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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | The altered PD-1/PD-L1 pathway delivers the ‘one-two punch’ effects to promote the Treg/Th17 imbalance in pre-eclampsia显示文摘The programmed cell death-1(PD-1)/PD-ligand 1(PD-L1)pathway is critical for normal pregnancy by promoting regulatory T(Treg)cell development and inhibiting the Th17 response.However,the relationship between the PD-1/PD-L1 pathway and the Treg/Th17 imbalance in pre-eclampsia(PE)is an enigma.In this study,decreased PD-1 and PD-L1 expression and a Treg/Th17 imbalance were observed at the maternal-fetal interface in PE.The regulatory effects of the PD-1/PD-L1 pathway on the Treg and Th17 cell quantities were determined in vitro by targeting T-cell proliferation,differentiation and transdifferentiation.First,decreased PD-1 expression might contribute to a higher Th17 cell frequency by promoting proliferation in PE.Second,the percentages of Treg but not Th17 cells differentiated from peripheral naive CD4+T cells were increased by PD-L1 Fc administration.This effect was accompanied by decreased PI3K/AKT/m-TOR and increased PTEN mRNA expression and was completely reversed by PD-1 blockade.Finally,the percentage of IL-17-producing Treg cells increased and was positively associated with the Th17 cell frequency in PE.Increased RORγt and IL-17 but not Foxp3 and IL-10 mRNA expression by Treg cells was observed with PD-1 blockade.Similar findings occurred when Treg cells were exposed to IL-6/IL-23/IL-1βand were reversed by PD-L1 Fc.Taken together,our findings indicate that the PD-1/PD-L1 pathway contributes to the Treg/Th17 imbalance via‘one-two punch’approaches:(i)promoting Th17 cell proliferation,(ii)inhibiting Treg cell differentiation and(iii)enhancing Treg cell plasticity into Th17 cells in PE.The therapeutic value of PD-L1 Fc for PE treatment will be explored in the future. | Yonghong Zhang Zhaozhao Liu Mei Tian Xiaohui Hu Liling Wang Jinlu Ji Aihua Liao | 2018 | Cellular & Molecular Immunology2018，15，7： | 21 |
| 3 | Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNA (Ser(UCN)) genes in two Chinese families显示文摘 | Zhu Y Qian YP Tang XW Wang JD Yang L Liao ZS Li RH Ji JZ Li ZY Chen JF Choo DI Lu JX Guan MX | 2006 | 中国生物学文摘2006，20，4： | 16 |
| 4 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 5 | Research and application of enterprise resource planning system for foundry enterprises显示文摘PPDB issues-four aspects of current management issues of foundry enterprises are discussed in this paper,including Production Management,Process Control,Duration Monitoring and Business Intelligence Data Analysis.Also a whole Enterprise Resource Planning(ERP) solution for foundry enterprises is proposed.The solution contains many models,four of which are used to solve the PPDB issues.These are called SPDB models,which separately are the Single-piece management model(based on casting lifecycle),Process management model(based on task-driven technology),Duration monitoring model(based on surplus period),and Business intelligence data analysis model(based on data mining).An ERP system for foundry enterprises,named HZERP,was researched and developed,and applied to a sand casting company of single piece and small batch production.Qualitatively and quantitatively comparing the application effect before and after implementing the HZERP system,the result demonstrated that the foundry ERP system based on the SPDB models can help metal casting enterprises achieve the single-piece management,better regulate the production processes,improve production and delivery management,shorten the production cycle,reduce costs,and speed up the capital turnover to a large extent. | Zhou Jianxin Ji Xiaoyuan Liao Dunming Guan Bifeng Guan Bihong Pang Shengyong Tang Hongtao | 2013 | China Foundry2013，10，1： | 16 |
| 6 | Study of Dynamics of Floodwater Nitrogen and Regulation of Its Runoff Loss in Paddy Field-Based Two-Cropping Rice with Urea and Controlled Release Nitrogen Fertilizer Application显示文摘The article deals with the effects of urea and controlled release nitrogen fertilizer (CRNF) on dynamics of pH, electronic conductivity (EC), total nitrogen (TN), NH4+-N and NO3--N in floodwater, and the regulation of runoff TN loss from paddy field-based two-cropping rice in Dongting Lake, China, and probes the best fertilization management for controlling N loss. Studies were conducted through modeling alluvial sandy loamy paddy soil (ASP) and purple calcareous clayey paddy soil (PCP) using lysimeter, following the sequence of the soil profiles identified by investigating soil profile. After application of urea in paddy field-based two-cropping rice, TN and NH4+-N concentrations in floodwater reached peak on the 1st and the 3rd day, respectively, and then decreased rapidly over time; all the floodwater NO3--N concentrations were very low; the pH of floodwater gradually rose in case of early rice within 15 d (late rice within 3 d) after application of urea, and EC remained consistent with the dynamics of NH4+-N. The applied CRNF, especially 70% CRNF, led to significantly lower floodwater TN and NH4+ concentrations, pH, and EC values compared with urea within 15 d after application. The monitoring result for N loss due to natural rainfall runoff indicated that the amount of TN lost in runoff from paddy field- based two-cropping rice with urea application in Dongting Lake area was 7.47 kg ha-1, which accounted for 2.49% of urea- N applied, and that with CRNF and 70% CRNF application decreased 24.5 and 27.2% compared with urea application, respectively. The two runoff events, which occurred within 20 d after application, contributed significantly to TN loss from paddy field. TN loss due to the two runoffs in urea, CRNF, and 70% CRNF treatments accounted for 72, 70, and 58% of the total TN loss due to runoff over the whole rice growth season, respectively. And the TN loss in these two CRNF treatments due to the first run-off event at the 10th day after application to early rice decreased 44.9 and 44.2% compared with urea, respectively. In conclusion, the 15-d period after application of urea was the critical time during which N loss occurred due to high floodwater N concentrations. But CRNF decreased N concentrations greatly in floodwater and runoff water during this period. As a result, it obviously reduced TN loss in runoff over the whole rice growth season. | JI Xiong-hui ZHENG Sheng-xian LUYan-hong LIAO Yu-lin | 2007 | Agricultural Sciences in China2007，6，2： | 12 |
| 7 | Effects of Water-Collecting and -Retaining Techniques on Photosynthetic Rates, Yield, and Water Use Efficiency of Millet Grown in a Semiarid Region显示文摘Field experiments were conducted in 2003 and 2004 to study the effects of plastic ridges and furrow film mulching (plastic film on sowing, as well as plastic film on flat soil and hole sowing) and chemicals (a drought resistant agent and a water- retaining agent) on growth, photosynthetic rate, yield, and water use efficiency (WUE) of spring millet (Setaria italica L.). The experimental results showed that water-collecting and -retaining techniques can effectively increase soil moisture content, the leaf photosynthetic rate and crop growth. Due to increased soil moisture under the plastic-covered ridge and furrow water-collecting in July and August, dry matter and plant height had a increase at the booting stage (late growth advantage). However, the plastic-covered flat soil and hole sowing reduced soil evaporation during early growth, the increase of dry matter and plant height appeared at the seedling stage (early growth advantage). Plastic-covered ridge and furrow sowing supplemented with chemical reagents had significant positive effects on water collection and soil moisture retention. Improvement of soil moisture resulted into the increase of the photosynthetic rate, dry matter accumulation yield and WUE. The water-collecting and -retaining techniques can improve WUE and enhance crop yield. Correlation analysis demonstrated that the photosynthetic rate under the water-collecting and -retaining techniques was significantly associated with the soil moisture, but had no significant relationship with leaf chlorophyll content. Plastic- covered ridge and furrow sowing supplemented with chemical reagents increased the yield and WUE by 114% and 8.16 kg ha-1 mm-1, respectively, compared with the control; while without the chemical reagents the yield and WUE were 95% and 7.42 kg ha-1 mm-1 higher, respectively, than those of the control. | WEN Xiao-xia ZHANG De-qi LIAO Yun-cheng JIA Zhi-kuan JI Shu-qin | 2012 | Journal of Integrative Agriculture2012，11，7： | 10 |
| 8 | Profiling of microbial communities in a bioreactor for treating hydrocarbon-sulfide-containing wastewater显示文摘A technology of polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE)was used to profile the structure and dynamic changes of microbial communities in a bioreactor for treating hydrocarbon-sulfide-containing(HSC)wastewater.The results showed that the heterotrophic genus of Acinetobacter and the autotrophic genera of Thiobacillus and Thiomonas could survive well in all of three operating conditions.Some special genera were also observed with changes of micro-ecoenvironment in the rea... | Liao Bo Ji Guodong Cheng Liqiu | 2008 | Journal of Environmental Sciences2008，20，8： | 10 |
| 9 | Honokiol:a promising small molecular weight natural agent for the growth inhibition of oral squamous cell carcinoma cells显示文摘Honokiol (HNK) is a small organic molecule purified from magnolia species and has demonstrated anticancer activities in a variety of cancer cell lines; however, its effect on oral squamous cell carcinoma (OSCC) cells is unknown. We investigated the antitumor activities of HNK on OSCC cells in vitro for the first time. The inhibitory effects of HNK on the growth and proliferation of OSCC cells were demonstrated via in vitro 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and propidium iodide (PI) assays, and the apoptotic cells were investigated by the observation of morphological changes and detection of DNA fragmentation via PI, TdT-mediated dUTP-biotin nick end labeling (TUNEL), and DNA ladder assays, as well as flow cytometry assay. The results showed that HNK inhibited the growth and proliferation of OSCC cells in vitro in a time and dose-dependent manner. The inhibitory effect was associated with the cell apoptosis induced by HNK, evidenced by the morphological features of apoptotic cells, TUNEL-positive cells and a degradation of chromosomal DNA into small internucleosomal fragments. The study also demonstrated here that the inhibition or apoptosis mediated by 15 μg·mL-1 or 20 μg·mL-1 of HNK were more stronger compared with those of 20 μg·mL-1 5-fluorouracil (5-Fu, the control) applied to OSCC cells, when the ratio of OSCC cell numbers were measured between the treatment of different concentrations of HNK to the 5-Fu treatment for 48 h. HNK is a promising compound that can be potentially used as a novel treatment agent for human OSCC. | Xi-rui Chen Rui Lu Hong-xia Dan Ga Liao Min Zhou Xiao-yu Li Ning Ji | 2011 | International Journal of Oral Science2011，3，1： | 8 |
| 10 | Al matrix composites fabricated by solid-state cold spray deposition:A critical review显示文摘Cold spraying(CS),or cold gas dynamic spray(CGDS),is an emerging solid-state powder deposition process,allowing fast and mass production and restoration of metallic components.CS of metal matrix composites(MMCs)has attracted increasing attention from academia and industry over the last decades,especially in the area of Al matrix composites(AMCs),which have demonstrated a high potential for applications in aerospace,automotive,and electronics industries.This article aims to summarize the recent development of CS-processed AMCs in terms of composite powder preparation,deposition processing,microstructure evolution,mechanical and corrosion properties.Furthermore,this review also reports the relevant research progress with the focus on post-treatments of the AMCs for CS additive manufacturing applications including heat treatment,hot rolling,and friction stir processing.Finally,the challenges and perspectives on the fabrication of advanced AMCs by CS are addressed. | Xinliang Xie Shuo Yin Rija-nirina Raoelison Chaoyue Chen Christophe Verdy Wenya Li Gang ji Zhongming Ren Hanlin Liao | 2021 | Journal of Materials Science & Technology2021，，27： | 8 |
| 11 | Hematopoietic stem cell-derived exosomes promote hematopoietic differentiation of mouse embryonic stem cells in vitro via inhibiting the miR126/Notch1 pathway显示文摘导出房间的 exosomes (前) 能经由他们带了的 microRNAs (米尔) 调制目标房间区别。以前的研究证明了 miR126 高度在造血的干细胞(HSC ) 被表示并且经由 modulating 在造血作用起一个作用参予祖先房间命运决定的槽口小径。在这研究,我们调查了导出 HSC 的前(HSC 前) 是否能影响老鼠的区别胚胎的干细胞(转换字符) 进 HSC。我们准备了 HSC 前 反对 ,HSC 前 sc 和 HSC 前 从控制 HSC 和 HSC transfected 与的 miR126 爬控制或 miR126 分别地模仿。HSC 前被 ultracentrifugation 孤立并且分析了使用追踪分析的 nanoparticle。我们孵化了在一个 10-d 区别正式就职时期上与老鼠转换字符收集了前,在哪个 HSC 前和槽口小径使活跃之物期间(Jagged1, 100 ng/mL ) 被加到文化每 3 d。在在转换字符的 10-d 区别时期, miR126 的表示层次, SSEA1, CD117, Sca1, Notch1 和 Hes1 被估计以后。产生 HSC 被流动 cytometry 对 HSC 标记(CD117, CD34 和 Sca1 ) 用抗体验证。我们的结果揭示了那:(1 ) 有 miR126 的 transfection 在 HSC 前 miR126 。(2 )HSC 前合作文化支持了老鼠转换字符区别进 HSC,最突出的效果在 HSC 前 miR126 合作文化。(3 ) HSC 区别被减少的 SSEA1 表示验证并且增加了 CD117 和 Sca1 表示。(4 )HSC 前引起的所有效果被 Notch1 和 Hes1 表示的重要减小伴随,这样 Notch1/Hes1 小径的抑制,而由 Jagged1 的槽口的激活废除了 HSC 前 miR126 。在结论, HSC 前由禁止 miR126/Notch1 小径在 vitro 支持老鼠转换字符的造血的区别。 | Feng-ling LIAO Lin TAN Hua LIU Jin-ju WANG Xiao-tang MA Bin ZHAO Yanfang CHEN Ji BIHL Yi YANG Ri-ling CHEN | 2018 | Acta Pharmacologica Sinica2018，39，4： | 7 |
| 12 | Clinical deep remission and related factors in a large cohort of patients with rheumatoid arthritis显示文摘Background:Clinical remission is the treatment target in rheumatoid arthritis (RA).This study aimed to investigate clinical remission and related factors in a large cohort of patients with RA.Methods:This study composed of 342 patients with RA.Data were collected by face-to-face interview of 1049 patients with RA who visited the Department of Rheumatology of three teaching hospitals from September 2015 to May 2016.The patients with RA were clinically assessed by rheumatologists and a four-page questionnaire was completed on site.Subsequently,patients fulfilled remission criteria were further analyzed.The practicability of different definitions of remission of RA was rated by a panel of rheumatologists.Sustained intensive disease modifying anti-rheumatic drug (DMARD) treatment was defined as a combination treatment with two or more DMARDs for at least 6 months.Results:In this cohort of 342 patients with RA,the proportions of patients achieving remission were 38.0%,29.5%,24.9%,21.1%,19.0%,18.1%,and 17.0%,based on criteria of disease activity score in 28 joints (DAS28) using CRP (DAS28-CRP),DAS28 using ESR (DAS28-ESR),routine assessment of patient index data 3 (RAPID-3),Boolean,simplified disease activity index (SDAI),clinical disease activity index,and the newly described clinical deep remission (CliDR),respectively.Boolean and CliDR are the best in practicability scored by rheumatologists (7.5 and 8.0,respectively).Compared with the non-sustained intensive group,sustained intensive treatment with DMARDs yielded higher remission rates of 25.6%,23.8%,and 21.3% in patients with RA based on Boolean (χ^2=3.937,P=0.047),SDAI (χ^2=4.666,P=0.031),and CliDR criteria (χ^2=4.297,P=0.038).The most commonly prescribed conventional synthesized DMARDs (csDMARDs) in patients with RA was leflunomide,followed by methotrexate,and hydroxychloroquine.Compared with the non-remission group,patients achieving remission had a longer median duration of DMARDs (45.0 [22.8–72.3] months,Z=-2.295,P=0.022).Conclusions:The findings in this study indicated that clinical deep remission is achievable in patients with RA.Sustained intensive DMARD treatment is needed to achieve a better outcome in RA. | Jia-Jia Liu Ru Li Yu-Zhou Gan Rui-Jun Zhang Jing Li Yue-Ming Cai Jin-Xia Zhao Hua Liao Jing Xu Lian-Jie Shi Ji Li Sheng-Guang Li Xiao-Lin Sun Jing He Xu Liu Hua Ye Zhan-Guo Li | 2019 | Chinese Medical Journal2019，，9： | 7 |
| 13 | Novel Ruthenium Catalyst (K-Ru/C_(60/70)) for Ammonia Synthesis显示文摘A novel ammonia-synthesis catalyst. potassium-promoted ruthenium supported on fullerene (K-Ru/C60/70 ). was prepared and evaluated, It was found that K-Ru/C60/70 was the most active catalyst for ammonia synthesis at atmospheric pressure and 623 K compared with other support materials such as silica, activated carbon. zeolite, λ-Al2O3 and rare earth metal oxide. | Guang WEI Li Hua WANG Yi Ji LIN Jun YI Hong Bo CHEN Dai Wei LIAO (Department of Chemistry, State Key Lab of Physical Chemistry on Solid Surfaces.Institute of Physical Chemistry, Xiamen University. Xiamen 361003) | 1999 | Chinese Chemical Letters1999，10，5： | 7 |
| 14 | An automated pulmonary parenchyma segmentation method based on an improved region growing algorithm in PET-CT imaging显示文摘 | Juanjuan ZHAO Guohua JI Xiaohong HAN Yan QIANG Xiaolei LIAO | 2016 | Frontiers of Computer Science2016，10，1： | 6 |
| 15 | Estimating biological reference points for Largehead hairtail(Trichiurus lepturus) fishery in the Yellow Sea and Bohai Sea显示文摘It is important to find a reliable method to estimate maximum sustainable yield(MSY)or total allowable catch(TAC)for fishery management,especially when the data availability is limited which is a case in China.A recently developed method(CMSY)is a data-poor method,which requires only catch data,resilience and exploitation history at the first and final years of the catch data.CMSY was used in this study to estimate the biological reference points for Largehead hairtail(Trichiurus lepturus,Temminck and Schlegel)in the Yellow Sea and Bohai Sea,based on the fishery data from China Fishery Statistical Year Books during 1986 to 2012.Additionally,Bayesian state-space Schaefer surplus production model(BSM)and the classical surplus production models(Schaefer and Fox)performed by software CEDA and ASPIC,were also projected in this study to compare with the performance of CMSY.The estimated MSYs from all models are about 19.7×104–27.0×104 t,while CMSY and BSM yielded more reasonable population parameter estimates(the intrinsic population growth rate and the carrying capacity).The biological reference points of B/BMSY smaller than 1.0,while F/FMSY higher than 1.0 revealed an over-exploitation of the fishery,indicating that more conservative management strategies are required for Largehead hairtail fishery. | Yupeng Ji Qun Liu Baochao Liao Qingqing Zhang Ya’nan Han | 2019 | Acta Oceanologica Sinica2019，38，10： | 5 |
| 16 | Construction of Co_(2)NiO_(4)@MnCo_(2)O_(4.5)nanoparticles with multiple hetero-interfaces for enhanced electromagnetic wave absorption显示文摘Nanocomposites with heterogeneous structures and magneto-electric synergistic losses have broad prospects for improving electromagnetic wave(EMW)absorption performance.In this study,we synthesized Co_(2)NiO_(4)@MnCo_(2)O_(4.5)nanoparticles with abundant hetero-interfaces and multiple magnetoelectric loss mechanisms by a facile hydrothermal method.The excess 0.5 oxygen atoms in MnCo_(2)O_(4.5) produce more vacancies and contribute to the enhancement of electrical conductivity.Sequential nanoneedle clusters facilitate multiple reflections and absorption of EMW in the materials,which are accompanied by an abundance of heterogeneous interfaces to improve the dielectric loss.The Co_(2)NiO_(4)@MnCo_(2)O_(4.5)composites showed a minimum reflection loss(RLmin)of30.01 dB and a superior effective absorption bandwidth(EAB)of 6.12 GHz(11.88 GHze18 GHz)at a thickness of 2.00 mm.Computer Simulation Technology(CST)revealed that the obtained particles show very low radar crosssection(RCS)values and almost full coverage angles.The maximum reduction of RCS at vertical incidence reaches 19.98 dB m2.The Co_(2)NiO_(4)@MnCo_(2)O_(4.5)nanoparticles exhibit outstanding radar attenuation properties,which can effectively inhibit the reflection and scattering of EMW.Therefore,the prepared Co_(2)NiO_(4)@MnCo_(2)O_(4.5)absorbers have great application potential in the field of EMW absorption. | Yi Zhang Shujuan Tan Zhuoting Zhou Xiaomeng Guan Yu Liao Chen Li Guangbin Ji | 2023 | Particuology2023，，10： | 5 |
| 17 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 18 | Leukotriene D4 induces amyloid-β generation via CysLT1R-mediated NF-κB pathways in primary neurons显示文摘 | Xiaoyun Wang SusuTang Yanlong Yongqi Li Mingxing Liao Mei Hu Hui Ji Hao Hong | 2013 | 中国药理通讯2013，30，2： | 4 |
| 19 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 20 | Cokriging of Soil Cation Exchange Capacity Using the First Principal Component Derived from Soil Physico-Chemical Properties显示文摘As soil cation exchange capacity (CEC) is a vital indicator of soil quality and pollutant sequestration capacity,a study was conducted to evaluate cokriging of CEC with the principal components derived from soil physico-chemical properties.In Qingdao,China,107 soil samples were collected.Soil CEC was estimated by using 86 soil samples for prediction and 21 soil samples for test.The first two principal components (PC1 and PC2) together explained 60.2% of the total variance of soil physico-chemical properties.The PC1 was highly correlated with CEC (r=0.76,P<0.01),whereas there was no significant correlation between CEC and PC2 (r=0.03).The PC1 was then used as an auxiliary variable for the prediction of soil CEC.Mean error (ME) and root mean square error (RMSE) of kriging for the test dataset were-1.76 and 3.67 cmolc kg-1,and ME and RMSE of cokriging for the test dataset were-1.47 and 2.95 cmolc kg-1,respectively.The cross-validation R2 for the prediction dataset was 0.24 for kriging and 0.39 for cokriging.The results show that cokriging with PC1 is more reliable than kriging for spatial interpolation.In addition,principal components have the highest potential for cokriging predictions when the principal components have good correlations with the primary variables. | LIAO Kai-hua XU Shao-hui WU Ji-chun JI Shu-hua LIN Qing | 2011 | Agricultural Sciences in China2011，10，8： | 4 |
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