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| 1 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
| 2 | Electroacupuncture at He-Mu points reduces P2X_4 receptor expression in visceral hypersensitivity显示文摘Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) was reported to improve visceral hypersensitivity in rats.Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome.Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment.Simultaneously,P2X 4 receptor immunoreactivity significantly increased in the colon and spinal cord.Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity,and significantly decreased P2X 4 receptor immunoreactivity in the colon and spinal cord.These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X 4 receptor immunoreactivity in the colon and spinal cord. | Xinxin Guo Jifei Chen Yuan Lu Luyi Wu Zhijun Weng Ling Yang Yuhu Xin Xianming Lin Yi Liang Jianqiao Fang | 2013 | Neural Regeneration Research2013，8，22： | 9 |
| 3 | Colorectal cancer burden,trends and risk factors in China:A review and comparison with the United States显示文摘Objective:China and the United States(the U.S.)have the heaviest colorectal cancer(CRC)burden with considerable variations in temporal trends.This study aims to analyze the temporal patterns of CRC burden and its risk factors in China and the U.S.across the past three decades.Methods:Data were extracted from the Global Burden of Disease(GBD)Study in 2019,including cases,deaths,disability-adjusted life-years(DALYs),age-standardized rate(ASR),and summary exposure value(SEV)of CRC in China and the U.S.between 1990 and 2019.Annual average percentage changes(AAPCs)of CRC burden were calculated using the Joinpoint regression model.The mortality in CRC attributable to potential risk factors was characterized by countries,gender,and age groups.Results:In 2019,there were 607,900 and 227,241 CRC cases,and 261,777 and 84,026 CRC deaths in China and the U.S.,respectively.The age-standardized incidence rate(ASIR)was 30.55 per 100,000 in China and 41.86 per100,000 in the U.S.,and the age-standardized mortality rate(ASMR)was 13.86 per 100,000 in China and 14.77 per100,000 in the U.S.CRC incidence,mortality,and DALY rate in the U.S.showed downward trends in the past three decades(AAPC=-0.47,-1.06,and-0.88,respectively),while upward trends were observed in China(AAPC=3.11,1.05,and 0.91,respectively).Among the cause of CRC,the leading risk factor contributing to CRC death was low milk in China and smoking in the U.S.,respectively.Conclusions:From 1990 to 2019,the burden of CRC in China increased dramatically,particularly for males and middle-aged and elderly people.The management of the major risk factors associated with the high burden of CRC should be enhanced. | Qianru Li Hongliang Wu Maomao Cao He Li Siyi He Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Changfa Xia Ji Peng Wanqing Chen | 2022 | Chinese Journal of Cancer Research2022，34，5： | 6 |
| 4 | The chromosome-level Hemerocallis citrina Borani genome provides new insights into the rutin biosynthesis and the lack of colchicine显示文摘Hemerocallis citrina Borani(huang hua cai in Chinese)is an important horticultural crop whose flower buds are widely consumed as a delicious vegetable in Asia.Here we assembled a high-quality reference genome of H.citrina using single-molecule sequencing and Hi-C technologies.The genome assembly was 3.77 Gb and consisted of 3183 contigs with a contig N50 of 2.09 Mb,which were further clustered into 11 pseudochromosomes.A larger portion(3.25 Gb or 86.20%)was annotated as a repetitive content and 54,295 protein-coding genes were annotated in the genome.Genome evolution analysis showed that H.citrina experienced a recent whole-genome duplication(WGD)event at~15.73 million years ago(Mya),which was the main factor leading to many multiple copies of orthologous genes.We used this reference genome to predict 20 genes involved in the rutin biosynthesis pathway.Moreover,our metabolomics data revealed neither colchicine nor its precursors in H.citrina,challenging the long-standing belief that this alkaloid causes poisoning by the plant.The results of our disruptive research are further substantiated by our genomic finding that H.citrina does not contain any genes involved in colchicine biosynthesis.The high-quality genome lays a solid foundation for genetic research and molecular breeding of H.citrina. | Zhixing Qing Jinghong Liu Xinxin Yi Xiubin Liu Guoan Hu Jia Lao Wei He Zihui Yang Xiaoyan Zou Mengshan Sun Peng Huang Jianguo Zeng | 2021 | Horticulture Research2021，8，1： | 6 |
| 5 | Whole-genome resequencing of Osmanthus fragrans provides insights into flower color evolution显示文摘Osmanthus fragrans is a well-known ornamental plant that has been domesticated in China for 2500 years.More than 160 cultivars have been found during this long period of domestication,and they have subsequently been divided into four cultivar groups,including the Yingui,Jingui,Dangui,and Sijigui groups.These groups provide a set of materials to study genetic evolution and variability.Here,we constructed a reference genome of O.fragrans‘Liuyejingui’in the Jingui group and investigated its floral color traits and domestication history by resequencing a total of 122 samples,including 119 O.fragrans accessions and three other Osmanthus species,at an average sequencing depth of 15×.The population structure analysis showed that these 119 accessions formed an apparent regional cluster.The results of linkage disequilibrium(LD)decay analysis suggested that varieties with orange/red flower color in the Dangui group had undergone more artificial directional selection;these varieties had the highest LD values among the four groups,followed by the Sijigui,Jingui,and Yingui groups.Through a genome-wide association study,we further identified significant quantitative trait loci and genomic regions containing several genes,such as ethylene-responsive transcription factor 2 and Arabidopsis pseudoresponse regulator 2,that are positively associated with petal color.Moreover,we found a frameshift mutation with a 34-bp deletion in the first coding region of the carotenoid cleavage dioxygenase 4 gene.This frameshift mutation existed in at least one site on both alleles in all varieties of the Dangui group.The results from this study shed light on the genetic basis of domestication in woody plants,such as O.fragrans. | Hongguo Chen Xiangling Zeng Jie Yang Xuan Cai Yumin Shi Riru Zheng Zhenqi Wang Junyi Liu Xinxin Yi Siwei Xiao Qiang Fu Jingjing Zou Caiyun Wang | 2021 | Horticulture Research2021，8，1： | 5 |
| 6 | Novel application of bergapten and quercetin with anti-bacterial,osteogenesis-potentiating,and anti-inflammation tri-effects显示文摘The bacteria-mediated inflammatory conditions adversely affect the osseointegration process of endosseous implants,which can even lead to implant malfunction or failure.Local drug delivery has been designed to exert anti-inflammatory and antibacterial activities,but whether this strategy has an effect on the compromised osseointegration under inflammation has rarely been studied.The present study focused on the osteoinductive efficacy of two known phytoestrogens[bergapten(BP)and quercetin(QE)]on implant sites under multiple bacteria-infected conditions in situ.Furthermore,the gene expression profiles of rat bone mesenchymal stem cells(rBMSCs)treated with BP and QE in the presence of Porphyromonas gingivalis-derived lipopolysaccharide were identified.The results showed that both drugs,especially QE,had significant potentiating effects on promoting osteogenic differentiation of rBMSCs,resisting multiple pathogens,and reducing inflammatory activity.Meanwhile,RNA sequencing analysis highlighted the enriched gene ontology terms and the differentially expressed genes(Vps25,Il1r2,Csf3,Efemp1,and Ccl20)that might play essential roles in regulating the above tri-effects,which provided the basis for the drug delivery system to be used as a novel therapeutic strategy for integrating peri-implant health.Overall,our study confirmed that QE appeared to outperform BP in osteogenesis and bacterial killing but not in anti-inflammation.Moreover,both drugs possess favorable tri-effects and can serve as the pivotal agents for the drug delivery system to boost osseointegration at inflammatory implant sites. | Jianxu Wei Xiaomeng Zhang Yuan Li Xinxin Ding Yi Zhang Xue Jiang Hongchang Lai Junyu Shi | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 4 |
| 7 | Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity显示文摘Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia. This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat model of irritable bowel syndrome where rats display chronic visceral hypersensitivity. Results showed that suspended moxibustion at Tianshu (ST25) point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased. Experimental findings indicate that prokineticin 1 and prokineticin receptor 1 are involved in the analgesia using suspended moxibustion in rats with chronic visceral hyperalgesia. | Chen Zhao Li Qit Luyi Wu Tao Yi Huangan Wu Xinxin Guo Cili Zhou Huirong Liu Xiaomei Wang | 2012 | Neural Regeneration Research2012，7，15： | 4 |
| 8 | Divergence, evolution and adaptation in ray-finned fish genomes显示文摘With the rapid development of next-generation sequencing technologies and bioinformatics, over 50 ray-finned fish genomes by far have been sequenced with high quality. The genomic work provides abundant genetic resources for deep understanding of divergence, evolution and adaptation in the fish genomes. They are also instructive for identification of candidate genes for functional verification, molecular breeding, and development of novel marine drugs. As an example of other omics data, the Fish-T1 K project generated a big database of fish transcriptomes to integrate with these published fish genomes for potential applications. In this review, we highlight the above-mentioned recent investigations and core topics on the ray-finned fish genome research, with a main goal to obtain a deeper understanding of fish biology for theoretical and practical applications. | Chao Bian Yu Huang Jia Li Xinxin You Yunhai Yi Wei Ge Qiong Shi | 2019 | Science China(Life Sciences)2019，62，8： | 3 |
| 9 | Stomach cancer burden in China: Epidemiology and prevention显示文摘In 2020, stomach cancer was the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death worldwide. Due to the relatively huge population base and the poor survival rate, stomach cancer is still a threat in China, and accounts for nearly half of the cases worldwide. Fortunately, in China, the incidence and mortality rates of stomach cancer presented a declining trend owing to the change of individual life styles and the persistent efforts to prevent stomach cancer from the governments at all levels. Helicobacter pylori(H. pylori)infection, poor eating habits, smoking, history of gastrointestinal disorders, and family history of stomach cancer are the main risk factors for stomach cancer in China. As a result, by taking risk factors for stomach cancer into account, specific preventive measures, such as eradicating H. pylori and implementing stomach cancer screening projects, should be taken to better prevent and decrease the burden of stomach cancer. | Xinxin Yan Lin Lei He Li Maomao Cao Fan Yang Siyi He Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen | 2023 | Chinese Journal of Cancer Research2023，35，2： | 2 |
| 10 | Mathematical Model and Its Application of Radial Effective Thermal Conductivity for Coil Heat Transfer in HPH Furnace显示文摘Temperature uniformity of steel coils in High Performance Hydrogen bell-type annealing furnace has a significant effect on their quality and production. The hot rolled coil can be considered as a periodically laminated material composed of steel layers and interface layers in radial direction. A new formula for the radial effective thermal conductivity has been proposed, which is based on surface characteristic, strip thickness and compressive stress of the rolled coil. Furthermore, it has been used to develop a heat transfer mathematical model for steel coils in the HPH furnace. The calculated annealing curves using this mathematical model are in good agreement with the experimental data. | Wenfei Wu Fan Yu Xinxin Zhang Yi Zuo | 2002 | Journal of Thermal Science2002，11，2： | 2 |
| 11 | Environmentally-Friendly Catalytic Oxidation of Cyclohexanone with 30% H_2O_2 Solution: A Comparison Study between Hollow Titanium Silicate and Dealuminated HBEA Zeolites显示文摘Two clean liquid–phase cyclohexanone oxidation routes catalyzed by DHBEA and HTS zeolites, in the absence of organic solvents, have been developed for producing high value-added chemical intermediates. Under optimized conditions,the cyclohexanone conversion reaches up to 60%, and the selectivity of total target products(ε-caprolactone, 6-hydroxyhexanoic acid and adipic acid) is over 90% achieved by the HTS zeolite; while both cyclohexanone conversion and the 6-hydroxyhexanoic acid selectivity are over 95% obtained on the DHBEA zeolite. Both the Lewis and Br鰊sted acid sites of DHBEA zeolite can preferentially activate the carbonyl group of cyclohexanone without any impact on H_2O_2 molecules.Meanwhile, the HTS zeolite can predominantly make H_2O_2 more reactive, which agrees well with the molecular calculation results. Hence, two different Baeyer-Villiger oxidation mechanisms based on the activation of H_2O_2 and cyclohexanone are proposed. Then, 6-hydroxyhexanoic acid is formed via the ring-opening of ε-caprolactone. However, C-OH groups cannot be reactivated by DHBEA zeolite, leading to insignificant adipic acid formation, while the selectivity of adipic acid is 28.5% obtained on the HTS zeolite. Consequently, the higher catalytic performance of the DHBEA zeolite is ascribed to its larger amount of active sites and greater diffusion features than those of HTS zeolite. | Xia Changjiu Zhao Yi Zhu Bin Lin Min Peng Xinxin Dai Zhenyu Shu Xingtian | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，4： | 2 |
| 12 | Amelioration of imiquimod-induced psoriasis-like dermatitis in mice by DSW therapy inspired hydrogel显示文摘Psoriasis is a long-lasting and recurrent autoimmune disease which is incurable so far.Dead Sea water(DSW)therapy is an effective approach to help control the symptoms of psoriasis due to the abundant mineral ions in DSW,which inspired the material formulation in this study.Rubidium–Sodium alginate/Polyacrylamide hydrogels(Rb-SA/PAAm gels)composed of sodium alginate and polyacrylamide interpenetrating network structure with different concentrations of rubidium and certain magnesium and zinc content were prepared for the treatment of psoriasis.The obtained results suggest the good mechanical properties of the Rb-SA/PAAm gels including toughness and swelling performance.In terms of in vitro tests,the Rb-SA/PAAm gels not only show nontoxicity to human keratinocyte cell line(Hacats)but also inhibits the activity against inflammatory NF-κβ signaling pathway.Meanwhile,they can release Rb+which enable the Rb-SA/PAAm gels have better antibacterial ability to Streptococcus and Escherichia coli.The results obtained from in vivo tests indicate that these hydrogels could alleviate the symptoms of psoriasis caused by Imiquimod(IMQ)in mice by reducing the inflammatory factor in STAT3 pathway and therefore reduce the immune stimulation of the spleen.In conclusion,the 100Rb-SA/PAAm gel has demonstrated great potential to be a topical wettable dressing for psoriasis treatment. | Xiang He Bing Zhu WeiJia Xie Yu He Jian Song Yi Zhang Chi Sun Hao Li QiYu Tang XinXin Sun Yanni Tan Yong Liu | 2021 | Bioactive Materials2021，6，2： | 2 |
| 13 | A low-density polyethylene composite with phosphorus-nitrogen based flame retardant and multi-walled carbon nanotubes for enhanced electrical conductivity and acceptable flame retardancy显示文摘Design and exploitation of flame retardant polymers with high electrical conductivity are desired for polymer applications in electronics.Herein,a novel phosphorus-nitrogen intumescent flame retardant was synthesized from pentaerythritol octahydrogen tetraphosphate,phenylphosphonyl dichloride,and aniline.Low-density polyethylene was combined with the flame retardant and multi-walled carbon nanotubes to form a nanocomposite material via a ball-milling and hot-pressing method.The electrical conductivity,mechanical properties,thermal performance,and flame retardancy of the composites were investigated using a four-point probe instrument,universal tensile machine,thermogravimetric analysis,and cone calorimeter tests,respectively.It was found that the addition of multi-walled carbon nanotubes can significantly improve the electrical conductivity and mechanical properties of the low-density polyethylene composites.Furthermore,the combination of multi-walled carbon nanotubes and phosphorus–nitrogen flame retardant remarkably enhances the flame retardancy of matrixes with an observed decrease of the peak heat release rate and total heat release of 49.8%and 51.9%,respectively.This study provides a new and effective methodology to substantially enhance the electrical conductivity and flame retardancy of polymers with an attractive prospect for polymer applications in electrical equipment. | Yong Luo Yuhui Xie Renjie Chen Ruizhi Zheng Hua Wu Xinxin Sheng Delong Xie Yi Mei | 2021 | Frontiers of Chemical Science and Engineering2021，15，5： | 2 |
| 14 | Single-phase P2-type layered oxide with Cu-substitution for sodium ion batteries显示文摘The development of high-performance layered oxide cathodes for sodium ion batteries (SIBs) continues to facing be hindered by severe challenges to date.Herein,a single-phase P2-Na0.67Mn0.6Ni0.2Co0.1Cu0.1O2(NMNCC) comprising multiple-layer-oriented stacked nanoflakes is designed and synthesized via a simple sol-gel method.The large lattice parameters ensure a large three-dimensional frame,which enables the diffusion of sodium ions.Owing to its optimal morphology structure modulation transition metal substitution strategy,the MNCC electrode delivers a reversible capacity of 131.3 mAh g^-1 at 0.1 C with retention of 86.7%after 200 cycles.In addition,it provides an initial capacity of 86.7 mAh g^-1,and a retention of 80.0%after 500 cycles even at a current density of up to 1 A g^-1.The stable single-phase structure and slight volume shrinkage observed after Na+extraction further delay structural degradation.High Na+mobility and low Na+diffusion resistance are also guarantee the excellent rate performance of the NMNCC electrode.Thus,we determine that the NMNCC cathode is significant in the advancement of promising novel layered oxide cathodes. | Tao Chen Weifang Liu Yi Zhuo Hang Hu Maolan Zhu Ruizheng Cai Xinxin Chen Jun Yan Kaiyu Liu | 2020 | Journal of Energy Chemistry2020，29，4： | 2 |
| 15 | Burden of liver cancer:From epidemiology to prevention显示文摘In this review,we offer a concise overview of liver cancer epidemiology in China and worldwide from the official databases of GLOBOCAN 2020 and the National Cancer Registry in China.We also summarized the evidence for the main risk factors associated with liver cancer risk and discuss strategies implemented in China to control the liver cancer burden.Overall,liver cancer was the sixth most commonly diagnosed cancer and the third leading cause of cancer-related death worldwide in 2020.Although China contributed to nearly half of cases across the world alone,the incidence and mortality rates of liver cancer presented a declining trend owing to the persistent efforts from the governments at all levels.The current liver cancer burden in China still faces an arduous challenge due to the relatively large population base as well as the substantially low survival rate(12.1%).To better control the liver cancer burden with the lowest cost,specific measures should be conducted by reducing exposure to established risk factors such as hepatitis B infection and aflatoxin.The promotion of surveillance is also an important method to prolong the survival of liver cancer.This review will provide basic information for future direction on the control of liver cancer burden. | Qianru Li Maomao Cao Lin Lei Fan Yang He Li Xinxin Yan Siyi He Shaoli Zhang Yi Teng Changfa Xia Wanqing Chen | 2022 | Chinese Journal of Cancer Research2022，34，6： | 2 |
| 16 | Cancer profiles in China and comparisons with the USA:a comprehensive analysis in the incidence,mortality,survival,staging,and attribution to risk factors显示文摘China faces a disproportionate cancer burden to the population size and is undergoing a transition in the cancer spectrum.We extracted data in five aspects of cancer incidence,mortality,survival,staging distributions,and attribution to risk factors in China,the USA and worldwide from open-source databases.We conducted a comprehensive secondary analysis of cancer profiles in China in the above aspects,and compared cancer statistics between China and the USA.A total of 4,546,400 new cancer cases and 2,992,600 deaths occurred in China in 2020,accounting for 25.1%and 30.2%of global cases,respectively.Lifestyle-related cancers including lung cancer,colorectal cancer,and breast cancer showed an upward trend and have been the leading cancer types in China.41.6%of new cancer cases and 49.3%of cancer deaths occurred in digestive-system cancers in China,and the cancers of esophagus,nasopharynx,liver,and stomach in China accounted for over 40%of global cases.Infection-related cancers showed the highest population-attributable fractions among Chinese adults,and most cancers could be attributed to behavioral and metabolic factors.The proportions of stage I for most cancer types were much higher in the USA than in China,except for esophageal cancer(78.2%vs.41.1%).The 5-year relative survival rates in China have improved substantially during 2000–2014,whereas survival for most cancer types in the USA was significantly higher than in China,except for upper gastrointestinal cancers.Our findings suggest that although substantial progress has been made in cancer control,especially in digestive system cancers in China,there was still a considerable disparity in cancer burden between China and the USA.More robust policies on risk factors and standardized screening practices are urgently warranted to curb the cancer growth and improve the prognosis for cancer patients. | Siyi He Changfa Xia He Li Maomao Cao Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Wanqing Chen | 2024 | Science China(Life Sciences)2024，67，1： | 2 |
| 17 | Dropping out: Why are students leaving junior high in China’s poor rural areas?显示文摘 | Hongmei Yi Linxiu Zhang Renfu Luo Yaojiang Shi Di Mo Xinxin Chen Carl Brinton Scott Rozelle | 2011 | International Journal of Educational Development2011，，4： | 1 |
| 18 | Study of the heat transfer in high performance hydrogen belltype annealing furnaces显示文摘 | Zuo Yi Wu Wenfei Zhang Xinxin | 2001 | Heat Treating Asian Research2001，30，8： | 1 |
| 19 | Transcriptomic analysis reveals the defense mechanisms of citrus infested with Diaphorina citri显示文摘Huanglongbing(HLB) is a devastating disease that has led to an acute crisis for growers of citrus, one of the world's most important fruit crops. The phloem-feeding Asian citrus psyllid(ACP), Diaphorina citri, is the main pest at the new shoot stage and is the only natural vector of HLB pathogenic bacteria. Little is known about how plants perceive and defend themselves from this destructive pest. Here, we characterized changes in the expression of various genes in citrus plants that were continuously infested by D. citri for different durations(12, 24, and 48 h). A total of 5 219 differentially expressed genes(DEGs) and 643 common DEGs were identified across all time points. Several pathways related to defense were activated, such as peroxisome, alpha-linolenic acid metabolism, and phenylpropanoid and terpenoid biosynthesis, and some pathways related to growth and signal transduction were suppressed in response to D. citri infestation. The expression of genes including kinases(CML44, CIPK6, and XTH6), phytohormones(SAMT, LOX6, and NPR3), transcription factors(bHLH162, WRKY70, and WRKY40), and secondary metabolite synthesis-related genes(PAL, 4CL2, UGT74B1 and CYP82G1) was significantly altered in response to D. citri infestation. The findings of this study greatly enhance our understanding of the mechanisms underlying the defense response of citrus plants to D. citri infestation at the molecular level. Functional characterization of the candidate defense-related genes identified in this study will aid the molecular breeding of insect-resistant citrus varieties. | Xueli Sun Ting Yu Minliang Bin Chunhua Hu Fangcheng Bi Xinxiang Peng Ganjun Yi Xinxin Zhang | 2023 | Horticultural Plant Journal2023，9，3： | 1 |
| 20 | MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation显示文摘 | Xiaorong Zhang Xinxin Zuo Bo Yang Zongran Li Yuanchao Xue Yu Zhou Jie Huang Xiaolu Zhao Jie Zhou Yun Yan Huiqiong Zhang Peipei Guo Hui Sun Lin Guo Yi Zhang Xiang-Dong Fu | 2014 | Cell2014，，： | 1 |
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