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| 1 | Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study显示文摘Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost was obtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness(ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalization were itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD=6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urban patients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancer patients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACI was associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among the population in China. Preferential policies of medical insurance should be designed to tackle with this burden and further reduce the health care inequalities. | Zhixun Yang Hongmei Zeng Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，4： | 22 |
| 2 | Reliability-based Robust Optimization Design of Automobile Components with Non-normal Distribution Parameters显示文摘In the reliability designing procedure of the vehicle components, when the distribution styles of the random variables are unknown or non-normal distribution, the result evaluated contains great error or even is wrong if the reliability value R is larger than 1 by using the existent method, in which case the formula is necessary to be revised. This is obviously inconvenient for programming. Combining reliability-based optimization theory, robust designing method and reliability based sensitivity analysis, a new method for reliability robust designing is proposed. Therefore the influence level of the designing parameters' changing to the reliability of vehicle components can be obtained. The reliability sensitivity with respect to design parameters is viewed as a sub-objective function in the multi-objective optimization problem satisfying reliability constraints. Given the first four moments of basic random variables, a fourth-moment technique and the proposed optimization procedure can obtain reliability-based robust design of automobile components with non-normal distribution parameters accurately and quickly. By using the proposed method, the distribution style of the random parameters is relaxed. Therefore it is much closer to the actual reliability problems. The numerical examples indicate the following: (1) The reliability value obtained by the robust method proposed increases (>0.04%) comparing to the value obtained by the ordinary optimization algorithm; (2) The absolute value of reliability-based sensitivity decreases (>0.01%), and the robustness of the products' quality is improved accordingly. Utilizing the reliability-based optimization and robust design method in the reliability designing procedure reduces the manufacture cost and provides the theoretical basis for the reliability and robust design of the vehicle components. | YANG Zhou ZHANG Yimin HUANG Xianzhen ZHANG Xufang TANG Le | 2013 | Chinese Journal of Mechanical Engineering2013，26，4： | 14 |
| 3 | Reliability Sensitivity-based Correlation Coefficient Calculation in Structural Reliability Analysis显示文摘The correlation coefficients of random variables of mechanical structures are generally chosen with experience or even ignored,which cannot actually reflect the effects of parameter uncertainties on reliability.To discuss the selection problem of the correlation coefficients from the reliability-based sensitivity point of view,the theory principle of the problem is established based on the results of the reliability sensitivity,and the criterion of correlation among random variables is shown.The values of the correlation coefficients are obtained according to the proposed principle and the reliability sensitivity problem is discussed.Numerical studies have shown the following results:(1) If the sensitivity value of correlation coefficient ρ is less than(at what magnitude 0.000 01),then the correlation could be ignored,which could simplify the procedure without introducing additional error.(2) However,as the difference between ρs,that is the most sensitive to the reliability,and ρR,that is with the smallest reliability,is less than 0.001,ρs is suggested to model the dependency of random variables.This could ensure the robust quality of system without the loss of safety requirement.(3) In the case of |Eabs|ρ0.001 and also |Erel|ρ0.001,ρR should be employed to quantify the correlation among random variables in order to ensure the accuracy of reliability analysis.Application of the proposed approach could provide a practical routine for mechanical design and manufactory to study the reliability and reliability-based sensitivity of basic design variables in mechanical reliability analysis and design. | YANG Zhou ZHANG Yimin ZHANG Xufang HUANG Xianzhen | 2012 | Chinese Journal of Mechanical Engineering2012，25，3： | 11 |
| 4 | System reliability analysis for kinematic performance of planar mechanisms显示文摘Based on the reliability and mechanism kinematic accuracy theories, we propose a general methodology for system reliability analysis of kinematic performance of planar mechanisms. The loop closure equations are used to estimate the kinematic performance errors of planar mechanisms. Reliability and system reliability theories are introduced to develop the limit state functions (LSF) for failure of kinematic performance qualities. The statistical fourth moment method and the Edgeworth series technique are used on system reliability analysis for kinematic performance of planar mechanisms, which relax the restrictions of probability distribution of design variables. Finally, the practicality, efficiency and accuracy of the proposed method are demonstrated by numerical examples. | ZHANG YiMin HUANG XianZhen ZHANG XuFang HE XiangDong WEN BangChun | 2009 | Chinese Science Bulletin2009，54，14： | 9 |
| 5 | Improving plasticity of the Zr46Cu46Al8 bulk metallic glass via thermal rejuvenation显示文摘In this paper,effects of cryogenic thermal cycling on deformation behavior and thermal stability of the Zr_(46)Cu_(46)Al_8bulk metallic glass(BMG)were studied.The results show that with the increase of the number of cryogenic thermal cycles(CTC),thermal stability remains almost unchanged,while the plasticity is increased,indicating that the cryogenic thermal cyclic treatment is an effective way to improve plasticity of metallic glasses without distinctly deteriorating thermal stability.Our analysis suggests that the increase in the defect density resulted from the cryogenic thermal treatments are responsible for the plasticity increment.Variation of yield strength can be well interpreted from microstructural percolation which affected by both density and characteristic volume of the defect sites. | Wenli Song Xiaohe Meng Yuan Wu Di Cao Hui Wang Xiongjun Liu Xianzhen Wang Zhaoping Lu | 2018 | Science Bulletin2018，63，13： | 9 |
| 6 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 7 | Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer显示文摘Identifying sensitive and specific biomarkers for early detection of cancer is immensely imperative for early diagnosis and treatment and better clinical outcome of cancer patients. This study aimed to construct a specific DNA methylation pattern of cancer suppressor genes and explore the feasibility of applying cell-free DNA based methylation as a biomarker for early diagnosis of esophageal squamous cell carcinoma(ESCC). We recruited early stage ESCC patients from Yangzhong County, China. The Illumina Infinium 450 K Methylation BeadChip was used to construct a genome-wide DNA methylation profile. Then, differentiated genes were selected for the validation study using the Sequenom MassARRAY platform. The frequency of methylation was compared between cancer tissues, matched cell-free DNAs and normal controls. The specific methylation profiles were constructed, and the sensitivity and specificity were calculated. Seven CG sites in three genes CASZ1, CDH13 and ING2 were significantly hypermethylated in ESCC as compared with normal controls. A significant correlation was found between the methylation of DNA extracted from cancer tissues and matched plasma cell-free DNA, either for individual CG site or for cumulative methylation analysis. The sensitivity and specificity reached 100% at an appropriate cut-point using these specific methylation biomarkers. This study revealed that aberrant DNA methylation is a promising biomarker for molecular diagnosis of esophageal cancer. Hypermethylation of CASZ1,CDH13 and ING2 detected in plasma cell-free DNA can be applied as a potential noninvasive biomarker for diagnosis of esophageal cancer. | Huanqiang Wang Congying Yang Siyuan Wang Tian Wang Jingling Han Kai Wei Fucun Liu Jida Xu Xianzhen Peng Jianming Wang | 2018 | The Journal of Biomedical Research2018，32，6： | 6 |
| 8 | Design and test of fault monitoring system for corn precision planter显示文摘With the growing demand and working complexity of corn precision planter,it becomes more important to monitor the working performance through intelligent systems.A new fault monitoring system for corn precision planters was designed and tested.This system consisted of the information acquisition module,controller module,alarm module,input module and display module.A capacitive sensor was utilized to monitor the seed flow without changing the track of a precision planter.This system can monitor the whole sowing process of a seed-metering device in real-time.The sowing status,fault type and fault location can be displayed on liquid crystal display(LCD).Warning light on the LCD reminds the operator of abnormal conditions.Bench tests and field tests showed that the minimum monitoring accuracies of missing sowing and total sowing number were 92.11%and 94.28%,respectively,and the seed level sensor and the opener sensor worked well.This system can accurately prompt the seed-metering mechanism in real-time. | Qi Jiangtao Jia Honglei Li Yang Yu Haibo Liu Xinhui Lan Yubin Feng Xianzhen Yang Yongxi | 2015 | International Journal of Agricultural and Biological Engineering2015，8，6： | 6 |
| 9 | Synchrotron radiation-based Fourier-transform infrared spectromicroscopy for characterization of the protein/peptide distribution in single microspheres显示文摘The present study establishes a visualization method for the measurement of the distribution and localization of protein/peptide constituents within a single poly-lactide-co-glycolide(PLGA) microsphere using synchrotron radiation–based Fourier-transform infrared spectromicroscopy(SR-FTIR).The representative infrared wavenumbers specific for protein/peptide(Exenatide) and excipient(PLGA) were identified and chemical maps at the single microsphere level were generated by measuring and plotting the intensity of these specific bands.For quantitative analysis of the distribution within microspheres,Matlab software was used to transform the map file into a 3D matrix and the matrix values specific for the drug and excipient were extracted.Comparison of the normalized SR-FTIR maps of PLGA and Exenatide indicated that PLGA was uniformly distributed,while Exenatide was relatively non-uniformly distributed in the microspheres.In conclusion,SR-FTIR is a rapid,nondestructive and sensitive detection technology to provide the distribution of chemical constituents and functional groups in microparticles and microspheres. | Manli Wang Xiaolong Lu Xianzhen Yin Yajun Tong Weiwei Peng Li Wu Haiyan Li Yan Yang Jingkai Gu Tiqiao Xiao Min Chen Jiwen Zhang | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 5 |
| 10 | High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer’s disease mice显示文摘Accumulating evidence indicates the critical importance of cerebrovascular dysfunction in the pathogenesis of Alzheimer’s disease(AD).However,systematic comparative studies on the precise brain vasculature of wild-type and AD model mice are still rare.Using an image-optimization method for analysing Micro-Optical Sectioning Tomography(MOST)data,we generated cross-scale whole-brain 3 D atlases that cover the entire vascular system from large vessels down to smallest capillaries at submicron resolution,for both wild-type mice and a transgenic(APP/PS1)mouse model of AD.In addition to distinct vascular patterns in different brain regions,we found that the main vessels of the molecular layer of the hippocampal dentate gyrus(DG-ml)undergo abrupt changes in both diameter and branch angle,spreading a unique comb-like pattern of capillaries.By using a quantitative analysis workflow,we identified in the hippocampus of AD mice an overall reduction of the mean vascular diameter,volume fraction and branch angle,with most significant impairment in the DG-ml.In addition,virtual endoscopy revealed irregular morphological features in the vessel lumen of the AD mice,potentially contributing to the impairment of blood flow.Our results demonstrate the capability of high-resolution cross-scale evaluation of brain vasculature and underscore the importance of studying hippocampal microcirculation for understanding AD pathogenesis. | Xiaochuan Zhang Xianzhen Yin Jingjing Zhang Anan Li Hui Gong Qingming Luo Haiyan Zhang Zhaobing Gao Hualiang Jiang | 2019 | National Science Review2019，6，6： | 4 |
| 11 | Anacardic acid(6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling显示文摘Anacardic acid(AA)is a mixture of 2-hydroxy-6-alkylbenzoic acid homologs.It is widely regarded as a non-specific histone acetyltransferase inhibitor of p300.The effects and the mechanisms of AA in LNCaP cells(prostate cancer cells) remain unknown.To investigate the effect of AA on LNCaP cells,we had carried out several experiments and found that AA inhibits LNCaP cell proliferation,induces G1/S cell cycle arrest and apoptosis of LNCaP cell.The mechanisms via which AA acts on LNCaP cells may be due to the following aspects.First,AA can regulate p300 transcription and protein level except for its mechanisms regulating function of p300 through post-translational modification in LNCaP cells.Second,AA can activate p53 through increasing the phosphorylation of p53 on Ser15 in LNCaP cells.AA can selectively activate p21(target genes of p53).Third,AA can down-regulates androgen receptor(AR)through supressing p300.Our study suggests that AA has multiple anti-tumor activities in LNCaP cells and warrants further investigation. | Jing Tan Binghai Chen Leye He Yuxin Tang Zhiqiang Jiang Guangmin Yin Jinrong Wang Xianzhen Jiang | 2012 | Chinese Journal of Cancer Research2012，24，4： | 3 |
| 12 | Optimization of taste-masking on ibuprofen microspheres with selected structure features显示文摘The microsphere was a primary particulate system for taste-masking with unique structural features defined by production process. In this article, ibuprofen lipid microspheres of octadecanol and glycerin monostearate were prepared to mask the undesirable taste of ibuprofen via three kinds of spray congealing processes, namely, air-cooling, water-cooling and citric acid solution-cooling. The stereoscopic and internal structures of ibuprofen microspheres were quantitatively analyzed by synchrotron radiation X-ray micro-computed tomography(SR-μCT) to establish the relationship between the preparation process and microsphere architectures. It was found that the microstructure and morphology of the microspheres were significantly influenced by preparation processes as the primary factors to determine the release profiles and taste-masking effects. The sphericity of ibuprofen microspheres congealed in citric acid solution was higher than that of other two and its morphology was more regular than that being congealed in air or distilled water, and the contact angles between congealing media and melted ibuprofen in octadecanol and glycerin monostearate well demonstrated the structure differences among microspheres of three processes which controlled the release characteristics of the microspheres. The structure parameters like porosity, sphericity, and radius ratio from quantitative analysis were correlated well with drug release behaviors. The results demonstrated that the exterior morphology and internal structure of microspheres had considerable influences on the drug release behaviors as well as taste-masking effects. | Wei Qin Yuanzhi He Zhen Guo Liu Zhang Li Wu Xianzhen Yin Shailendra Shakya Abi Maharjan Yan Tang Weifeng Zhu Jiwen Zhang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 3 |
| 13 | Construction and characterization of a hrpG mutant rendering constitutive expression of hrp genes in Xanthomonas campestris pv.campestris显示文摘在 Xanthomonas 的 hrp 基因的表示被 hrpG, OmpR 类型 transcriptional 使活跃之物,和罐头调整被导致由人工模仿中等 XVM2,但是在富有的中等 NYG 镇压了。在这研究,在 Xanthomonas campestris pv 的 hrpG 的一个地点特定的变化。campestris (Xcc ) 被指导 PCR 的点傻瓜发育不全产生并且被它的显型和 transcriptional 表示分析描绘。结果显示 E45K 变异 hrpG 显示了在抑制媒介 NYG 组成地表示的所有 hrp 基因。植物测试证明那变异的 hrpG 提高了预定和过分敏感的反应(HR ) 的紧张在上上非招待植物辣椒,但是没在文化媒介和植物影响 Xcc 的生长。E45K 变化没引起 exopolysaccharide 绗维素酶和淀粉酶的生产的重要变化,但是在里面禁止了细胞外的朊酶的分泌物。这异种 8004 比对在学习 transcriptional 规定的 vitroand 识别 hrp 家属受动器的野类型更合适染色体宽。 | JIANG Bole XU Rongqi LI Xianzhen WEI Hongyu BAI Faan HU Xi HE Yongqiang TANG Jiliang | 2006 | Progress in Natural Science:Materials International2006，16，5： | 3 |
| 14 | Promoting lacunar bone regeneration with an injectable hydrogel adaptive to the microenvironment显示文摘Injectable hydrogel is suitable for the repair of lacunar bone deficiency.This study fabricated an injectable,self-adaptive silk fibroin/mesoporous bioglass/sodium alginate(SMS)composite hydrogel system.With controllable and adjustable physical and chemical properties,the SMS hydrogel could be easily optimized adaptively to different clinical applications.The SMS hydrogel effectively showed great injectability and shapeability,allowing defect filling with no gap.Moreover,the SMS hydrogel displayed self-adaptability in mechanical reinforcement and degradation,responsive to the concentration of Ca2+and inflammatory-like pH value in the microenvi-ronment of bone deficiency,respectively.In vitro biological studies indicated that SMS hydrogel could promote osteogenic differentiation of bone marrow mesenchymal stem cells by activation of the MAPK signaling pathway.The SMS hydrogel also could improve migration and tube formation of human umbilical vein endothelial cells.Investigations of the crosstalk between osteoblasts and macrophages confirmed that SMS hydrogel could regulate macrophage polarization from M1 to M2,which could create a specific favorable environment to induce new bone formation and angiogenesis.Meanwhile,SMS hydrogel was proved to be antibacterial,especially for gram-negative bacteria.Furthermore,in vivo study indicated that SMS could be easily applied for maxillary sinus elevation,inducing sufficient new bone formation.Thus,it is convincing that SMS hydrogel could be potent in a simple,minimally invasive and efficient treatment for the repair of lacunar bone deficiency. | Ao Zheng Xiao Wang Xianzhen Xin Lingjie Peng Tingshu Su Lingyan Cao Xinquan Jiang | 2023 | Bioactive Materials2023，，3： | 3 |
| 15 | Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography显示文摘This study investigated the formulation mechanism of microspheres via internal surfactant distribution. Eudragit L100 based microspheres loaded with bovine serum albumin were prepared by solid in oil in oil emulsion solvent evaporation method using acetone and liquid paraffin system containing sucrose stearate as a surfactant. The fabricated microspheres were evaluated for encapsulation efficiency, particle size, production yield, and in vitro release characteristics. The internal structures of microspheres were characterized using synchrotron radiation X-ray microcomputed tomography(SR-μCT). The enhanced contrast made the sucrose stearate distinguished from Eudragit to have its three dimensional(3D) distribution. Results indicated that the content and concentration determined the state of sucrose stearate and had significant influences on the release kinetics of protein. The dispersity of sucrose stearate was the primary factor that controlled the structure of the microspheres and further affected the encapsulation efficiency, effective drug loading, as well as in vitro release behavior. In conclusion, the 3D internal distribution of surfactant in microspheres and its effects on protein release behaviors have been revealed for the first time. The highly resolved 3D architecture provides new evidence for the deep understanding of the microsphere formation mechanism. | Li Wu Manli Wang Vikramjeet Singh Haiyan Li Zhen Guo Shuangying Gui Peter York Tiqiao Xiao Xianzhen Yin Jiwen Zhang | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，4： | 2 |
| 16 | A new model in correlating and calculating the solid–liquid equilibrium of salt–water systems显示文摘In this work, a new activity coefficient model was deduced for the correlation of solid–liquid equilibrium(SLE) in electrolyte solutions. The new excess Gibbs energy equation for SLE contains two parts: the single electrolyte item and the mixed electrolyte item. Then a new hypothesis for the reference state of activity coefficients was proposed in the work. Literature data for single electrolyte solution and mixed electrolyte solution systems,with temperature spanning from 273.15 to 373.15 K, were successfully correlated using the developed model. | Xianzhen Xu Yangdong Hu Lianying Wu Xia Chen | 2016 | Chinese Journal of Chemical Engineering2016，24，8： | 2 |
| 17 | Regulation of eight avr genes by hrpG and hrpX in Xanthomonas campestris pv. campestris and their role in pathogenicity显示文摘Eight putative avirulence genes in Xanthomonas campestris pv. campestris (Xcc) strain 8004 were characterized by Tn5gusA5 mutagenesis and gene expression analysis. The virulence test of mutants on Chinese radish showed that all mutants in individual avr genes except avrBs2 mutant were not significantly different from the wild type in virulence. The avrBs2 mutant showed reduced virulence and bacterial growth in planta. Gene expression analysis using β-glucuronidase as reporter indicated that avrBs1.1,avrBs1,avrXccB,avrXccC,avrXccE1 were regulated by hrpG, whereas avrXccA1, avrXccA2 and avrBs2 were not. RT-PCR analysis showed that all hrpG-regulated genes except avrBs1 were also regulated by hrpX. In addition, it was demonstrated that avrBs1 was responsible for elicitation of a type III dependent hypersensitive reaction (HR) on nonhost plant pepper ECW-10R, and wild type Xcc 8004 was unable to cause HR on pepper ECW-20R. | XU Rongqi LI Xianzhen WEI Hongyu JIANG Bole LI Kai HE Yongqiang FENG Jiaxun TANG jiliang | 2006 | Progress in Natural Science:Materials International2006，16，12： | 2 |
| 18 | Interpretable machine-learning strategy for soft-magnetic property and thermal stability in Fe-based metallic glasses显示文摘Fe-based metallic glasses(MGs)have been extensively investigated due to their unique properties,especially the outstanding soft-magnetic properties.However,conventional design of soft-magnetic Fe-based MGs is heavily relied on“trial and error”experiments,and thus difficult to balance the saturation flux density(Bs)and thermal stability due to the strong interplay between the glass formation and magnetic interaction.Herein,we report an eXtreme Gradient Boosting(XGBoost)machine-learning(ML)model for developing advanced Fe-based MGs with a decent combination of Bs and thermal stability. | Zhichao Lu Xin Chen Xiongjun Liu Deye Lin Yuan Wu Yibo Zhang Hui Wang Suihe Jiang Hongxiang Li Xianzhen Wang Zhaoping Lu | 2020 | npj Computational Materials2020，，1： | 2 |
| 19 | Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets显示文摘The shapes of particles and their distribution in tablets, controlled by pretreatment and tableting process, determine the pharmaceutical performance of excipient like lubricant. This study aims to provide deeper insights to the relationship of the morphology and spatial distribution of stearic acid(SA) with the lubrication efficiency, as well as the resulting tablet property. Unmodified SA particles as flat sheet-like particles were firstly reprocessed by emulsification in hot water to obtain the reprocessed SA particles with spherical morphology. The three-dimensional(3 D) information of SA particles in tablets was detected by a quantitative and non-invasive 3 D structure elucidation technique, namely, synchrotron radiation X-ray micro-computed tomography(SR-μCT). SA particles in glipizide tablets prepared by using unmodified SA(GUT), reprocessed SA(GRT), as well as reference listed drug(RLD) of glipizide tablets were analyzed by SR-μCT. The results showed that the reprocessed SA with better flowability contributed to similarity of breaking forces between that of GRT and RLD. SA particles in GRT were very similar to those in RLD with uniform morphology and particle size, while SA particles in GUT were not evenly distributed. These findings not only demonstrated the feasibility of SR-μCT as a new method in revealing the morphology and spatial distribution of excipient in drug delivery system, but also deepened insights of solid dosage form design into a new scale by powder engineering. | Liu Zhang Shailendra Shakya Li Wu Jiangtao Wang Guanghui Jin Huimin Sun Xianzhen Yin Lixin Sun Jiwen Zhang | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，1： | 2 |
| 20 | Self-supporting nanoporous Ni/metallic glass composites with hierarchically porous structure for efficient hydrogen evolution reaction显示文摘Searching for free-standing and cost-efficient hydrogen evolution reaction(HER)electrocatalysts with high efficiency and excellent durability remains a great challenge for the hydrogen-based energy industry.Here,we report fabrication of a unique hierarchically porous structure,i.e.,nanoporous Ni(NPN)/metallic glass(MG)composite,through surface dealloying of the specially designed Ni_(40)Zr_(40)Ti_(20)MG wire.This porous composite is composed of micrometer slits staggered with nanometer pores,which not only enlarges effective surface areas for the catalytic reaction,but also facilitates the release of H2 gas.As a result,the NPN/MG hybrid electrode exhibited the prominent HER performance with a low overpotential of 78 m V at 10 m A cm^(-2)and Tafel slope of 42.4 m V dec^(-1),along with outstanding stability in alkaline solutions.Outstanding catalytic properties,combining with their free-standing capability and cost efficiency,make the current composite electrode viable for HER applications. | Jing Wang Li You Zhibin Li Xiongjun Liu Rui Li Qing Du Xianzhen Wang Hui Wang Yuan Wu Suihe Jiang Zhaoping Lu | 2021 | Journal of Materials Science & Technology2021，，14： | 2 |
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