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| 1 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 2 | Whole-genome resequencing of Osmanthus fragrans provides insights into flower color evolution显示文摘Osmanthus fragrans is a well-known ornamental plant that has been domesticated in China for 2500 years.More than 160 cultivars have been found during this long period of domestication,and they have subsequently been divided into four cultivar groups,including the Yingui,Jingui,Dangui,and Sijigui groups.These groups provide a set of materials to study genetic evolution and variability.Here,we constructed a reference genome of O.fragrans‘Liuyejingui’in the Jingui group and investigated its floral color traits and domestication history by resequencing a total of 122 samples,including 119 O.fragrans accessions and three other Osmanthus species,at an average sequencing depth of 15×.The population structure analysis showed that these 119 accessions formed an apparent regional cluster.The results of linkage disequilibrium(LD)decay analysis suggested that varieties with orange/red flower color in the Dangui group had undergone more artificial directional selection;these varieties had the highest LD values among the four groups,followed by the Sijigui,Jingui,and Yingui groups.Through a genome-wide association study,we further identified significant quantitative trait loci and genomic regions containing several genes,such as ethylene-responsive transcription factor 2 and Arabidopsis pseudoresponse regulator 2,that are positively associated with petal color.Moreover,we found a frameshift mutation with a 34-bp deletion in the first coding region of the carotenoid cleavage dioxygenase 4 gene.This frameshift mutation existed in at least one site on both alleles in all varieties of the Dangui group.The results from this study shed light on the genetic basis of domestication in woody plants,such as O.fragrans. | Hongguo Chen Xiangling Zeng Jie Yang Xuan Cai Yumin Shi Riru Zheng Zhenqi Wang Junyi Liu Xinxin Yi Siwei Xiao Qiang Fu Jingjing Zou Caiyun Wang | 2021 | Horticulture Research2021，8，1： | 5 |
| 3 | Inactivation of LARS2, located at the commonly deleted region 3p21.3, by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma显示文摘包括 3p21.3 区域,染色体 3p 的突变而产生之遗传的损失在 95100% 主要的鼻咽的癌(NPC ) 被发现活体检视,建议这个区域应该与 NPC 开发有关仔细怀有一些肿瘤 suppressor 基因(TSG ) 。在 3p21.3 定位的几 TSG 例如 RASSF1A, LTF 和 BLU,被表明了涉及 NPC 开发。LARS2 (leucyl-tRNA 合成酶 2, mitochondrial ) 另一基因位于染色体在 3p21.3 的 3 普通消除 region-1 (C3CER1 ) 。在这研究,我们在 NPC 集中了于 epigenetic 和 LARS2 的基因改变。LARS2 的 mRNA 表示被半量的反向的抄写聚合酶链反应(RTPCR ) 和即时 RTPCR 在 36 NPC 和 8 长期的鼻咽炎(NP ) 纸巾检测。随后, LARS2 的变化,突变而产生之遗传的损失,和 methylation 地位被聚合酶链 reaction-single-strand 符合构造多型性(PCR-SSCP ) 分析,同型结合的删除(HD ) 分析和 methylation 特定的聚合酶在主要 NPC 纸巾锁住反应。LARS2 的表示或下面规定都没在 78% 主要 NPC 纸巾被观察。没有变化,由定序的 PCR-SSCP 和 DNA 估计了,在倡导者区域和 exon 被发现在 NPC 纸巾的 1 LARS2,而 HD 在 LARS2 地点在 28% NPC 标本被检测。另外, LARS2 的 hypermethylation 在 64% NPC 样品被发现。我们的数据显示 LARS2 的那 inactivation 由基因并且 epigenetic 机制可以是在 NPC 的 carcinogenesis 的一个普通、重要的事件。 | Wen Zhou Xiangling Feng Hong Li Lei Wang Bin Zhu Weidong Liu Ming Zhao Kaitai Yao Caiping Ren | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 5 |
| 4 | Aeolian Facies Belts in the Taklimakan Desert显示文摘At least at the beginning of the last glacial epoch, the facies belts of dune sand, sandy loam and loess formed by winds had existed in the Taklimakan desert and areas south of it. There were no appreciable changes in the NE and NW wind systems and their wind fqrces that deposited dune sand, sandy loam and loess in the global cold stage since the last glacial epoch (accordingly no marked shifts of the boundaries of these aeolian facies belts took place. In the global warm stage since then, the climate in the Taklimakan desert and areas south of it became warm and dry, resulting in ablation of substantial volumes of ice and snow in their surrounding mountains and thus forming alluvial and diluvial deposits in the region. The alluvial-diluvial actions, however, failed to change the general framework of aeolian facies belts. | Li Baosheng, Dong Guangrong, Zhang Jiasheng, Li Sen,Jin Heling, Chen Huizhong, Wen Xiangle, Wang Yao, Lanzhou Desert Research Institute, Chinese Academy of Sciences, Lamhou, Gansuand Zhu YizhiXi’an Open Laboratory of Loess and Quaternary Geology, Chinese Academy of Sciences, Xi’an, Gansu Fei Zhenbi | 1995 | Acta Geologica Sinica(English Edition)1995，69，3： | 4 |
| 5 | Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice显示文摘Flaxseed has displayed the potential beneficial as functional foods.However,most studies focused on effects of flaxseed extracts or ingredients in flaxseed.Besides,few studies showed that flaxseed extracts contributed to anti-type 1 diabetes(T1D),yet the underlying mechanism is still unknown.In the present study,16.7% of milled flaxseed(MF)-added diet was given to diabetic mice induced by streptozocin for 6 weeks.The results showed that MF feeding 1)slightly decreased blood glucose levels and improved the ability of glucose tolerance by oral glucose tolerance test,2)decreased liver tumor necrosis factor-αlevels and increased liver glycogen levels with significance via down-regulating TLR4/NF-κB pathways,3)and significantly altered some beneficial bacteria in gut microbiota.In conclusion,the present study showed that milled flaxseed showed the potential on anti-T1D through anti-inflammation via TLR4/NF-κB and altering the gut microbiota in STZ-induced diabetic mice. | Hui Xia Xiangling Shi Beijia Zhou Jing Sui Chao Yang Hechun Liu Ligang Yang Shaokang Wang Guiju Sun | 2022 | Food Science and Human Wellness2022，11，1： | 3 |
| 6 | Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase显示文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) has become one major threat to human population health.The RNA-dependent RNA polymerase(RdRp) presents an ideal target of antivirals,whereas nucleoside analogs inhibitor is hindered by the proofreading activity of coronavirus.Herein,we report that corilagin(RAI-S-37) as a non-nucleoside inhibitor of SARS-CoV-2 RdRp,binds directly to RdRp,effectively inhibits the polymerase activity in both cell-free and cell-based assays,fully resists the proofreading activity and potently inhibits SARS-CoV-2 infection with a low 50% effective concentration(EC50) value of 0.13 μmol/L.Computation modeling predicts that RAI-S-37 lands at the palm domain of RdRp and prevents conformational changes required for nucleotide incorporation by RdRp.In addition,combination of RAI-S-37 with remdesivir exhibits additive activity against antiSARS-CoV-2 RdRp.Together with the current data available on the safety and pharmacokinetics of corilagin as a medicinal herbal agent,these results demonstrate the potential of being developed into one of the much-needed SARS-CoV-2 therapeutics. | Quanjie Li Dongrong Yi Xiaobo Lei Jianyuan Zhao Yongxin Zhang Xiangling Cui Xia Xiao Tao Jiao Xiaojing Dong Xuesen Zhao Hui Zeng Chen Liang Lili Ren Fei Guo Xiaoyu Li Jianwei Wang Shan Cen | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 2 |
| 7 | Superoxide dismutase mimetic ability of Mn-doped ZnS QDs显示文摘Superoxide dismutase(SOD) is an important antioxidant enzyme in the body. SOD has special physiological activity and is the primary substance for scavenging free radicals in living organisms.However, the expensive and complex extraction processes, low SOD yield, as well as difficult to store at room temperature have seriously hindered its application pace. Herein, the enzyme mimetic function of Mn-doped ZnS quantum dots(QDs) was discovered. The improved Marklund and McCord method both showed that Mn-doped ZnS QDs possess intrinsic SOD-like activity. The effects of temperature and pH on the mimetic enzyme activity of Mn-doped ZnS QDs have been investigated compared with SOD enzymes.The low cost and easy to synthesize white Mn-doped ZnS QDs with good biocompatibility are expected to be used as a new type of SOD nanozymes in the biology-relevant fields. | Xiangling Ren Mingqian Wang Xing He Zheng Li Jing Zhang Wei Zhang Xudong Chen Hong Ren Xianwei Meng | 2018 | Chinese Chemical Letters2018，29，12： | 2 |
| 8 | Construction and characterization of a full-length infectious clone of Getah virus in vivo显示文摘Getah virus(GETV)is a mosquito-borne virus of the genus Alphavirus in the family Togaviridae and,in recent years,it has caused several outbreaks in animals.The molecular basis for GETV pathogenicity is not well understood.Therefore,a reverse genetic system of GETV is needed to produce genetically modified viruses for the study of the viral replication and its pathogenic mechanism.Here,we generated a CMV-driven infectious cDNA clone based on a previously isolated GETV strain,GX201808(pGETV-GX).Transfection of pGETV-GX into BHK-21 cells resulted in the recovery of a recombinant virus(rGETV-GX)which showed similar growth characteristics to its parental virus.Then three-day-old mice were experimentally infected with either the parental or recombinant virus.The recombinant virus showed milder pathogenicity than the parental virus in the mice.Based on the established CMV-driven cDNA clone,subgenomic promoter and two restriction enzyme sites(BamHI and EcoRI)were introduced into the region between E1 protein and 3’UTR.Then the green fluorescent protein(GFP),red fluorescent protein(RFP)and improved light-oxygen-voltage(iLOV)genes were inserted into the restriction enzyme sites.Transfection of the constructs carrying the reporter genes into BHK-21 cells proved the rescue of the recombinant reporter viruses.Taken together,the establishment of a reverse genetic system for GETV provides a valuable tool for the study of the virus life cycle,and to aid the development of genetically engineered GETVs as vectors for foreign gene expression. | Tongwei Ren Xiangling Min Qingrong Mo Yuxu Wang Hao Wang Ying Chen Kang Ouyang Weijian Huang Zuzhang Wei | 2022 | Virologica Sinica2022，37，3： | 2 |
| 9 | MiR-200, a new star miRNA in human cancer显示文摘 | Xiangling Feng Zhengming Wang Rebecca Fillmore Yaguang Xi | 2013 | Cancer Letters2013，，： | 1 |
| 10 | Clinical and laboratory profiles of refractory Mycoplasma pneumoniae pneumonia in children显示文摘 | Meijuan Wang Yuqing Wang Yongdong Yan Canhong Zhu Li Huang Xuejun Shao Jun Xu Hong Zhu Xiangle Sun Wei Ji Zhengrong Chen | 2014 | International Journal of Infectious Diseases2014，，： | 1 |
| 11 | Studies on the EBV, B7 and active immunotherapy of multiple myeloma patients 显示文摘 | Zhang Wanggang Cao Xingmei Wang Xiangling | 1998 | Bri J Haematol1998，102，： | 1 |
| 12 | Removal of phosphate from water by activated carbon fiber loaded with lanthanum oxide显示文摘 | Ling Zhang Lihua Wan Ning Chang Jianyong Liu Chao Duan Qi Zhou Xiangling Li Xinze Wang | 2011 | Journal of Hazardous Materials2011，，1： | 1 |
| 13 | Porcine Picornavirus 3C Protease Degrades PRDX6 to Impair PRDX6-mediated Antiviral Function显示文摘Peroxiredoxin-6(PRDX6)is an antioxidant enzyme with both the activities of peroxidase and phospholipase A2(PLA2),which is involved in regulation of many cellular reactions.However,the function of PRDX6 during virus infection remains unknown.In this study,we found that the abundance of PRDX6 protein was dramatically decreased in foot-and-mouth disease virus(FMDV)infected cells.Overexpression of PRDX6 inhibited FMDV replication.In contrast,knockdown of PRDX6 expression promoted FMDV replication,suggesting an antiviral role of PRDX6.To explore whether the activity of peroxidase and PLA2 was associated with PRDX6-mediated antiviral function,a specific inhibitor of PLA2(MJ33)and a specific inhibitor of peroxidase activity(mercaptosuccinate)were used to treat the cells before FMDV infection.The results showed that incubation of MJ33 but not mercaptosuccinate promoted FMDV replication.Meanwhile,overexpression of PRDX6 slightly enhanced type I interferon signaling.We further determined that the viral 3Cprowas responsible for degradation of PRDX6,and 3Cpro-induced reduction of PRDX6 was independent of the proteasome,lysosome,and caspase pathways.The protease activity of 3Cprowas required for induction of PRDX6 reduction.Besides,PRDX6 suppressed the replication of another porcine picornavirus Senecavirus A(SVA),and the 3Cproof SVA induced the reduction of PRDX6 through its proteolytic activity as well.Together,our results suggested that PRDX6 plays an important antiviral role during porcine picornavirus infection,and the viral 3Cproinduces the degradation of PRDX6 to overcome PRDX6-mediated antiviral function. | Congcong Wang Huanhuan Feng Xiangle Zhang Kangli Li Fan Yang Weijun Cao Huisheng Liu Lili Gao Zhaoning Xue Xiangtao Liu Zixiang Zhu Haixue Zheng | 2021 | Virologica Sinica2021，36，5： | 1 |
| 14 | Preparation and structure analysis of expanded graphite-based composites made by phosphoric acid activation显示文摘 | Chengbao Liu Zhigang Chen Xiangle Cheng Zhenbang Wang Xiaotao Duan | 2010 | Journal of Porous Materials2010，，4： | 1 |
| 15 | Gold occurrence of Jiaojia gold mine in Shangdong province显示文摘 | Yang Hongying Wang Sihui Song Xiangling | 2011 | Transactions of Non- ferrous Metals Society of China2011，21，： | 1 |
| 16 | Molybdenite Re-Os,titanite and garnet U-Pb dating of the Magushan skarn Cu-Mo deposit,Xuancheng district,Middle-Lower Yangtze River Metallogenic Belt显示文摘The Magushan skarn Cu-Mo deposit is a representative example of the skarn mineralization occurring within the Xuancheng ore district of the Middle-Lower Yangtze River Metallogenic Belt of eastern China.The precise age of an ore deposit is important for understanding the timing of mineralization relative to other geological events in a region and to fully place the formation of a mineral deposit within the geological context of other processes that occur within the study area.Here,we present new molybdenite Re-Os and titanite and andradite garnet U-Pb ages for the Magushan deposit and use these data to outline possible approaches for identifying genetic relationships in geologically complex areas.The spatial and paragenetic relationships between the intrusions,alteration,and mineralization within the study area indicates that the formation of the Magushan deposit is genetically associated with the porphyritic granodiorite.However,this is not always the case,as some areas contain complexly zoned plutons with multiple phases of intrusion or mineralization may be distal from or may not have any clear spatial relationship to a pluton.This means that it may not be possible to determine whether the mineralization formed as a result of single or multiple magmatic/hydrothermal events.As such,the approaches presented in this study provide an approach that allows the identification of any geochronological relationships between mineralization and intrusive events in areas more complex than the study area.Previously published zircon U-Pb data for the mineralization-related porphyritic granodiorite in this area yielded an age of 134.2±1.2 Ma(MSWD=1.4)whereas the Re-Os dating of molybdenite from the study area yielded an isochron age of 137.7±2.5 Ma(MSWD=0.43).The timing of the mineralizing event in the study area was further examined by the dating of magmatic accessory titanite and skarn-related andradite garnet,yielding U-Pb ages of 136.3±2.5 Ma(MSWD=3.2)and 135.9±2.7 Ma(MSWD=2.5),respectively.The dating of magmatic and hydrothermal activity within the Magushan area yields ages around 136 Ma,strongly suggesting that the mineralization in this area formed as a result of the emplacement of the intrusion.The dates presented in this study also provide the first indication of the timing of mineralization within the Xuancheng district.providing evidence of a close genetic relationship between the formation of the mineralization within the Xuancheng district and the Early Cretaceous magmatism that occurred in this area.This in turn suggests that other Early Cretaceous intrusive rocks within this region are likely to be associated with mineralization and should be considered highly prospective for future mineral exploration.This study also indicates that the dating of garnet and titanite can also provide reliable geochronological data and evidence of the timing of mineralization and magmatism,respectively,in areas lacking other dateable minerals(e.g.,molybdenite)or where the relationship between mineralization and magmatism is unclear,for example in areas with multiple stages of magmatism,with complexly zoned plutons,and with distal skarn mineralization. | Yue Li Feng Yuan Simon M.Jowitt Fangyue Wang Xiangling Li Yufeng Deng Yunyue Wang Taofa Zhou | 2021 | Geoscience Frontiers2021，12，3： | 1 |
| 17 | THE CONSTRUCTION OF HPV16-L1 RECOMBINANT PLASMID AND ITS EXPRESSION IN MAMMALIAN CELLS显示文摘Infection with high risk human papillomavirus is regarded as the major risk factor in the development of cervical cancer. In this study, HPV16 L1 eukaryotic expression plasmids pcDNA LI were constructed, which were transfected into mammalian cells Cos 7. The expression of HPV16 L1 in transfected cells were identified by in situ hybridization, immunospot and immunocytochemistry. HPV16 L1 mRNA transcription and L1 protein expression were found in recombinant plasmid transfected cells. This expression system will provide us with plentiful resource for HPV16 L1 immunological study and will be helpful for the design of HPV16 prophylactic vaccine. | Sun Xiangle),Si Lüsheng,Cao Zansun Department of Obstetrics & Gynecology,Wang Yili,Liu Tianju,Guo Jianfen,Song Jianming Institute of Immunopathology, Xi′an Medical University, Xi′an 710061 | 1999 | Journal of Pharmaceutical Analysis1999，13，2： | 1 |
| 18 | STUDIES ON THE RELATIONSHIP BETWEEN EPSTEIN BARR VIRUS (EBV) AND PATHOGENESIS OF MULTIPLE MYELOMA显示文摘In order to explore the relationship between Epstein Barr virus (EBV) and pathogenesis of multiple myeloma (MM), the presence of EBV DNA in mononuclear cells of bone marrow (BMMC) and peripheral blood (PBMC) taken from 23 multiple myeloma patients who were neither posttransplanted nor HIV positive were examined by polymerase chain reaction (PCR). Meanwhile the presence of EBV EBERs in bioptic bone marrow’s specimens of 4 MM patients were examined by in situ hybridization (ISH). Acute leukemia, aplastic anemia and malnourished anemia patients were taken as control. It showed EBV DNA detective rate in BMMC (69 6%) and in PBMC (39 1%) of MM patients were higher significantly than control groups (P<0 05). The positive signals of EBERs were located in BMMC and the EBV positive samples detected by ISH were consistent with those by PCR. The results indicate that EBV is closely correlated to pathogenesis of MM. | Wang Jianli,Zhang Wanggang,Wang Xiangling, Cao Xingmei,Chen YinxiaDepartment of Hematology, Second Affiliated Hospital, of Xi′an Medical University Xi′an 710004 | 1999 | Journal of Pharmaceutical Analysis1999，13，2： | 1 |
| 19 | miR-125b reverses cisplatin resistance by regulating autophagy via targeting RORA/BNIP3L axis in lung adenocarcinoma显示文摘The platinum-based chemotherapy is one of the most frequently used treatment protocols for lung adenocarcinoma(LUAD),and chemoresistance,however,usually results in treatment failure and limits its application in the clinic.It has been shown that microRNAs(miRNAs)play a significant role in tumor chemoresistance.In this study,miR-125b was identified as a specific cisplatin(DDP)-resistant gene in LUAD,as indicated by the bioinformatics analysis and the real-time quantitative PCR assay.The decreased serum level of miR-125b in LUAD patients was correlated with the poor treatment response rate and short survival time.MiR-125b decreased the A549/DDP proliferation,and the multiple drug resistance-and autophagy-related protein expression levels,which were all reversed by the inhibition of miR-125b.In addition,xenografts of human tumors in nude mice were suppressed by miR-125b,demonstrating that through autophagy regulation,miR-125b could reverse the DDP resistance in LUAD cells,both in vitro and in vivo.Further mechanistic studies indicated that miR-125b directly repressed the expression levels of RORA and its downstream BNIP3L,which in turn inhibited autophagy and reversed chemoresistance.Based on these findings,miR-125b in combination with DDP might be an effective treatment option to overcome DDP resistance in LUAD. | LEI LIU NA GUO XIANGLING LI QIAN XU RUILONG HE LIMIN CHENG CHUNYAN DANG XINYU BAI YIYING BAI XIN WANG QIANHUI CHEN LI ZHANG | 2024 | Oncology Research2024，32，4： | 0 |
| 20 | Screening of Effective Fractions for Antitussive and Anti-inflammatory Effects of Miao Medicine Aspidistra caespitosa显示文摘[Objectives]This study was conducted to investigate the antitussive and anti-inflammatory effects of Miao medicine Aspidistra caespitosa C.Pei.[Methods]A mouse cough model was made by the SO 2 cough induction method,and the antitussive effects of different extraction fractions of A.caespitosa were observed.The inflammation models of acute inflammatory ear swelling in mice caused by xylene,granuloma in mice caused by cotton balls,and footpad swelling in mice caused by carrageenan were made,and the different extraction fractions were used to observe the effects of different extraction fractions on mouse ear swelling,granuloma and footpad swelling.And the levels of interleukin 6(IL-6)and tumor necrosis factor(TNF-a)in the serum of different groups of mice were detected to screen out the extraction fractions of A.caespitosa with good antitussive and anti-inflammatory activity.[Results]Antitussive experiments on mice showed that the water layer extraction fraction,ethyl acetate extraction fraction and petroleum ether extraction fraction of Miao medicine A.caespitosa could prolong the incubation period of cough in mice and reduce the number of coughs within 2 min to varying degrees,and its different extraction fractions all had different inhibitory effects on mouse ear swelling,granuloma and footpad swelling.Compared with the blank control group,the different extraction fractions could reduce IL-6,TNF-a and other indicators to different degrees.[Conclusions]Ethyl acetate extraction fraction of A.caespitosa has good antitussive and anti-inflammatory effects. | Yongyue GAO Xiangling QU Pu WANG Ying LIN Hai ZHAO | 2021 | Agricultural Biotechnology2021，10，5： | 0 |
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