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| 1 | Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of prenatal and adult stress显示文摘BACKGROUND Chronic stress during pregnancy may increase visceral hyperalgesia of offspring in a sex-dependent way.Combining adult stress in offspring will increase this sensitivity.Based on the evidence implicating estrogen in exacerbating visceral hypersensitivity in female rodents in preclinical models,we predicted that chronic prenatal stress(CPS)+chronic adult stress(CAS)will maximize visceral hyperalgesia;and that estrogen plays an important role in colonic hyperalgesia.AIM The aim was to illuminate the role of estrogen in colonic hyperalgesia and its underlying mechanisms.METHODS We established a CPS plus CAS rodent model in which the balloon was used to distend the colorectum.The single-fiber recording in vivo and patch clamp experiments in vitro were used to monitor the colonic neuron’s activity.The reverse transcription-polymerase chain reaction,western blot,and immunofluorescence were used to study the effects of CPS and CAS on colon primary afferent sensitivity.We used ovariectomy and letrozole to reduce estrogen levels of female rats respectively in order to assess the role of estrogen in female-specific enhanced primary afferent sensitization.RESULTS Spontaneous activity and single fiber activity were significantly greater in females than in males.The enhanced sensitization in female rats mainly came from lowthreshold neurons.CPS significantly increased single-unit afferent fiber activity in L6-S2 dorsal roots in response.Activity was further enhanced by CAS.In addition,the excitability of colon-projecting dorsal root ganglion(DRG)neurons increased in CPS+CAS rats and was associated with a decrease in transient Atype K+currents.Compared with ovariectomy,treatment with the aromatase inhibitor letrozole significantly reduced estrogen levels in female rats,confirming the gender difference.Moreover,mice treated with letrozole had decreased colonic DRG neuron excitability.The intrathecal infusion of estrogen increased brain-derived neurotrophic factor(BDNF)protein levels and contributed to the response to visceral pain.Western blotting showed that nerve growth factor protein was upregulated in CPS+CAS mice.CONCLUSION This study adds to the evidence that estrogen-dependent sensitization of primary afferent colon neurons is involved in the development of chronic stress-induced visceral hypersensitivity in female rats. | Jing-Hong Chen Ying Sun Pei-Jun Ju Jin-Bao Wei Qing-Jie Li John H Winston | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 2 | Nerve growth factor expression is up-regulated in the rat model of L-arginine-induced acute pancreatitis显示文摘 | Toma H Winston J Micci MA | 2000 | Gastroenterology2000，119，5： | 1 |
| 3 | Efficient light coupler for threshold C∨erenkov counters显示文摘 | Winston H R | 1966 | Review of Scientific Instruments1966，37，8： | 1 |
| 4 | Overcoming public aversion to congestion pricing显示文摘 | Winston H Alan J Krupnick | 2001 | Transportation Research Part A2001，35，： | 1 |
| 5 | Beauty in a smile: the role of medial orbitofrontal cortex in facial attractiveness 显示文摘 | O'Doherty J Winston J Critchley H | 2003 | Neuropsychologia2003，41，： | 1 |
| 6 | Effects of glucose, glutamine, ethylenediaminetetraacetic acid and oxygen tension on the concentration of reactive oxygen species and on development of the mouse preimplantation embryo in vitro显示文摘 | Nasr-Esfahani M H Winston N J Johnson M H | 1992 | J Reprod Fertil1992，96，1： | 1 |
| 7 | The role of mast cells in the pathogenesis of pain in chronic pancreatitis显示文摘 | Hoogerwerf W A Gondesen K Xiao S Y Winston J H Willis W D Pasricha P J | 2005 | BMC Gastroenterol2005，5，： | 1 |
| 8 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 9 | Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons显示文摘 | Winston J Toma H Shenoy M | 2001 | Pain2001，89，23： | 1 |
| 10 | Beauty in a smile: the role of medial orbitofrontal cortex in facial attractiveness 显示文摘 | O'Doherty J Winston J Critchley H | 2003 | Neuropsychologia2003，41，2： | 1 |
| 11 | Variation of the prognostic significance of HER-2 expression in breast cancer according to tumor size显示文摘 | Swede H Moysich KB Winston JS | 2003 | Breast J2003，9，2： | 1 |
| 12 | Bank Lending and Real Estate in Asia: Market Optimism and Asset Bubbles 显示文摘 | Winston T H Koh Boberto S Mariano Andrey Pavlov | 2004 | Journal of Asian Economics2004，2004，： | 1 |
| 13 | Focus on China: should clinicians engage in research? and lessons from other countries 显示文摘 | Zhang Z Winston G P Zhao H T | 2014 | Quant Imaging Med Surg2014，4，5： | 1 |
| 14 | Supported liquid membranes for removal and recovery of metals from waste waters and process streams显示文摘 | WINSTON H W S WANG B NEUMULER T E | 2001 | Environmental Progress2001，20，2： | 1 |
| 15 | A generalized decision support system using predicate calculus and network data base management 显示文摘 | Holsapple C W Winston A B | 1981 | Operations Research1981，29，2： | 1 |
| 16 | Space-time registration of radar and ESM using unscented Kalman filter 显示文摘 | LI Winston Leung H Zhou Yifeng | 2004 | IEEE Tran on AES2004，40，3： | 1 |
| 17 | Nerve growth factor regulates VR-I mRNA levels in cultures of adult dorsal root ganglion new rons 显示文摘 | Winston J Toma H Shenoy M | 2001 | Pain2001，89，23： | 1 |
| 18 | Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients:a multicenter,randomized trial显示文摘 | Winston D J Maziarz R T Chandrasekar P H | 2003 | Ann Intern Med2003，138，： | 1 |
| 19 | Beauty in a smile: the role of medial orbitofrontal cortex in facial attractiveness显示文摘 | J O’Doherty J Winston H Critchley D Perrett D.M Burt R.J Dolan | 2002 | Neuropsychologia2002，，2： | 1 |
| 20 | Tailored edge-ray reflectors for illumination 显示文摘 | RIES H WINSTON R | 1994 | Journal of the Optical Society of America1994，11，4： | 1 |
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