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| 1 | Sedimentary Facies of Marine Shale Gas Formations in Southern China: The Lower Silurian Longmaxi Formation in the Southern Sichuan Basin显示文摘Sedimentary facies is an important factor influencing shale gas accumulation. It not only controlls hydrocarbon generation, but also affects reservoir characteristics and distribution. This paper discusses the Lower Silurian Longmaxi Formation in the south of the Sichuan Basin. Outcrop, core, drilling and logging data identify the sedimentary facies of the formation as continental shelf facies, which is divided into two subfacies: an inner shelf and an outer shelf subfacies. These two subfacies can be further divided into seven microfacies: muddy silty shallow shelf, calcareous silty shallow shelf, muddy limy shallow shelf, storm flow, muddy deep shelf, silty muddy deep shelf and contour current microfacies. Vertical and horizontal distribution of microfacies establishes a sedimentation model of the continental shelf facies. Combined with analization or calculation of geochemical, mineralogical, physical and gas-bearing properties of samples, sedimentary microfacies is evaluated using nine parameters: total organic carbon content, effective shale continuous thickness, vitrinite reflectance, kerogen type, mineral components, porosity, permeability, water saturation and gas content. The evaluation revealed that the most favorable facies for shale gas exploration and development are the muddy deep shelf and part of the silty muddy deep shelf microfacies, with TOC more than 2%, siliceous component over 50%, clay less than 30%, porosity more than 3%, water saturation lower than 40%, gas content greater than 2 m3/t. These results provide a theoretical basis for deciston-making on the most promising areas for shale gas exploration in the Sichuan Basin and for marine shale gas exploration and development in South China. | Yizhen Li Xingzhi Wang Bin Wu Guoqin Li Dule Wang | 2016 | Journal of Earth Science2016，27，5： | 11 |
| 2 | Origin and evolution of waters in the Hancheng coal seams,the Ordos Basin,as revealed from water chemistry and isotope(H,O,^(129)I) analyses显示文摘The coal seams in the Permian Taiyuan Formation and the Carboniferous Shanxi Formation are the primary reservoirs for the coalbed methane(CBM)in the Hancheng region in the Ordos Basin.In this paper,the origin and evolution of waters associated with CBM production were studied on the basis of water chemistry and isotopes including the chloride and iodine compositions,oxygen and hydrogen stable isotopes,and radioactive isotope ratio of129I/127I.The ratio of129I/127I of water was determined by accelerator mass spectrometry(AMS).The result shows that the formation water is of NaHCO3and NaCl types with the total dissolved solids(TDS)varying from 1532.29 mg/L to 7061.12 mg/L.The values of129I and I/Cl ratio indicate that the formation waters were diluted by meteoric water.The129I/127I ratios range from 6.6×10 13to 1459.5×10 13.The129I/127I ratios for most of the samples are between the129I/127I initial value and that of recent anthropogenic water.This age of the formation water samples,obtained through the129I decay curve method,ranges from 0 Ma to 18.5 Ma,suggesting that the waters from the Taiyuan Formation and the Shanxi Formation are very young.Two different origins of water are identified in the Hancheng region.One group is dominated by pre-anthropogenic meteoric water,and is characterized by129I/127I ratios lower than the initial value of 15×10 13andδD,δ18O values of waters below the Global Meteoric Water Line.The other group is characterized by129I/127I ratios in excess of 15×10 13,which has undergone variable degrees of dilution by recent anthropogenic water. | MA XingZhi SONG Yan LIU ShaoBo JIANG Lin HONG Feng | 2013 | Science China Earth Sciences2013，56，11： | 8 |
| 3 | DNA 双海滨裂缝修理: 小径选择的一个故事显示文摘脱氧核糖核酸酸 ? 双海滨裂缝(DSB ) 是也必须通过相应再结合(HR ) 被修理的细胞毒素的损害或非相应加入结束(NHEJ ) 小径。DSB 修理为染色体正直是批评的,细胞的动态平衡 andalso 为放射疗法和化疗的多数组成生物基础。在建筑群还不完全理解的 HR 和 NHEJis 之间的选择将必要的过程更多的未来努力。此处,我们考察我们的当前的 understandingsabout 选择怎么在在 p53 有约束力的蛋白质之间的反对平衡上被做 1 和乳癌 1 ? 在 contextof 房间周期阶段,下游的效果,和不同 chromosomal, histone 标记。关于 DSB 的更机械学的卓见修理的研究愿望 surelybring 的这些令人激动的区域并且在临床的背景被利用。 | Jing Li Xingzhi Xu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，7： | 7 |
| 4 | Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway显示文摘The stiffness of the extracellular matrix(ECM)plays an important role in regulating the cellular programming.However,the mechanical characteristics of ECM affecting cell differentiation are still under investigated.Herein,we aimed to study the effect of ECM substrate stiffness on macrophage polarization.We prepared polyacrylamide hydrogels with different substrate stiffness,respectively.After the hydrogels were confirmed to have a good biocompatibility,the bone marrow-derived macrophages(BMMs)from mice were incubated on the hydrogels.With simulated by the low substrate stiffness,BMMs displayed an enhanced expression of CD86 on the cell surface and production of reactive oxygen species(ROS)in cells,and secreted more IL-1βand TNF-αin the supernatant.On the contrary,stressed by the medium stiffness,BMMs expressed more CD206,produced less ROS,and secreted more IL-4 and TGF-β.In vivo study by delivered the hydrogels subcutaneously in mice,more CD68+CD86+cells around the hydrogels with the low substrate stiffness were observed while more CD68+CD206+cells near by the middle stiffness hydrogels.In addition,the expressions of NIK,phosphorylated p65(pi-p65)and phosphorylated IκB(pi-IκB)were significantly increased after stimulation with low stiffness in BMMs.Taken together,these findings demonstrated that substrate stiffness could affect macrophages polarization.Low substrate stiffness promoted BMMs to shift to classically activated macrophages(M1)and the middle one to alternatively activated macrophages(M2),through modulating ROS-initiated NF-κB pathway.Therefore,we anticipated ECM-based substrate stiffness with immune modulation would be under consideration in the clinical applications if necessary. | Mimi Chen Yu Zhang Pinghui Zhou Xingzhi Liu Huan Zhao Xichao Zhou Qiaoli Gu Bin Li Xuesong Zhu Qin Shi | 2020 | Bioactive Materials2020，5，4： | 7 |
| 5 | Dolomitization by Penesaline Sea Water in Early Cambrian Longwangmiao Formation, Central Sichuan Basin, China显示文摘The Lower Cambrian Longwangmiao Formation shoal dolostone reservoir in Sichuan Basin is currently an exploration and research highlight in China. Reservoir rocks mainly consist of crystalline dolomite with residual grain texture, and dolarenite of which the arene is mainly composed of muddy to micritic dolomite with some crystalline grain directionally aligned. The trace element indicates that the dolomites of Longwangmiao Formation may be related to the high salinity of sea water. The oxygen isotope values of crystalline dolomite and dolarenite are both similar to that of the Early Cambrian marine dolomites, and the carbon isotope values of every kind of dolomites are completely overlapped with that of the seawater in Early Cambrian, indicating the dolomitization fluid is originated from the Early Cambrian sea water. The restricted marine biological communities and a small amount of gypsum pseudonodule seen in muddy to micritic dolomite indicate that the sea water in Early Cambrian was restricted and evaporated. However, the general lack of massive evaporite mineral and gypsum karst breccia indicates that the salinity of sea water during dolomitization was lower than the value of gypsum's precipitation. The Longwangmiao Formation consists of several high-frequency sedimentary cycles, indicating frequent sea level changes. This study indicates that massive dolomitization may also occur in underwater palaeohigh in carbonate platform through the reflux of penesaline sea water driven by a combination of high-and low-frequency sea-level changes. This kind of dolomitization can explain the generation of massive dolomites in the absence of evaporite precipitation, and further indicates that replacement dolomites can be produced by sea water with a wide range of salinity(normal, penesaline to hypersaline). | Xuefei Yang Hao Tang Xingzhi Wang Yaping Wang Yueming Yang | 2017 | Journal of Earth Science2017，28，2： | 6 |
| 6 | Influence of the Chuxiong Yao'an Earthquake on the Mineralization of Hot Springs in the Tengchong Geothermal Area,Southwestern China显示文摘Tengchong 地热的区域,有经常的地震的一个活跃构造区域,位于西南的中国的云南省。这个区域包含丰富的活跃温泉,它经常显示高金属集中和明显的矿化作用现象。在 19:19 在 2009 年 7 月 9 日,地震发生在 Yao'an, Chuxiong,云南省,它是到 Tengchong 地热的区域的东北的 300 km。我们从 7 月 4 日在 Tengchong 区域在温泉取样了水到 2009 年 7 月 9 日并且从 7 月 10 日到 2009 年 7 月 15 日在地震前后学习元素的集中的变化并且在温泉的矿化作用上讨论地震的影响。大多数踪迹元素的集中稍微增加了,但是 REE (稀土元素元素) 的集中在一个趋势 NS 差错附近在温泉在地震以后在 50% 减少了。元素的集中在 Longtan 和 Suanshuigou 仍然保持未改变,它与一个不活跃的坑有关。在表面、小规模的差错控制的另外的弹簧的元素的集中在地震以后减少了。地震能刺激深差错和岩浆房间的活动,作为为沿着趋势 NS 深差错的温泉的金属集中的增加负责;而它能减少可渗透的岩石的孔,在与表面的差错有关的温泉导致忍受矿石的液体和相应矿化作用的流动的衰落。 | DENG Jun XIAO Changhao WANG Qingfei ZHOU Xingzhi YANG Liqiang ZHANG Jing ZHAO Yan | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 6 |
| 7 | Evaluation of dolomite reservoirs in the Longwangmiao Formation,Lower Cambrian in Northern Sichuan basin,China显示文摘With the extended petroleum exploration of the carbonate reservoir in the Longwangmiao Formation,Lower Cambrian in Sichuan basin,looking for a new favorable exploration area is the primary task in current exploration.This paper focusing on the dolomite reservoir in the Longwangmiao Formation in the Northern Sichuan basin,will evaluate the reservoir conditions,including reservoir lithology,reservoir spaces,physical properties and other basic characteristics.Combined with sedimentary environment study and diagenesis analysis,the genetic mechanism of Longwangmiao reservoir in study area will be discussed.It indicates that the reservoir rocks of Longwangmiao Formation in the study area are composed of dolarenite and crystalline dolomite,and the main reservoir spaces are intergranular dissolved pores,intragranular dissolved pores and intercrystalline dissolved pores.However,most of dissolved pores have been filled with bitumen,which lead to the reservoir properties very poor,both the porosity and permeability are worse than that of central Sichuan basin,so the reservoir in the Longwangmiao Formation in the Northern Sichuan basin is low-porosity and low-permeability reservoir.During the Early Cambrian Longwangmiao period,the study was near the old-land,and the energy of sea water was not enough to deposit many grain shoals,which cause the sediments are small with lots of quartz and muds.Moreover,because lacking of large scale karstification in the late diagenesis,there isn't much dissolved pores and vugs develop in the Longwangmiao Formation.Some Intergranular dissolved pores and intercrystalline dissolved pores formed by the early atmosphere water dissolved exist as some reservoir spaces,but most of them have been filled with bitumen,which was residual when the ancient oil reservoir transformed.Above factors cause the Longwangmiao Formation in the Northern Sichuan basin become not a very favorable reservoir in Sichuan basin. | Xuefei Yang Yaping Wang Xingzhi Wang Deming Zeng Longbo Xu Zisang Huang | 2017 | Petroleum2017，3，4： | 3 |
| 8 | Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair显示文摘连接器 histone H1 在 DNA 损坏反应是更高的顺序染色质结构,而是它的参与的一个主人管理者,修理是不清楚的。这里,我们报导连接器 histone H1.2 是混乱毛细管扩张的一个必要管理者变异(ATM ) 激活。我们证明 H1.2 通过和 ATM 热重复领域和 MRE11-RAD50-NBS1 (MRN ) 的抑制的直接相互作用保护染色质免受异常 ATM 激活的伤害复杂依赖者的 ATM 招募。在 DNA 损坏之上, H1.2 通过它的 C 终点和进一步的 proteasomal 降级的 poly-ADP-ribosylation (PARylation ) 经历快速的 PARP1 依赖的染色质分离。由 PARylation 死了的变化妥协 ATM 激活和 DNA 损坏修理的 PARP1 弄空或 H1.2 的 H1.2 排水量的抑制,因此导致损害了房间幸存。一起拿,我们的调查结果建议连接器 histone H1.2 作为一个生理的障碍工作因为指向染色质的 ATM,和调停 PARylation 的活跃 H1.2 周转为柔韧的 ATM 激活和 DNA 损坏修理被要求。 | Zhiming Li Yinglu Li Ming Tang Bin Peng Xiaopeng Lu Qiaoyan Yang Qian Zhu Tianyun Hou Meiting Li Chaohua Liu Lina Wang Xingzhi Xu Ying Zhao Haiying Wang Yang Yang Wei-Guo Zhu | 2018 | Cell Research2018，28，7： | 3 |
| 9 | Cytokinesis and cancer:Polo loves ROCK'n' Rho(A)显示文摘Cytokinesis is the last step of the M (mitosis) phase, yet it is crucial for the faithful division of one cell into two. Cytokinesis failure is often associated with cancer. Cytokinesis can be morphologically divided into four steps: cleavage furrow initiation, cleavage furrow ingression, midbody formation and abscission. Molecular studies have revealed that RhoA as well as its regulators and effectors are important players to ensure a successful cytokinesis. At the same time, Polo-like kinase 1 (Plk1) is an important kinase that can target many substrates and carry out different functions during mitosis, including cytokinesis. Recent studies are beginning to unveil a closer tie between Plk1 and RhoA networks. More specifically, Plk1 phosphorylates the centralspindlin complex Cyk4 and MKLP1/CHO1, thus recruiting RhoA guanine nucleotide-exchange factor (GEF) Ect2 through its phosphopeptide-binding BRCT domains. Ect2 itself can be phosphorylated by Plk1 in vitro. Plk1 can also phosphorylate another GEF MyoGEF to regulate RhoA activity. Once activated, RhoA-GTP will activate downstream effectors, including ROCK1 and ROCK2. ROCK2 is among the proteins that associate with Plk1 Polo-binding domain (PBD) in a large proteomic screen, and Plk1 can phosphorylate ROCK2 in vitro. We review current understandings of the interplay between Plk1, RhoA proteins and other proteins (e.g., NudC, MKLP2, PRC1, CEP55) involved in cytokinesis, with particular emphasis of its clinical implications in cancer. | Jing Li Jue Wang Hong Jiao Ji Liao Xingzhi Xu | 2010 | Journal of Genetics and Genomics2010，37，3： | 3 |
| 10 | Serine/threonine protein phosphatases in DNA damage response显示文摘DNA damage response (DDR) is among the most important of the mechanisms that maintain genome stability which, when destabilized, predisposes organs to cancer. Reversible phosphorylation mediated by protein kinases and protein phosphatases regulates most, if not all, cellular activities, including DDR. Protein kinase inhibitors have become the main focus of targeted therapy and anticancer drug development. However, our limited knowledge of protein phosphatase function is compromising our capacity to develop therapeutic agents against phosphatases. In this review, we summarize the roles of serine/threonine protein phosphatases involved in DDR and propose that in situ dephosphorylation of phosphoproteins by protein phosphatases, instead of proteasome-mediated degradation of phosphoproteins, is mainly employed by cells. | LIU Bo XU XingZhi | 2011 | Chinese Science Bulletin2011，56，30： | 3 |
| 11 | A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle显示文摘Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles.However,ordinary antimicrobial treatments usually failed to combat multiple waves of infections during arthroplasty and prosthesis revisions etc.As these incidents could easily introduce new microbial pathogens in/onto the implants.Herein,we demonstrate that an antimicrobial trilogy strategy incorporating a sophisticated multilayered coating system leveraging multiple ion exchange mechanisms and fine nanotopography tuning,could effectively eradicate bacterial infection at various stages of implantation.Early stage bacteriostatic effect was realized via nano-topological structure of top mineral coating.Antibacterial effect at intermediate stage was mediated by sustained release of zinc ions from doped CaP coating.Strong antibacterial potency was validated at 4 weeks post implantation via an implanted model in vivo.Finally,the underlying zinc titanate fiber network enabled a long-term contact and release effect of residual zinc,which maintained a strong antibacterial ability against both Staphylococcus aureus and Escherichia coli even after the removal of top layer coating.Moreover,sustained release of Sr2+and Zn2+during CaP coating degradation substantially promoted implant osseointegration even under an infectious environment by showing more peri-implant new bone formation and substantially improved bone-implant bonding strength. | Yikai Wang Wangsiyuan Teng Zengjie Zhang Xingzhi Zhou Yuxiao Ye Peng Lin An Liu Yan Wu Binghao Li Chongda Zhang Xianyan Yang Weixu Li Xiaohua Yu Zhongru Gou Zhaoming Ye | 2021 | Bioactive Materials2021，6，7： | 3 |
| 12 | Nampt is involved in DNA double-strand break repair显示文摘DNA double-strand break(DSB) is the most severe form of DNA damage,which is repaired mainly through high-fidelity homologous recombination(HR) or error-prone non-homologous end joining(NHEJ).Defects in the DNA damage response lead to genomic instability and ultimately predispose organs to cancer.Nicotinamide phosphoribosyltransferase(Nampt),which is involved in nicotinamide adenine dinucleotide metabolism,is overexpressed in a variety of tumors.In this report,we found that Nampt physically associated with CtIP and DNA-PKcs/Ku80,which are key factors in HR and NHEJ,respectively.Depletion of Nampt by small interfering RNA(siRNA) led to defective NHEJ-mediated DSB repair and enhanced HR-mediated repair.Furthermore,the inhibition of Nampt expression promoted proliferation of cancer cells and normal human fibroblasts and decreased β-galactosidase staining,indicating a delay in the onset of cellular senescence in normal human fibroblasts.Taken together,our results suggest that Nampt is a suppressor of HR-mediated DSB repair and an enhancer of NHEJ-mediated DSB repair,contributing to the acceleration of cellular senescence. | Bingtao Zhu Xiaoli Deng Yifan Sun Lin Bai Zhikai Xiahou Yusheng Cong Xingzhi Xu | 2012 | Chinese Journal of Cancer2012，31，8： | 2 |
| 13 | UFMylation:A Unique & Fashionable Modification for Life显示文摘Ubiquitin-fold modifier 1(UFM1) is one of the newly-identified ubiquitin-like proteins.Similar to ubiquitin,UFM1 is conjugated to its target proteins by a three-step enzymatic reaction.The UFM1-activating enzyme,ubiquitin-like modifier-activating enzyme 5(UBA5),serves as the E1 to activate UFM1;UFM1-conjugating enzyme 1(UFC1) acts as the E2 to transfer the activated UFM1 to the active site of the E2;and the UFM1-specific ligase 1(UFL1) acts as the E3 to recognize its substrate,transfer,and ligate the UFM1 from E2 to the substrate.This process is called ufmylation.UFM1 chains can be cleaved from its target proteins by UFM1-specific proteases(Uf SPs),suggesting that the ufmylation modification is reversible.UFM1 cascade is conserved among nearly all of the eukaryotic organisms,but not in yeast,and associated with several cellular activities including the endoplasmic reticulum stress response and hematopoiesis.Furthermore,the UFM1 cascade is closely related to a series of human diseases.In this review,we summarize the molecular details of this reversible modification process,the recent progress of its functional studies,as well as its implication in tumorigenesis and potential therapeutic targets for cancer. | Ying Wei Xingzhi Xu | 2016 | Genomics, Proteomics & Bioinformatics2016，14，3： | 2 |
| 14 | Implication of Sedimentary Facies and Shale Gas Accumulation in the Lower Silurian Longmaxi Formation,Eastern Sichuan Basin,China显示文摘1 Introduction The Lower Silurian Longmaxi Formation is the most prolific shale gas producing unit in the Sichuan Basin by the large thickness and rich resources,which also indicate a bright exploration prospect for the unconventional shale gas.Eastern Sichuan region,the relatively active high and steep structural belt between the stable massifs in Sichuan basin(Fig.1),is influenced by the factors of deepburied,intense tectonic reworking and fault development.Previous research | FENG Mingyou ZENG Zhen WANG Xingzhi ZHANG Fan LI Yizhen LI Ke | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 2 |
| 15 | Protein phosphatase PP4 is overexpressed in human breast and lung tumors显示文摘 | Bo Wang Ailian Zhao Lingling Sun Xueyan Zhong Jianing Zhong Haibo Wang Minhua Cai Jing Li Yi Xu Ji Liao Jianli Sang Dipanj an Chowdhury Gerd P Pfeifer Yun Yen Xingzhi Xu | 2008 | Cell Research2008，18，9： | 2 |
| 16 | Effect of Substrate Component on the Growth and Survival of Juvenile Sunray Surf Clam(Mactra chinensis Philippi)显示文摘Substrate is a critical environmental factor affecting the activity of bivalves. To examine the effect of the substrate component on the growth and survival of juvenile sunray surf clam(Mactra chinensis Philippi), a series of short-term experiments were conducted using a variety of substrates with different ratios of sand to mud. The experimental group cultured without substrate showed poor survival, with all juveniles died after day 20. The juveniles cultured in mud without sand showed a lower survival rate(25.54% ± 0.40% on day 45) than those in other groups. The juveniles cultured in sand without mud, or the mixtures of sand and mud with a ratio of 1:1 and 2:1, respectively, exhibited modest survival at day 45. Maximal weight gain rate(WGR), shell length growth rate(LGR), and specific growth rate(SGR) were observed when the sand concentration was 61.97%, 77.69%, and 64.64%, respectively. As the fast growth and high survival were observed when the sand to mud ratio was 1:1(50% sand) and 2:1(67% sand), a sand concentration of more than 50% is optimal. The optimal concentration of sand in the substrate for rearing juvenile sunray surf clams was 67% which resulted in the fastest growth and highest survival. These results can be used to developing a nursery/farming technique of improving the yield of sunray surf clams. | ZHANG Xuekai LI Zhuang HUO Zhongming YAN Xiwu YANG Feng LIU Hui ZHANG Xingzhi | 2016 | Journal of Ocean University of China2016，15，4： | 2 |
| 17 | Reversing the imbalance in bone homeostasis via sustained release of SIRT-1 agonist to promote bone healing under osteoporotic condition显示文摘The imbalance of bone homeostasis is the root cause of osteoporosis.However current therapeutic approaches mainly focus on either anabolic or catabolic pathways,which often fail to turn the imbalanced bone metabolism around.Herein we reported that a SIRT-1 agonist mediated molecular therapeutic strategy to reverse the imbalance in bone homeostasis by simultaneously regulating osteogenesis and osteoclastogenesis via locally sustained release of SRT2104 from mineral coated acellular matrix microparticles.Immobilization of SRT2104 on mineral coating(MAM/SRT)harnessing their electrostatic interactions resulted in sustained release of SIRT-1 agonist for over 30 days.MAM/SRT not only enhanced osteogenic differentiation and mineralization,but also attenuated the formation and function of excessive osteoclasts via integrating multiple vital upstream signals(β-catenin,FoxOs,Runx2,NFATc1,etc.)in vitro.Osteoporosis animal model also validated that it accelerated osteoporotic bone healing and improved osseointegration of the surrounding bone.Overall,our work proposes a promising strategy to treat osteoporotic bone defects by reversing the imbalance in bone homeostasis using designated small molecule drug delivery systems. | Wei Zhang Xingzhi Zhou Weiduo Hou Erman Chen Chenyi Ye Mo Chen Qian Lu Xiaohua Yu Weixu Li | 2023 | Bioactive Materials2023，，1： | 2 |
| 18 | Digital twin-driven complexity management in intelligent manufacturing[version 1;peer review:2 approved]显示文摘Complexity management is one of the most crucial and challenging issues in manufacturing.As an emerging technology,digital twin provides an innovative approach to manage complexity in a more autonomous,analytical and comprehensive manner.This paper proposes an innovative framework of digital twin-driven complexity management in intelligent manufacturing.The framework will cover three sources of manufacturing complexity,including product design,production lines and supply chains.Digital twin provides three services to manage complexity:(1)real-time monitors and data collections;(2)identifications,diagnoses and predictions of manufacturing complexity;(3)fortification of human-machine interaction.A case study of airplane manufacturing is presented to illustrate the proposed framework. | Yuchen Wang Xingzhi Wang Fei Tao Ang Liu | 2021 | Digital Twin2021，1，1： | 2 |
| 19 | Interactions between the Design and Operation of Shale GasNetworks, Including C02 Sequestration显示文摘As the demand for energy continues to increase, shale gas, as an unconventional source of methane (CH4),shows great potential for commercialization. However, due to the ultra-low permeability of shale gas reser-voirs, special procedures such as horizontal drilling, hydraulic fracturing, periodic well shut-in, and carbondioxide (C02) injection may be required in order to boost gas production, maximize economic benefits, andensure safe and environmentally sound operation. Although intensive research is devoted to this emergingtechnology, many researchers have studied shale gas design and operational decisions only in isolation. Infact, these decisions are highly interactive and should be considered simultaneously. Therefore, the researchquestion addressed in this study includes interactions between design and operational decisions. In thispaper, we first establish a full-physics model for a shale gas reservoir. Next, we conduct a sensitivity analysisof important design and operational decisions such as well length, well arrangement, number of fractures,fracture distance, C02 injection rate, and shut-in scheduling in order to gain in-depth insights into the com-plex behavior of shale gas networks. The results suggest that the case with the highest shale gas productionmay not necessarily be the most profitable design; and that drilling, fracturing, and CO2 injection have greatimpacts on the economic viability of this technology. In particular, due to the high costs, enhanced gas re-covery (EGR) using CO2 does not appear to be commercially competitive, unless tax abatements or subsidiesare available for CO2 sequestration. It was also found that the interactions between design and operationaldecisions are significant and that these decisions should be optimized simultaneously. | Sharifzadeh Mahdi Xingzhi Wang Nilay Shah | 2017 | Engineering2017，3，2： | 1 |
| 20 | Tunable excitonic emission of monolayer WS2 for the optical detection of DNA nucleobases显示文摘 | Shun Feng Chunxiao Cong Namphung Peimyoo Yu Chen Jingzhi Shang Chenji Zou Bingchen Cao Lishu Wu Jing Zhang Mustafa Eginligil Xingzhi Wang Qihua Xiong Arundithi Ananthanarayanan Peng Chen Baile Zhang Ting Yu | 2018 | Nano Research2018，11，3： | 1 |
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