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| 1 | Relationship between Fas/ FasL expression and apoptosis of colon adenocarcinoma cell lines显示文摘INTRODUCTIONFas/ FasL system has been identified as a keymediator of apoptosis in tumor cells[1-4]. Theoccurrence and development of neoplasm are closelyrelated to apoptosis[5-7] Most chemotherapeuticdrugs kill cancer cells mainly by inducingapoptosis[8-14].' | Zhi Hai Peng Tong Hai Xing Guo Qiang Qiu Hua Mei Tang Shanghai No. 1 People’s Hospital, Shanghai 200080, China | 2001 | World Journal of Gastroenterology2001，7，1： | 15 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | 茶叶摄入与中国成年人高密度脂蛋白胆固醇浓度纵向变化的关系显示文摘茶叶摄入与高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)浓度的年龄相关变化之间的关系仍不清楚。该研究目的是探索茶摄入量与HDL-C浓度纵向变化之间的关系。研究人员通过调查问卷评估基线(2006年)的茶叶消费量,并在2006、2008、2010和2012年测量了未患有心血管病或癌症. | 刘莉 叶鹏 Huang S Li J Wu Y Ranjbar S Xing A Zhao H Wang Y Shearer GC Bao L Lichtenstein AH Wu S Gao X | 2018 | 中华高血压杂志2018，26，8： | 5 |
| 4 | Pathways of N 2 O emission from rice paddy soil显示文摘 | X Yan S Shi L Du G Xing | 2000 | Soil Biology and Biochemistry2000，，3： | 2 |
| 5 | “Trends” and variations of global oceanic evaporation data sets from remote sensing显示文摘The variability in global oceanic evaporation data sets was examined for the period 1988-2000.These data sets are satellite estimates based on bulk aerodynamic formulations and include the NASA/Goddard Space Flight Center Satellite-based Surface Turbulent Flux version 2(GSSTF2),the Japanese-ocean flux using remote sensing observations(J-OFURO),and the Hamburg Ocean-Atmosphere Parameters and Fluxes from Satellite version 2(HOAPS2).The National Center for Environmental Prediction(NCEP)reanalysis is also included for comparison.An increase in global average surface latent heat flux(SLHF)can be observed in all the data sets.Empirical mode decomposition(EMD)shows long-term increases that started around 1990 for all remote sensing data sets.The effect of Mt.Pinatubo eruption in 1991 is clearly evident in HOAPS2 but is independent of the long-term increase.Linear regression analyses show increases of 9.4%,13.0%,7.3%,and 3.9% for GSSTF2,J-OFURO,HOAPS2 and NCEP,for the periods of the data sets.Empirical orthogonal function(EOF)analyses show that the pattern of the first EOF of all data sets is consistent with a decadal variation associated with the enhancement of the tropical Hadley circulation,which is supported by other satellite observations.The second EOF of all four data sets is an ENSO mode,and the correlations between their time series and an SOI are 0.74,0.71,0.59,and 0.61 for GSSTF2,J-OFURO,HOAPS2,and NCEP in that order.When the Hadley modes are removed from the remote sensing data,the residue global increases are reduced to 2.2%,7.3%,and <1% for GSSTF2,J-OFURO and HOAPS,respectively.If the ENSO mode is used as a calibration standard for the data sets,the Hadley mode is at least comparable to,if not larger than,the ENSO mode during our study period. | CHIU Long S CHOKNGAMWONG R XING Yukun YANG Ruixin SHIE Chung-Lin | 2008 | Acta Oceanologica Sinica2008，27，3： | 2 |
| 6 | Effect of physical forms of soil organic matter on phenanthrene sorption 显示文摘 | Pan B Xing B Tao S | 2007 | Chemosphere2007，68，： | 1 |
| 7 | Phenanthrene sorption to sequentially extracted soil humic acids and humans显示文摘 | Kang S H Xing B S | 2005 | Environ Sci Technol2005，39，： | 1 |
| 8 | Extensive neurite out-growth and active synapse formation on self-assembling peptide scaffolds 显示文摘 | Todd C H Sonsoles L Xing S | 2000 | PNAS2000，97，12： | 1 |
| 9 | Time-frequency imaging algorithm for high speed spinning targets in two dis- mensions 显示文摘 | Li J Qiu C W Xing M D Bao Z Yeo T S | 2010 | lET2010，4，6： | 1 |
| 10 | 1-3-n-butylphth- alide improves cognitive impairment induced by intracerebroventricular infusion of amy- loid-beta peptide in rats 显示文摘 | Peng Y Xing C Xu S | 2009 | Eur J Pharmacol2009，621，13： | 1 |
| 11 | A miniature integrated device for automated multistep genetic assays显示文摘 | ANDERSON R C XING S | 2000 | Nucleic Acids Res2000，28，12： | 1 |
| 12 | Analysis of α and β-tubulin genes of Bombyx mori using an EST database显示文摘 | Hideki K Kimihiko S Guo Xing Q | 2003 | Insect Biochemy Mol Biol2003，33，： | 1 |
| 13 | Dynamic spectrum access in open spectrum wireless networks显示文摘 | XING Y CHANDDRAMOULI R MANGOLD S | 2006 | IEEE J Sel Areas Commun2006，24，3： | 1 |
| 14 | Microelectronic cell sensor assayfor detection of cytotoxicity and prediction of acute toxicity 显示文摘 | Xing JZ Zhu L Gabos S | 2006 | Toxicol in Vitro2006，20，6： | 1 |
| 15 | Overexpression of activated nuclear factor-k B in aorta of patients with coro- nary atherosclerosis 显示文摘 | Zhang W Xing S S Sun X L | 2009 | Clin Cardiol2009，32，12： | 1 |
| 16 | Porcine TEF1 and RTEFI: Mo- lecular characterization and association analyses with growth traitsr显示文摘 | Xu X Xing S Du Z Q | 2008 | Comparative Biochemistry and Physiology Part B: Bi-ochemistry and Molecular Biology2008，150，4： | 1 |
| 17 | 查看详情显示文摘 | Li Y F Xing Z Z Luo S | | 0，，： | 1 |
| 18 | Results of thousand-grain weight in wheat varietes显示文摘 | XING J TIAN LZ XU S | 2011 | Bulletin of Anhui Agronomy2011，17，98： | 1 |
| 19 | A strip-map SARcoherent jammer structure utilizing periodic modulationtechnology 显示文摘 | Liu Q F Xing S X Wang X S | 2011 | Progress in Electromagnetics Research B PIER-B2011，28，： | 1 |
| 20 | Durable hydrophobic cellulose fabric prepared with polycarboxylic acid catalyzed silica sol 显示文摘 | Huang W Yang S Xing Y | 2010 | Industrial & Engineering Chemistry Research2010，49，19： | 1 |
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