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| 1 | LRIF1 interacts with HPla to coordinate accurate chromosome segregation during mitosis显示文摘Heterochromatin protein 1α (HP1α)regulates chromatin specification and plasticity during cell fate decision.Different structural determinants account for HP1α Localization and function during cell division cycle.Our earlier study showed that centromeric Localization of HP1α depends on the epigenetic mark H3K9me3 in interphase,while its centromeric location in mitosis relies on uncharacterized PXVXL-containing factors.Here,we identified a PXVXL-containing protein,Ligand-dependent nuclear receptorinteracting factor 1 (LRIF1),which recruits HPla to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during mitosis.LRIF1 interacts directly with HPla chromoshadow domain via an evolutionariLy conserved PXVXL motif within its C-terminus.Importantly,the LRIF1-HPla interaction is critical for Aurora B activity in the inner centromere.Mutation of PXVXL motif of LRIF1 Leads to defects in HPla centromere targeting and aberrant chromosome segregation.These findings reveal a previously unrecognized direct Link between LRIF1 and HP1α in centromere plasticity control and illustrate the critical role of LRIF1-HP1α interaction in orchestrating accurate cell division. | Saima Akram Fengrui Yang Junying Li Gregory Adams Yingying Liu Xiaoxuan Zhuang Lingluo Chu Xu Liu Nerimah Emmett Winston Thompson McKay Mullen Saravana Muthusamy Wenwen Wang Fei Mo Xing Liu | 2018 | Journal of Molecular Cell Biology2018，10，6： | 5 |
| 2 | Solvent-free nanocasting toward universal synthesis of ordered mesoporous transition metal sulfide@N-doped carbon composites for electrochemical applications显示文摘Transition metal sulfides (TMSs) have a wide range of applications owing to their intriguing properties.Significant efforts have been devoted to nanostructuring TMSs to enhance their properties and performance,still there is a high need in general synthesis of TMS nanostructures.Herein,for the first time,a simple solvent free reactive nanocasting approach that integrates solid precursor loading,in-situ sulfuration and carbonization into a single heating step is developed for the universal synthesis of ordered mesoporous TMS@N-doped carbon composites (denoted as OM-TMS@NCs) with methionine (Met) and metal chlorides as the precursors and the mesoporous silica (SBA-15) as the hard template.A series of OM-TMS@NCs with a hexagonal mesostructure,ultra-high surface areas (430-754 m2·g-1),large pore volumes (0.85-1.32 cm3·g-1),and unique TMS stoichiometries,including MoS2,Fe7S8,Co9S8,NiS,Cu7S4 and ZnS,are obtained.Two distinct structure configurations,namely,highly dispersed ultrathin TMS nanosheets within NCs and TMS@NC co-nanowire arrays,can be obtained depending on different metals.The structure evolution of the OM-TMS@NCs over the solvent-free nanocasting process is studied in detail for a deep understanding of the synthesis.As demonstrations,these materials are promising for electrocatalytic hydrogen evolution reaction and lithium ion storage with high performances. | Jiahui Zhu Zhi Chen Lin Jia Yuqi Lu Xiangru Wei Xiaoning Wang Winston Duo Wu Na Han Yanguang Li Zhangxiong Wu | 2019 | Nano Research2019，12，9： | 5 |
| 3 | Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of prenatal and adult stress显示文摘BACKGROUND Chronic stress during pregnancy may increase visceral hyperalgesia of offspring in a sex-dependent way.Combining adult stress in offspring will increase this sensitivity.Based on the evidence implicating estrogen in exacerbating visceral hypersensitivity in female rodents in preclinical models,we predicted that chronic prenatal stress(CPS)+chronic adult stress(CAS)will maximize visceral hyperalgesia;and that estrogen plays an important role in colonic hyperalgesia.AIM The aim was to illuminate the role of estrogen in colonic hyperalgesia and its underlying mechanisms.METHODS We established a CPS plus CAS rodent model in which the balloon was used to distend the colorectum.The single-fiber recording in vivo and patch clamp experiments in vitro were used to monitor the colonic neuron’s activity.The reverse transcription-polymerase chain reaction,western blot,and immunofluorescence were used to study the effects of CPS and CAS on colon primary afferent sensitivity.We used ovariectomy and letrozole to reduce estrogen levels of female rats respectively in order to assess the role of estrogen in female-specific enhanced primary afferent sensitization.RESULTS Spontaneous activity and single fiber activity were significantly greater in females than in males.The enhanced sensitization in female rats mainly came from lowthreshold neurons.CPS significantly increased single-unit afferent fiber activity in L6-S2 dorsal roots in response.Activity was further enhanced by CAS.In addition,the excitability of colon-projecting dorsal root ganglion(DRG)neurons increased in CPS+CAS rats and was associated with a decrease in transient Atype K+currents.Compared with ovariectomy,treatment with the aromatase inhibitor letrozole significantly reduced estrogen levels in female rats,confirming the gender difference.Moreover,mice treated with letrozole had decreased colonic DRG neuron excitability.The intrathecal infusion of estrogen increased brain-derived neurotrophic factor(BDNF)protein levels and contributed to the response to visceral pain.Western blotting showed that nerve growth factor protein was upregulated in CPS+CAS mice.CONCLUSION This study adds to the evidence that estrogen-dependent sensitization of primary afferent colon neurons is involved in the development of chronic stress-induced visceral hypersensitivity in female rats. | Jing-Hong Chen Ying Sun Pei-Jun Ju Jin-Bao Wei Qing-Jie Li John H Winston | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 4 | Space-time registration of radar and ESM using unscented Kalman filter 显示文摘 | LI Winston Leung H Zhou Yifeng | 2004 | IEEE Tran on AES2004，40，3： | 1 |
| 5 | Space-Time Registration of Radar and ESM Using Unscented Kalman Filter 显示文摘 | Li Winston Leung Henry Zhou Yifeng | 2004 | IEEE Transaction on Aerospace and Electronic Systems2004，40，3： | 1 |
| 6 | Simultaneous registration and fusion of multiple dissimilar sensors for cooperative driving显示文摘 | Winston Li Henry Leung | 2004 | IEEE Trans on Intelligent Transportation Systems2004，5，2： | 1 |
| 7 | Numerical investigation of droplet pre-dispersion in a monodisperse droplet spray dryer显示文摘 | Jie Xiao Yang Li Oluwafemi Ayodele George Zhihao Li Shujun Yang Meng Wai Woo Winston Duo Wu Xiao Dong Chen | 2018 | Particuology2018，16，3： | 1 |
| 8 | Efficacy of shortcourse antibiotic regimens for community-acquired pneumonia: a meta-analysis显示文摘 | Li JZ Winston LG Moore DH | 2007 | Am JMed2007，120，9： | 1 |
| 9 | A maximum likelihood approach for image registration using control point and intensity显示文摘 | Winston LI Henry LEUNG | 2004 | IEEE Transactions on Image Processing2004，13，8： | 1 |
| 10 | Space-Time Registration of Radar and ESM Using Unscented Kalman Filter显示文摘 | Li Winston Henry Leung YiFeng Zhou | 2004 | IEEE Transaction on Aerospace and Electronic2004，40，3： | 1 |
| 11 | Correlation of dose computed using different algorithms with local control following stereotactic ablative radiotherapy (SABR)-based treatment of non-small-cell lung cancer显示文摘 | Indrin J. Chetty Suneetha Devpura Dezhi Liu Daiquan Chen Haisen Li Ning (Winston) Wen Sanath Kumar Correen Fraser M. Salim Siddiqui Munther Ajlouni Benjamin Movsas | 2013 | Radiotherapy and Oncology2013，，3： | 1 |
| 12 | Efficacy of short-course antibiotic regimens for community-acquired pneumonia:a metaanalysis显示文摘 | Li JZ Winston LG Moore DH | 2007 | Am J Med2007，120，9： | 1 |
| 13 | Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways显示文摘 | Porfirio Nava Stefan Koch Mike G. Laukoetter Winston Y. Lee Keli Kolegraff Christopher T. Capaldo Neal Beeman Caroline Addis Kirsten Gerner-Smidt Irmgard Neumaier Arne Skerra Linheng Li Charles A. Parkos Asma Nusrat | 2010 | Immunity2010，，3： | 1 |
| 14 | Efficacy of short-course antibiotic Regimens for community acquired Pneumonia:a meta-analysis显示文摘 | Li JZ Winston LG Moore DH Bent S | 2007 | Am J Mcd2007，120，9： | 1 |
| 15 | Space-time registration of radar and ESM using unscented Kalman filter显示文摘 | Li Winston Leung Henry Zhou Yifeng | 2004 | IEEE Transactions on AES2004，40，4： | 1 |
| 16 | Chronic prenatal stress epigenetically modifies spinal cord BDNF expression to induce sex specific visceral hypersensitivity in offspring 显示文摘 | Winston J H Li Q Sarna S K | 2014 | Neurogastroenterol Motil2014，26，： | 1 |
| 17 | Performance evaluation of digital beamforming strategies for satellite communications显示文摘 | Li Winston Huang Xinping Leung Henry | 2004 | Aerospace and Electronic Systems IEEE2004，40，1： | 1 |
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