbe assay,respectively.Sanger sequencing was employed for specimens showing an aberrant peak to confirm the targeted mutation as well as the unknown aberrant peaks detected.Frequencies of the mutations identified were compared in each region.Carrier frequency and disease prevalence of citrin deficiency caused by SCL25A13 mutations were estimated.RESULTS:p.Met1?was identified in the heterozygous state in 85 individuals,giving a carrier frequency of1/18,which suggests possible selective advantage of this variant.The question of p.Met1?homozygote lethality remains unanswered which may serve as an explanation as to why this homozygote has yet to be identified in patients/controls even with high allele frequency.The p.Met1?mutation has rarely been studied in populations other than Thai and Chinese;therefore,may have been overlooked.Development of the TaqMan assay in the present study would allow a simple,rapid,and cost-effective method for mass screening.Heterozygous mutations:[XIX]and[Ⅰ]were identified in 17 individuals,giving a carrier rate of 1/90 and a calculated homozygote rate of 1/33000.Two novel variants,g.IVS11+17C>G and c.1311C>T,of unknown clinical significance were identified at low frequency.CONCLUSION:This study highlighted the current underestimation of citrin deficiency and suggests the possible selective advantage of the p.Met1?allele. | Parith Wongkittichote Chonlaphat Sukasem Atsuo Kikuchi Wichai Aekplakorn Laran T Jensen Shigeo Kure Duangrurdee Wattanasirichaigoon | 2013 | World Journal of Gastroenterology2013，19，43： | 4 |
| 5 | 锁阳治疗前列腺增生的研究现状显示文摘前列腺增生症(BPH)属中老年男性泌尿外科的常见疾病。患者不具备手术指征的较多,因此药物成为治疗BPH的首选。中药锁阳为补肾壮阳的常用药,临床上用于BPH的治疗。锁阳具有调节肾功能、缓解肾阳虚、抗氧化、抗应激、抗疲劳以及激素样等方面作用;其含有黄酮类、三萜类、多糖类等多种活性成分。但其作用机制和药效物质基础尚不十分明确。为此本文综述了锁阳及其活性成分与治疗BPH相关的药理作用。 | 陶蕊 苗琳 王雪妮 WICHAI Nuttapong | 2016 | 中国临床药理学杂志2016，32，12： | 3 |
| 6 | 盐酸小檗碱抑制大鼠良性前列腺增生诱发的下尿路症状显示文摘目的良性前列腺增生症(BPH)是一类在老年男性中常见的增生性泌尿系统疾病,其中大部分患者会发展表现为下尿路症状(LUTS)。寻找抑制膀胱平滑肌收缩的药物成为治疗BPH诱发的LUTS最有前景的策略之一。本文研究传统中药黄连(CCF)对BPH诱发的LUTS的抑制作用,并进一步探索其发挥作用的活性成分以及相关的分子机制。方法建立大鼠BPH模型,口服黄连提取物,用HE染色法检测前列腺和膀胱病理改变,计算前列腺指数PI和膀胱指数BI的变化。用肌条收缩舒张实验检测CCF及其活性成分盐酸小檗碱(Ber)对KCl或Ach诱导的膀胱逼尿肌的影响。用离体灌流法检测对排尿功能的影响。原代培养大鼠膀胱逼尿肌细胞,检测CCF和Ber对钙离子细胞内流和ROCK-1的表达的调控作用。结果BPH大鼠前列腺和膀胱均表现出平滑肌明显增多的病理改变;其PI和BI值明显升高,并且出现排尿功能障碍;口服CCF可明显改善上述症状。CCF或Ber可以抑制Ach或KCL诱导的膀胱逼尿肌肌条收缩,并且显著延长大鼠排尿间隔,缩短大鼠排尿时间以及增加其排尿量。在机制方面,与CCF类似Ber可以抑制Ach诱导的钙离子细胞内流和ROCK-1的表达。结论CCF以Ber为主要活性成分,具有调节膀胱平滑肌收缩的作用,可作为BPH-LUTS治疗的潜在药物。 | 贾思童 苗琳 员小婷 焦婵媛 邵瑞 郝佳 常艳旭 樊官伟 张琚 耿强 Nuttapong WICHAI 高秀梅 | 2019 | 中国药理学与毒理学杂志2019，33，9： | 2 |
| 7 | HN Saponin F通过雄激素受体抑制雄激素依赖的前列腺癌细胞LNCaP增殖显示文摘目的研究HN Saponin F的类雄激素活性,探讨其对雄激素依赖性前列腺癌细胞LNCa P增殖的调控作用及作用机制。方法细胞免疫荧光法检测HN Saponin F对LNCa P细胞中本底水平和双氧睾酮DHT刺激时雄激素受体AR的细胞核转位的影响;MTT法检测HN Saponin F对本底水平和DHT诱导的LNCa P细胞增殖的影响;转染AR的特异si RNA进一步检测HN Saponin F调节LNCa P细胞增殖的机制。结果与DHT类似,HN Saponin F剂量依赖性地促进LNCa P细胞中AR从细胞质转位到细胞核;与DHT联用后,HN Saponin F还可抑制DHT诱导的AR核转位。DHT可以明显促进LNCa P细胞增殖,HN Saponin F可以剂量依赖性地抑制LNCa P细胞的增殖,且可以抑制DHT诱导的LNCa P细胞增殖。AR的特异si RNA抑制AR的表达后,LNCa P细胞本底和DHT诱导的增殖水平被明显抑制,但HN Saponin F失去了进一步抑制LNCa P细胞增殖的作用。结论 HN Saponin F通过AR拮抗雄激素活性,抑制雄激素依赖的前列腺癌细胞增殖,提示HN Saponin F可以作为潜在的AR拮抗剂,用于雄激素依赖性前列腺癌药物的开发。 | 史梦瑶 Nuttapong Wichai 王雪妮 王彧 刘二伟 邵瑞 Charupan Phosat 于海洋 苗琳 | 2019 | 中南药学2019，17，10： | 2 |
| 8 | Intextrochanteric fractures of the femur: results of treatment with 95 condylar blade plate显示文摘 | Wichai Suriyajakyuthana MD | 2004 | J Med Assoc Thai2004，87，12： | 1 |
| 9 | Herceptin-induced inhibition of Phosphatidylinositol-3 Kinase and Akt is required for antibody-mediated effects on p27^Kip1, CyclinDl, and Antitumor action显示文摘 | FMichael Yakes Wichai Chinratalab Christoph ARitter | 2002 | Cancer Res2002，62，15： | 1 |
| 10 | Synthesis of water dispersible magnetite nanoparticles in the presence of hydrophilic polymers显示文摘 | Thapanapong Theppaleak Gamolwan Tumcharern Uthai Wichai | 2009 | Original Paper2009，63，： | 1 |
| 11 | Antimutagenic potential of the Thai herb,Mucuna collettii Lace显示文摘 | WICHAI CHERDSHEWASART WANDEE SUTJIT KADE PULCHAROEN | 2008 | Journal of Ethnopharmacology2008，115，1： | 1 |
| 12 | Preventive effects of Pueraria minfica on bone loss in ovariectomized rats 显示文摘 | Nontakorn Urasopon Yuzuru Hamada Wichai Cherdshewasart | 2008 | Matttritas2008，59，2： | 1 |
| 13 | Pretreatment with phytoestrogen-rich plant decreases breast tumor incidence and exhibits lower profile of mammary ERα and ERβ显示文摘 | Wichai Cherdshewasart Rattana Panriansaen Pomtipa Picha | 2007 | Maturitas2007，58，2： | 1 |
| 14 | 应用斑点免疫结合法检测植物病毒显示文摘 | 郑光宇 Wichai Kositratana David J. Gumpf | 1988 | 病毒学报1988，，02： | 1 |
| 15 | 查看详情显示文摘 | Rodkate N Wichai U Boontha B Rutnakornpituk M | | 0，，： | 1 |
| 16 | Myelodysplastic syndromes in Thailand: a retrospective pathologic and clinical analysis of 117 cases显示文摘 | Tanin Intragumtornchai Wichai Prayoonwiwat Daratana Swasdikul Nipha Suwanwela Boonsom Chaimongkol Saengsuree Jootar Kanchana Chansung Suporn Chancharunee Apichai Leelasiri Yataro Yoshida | 1998 | Leukemia Research1998，，： | 1 |
| 17 | 应用斑点免疫结合法检测植物病毒显示文摘 | 郑光宇 Wichai Kositratana David J. Gumpf | 1988 | 病毒学报1988，，02： | 1 |
| 18 | Preventive effects of Pueraria mirifica on bone loss in ovariectomized rats 显示文摘 | Nontakorn Urasopon Yuzuru Hamada Wichai Cherdshe- wasart | 2008 | Maturitas2008，59，2： | 1 |
| 19 | Microvascular dysfunction in hepatic ischemia–reperfusion injury in pigs显示文摘 | Borimas K. Hanboon Wichai Ekataksin Guido Alsfasser Peter Schemmer Bernhard Urbaschek Robert S. McCuskey Ernst Klar | 2010 | Microvascular Research2010，，1： | 1 |
| 20 | 国外心肺耐力/心肺适能与学前儿童健康相关性研究的系统综述显示文摘目的:通过系统综述国外心肺耐力/心肺适能(CRF)与学前儿童若干健康指标相关性研究,揭示心肺适能是评价学前儿童健康的重要指标,并提供该指标的测评方法。方法:从1999-2019年发表在PubMed,Scopus数据库的英文文献中,选取健康学前儿童(年龄在2.5~6.9岁)为对象,涉及心肺适能与儿童健康相关测评指标(含心血管健康、肥胖、身体活动、动作技能能力和认知发展)研究。结果:共有21项质量中高等的文献探讨了学前儿童心肺适能水平与健康测评指标的相关性:学前儿童低水平的心肺适能与高心血管疾病风险、肥胖/超重密切相关,中高强度的身体活动水平有助于学前儿童心肺适能的提高,极少数研究调查学前儿童动作和认知发展与心肺适能的关系,且结论不一致。提示我国学者需要重新审视学前儿童的心肺适能发展的重要性,并获得更多的证据。 | 吴华 张新定 阮辉 Wichai Eungpinichpong | 2021 | 成都体育学院学报2021，47，6： | 1 |
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