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| 1 | Pingchuan formula(平喘方) improves allergic asthma in mice through inhibiting nuclear factor-kappa B/mitogen-activated protein kinase signaling pathway显示文摘OBJECTIVE:To examine the role and decipher the mechanism of Pingchuan formula(平喘方,PCF)in treating allergic asthma.METHODS:The mice were treated with saline,dexamethasone(DXM)and PCF for 1 week after the asthma model was established and their respiratory function including respiratory resistance(RI),pulmonary dynamic compliance(Cdyn)and maximum voluntary ventilation(MVV)were measured.In addition,cellular changes in bronchoalveolar lavage fluid(BALF)and pathological changes in lung biopsy as well as the expression level ofα-smooth muscle actin(α-SMA),transforming growth factor-beta1(TGF-β1)in BALF and interleukin-5(IL-5),interleukin-13(IL-13),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),nuclear factor-kappa B-p65(NF-κBp65),inhibitor-αof nuclear transcription factorκB(IκBα),p38 mitogen-activated protein kinase(p38 MAPK),c-jun n-terminal kinase(JNK)and its phosphorylated proteins in lung tissue were also examined and compared among different groups.RESULTS:Our data suggested that the respiratory functions were significantly improved and the pathological changes ameliorated in the DXM group and the PCF group compared to the model group.Both DXM and PCF effectively decreased the number of eosinophils,lymphocytes,and neutrophils in BAL as well as the secretion ofα-SMA and TGF-β1,IL-5,IL-13,while increased the expression of TNF-αand IFN-γ.Furthermore,our study indicated that the NF-κBp65,IκBα,p38 MAPK and JNK pathways were inhibited under the treatment of PCF.CONCLUSION:Our data indicated that PCF can attenuate the inflammatory response in asthma through inhibiting the NF-κB/MAPK signaling pathway.This study not only supported the use of PCF in allergic asthma in clinic but also shed light upon afurther understanding of the disease pathogenesis. | WU Mingyun YU Jianer BAI Li XUE Zheng JIANG Shenhua LI Liqing PIAO Xiang XU Wanchao WANG Jiani SHEN Qian | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 4 |
| 2 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | 2013 (9881)2013，，9881： | 2 |
| 3 | On the parameterized vertex cover problem for graphs with perfect matching显示文摘A vertex cover of an n-vertex graph with perfect matching contains at least n/2 vertices.In this paper,we study the parameterized complexity of the problem vc-pm*that decides if a given graph with perfect matching has a vertex cover of size bounded by n/2+k.We first present an algorithm of running time O*(4k)for a variation of the vertex cover problem on K¨onig graphs with perfect matching.This algorithm combined with the iterative compression technique leads to an algorithm of running time O*(9k)for the problem vc-pm*.Our result improves the previous best algorithm of running time O*(15k)for the vc-pm*problem,which reduces the problem to the almost 2-sat problem and solves the latter by Razgon and O’Sullivan’s recent algorithm. | WANG JianXin LI WenJun LI ShaoHua CHEN JianEr | 2014 | Science China(Information Sciences)2014，57，7： | 2 |
| 4 | Clinical features and risk factors for post-partum depression in a large cohort of Chinese women with recurrent major depressive disorder显示文摘 | Tian Tian Yihan Li Dong Xie Yifeng Shen Jianer Ren Wenyuan Wu Chengbin Guan Zhen Zhang Danning Zhang Chengge Gao Xiaoming Zhang Jinbo Wu Hong Deng Gang Wang Yunshu Zhang Yun Shao Han Rong Zhaoyu Gan Yan Sun Bin Hu Jiyang Pan Yi Li Shufan Sun Libo Song Xue | 2011 | Journal of Affective Disorders2011，，3： | 1 |
| 5 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 6 | Hydrophilic modification of A1203 microfihration membrane with nano-sized yA1203 coating 显示文摘 | Chang Qibing Zhou Jianer Wang Yongqing etal | 2010 | Desalination2010，262，123： | 1 |
| 7 | Separation of stable oil-water emulsion by the hydrophilic nano-sized ZrO2 modified AI03 microfiltration membrane 显示文摘 | Zhou Jianer Chang Qibing Wang Yongqing | 2010 | Separation and Purification Technology2010，75，3： | 1 |
| 8 | Guaranteeing the 2-manifold property for meshes with doubly linked face list显示文摘 | AKLEMAN E CHEN Jianer | 1999 | Interna- tional Journal of Shape Modeling1999，2，5： | 1 |
| 9 | Vertex-Disjoint Routings in Star Graphs 显示文摘 | Chen Chichang Chen Jianer | 1995 | IEEE Algorithms and Architectures for Parallel Processing1995，，1： | 1 |
| 10 | Optimal Parallel Routing in Star Networks 显示文摘 | Chen Chichang Chen Jianer | 1997 | IEEE Transactions on Computers1997，46，12： | 1 |
| 11 | General multiprocessor task scheduling显示文摘 | JIANER C CHUNG Y L | 1999 | Naval Research Logistics1999，46，1： | 1 |
| 12 | The cost of becoming anonymous: on the participant payload in Crowds显示文摘 | Hongfei Sui Jianxin Wang Jianer Chen Songqiao Chen | 2004 | Information Processing Letters2004，，： | 1 |
| 13 | Vertex-Disjoint Routings in Star Graphs显示文摘 | Chen Chi-Chang Chen Jianer | 1995 | IEEE Algorithms and Architectures for Parallel Processing1995，1，46： | 1 |
| 14 | On counting 3-D matchingof size 显示文摘 | Liu Yunlong Chen Jianer Wang Jiaxin | 2009 | Algorithmica2009，54，10： | 1 |
| 15 | Locally subcub_connected hypercube networks: Theoretical analysis and-experimental results 显示文摘 | Chen Jianer Wang Guo-Jun Chen Song-Qiao | 2002 | IEEE Transactions on Computers2002，51，5： | 1 |
| 16 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 17 | An Algorithm for Minimum Vertex Cover Based on Max-I Share Degree显示文摘 | Li Shaohua Wang Jianxin Chen Jianer | 2011 | Journal of Computers2011，6，8： | 1 |
| 18 | Reaction-sintcred porous mineral-based mullite ceramic membrane supports made from recy- cled materials 显示文摘 | Dong Yingehao Zhou Jianer Lin Bin et cd | 2009 | J Hazard Mater2009，172，1： | 1 |
| 19 | Labeled Search Trees and Amortized Analysis: Improved Upper Bounds for NP-Hard Problems显示文摘 | Jianer Chen Iyad A. Kanj Ge Xia | 2005 | Algorithmica2005，，4： | 1 |
| 20 | Locally Subcube-Connected Hypercube Networks:Theoretical Analysis and Experimental Results显示文摘 | Chen Jianer Wang Guojun Chen Songqiao | 2002 | IEEE Trans on Computers2002，51，5： | 1 |
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