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| 1 | Microstructure and Mechanical Properties of C/C-ZrC-SiC Composites Fabricated by Reactive Melt Infiltration with Zr,Si Mixed Powders显示文摘To meet the increasing demand for advanced materials capable of operation over 2000℃for future thermal protection systems application,C/C—ZrC—SiC composites were fabricated by reactive melt infiltration(RMI) with Zr,Si mixed powders as raw materials.The structural evolution and formation mechanism of the C/C—ZrC -SiC composites were discussed,and the mechanical property of the as-prepared material was investigated by compression test.The results showed that after the RMI process,a special structure with ZrC-SiC multi-coating as outer layer and ZrC-SiC-PyC ceramics as inner matrix was formed.ZrC and SiC rich areas were formed in the composites and on the coating surface due to the formation of Zr-Si intermetallic compounds in the RMI process.Mechanical tests showed that the average compression strength of the C/C-ZrC-SiC composites was 133.86 MPa,and the carbon fibers in the composites were not seriously damaged after the RMI process. | Xin Yang Zhean Su Qizhong Huang Xiao Fang Liyuan Chai | 2013 | Journal of Materials Science & Technology2013，29，8： | 25 |
| 2 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 3 | Gefitinib plus Fuzheng Kang'ai Formula(扶正抗癌方) in Patients with Advanced Non-Small Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation:A Randomized Controlled Trial显示文摘Objective: To evaluate the effect of Fuzheng Kang'ai Formula(扶正抗癌方, FZKA) plus gefitinib in patients with advanced non-small cell lung cancer with epidermal growth factor receptor(EGFR) mutations. Methods: A randomized controlled trial was conducted from 2009 to 2012 in South China. Seventy chemotherapynaive patients diagnosed with stage ⅢB/Ⅳ non-small cell lung cancer with EGFR mutations were randomly assigned to GF group [gefitinib(250 mg/day orally) plus FZKA(250 m L, twice per day, orally); 35 cases] or G group(gefitinib 250 mg/day orally; 35 cases) according to the random number table and received treatment until progression of the disease, or development of unacceptable toxicities. The primary endpoint [progression-free survival(PFS)] and secondary endpoints [median survival time(MST), objective response rate(ORR), disease control rate(DCR) and safety] were observed. Results: No patient was excluded after randomization. GF group had significantly longer PFS and MST compared with the G group, with median PFS of 12.5 months(95% CI 3.30–21.69) vs. 8.4 months(95% CI 6.30–10.50; log-rank P<0.01), MST of 21.5 months(95% CI 17.28–25.73) vs. 18.3 months(95% CI 17.97–18.63; log-rank P<0.01). ORR and DCR in GF group and G group were 65.7% vs. 57.1%, 94.3% vs. 80.0%, respectively(P>0.05). The most common toxic effects in the GF group and G group were rash or acne(42.8% vs. 57.1%, P>0.05), diarrhea(11.5% vs. 31.4%, P<0.05), and stomatitis(2.9% vs. 8.7%, P>0.05). Conclusion: Patients with advanced non-small cell lung cancer selected by EGFR mutations have longer PFS, MST with less toxicity treated with gefitinib plus FZKA than gefitinib alone. | YANG Xiao-bing CHAI Xiao-shu WU Wan-yin LONG Shun-qin DENG Hong PAN Zong-qi HE Wen-feng ZHOU Yu-shu LIAO Gui-ya XIAO Shu-jing | 2018 | Chinese Journal of Integrative Medicine2018，24，10： | 15 |
| 4 | Effects of rare earth elements La and Yb on the morphological and functional development of zebrafish embryos显示文摘In recent years,with the wide applications and mineral exploitation of rare earth elements,their potential environmental and health effects have caused increasing public concern.Effect of rare earth elements La and Yb on the morphological and functional development of zebrafish embryos were studied.The embryos were exposed to La3+ or Yb3+ at 0,0.01,0.1,0.3,0.5 and 1.0 mmol/L,respectively.Early life stage parameters such as egg and embryo mortality,gastrula development,tail detachment,eyes,somite formation,circulatory system,pigmentation,malformations,hatching rate,length of larvae and mortality were investigated.The results showed La3+ and Yb3+ delayed zebrafish embryo and larval development,decreased survival and hatching rates,and caused tail malformation in a concentration-dependent way.Moreover,heavy rare-earth ytterbium led to more severe acute toxicity of zebrafish embryo than light rare-earth lanthanum. | Jun'an Cui Zhiyong Zhang Wei Bai Ligang Zhang Xiao He Yuhui Ma Yan Liu Zhifang Chai | 2012 | Journal of Environmental Sciences2012，24，2： | 8 |
| 5 | Multipoint optimization on fuel efficiency in conceptual design of wide-body aircraft显示文摘Aircraft conceptual design optimizations that maximize the performance at a design condition(single-point) may result in designs with unsatisfying off-design performance.To further improve aircraft efficiency under actual flight operations, there is a need to consider multiple flight conditions(multipoint) in aircraft conceptual design and optimization.A new strategy for multipoint optimizations in aircraft conceptual design is proposed in this paper.A wide-body aircraft is taken as an example for both single-point and multipoint optimizations with the objective of maximizing the specific hourly productivity.Boeing 787-8 flight data was used in the multipoint optimization to reflect the true objective function.The results show that the optimal design from the multipoint optimization has a 7.72% total specific hourly productivity increase of entire flight missions compared with that of the baseline aircraft, while the increase in the total specific hourly productivity from the single-point optimal design is only 5.73%.The differences between the results of single-point and multipoint optimizations indicate that there is a good option to further improve aircraft efficiency by considering actual flight conditions in aircraft conceptual design and optimization. | Xiao CHAI Xiongqing YU Yu WANG | 2018 | Chinese Journal of Aeronautics2018，31，1： | 7 |
| 6 | Diagnostic value of the fluoroscopic triggering 3D LAVA technique for primary liver cancer显示文摘BACKGROUND:Primary liver cancer(PLC)is one of the common malignant tumors.Liver acquisition with acceleration volume acquisition(LAVA),which allows simultaneous dynamic enhancement of the hepatic parenchyma and vascu- lature imaging,is of great help in the diagnosis of PLC.This study aimed to evaluate application of the fluoroscopic triggering 3D LAVA technique in the imaging of PLC and liver vasculature. METHODS:The clinical data and imaging findings of 38 adults with PLC(22 men and 16 women;average age 52 years),pathologically confirmed by surgical resection or biopsy,were collected and analyzed.All magnetic resonance images were obtained with a 1.5-T system(General Electrics Medical Systems) with an eight-element body array coil and application of the fluoroscopic triggering 3D LAVA technique.Overall image quality was assessed on a 5-point scale by two experienced radiologists. All the nodules and blood vessel were recorded and compared. The diagnostic accuracy and feasibility of LAVA were evaluated. RESULTS:Thirty-eight patients gave high quality images of 72 nodules in the liver for diagnosis.The accuracy of LAVA was 97.2%(70/72),and the coincidence rate between the extent of tumor judged by dynamic enhancement and pathological examination was 87.5%(63/72).Displayed by the maximum intensity projection reconstruction,nearly all cases gave satisfactory images of branchesⅢandⅣof the hepatic artery. Furthermore,small early-stage enhancing hepatic lesions and the parallel portal vein were also well displayed. CONCLUSIONS:Sequence of LAVA provides good multi-phase dynamic enhancement scanning of hepatic lesions.Combined with conventional scanning technology,LAVA effectively and safely displays focal hepatic lesions and the relationship between tumor and normal tissues,especially blood vessels. | Shen, Xiao-Yong Chai, Chun-Hua Xiao, Wen-Bo Wang, Qi-Dong | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，2： | 7 |
| 7 | Integrated simulation and assessment of water quantity and quality for a river under changing environmental conditions显示文摘The water cycle and water resources within river basins under changing environmental conditions undergo profound changes, which have significant effects on the water environment of the river. Owing to the water resources demanded for economic and social development, water quantity and quality are becoming the core constraints of water resources development and utilization. In this paper, the dual attributes of water resources, progress into research regarding water quantity and quality joint assessment and simulation and the shortcomings associated with these techniques are summarized and described with respect to water quantity and quality. The results indicated that under the current environmental conditions, the method used for traditional water quality assessment of single water bodies cannot meet the requirements for water resources management. Moreover, a coupled hydrodynamic and water quality numerical model for river networks and lakes that applies to the river water environment system was developed for the river network flow and pollutant migration and transformation process and validated. This validation revealed that the error between the simulated values calculated by the model and the monitored values was small, meeting the application requirements and realizing the integrated and dynamic simulation of water quantity and quality of the river water environmental system. On this basis, the integrated simulation model was applied to the Luanhe River Basin. | WANG JianHua XIAO WeiHua WANG Hao CHAI ZengKai NIU CunWen LI Wei | 2013 | Chinese Science Bulletin2013，58，27： | 7 |
| 8 | In-situ electrochemical activation designed hybrid electrocatalysts for water electrolysis显示文摘Developing transition metal-based electrocatalysts with rich active sites for water electrolysis plays important roles in renewable energy fields. So far, some strategies including designing nanostructures,incorporating conductive support or foreign elements have been adopted to develop efficient electrocatalysts. Herein, we summarize recent progresses and propose in-situ electrochemical activation as a new pretreating technique for enhanced catalytic performances. The activation techniques mainly comprise facile electrochemical processes such as anodic oxidation, cathodic reduction, etching, lithium-assisted tuning and counter electrode electro-dissolution. During these electrochemical treatments, the catalyst surfaces are modified from bulk phase, which can tune local electronic structures, create more active species, enlarge surface area and thus improve the catalytic performances. Meanwhile, this technique can couple the atomic, electronic structures with electrocatalysis mechanisms for water splitting.Compared to traditional chemical treatment, the in-situ electrochemical activation techniques have superior advantages such as facile operation, mild environment, variable control, high efficiency and flexibility. This review may provide guidance for improving water electrolysis efficiencies and hold promising for application in many other energy-conversion fields such as supercapacitors, fuel cells and batteries. | Xiao Shang Bin Dong Yong-Ming Chai Chen-Guang Liu | 2018 | Science Bulletin2018，63，13： | 6 |
| 9 | Wholesale Pricing and Evolutionarily Stable Strategy in Duopoly Supply Chains with Social Responsibility显示文摘This paper analyzes manufacturers’ wholesale price decisions and the evolutionarily stable strategies of the retailers’ marketing behavior in duopoly supply chains, where each chain consists of one manufacturer and many retailers. Each retailer chooses one of two marketing strategies: social responsibility or non-social responsibility (i.e., a firm only cares about the benefits of its shareholders). We identify the conditions under which a strategy profile is evolutionarily stable. Furthermore, we investigate the manufacturers’ wholesale prices and find the following:(i) the retailer’s social responsibility decreases the unit wholesale price;(ii) when the degree of the retailer’s social responsibility is medium, the social responsibility of the retailer in a supply chain increases the profit of the retailer’s own manufacturer and decreases the profit of the rival’s manufacturer;otherwise, it decreases the profits of the two manufacturers;and (iii) when each retailer exhibits its social responsibility moderately, a triple-win situation can be achieved. | Caichun Chai Tiaojun Xiao | 2019 | Journal of Systems Science and Systems Engineering2019，28，1： | 5 |
| 10 | Design and synthesis of novel triazole antifungal derivatives based on the active site of fungal lanosterol 14a-demethylase(CYP51)显示文摘一系列 1-(1H-1,2,4-triazole-1-yl )-2-(2,4-difluorophenyl)-3-(N-isoproyl-N-substituted-amino)-2-propanols 根据 lanosterol 14a-demethylase (CYP51 ) 的活跃地点被设计了并且综合。他们的结构被 MS 和 1 H NMR。在 vitro,这些综合混合物的抗真菌的活动与八人的病原的真菌被作比较。结果证明所有标题混合物对测试到某程度的真菌展出了活动。混合物 3c, 3d, 7a, 7b 和 7c 展出了更多的有势力对将近除了曲霉属菌 fumigatus,真菌比 fluconazole 测试了的所有的抗真菌的活动。 | Zhi Gang Dan Jun Zhang Shi Chong Yu Hong Gang Hu Xiao Yun Chai Qing Yan Sun Qiu Ye Wu | 2009 | Chinese Chemical Letters2009，20，8： | 5 |
| 11 | Evolution of surface microstructure of Cu-50Cr alloy treated by high current pulsed electron beam显示文摘A Cu-50Cr alloy was treated by the high current pulsed electron beam(HCPEB)at 20 and 30 ke V with pulse numbers ranging from 1 to 100.Surface morphologies and microstructures of specimens before and after the treatments were investigated by employing scanning electron microscopy and X-ray diffraction.Results show that the HCPEB technique is able to induce remarkable surface modifications for the Cu-50Cr alloy.Cracks in Cr phases appear even after one-pulse treatment and their density always increases with the pulse number.Formation reason for these cracks is attributed to quasi-static thermal stresses accumulated along the specimen surface.Craters with typical morphologies are formed due to the dynamic thermal field induced by the HCPEB and they are found to prefer the sites near cracks or boundaries between neighboring Cr phases.Another microstructural characteristic produced by the HCPEB is the fine Cr spheroids,which are determined to be due to occurrence of liquid phase separation in the Cu-50Cr alloy.Finally,a general microstructural evolution profile that incorporates various HCPEB-induced surface features is tentatively outlined. | CHAI LinJiang ZHOU ZhiMing XIAO ZhiPei TU Jian WANG YaPing HUANG WeiJiu | 2015 | Science China(Technological Sciences)2015，58，3： | 5 |
| 12 | Periodontal status and associated risk factors among childbearing age women in Cixi City of China显示文摘Objective:To investigate the periodontal status and associated risk factors among women of childbearing age to increase the awareness of oral health.Methods:The study was conducted on childbearing age women in Cixi,a city in Zhejiang Province in the southeast of China.A total of 754 women participated in periodontal examination while receiving prenatal care.Data of the women were collected from the Cixi Family Planning Commission and during an interview.Clinical periodontal indices,such as bleeding on probing(BOP),probing depth(PD),and clinical attachment level(CAL) were measured during the examination.Statistical analysis on subject-based data was performed.Results:The prevalence of periodontal disease among childbearing age women in Cixi was high(84.7%).A significant association was found between the disease and educational level,pregnancy,taking oral contraceptives,stress,alcohol consumption,overweight,dental visit,and teeth brushing(P<0.05).Women who suffered periodontal disease showed deep PD,obvious BOP,and clinical attachment loss.Among this population,pregnancy was closely associated with higher BOP percentage;teeth brushing no more than once per day or brushing for less than 1 min(P<0.001) after adjusting for age and stress.Conclusions:The periodontal status of childbearing age women in Cixi needs to be improved urgently.Attention towards the periodontal health should be warranted,especially for those in special statuses and with poor awareness. | Yan-min WU Jia LIU Wei-lian SUN Li-li CHEN Li-guo CHAI Xiang XIAO Zheng CAO | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，3： | 4 |
| 13 | Selective feeding of bay scallop Argopecten irradians on phytoplankton community revealed by HPLC analysis of phytopigments in Bohai Sea, China显示文摘Understanding the feeding selectivity on phytoplankton by shellfi sh is currently a big challenge. In order to investigate the feeding behavior of bay scallop ( Argopecten irradians ) on phytoplankton, we compared its compositions of phytopigments in digestive glands with those in the surrounding seawater, and conducted fi ve consecutive investigations between July and November 2016 in a bay scallop culture area along coast of Qinghuangdao City, northwest of the Bohai Sea, China. Phytopigments in four-size fractionated phytoplankton of seawater (micro-(20-200 μm);nano(L)-[10-20 μm];nano(S)-[2.7-10 μm], and pico-[<2.7 μm]) and digestive glands of A . irradians were examined to investigate the selective feeding of A . irradians . Results show that fucoxanthin and peridinin constituted the major part of taxonomically diagnostic carotenoids (TDCs) in the micro- and nano(L)-phytoplankton in seawater. Compared with total phytoplankton biomass of seawater (TPB, sum of the four sizes), a substantial decrease of fucoxanthin proportion to total DCs in digestive glands was observed while that of peridinin, 19′-butanoyloxyfucoxanthin, alloxanthin and 19′-hexanoyloxy-fucoxanthin showed an obvious increase when those pigments were mainly confi ned to micro-sized phytoplankton (20-200 μm). However, zeaxanthin and prasinoxanthin were mainly confi ned to nano(s)- and pico-phytoplankton, of which the proportions in digestive glands were usually lower in TPB. The contribution of lutein to total DCs in digestive glands (with an average of 7.23%) increased compared with TPB of seawater (with an average of 0.63%) during all fi ve sampling times. | JIANG Tao WANG Longhua ZHANG Fuchong FANG Xiao LU Lin ZHANG Jihong WANG Wei QU Keming CHAI Chao | 2019 | Journal of Oceanology and Limnology2019，37，5： | 4 |
| 14 | Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases显示文摘Ras homolog(Rho)-associated kinases(ROCKs)belong to the serine-threonine kinase family,which plays a pivotal role in regulating the damage,survival,axon guidance,and regeneration of neurons.ROCKs are also involved in the biological effects of immune cells and glial cells,as well as the development of neurodegenerative disorders such as Alzheimer’s disease,Parkinson’s disease,and multiple sclerosis.Previous studies by us and others confirmed that ROCKs inhibitors attenuated the symptoms and progression of experimental models of the abovementioned neurodegenerative diseases by inhibiting neuroinflammation,regulating immune imbalance,repairing the blood-brain barrier,and promoting nerve repair and myelin regeneration.Fasudil,the first ROCKs inhibitor to be used clinically,has a good therapeutic effect on neurodegenerative diseases.Fasudil increases the activity of neural stem cells and mesenchymal stem cells,thus optimizing cell therapy.This review will systematically describe,for the first time,the effects of abnormal activation of ROCKs on T cells,B cells,microglia,astrocytes,oligodendrocytes,and pericytes in neurodegenerative diseases of the central nervous system,summarize the therapeutic potential of fasudil in several experimental models of neurodegenerative diseases,and clarify the possible cellular and molecular mechanisms of ROCKs inhibition.This review also proposes that fasudil is a novel potential treatment,especially in combination with cell-based therapy.Findings from this review add support for further investigation of ROCKs and its inhibitor fasudil for the treatment of neurodegenerative diseases. | Qing Wang Li-Juan Song Zhi-Bin Ding Zhi Chai Jie-Zhong Yu Bao-Guo Xiao Cun-Gen Ma | 2022 | Neural Regeneration Research2022，17，12： | 3 |
| 15 | High Impact Resistance Epoxy Resins by Incorporation of Quadruply Hydrogen Bonded Supramolecular Polymers显示文摘A bisphenol A based epoxy was incorporated with a quadruply hydrogen bonded supramolecular polymer as a toughening agent to prepare a composite epoxy resin with higher impact resistance. The supramolecular polymer comprising poly-(propylene glycol) bis(2-aminopropyl) ether chains and 2-ureido-4[1H]-pyrimidinone moieties(UPy) self-assembled into spherical domains with sizes of 300 nm to 600 nm in diameter by micro phase separation in bulk epoxy matrixes. A significant improvement of 300% in impact resistance of the supramolecular polymer incorporated epoxy resin was obtained when the content of supramolecular polymer was 10 wt%. Tensile tests showed that the mechanical properties of the modified epoxy resin containing the hydrogen-bonded supramolecular polymers are also improved compared with those of the neat epoxy resin. | Zhuo-ye Chai 谢众 Peng Zhang Xiao Ouyang Rui Li Shan Gao 魏浩 Lian-he Liu Zhi-jun Shuai | 2016 | Chinese Journal of Polymer Science2016，34，7： | 2 |
| 16 | Evolution of Specialization with Reachable Transaction Scope Based on a Simple and Symmetric Firm Resource Allocation Model显示文摘In the last decade, as an emerging transaction measure driven by computer and internet technology,e-commerce experienced explosive growth in many areas. It has greatly broken down the limitations of space and time to economic activities, thus changing the rules of business fundamentally. Significant work has been done to understand the laws of e-commerce from multiple dimensions, but the question of how e-commerce shapes firms' specialization and market structure from the perspective of spatial factors remains obscure. In this paper, we propose a simple and symmetric firm resource allocation model with a specialized-economy production function and market size constraint, to investigate how individual firms adjust resource allocation with reachable transaction scope expanded. It is shown that with the expansion of reachable transaction scope, individual firms discretely take back one unit resource from a low-investment direction and, instead, channel it to a 'specialized direction'.Meanwhile, at the macro level, an optimal division network evolves from a static self-sufficient stage to a diverse semi-specialized stage, and finally to a highly integrated completely specialized stage. Ergo, a Complex Adaptive System(CAS) based simulation framework is constructed. Designed simulation experiments are carried out and confirm to the analysis result of our proposed model. | Xiao Sun Yueting Chai Yi Liu Jianping Shen Yadong Huang | 2017 | Tsinghua Science and Technology2017，22，1： | 2 |
| 17 | Subcellular distribution and chemical forms of cadmium in Bechmeria nivea (L.) Gaud.显示文摘 | Xin Wang Yunguo Liu Guangming Zeng Liyuan Chai Xiaochen Song Zongyi Min Xin Xiao | 2007 | Environmental and Experimental Botany2007，，3： | 2 |
| 18 | Electrochemical Lithium Storage Performance of Molten Salt Derived V_(2)SnC MAX Phase显示文摘MAX phases are gaining attention as precursors of two-dimensional MXenes that are intensively pursued in applications for electrochemical energy storage.Here,we report the preparation of V_(2)SnC MAX phase by the molten salt method.V_(2)SnC is investigated as a lithium storage anode,showing a high gravimetric capacity of 490 mAh g−1 and volumetric capacity of 570 mAh cm^(−3) as well as superior rate performance of 95 mAh g^(−1)(110 mAh cm^(−3))at 50 C,surpassing the ever-reported performance of MAX phase anodes.Sup-ported by operando X-ray diffraction and density functional theory,a charge storage mechanism with dual redox reaction is proposed with a Sn-Li(de)alloying reaction that occurs at the edge sites of V_(2)SnC particles where Sn atoms are exposed to the electrolyte followed by a redox reaction that occurs at V_(2)C layers with Li.This study offers promise of using MAX phases with M-site and A-site elements that are redox active as high-rate lithium storage materials. | Youbing Li Guoliang Ma Hui Shao Peng Xiao Jun Lu Jin Xu Jinrong Hou Ke Chen Xiao Zhang Mian Li Per OÅPersson Lars Hultman Per Eklund Shiyu Du Zhifang Chai Zhengren Huang Na Jin Jiwei Ma Ying Liu Zifeng Lin Qing Huang | 2021 | Nano-Micro Letters2021，13，10： | 2 |
| 19 | Chinese clinical practice guidelines for ultrasound-guided irreversible electroporation of liver cancer(version 2022)显示文摘Introduction Liver cancer remains a global health challenge,and its incidence is increasing worldwide.It is estimated that by 2025,more than one million individuals will be affected by liver cancer annually[1,2].In recent years,ablation has become a widely accepted treatment option for patients with primary and secondary liver malignancies[3].The commonly used ablation method for liver cancer is thermal ablation,including radiofrequency ablation. | Min Xu Li-Ting Xie Yue-Yong Xiao Ping Liang Qi-Yu Zhao Zhong-Min Wang Wei-Lu Chai Ying-Tian Wei Lin-Feng Xu Xiao-Kun Hu Ming Kuang Li-Zhi Niu Chen-Guo Yao Hai-Ying Kong Guo Tian Xiao-Yan Xie Xin-Wu Cui Dong Xu Jun Zhao Tian-An Jiang The Interventional Diagnosis and Treatment Group of the Ultrasonic Medicine Branch of Chinese Medical Association,The Nanoknife Tumor Ablation Society of the Interventional Minimally Invasive Therapy Special Committee of China Medicine Education Association | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，5： | 2 |
| 20 | Effects of Blast Wave-induced Biomechanical Changes on Lung Injury in Rats显示文摘Objective To observe the dynamic impacts of shock waves on the severity of lung injury in rats with different injury distances.Methods Simulate open-field shock waves;detect the biomechanical effects of explosion sources at distances of 40,44,and 48 cm from rats;and examine the changes in the gross anatomy of the lungs,lung wet/dry weight ratio,hemoglobin concentration,blood gas analysis,and pathology.Results Biomechanical parameters such as the overpressure peak and impulse were gradually attenuated with an increase in the injury distance.The lung tissue hemorrhage,edema,oxygenation index,and pathology changed more significantly for the 40 cm group than for the 44 and 48 cm groups.The overpressure peak and impulse were significantly higher for the 40 cm group than for the 44 and 48 cm groups(P<0.05 or P<0.01).The animal mortality was significantly higher for the 40 cm group than for the other two groups(41.2%vs.17.8%and 10.0%,P<0.05).The healing time of injured lung tissues for the 40 cm group was longer than those for the 44 and 48 cm groups.Conclusions The effects of simulated open-field shock waves on the severity of lung injuries in rats were correlated with the injury distances,the peak overpressure,and the overpressure impulse. | LIU Wei CHAI Jia Ke QIN Bin HAN Shao Fang WANG Xiao Teng JIANG Shuai BAI Hai Liang LIU Ling Ying CHANG Yang YUE Xiao Tong WU Yu Shou ZHANG Zi Hao TANG Lang | 2020 | Biomedical and Environmental Sciences2020，33，5： | 2 |
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