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| 1 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 2 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | 2013 (9881)2013，，9881： | 2 |
| 3 | In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment 显示文摘 | Sipkins DA We i X Wu JW | 2005 | Nature2005，435，7044： | 1 |
| 4 | Non-doped-type white organic light-emitting devices based on yellowemitting ultrathin 5,6,11,12-tetraphenylnaphthacene and blue-emitting 4,4'-bis (2,2'-diphenyl vinyl)-1,1'-biphenyl显示文摘 | Xie WE Wu Z J Liu S Y | | 0，，： | 1 |
| 5 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 6 | Dielectric properties of ( Ba, St) O - ( Sin, La)2O3 - TiO2 ceramics at microwave frequencies显示文摘 | SUN Jwo-Shiun WE! Chung-Chuang WU Long | 2005 | Journal of Materials Science2005，27，21： | 1 |
| 7 | Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance显示文摘Latent membrane protein 1(LMP1)is a major Epstein–Barr virus(EBV)-encoded oncoprotein involved in latency infection that regulates mitochondrial functions to facilitate cell survival.Recently,mitochondrial fission has been demonstrated as a crucial mechanism in oncovirus-mediated carcinogenesis.Mitochondrial dynamin-related protein 1(Drp1)-mediated mitochondrial fission has an impact on the chemoresistance of cancers.However,the mechanism by which oncogenic stress promotes mitochondrial fission,potentially contributing to tumorigenesis,is not entirely understood.The role of Drp1 in the oncogenesis and prognosis of EBV-LMP1-positive nasopharyngeal carcinoma(NPC)was determined in our study.We show that EBV-LMP1 exhibits a new function in remodeling mitochondrial morphology by activating Drp1.A high level of p-Drp1(Ser616)or a low level of p-Drp1(Ser637)correlates with poor overall survival and disease-free survival.Furthermore,the protein level of p-Drp1(Ser616)is related to the clinical stage(TNM stage)of NPC.Targeting Drp1 impairs mitochondrial function and induces cell death in LMP1-positive NPC cells.In addition,EBV-LMP1 regulates Drp1 through two oncogenic signaling axes,AMPK and cyclin B1/Cdk1,which promote cell survival and cisplatin resistance in NPC.Our findings provide novel insight into the role of EBV-LMP1-driven mitochondrial fission in regulating Drp1 phosphorylation at serine 616 and serine 637.Disruption of Drp1 could be a promising therapeutic strategy for LMP1-positive NPC. | Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu Lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao Weizhong Wu Xin Zhang Weihua Liao Ann MBode Ya Cao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 8 | Phytoextraction of metal-contaminated soil by Sedum alfredii H:Effects of chelator and co-planting显示文摘 | Wu Q T We Z B Ouyang Y | 2007 | Water Air Soil Pollut2007，180，： | 1 |
| 9 | The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis显示文摘 | Wu JC Bunney WE | 1990 | Am J Psychiatry1990，147，： | 1 |
| 10 | Somatostatin receptor subtype 2 gene therapy inhibits pancreatic cancer in vitro 显示文摘 | Fisher WE Wu Y Amaya F | 2002 | J Surg Res2002，105，1： | 1 |
| 11 | Topiramate monotherapy in newly diagnosed epilepsy in children and adolescents 显示文摘 | Glauser TA Dlugos DJ Dodson WE Grinspan A Wang S Wu SC | 2007 | J Child Neurol2007，22，6： | 1 |
| 12 | Somatostatin receptor subtype 2 gene therapy inhibits pancreatic cancer in vitro显示文摘 | Fisher WE Wu Y Amaya F | 2002 | J Surg Res2002，105，1： | 1 |
| 13 | Biofabrication with chitosan显示文摘 | Yi HM Wu LQ Bentley WE | | 0，，06： | 1 |
| 14 | Tolerability and immune responses in humans to a PowderJect DNA vaccine for hepatitis B 显示文摘 | Swain WE Heydenburg Fuller D Wu MS | 2000 | Dev Biol (Basel)2000，104，： | 1 |
| 15 | Cardioprotective effects of transhinone ⅡA on my- ocardial ischemia injury in rats 显示文摘 | We X Jun Y Wu LM | 2009 | Die Pharmazie2009，64，5： | 1 |
| 16 | Characteristics of phenotype and genetic mutations in rice after spaceflight显示文摘 | Yu X Wu H We L J Cheng Z L Xin P Huang C L Zhang K P Sun Y Q | 2007 | Advances in Space Research2007，，40： | 1 |
| 17 | Synthesis of graphene oxide - Ag2CO3 composites with improved photoactivity and anti-photocorrosion显示文摘 | DONG C WU K L WE] X W | 2014 | CrystEngComm2014，，16： | 1 |
| 18 | The hnpaet of Lifestyle on Energy Use and CO2 Emission : An Empirical Analysis of China' s Residents 显示文摘 | We Yiming Liu Lancui Fan Ying Wu Gang | 2007 | Energy Policy2007，，35： | 1 |
| 19 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 20 | (Ba,Ca)(Ti,Zr)O3-BiFeO3 lead -free piezoelectric ce ramics 显示文摘 | WU J WE W XIAO D | 2012 | Cur rent Applied Physics2012，12，2： | 1 |
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