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| 1 | Incremental value of contrast echocardiography in the diagnosis of left ventricular noncompaction显示文摘 | Xiaoxiao Zhang Li Yuan Linli Qiu Yali Yang Qing Lv Lin Li Jing Wang Lin He Li Zhang Xinfang Wang Mingxing Xie Xu Yu Jin | 2016 | Frontiers of Medicine2016，10，4： | 10 |
| 2 | Experimental modeling of sanding fracturing and conductivity of propped fractures in conglomerate:A case study of tight conglomerate of Mahu sag in Junggar Basin,NW China显示文摘True tri-axial sanding fracturing experiments are carried out on conglomerate samples from the Permian Wuerhe Formation of Mahu sag,Junggar Basin,to study hydraulic fracture propagation geometry and quartz sand transport in ma-trix-supported fine conglomerate and grain-supported medium conglomerate.The effect of rough fracture surface on conduc-tivity is analyzed using the 3D-printing technology to reconstruct the rough surface formed in the fractured conglomerate.The hydraulic fractures formed in the matrix-supported fine conglomerate are fairly straight,and only more tortuous when en-countering large gravels at local parts;thus,proppants can get into the fractures easily with transport distance about 70%–90%of the fracture length.By contrast,in the grain-supported medium conglomerate,hydraulic fractures tend to bypass the gravels to propagate in tortuous paths and frequently change in width;therefore,proppants are difficult to transport in these fractures and only move less than 30%of the fracture length.As the ma trix-supported fine conglomerate has high matrix content and low hardness,proppants embed in the fracture surface severely.In contrast,the grain-supported medium conglomerate has higher gravel content and hardness,so the quartz sand is crushed more severely.Under the high proppant concentration of 5 kg/m^(2),when the closure stress is increased(above 60 MPa),fractures formed in both matrix-supported fine conglomerate and grain-supported medium conglomerate decrease in width significantly,and drop 88%and 92%in conductivity respectively compared with the case under the low closure stress of 20 MPa.The field tests prove that under high closure stress above 60 MPa,using a high proportion of fine proppants with high concentration allow the proppant to move further in the fracture;meanwhile proppant places more uniformly in the ro ugh fracture,resulting in a higher fracture conductivity and an improved well per-formance. | ZOU Yushi SHI Shanzhi ZHANG Shicheng YU Tianxi TIAN Gang MA Xinfang ZHANG Zhaopeng | 2021 | Petroleum Exploration and Development2021，48，6： | 1 |
| 3 | Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance显示文摘Latent membrane protein 1(LMP1)is a major Epstein–Barr virus(EBV)-encoded oncoprotein involved in latency infection that regulates mitochondrial functions to facilitate cell survival.Recently,mitochondrial fission has been demonstrated as a crucial mechanism in oncovirus-mediated carcinogenesis.Mitochondrial dynamin-related protein 1(Drp1)-mediated mitochondrial fission has an impact on the chemoresistance of cancers.However,the mechanism by which oncogenic stress promotes mitochondrial fission,potentially contributing to tumorigenesis,is not entirely understood.The role of Drp1 in the oncogenesis and prognosis of EBV-LMP1-positive nasopharyngeal carcinoma(NPC)was determined in our study.We show that EBV-LMP1 exhibits a new function in remodeling mitochondrial morphology by activating Drp1.A high level of p-Drp1(Ser616)or a low level of p-Drp1(Ser637)correlates with poor overall survival and disease-free survival.Furthermore,the protein level of p-Drp1(Ser616)is related to the clinical stage(TNM stage)of NPC.Targeting Drp1 impairs mitochondrial function and induces cell death in LMP1-positive NPC cells.In addition,EBV-LMP1 regulates Drp1 through two oncogenic signaling axes,AMPK and cyclin B1/Cdk1,which promote cell survival and cisplatin resistance in NPC.Our findings provide novel insight into the role of EBV-LMP1-driven mitochondrial fission in regulating Drp1 phosphorylation at serine 616 and serine 637.Disruption of Drp1 could be a promising therapeutic strategy for LMP1-positive NPC. | Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu Lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao Weizhong Wu Xin Zhang Weihua Liao Ann MBode Ya Cao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 4 | The ubiquitin ligase Pelil inhibits ICOS and thereby Tfh-mediated immunity显示文摘T follicular helper(Tfh)cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection.However,the molecular mechanism controlling Tfh cell differentiation is poorly understood.Here,through two mixed bone marrow chimeric experiments,we identified Peli1,a T cell-enriched E3 ubiquitin ligase,as an intrinsic regulator that inhibits Tfh cell differentiation.Peli1 deficiency significantly promoted c-Rel-mediated inducible T-cell costimulator(ICOS)expression,and PELI1 mRNA expression was negatively associated with ICOS expression on human CD4^(+)T cells.Mechanistically,increased ICOS expression on Peli1-KO CD4^(+)T cells enhanced the activation of PI3K-AKT signaling and thus suppressed the expression of Klf2,a transcription factor that inhibits Tfh differentiation.Therefore,reconstitution of Klf2 abolished the differences in Tfh differentiation and germinal center reaction between WT and Peli1-KO cells.As a consequence,Peli1-deficient CD4^(+)T cells promoted lupus-like autoimmunity but protected against H1N1 influenza virus infection in mouse models.Collectively,our findings established Peli1 as a critical negative regulator of Tfh differentiation and indicated that targeting Peli1 may have beneficial therapeutic effects in Tfhrelated autoimmunity or infectious diseases. | Xinfang Huang Shumeng Hao Junli Liu Yuanyuan Huang Manman Liu Chunyuan Xiao Yan Wang Siyu Pei Tao Yu Jing Xu Haikun Wang Dongfang Dai Xiao Su Yichuan Xiao | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 5 | Morphological structures of poly(vinylidene fluoride)/montmorillonite nanocomposites显示文摘Poly(vinylidene fluoride) (PVDF)/montmorillonite (MMT) nanocomposites were prepared by melt blen- ding a kind of organically modified montmorillonite with PVDF. The morphological structures of the nanocomposites were studied using X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and differential scanning calorimetry (DSC). The re- sults indicate that organically modified montmorillonites are in the form of intercalation, exfoliation, and fragments in the PVDF matrix. For the composites, the (001) peak position of MMT was found to shift to a lower angle in XRD patterns, and some MMT fragments could be observed under TEM. MMT loading was favorable to producing the piezoelectric β phase in the PVDF matrix and caused internal stress in α crystals. At the same time, the crystallinity and spherulite size of PVDF decreased with the MMT content. MMT induced β phase is stable even at high temperatures (160℃). For these changes in morphological structures, some possible explanations were proposed based on the experimental re- sults. | SONG YuMing ZHAO ZhuDi YU WenXue LI Bo CHEN XinFang | 2007 | Science China Chemistry2007，50，6： | 1 |
| 6 | Correction:Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance显示文摘Correction to:Signal Transduction and Targeted Therapy(2020)5:56,https://doi.org/10.1038/s41392-020-0151-9,published online 20 May 2020 In this article1 an error was noticed in Fig.3d left(p-Drp1 Ser637).The images were misassigned.And one writing error was found in Fig.S1c.The correct figures are given.The authors confirm that these corrections do not change the result interpretation or conclusions of the article. | Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu Lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao Weizhong Wu Xin Zhang Weihua Liao Ann M.Bode Ya Cao | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
| 7 | Targeting the signaling in Epstein-Barr virus-associated diseases: mechanism, regulation, and clinical study显示文摘Epstein-Barr virus-associated diseases are important global health concerns.As a group I carcinogen,EBV accounts for 1.5%of human malignances,including both epithelial-and lymphatic-originated tumors.Moreover,EBV plays an etiological and pathogenic role in a number of non-neoplastic diseases,and is even involved in multiple autoimmune diseases(SADs).In this review,we summarize and discuss some recent exciting discoveries in EBV research area,which including DNA methylation alterations,metabolic reprogramming,the changes of mitochondria and ubiquitin-proteasome system(UPS),oxidative stress and EBV lytic reactivation,variations in non-coding RNA(ncRNA),radiochemotherapy and immunotherapy.Understanding and learning from this advancement will further confrm the far-reaching and future value of therapeutic strategies in EBV-associated diseases. | Ya Cao Longlong Xie Feng Shi Min Tang Yueshuo Li Jianmin Hu Lin Zha Luqing Zhao Xinfang Yu Xiangjian Luo Weihua Liao Ann MBode | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 0 |
| 8 | Preliminary Investigation of Preparing High Burn-Up Structure in Nuclear Fuel by Flash Sintering Using CeO_(2) as a Surrogate显示文摘The high burn-up structure(HBS)is characterized by the grain size of 100-300 nm and a porosity of up to 20%,which is formed at the rim of the nuclear fuel pellet due to 2-3 times higher local burn-up during the in-pile irradiation.HBS is considered a new potential structure for high-performance fuels.However,it is difficult to prepare HBS by conventional sintering methods.In this study,flash sintering was used to prepare HBS using CeO_(2)as a surrogate for a preliminary investigation.A new experimental configuration for rapid sintering of CeO_(2)pellets was provided,in which the green body can be rapidly preheated and pressure-assisted by the induction heating electrodes.An insulated quartz tube was used as the die for the flash sintered samples,allowing the current to flow through the sample and providing a stable condition for applying an external pressure of approximately 5.3-7.0 MPa during flash sintering process.Using an initial electric field of 141 V cm-1 and holding for 1-7 min at the maximum current density of~98 mA mm^(-2),CeO_(2)ceramics with a grain size of 114-282 nm and a relative density of 75.4-99.7%were prepared.The densification and microstructure evolution behaviors during flash sintering in this new experimental configuration have been discussed in detail.This new experimental configuration may provide a promising approach for preparing UO_(2)ceramics and their HBS. | Tongye Li Jing Yang Chong Yu Yihan Liang Yang Li Xinfang Zhang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，12： | 0 |
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