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| 1 | Ternary NiCoP nanosheet arrays: An excellent bifunctional catalyst for alkaline overall water splitting显示文摘为氢和氧进化反应探索 bifunctional 催化剂(她和 OER ) 与高度,效率,低费用,和容易的集成为未来是极其关键的可更新的精力系统。此处,第三的 NiCoP nanosheet 数组(NSA ) 被 phosphorization 跟随的一个灵巧的热水的方法在 3D Ni 泡沫上制作。这些数组作为 bifunctional 服务碱的催化剂,展出为 HER 和 OER 的优秀 electrocatalytic 性能和好工作稳定性。分别地,要求为 HER 和 OER 驾驶 50 妈 / 厘米 2 的当前的密度的 NiCoP NSA 电极的过电位象 133 和 308 mV 一样低它被归功于到优秀内在的 electrocatalytic 活动,快电子运输,和唯一的 superaerophobic 结构。当 NiCoP 综合作为时阳极并且 cathodic 材料, electrolyzer 要求了象~一样低的一个潜力为切开的全面的水驾驶 50 妈/厘米2的当前的密度的 1.77 V ,它是比用基于磷化物的材料的一样的类型的报导 electrolyzer 小得多的并且比 Pt/C 和 Ir/C 的联合甚至好,最好已知的高贵基于金属的电极。联合令人满意的工作稳定性和高活动,这个 NiCoP 电极为探索切开催化剂的全面的水铺平道路。 | Yingjie Li Haichuan Zhang Ming Jiang Yun Kuang Xiaoming Sun Xue Duan | 2016 | Nano Research2016，9，8： | 20 |
| 2 | Microwave ablation is as effective as radiofrequency ablation for very-early-stage hepatocellular carcinoma显示文摘Background: Percutaneous radiofrequency ablation(RFA) is a first?line treatment for very?early?stage hepatocellular carcinoma(HCC), whereas the efficacy of percutaneous microwave ablation(MWA) for very?early?stage HCC remains unclear. The purpose of this study was to clarify this issue by comparing the safety and efficacy of percutaneous MWA with percutaneous RFA in treating very?early?stage HCC.Methods: Clinical data of 460 patients who were diagnosed with very?early?stage HCC and treated with percutane?ous MWA or RFA between January 2007 and July 2012 at the Eastern Hepatobiliary Surgery Hospital, The Second Mili?tary Medical University, in Shanghai, China were retrospectively analyzed. Of these 460 patients, 159 received RFA, 301 received MWA. Overall survival(OS), recurrence?free survival(RFS), local tumor progression(LTP), complete ablation, and complication occurrence rates were compared between the two groups, and the prognostic factors associated with survival were analyzed.Results: No significant differences were observed between the two groups in terms of the 1?, 3?, or 5?year OS rates(99.3%, 90.4%, and 78.3% for MWA vs. 98.7%, 86.8%, and 73.3% for RFA, respectively; P = 0.331). Furthermore, no signif?icant differences were observed between the two groups in terms of the corresponding RFS rates(94.4%, 71.8%, and 46.9% for MWA vs. 89.9%, 67.3%, and 54.9% for RFA, respectively; P ete ablation rates(98.3% vs. 98.1%, P = 0.309), the LTP rates(9.6% vs. 10.1%, P = 0.883), the compl multivariate analysis, LTP, an= 0.860), or the occurrence rates of major complications(0.7% vs. 0.6%, P = 0.691). Bytiviral therapy, and treatment of recurrence were independent risk fac?tors for OS(P < 0.001), and the alpha?fetoprotein level was an independent prognostic factor for RFS(P = 0.002).Conclusions: MWA is as safe and effective as RFA in treating very?early?stage HCC, supporting MWA as a first?line treatment option for this disease. | Yun Xu Qiang Shen Neng Wang Pan-Pan Wu Bin Huang Ming Kuang Guo-Jun Qian | 2017 | Chinese Journal of Cancer2017，36，5： | 15 |
| 3 | Differentiation of intrahepatic cholangiocarcinoma from hepatocellular carcinoma in high-risk patients: a predictive model using contrast-enhanced ultrasound显示文摘AIM To develop a contrast-enhanced ultrasound(CEUS)predictive model for distinguishing intrahepatic cholangiocarcinoma(ICC) from hepatocellular carcinoma(HCC) in high-risk patients.METHODS This retrospective study consisted of 88 consecutive high-risk patients with ICC and 88 high-risk patients with HCC selected by propensity score matching between May 2004 and July 2016. Patients were assigned to two groups, namely, a training set and validation set, at a 1:1 ratio. A CEUS score for diagnosing ICC was generated based on significant CEUS features. Then, a nomogram based on the CEUS score was developed, integrating the clinical data. The performance of the nomogram was then validated and compared with that of the LR-M of the CEUS Liver Imaging Reporting and Data System(LI-RADS).RESULTS The most useful CEUS features for ICC were as follows: rim enhancement(64.5%), early washout(91.9%), intratumoral vein(58.1%), obscure boundary of intratumoral non-enhanced area(64.5%), and marked washout(61.3%, all P < 0.05). In the validation set, the area under the curve(AUC) of the CEUS score(AUC = 0.953) for differentiation between ICC and HCC was improved compared to the LI-RADS(AUC = 0.742)(P < 0.001). When clinical data were added, the CEUS score nomogram was superior to the LI-RADS nomogram(AUC: 0.973 vs 0.916, P = 0.036, Net Reclassification Improvement: 0.077, Integrated Discrimination Index: 0.152). Subgroup analysis demonstrated that the CEUS score model was notably improved compared to the LIRADS in tumors smaller than 5.0 cm(P < 0.05) but not improved in tumors smaller than 3.0 cm(P > 0.05).CONCLUSION The CEUS predictive model for differentiation between ICC and HCC in high-risk patients had improved discrimination and clinical usefulness compared to the CEUS LIRADS. | Li-Da Chen Si-Min Ruan Jin-Yu Liang Zheng Yang Shun-Li Shen Yang Huang Wei Li Zhu Wang Xiao-Yan Xie Ming-De Lu Ming Kuang Wei Wang | 2018 | World Journal of Gastroenterology2018，24，33： | 14 |
| 4 | Combined vascular resection and analysis of prognostic factors for hilar cholangiocarcinoma显示文摘BACKGROUND: Hilar cholangiocarcinoma(HCCA) is a devastating malignancy arising from the bifurcation of the hepatic duct,whether combined vascular resection benefits HCCA patients is controversial. This study was undertaken to assess the effect of combined vascular resection in HCCA patients and to analyze the prognostic factors. METHODS: Clinical data of 154 HCCA patients who had been treated from January 2005 to December 2012 were retrospectively analyzed. The patients were divided into three groups based on vascular resection: those without vascular resection; those with portal vein resection alone and those with hepatic artery resection. The survival and complication rates were compared among the three groups. Multivariate analysis was made to determine prognostic factors.RESULTS: No significant differences were found in survival and complication rates among the three groups(P>0.05). Multivariate analysis showed that 3 factors were related to survival: lymph node metastasis,tumor size(>2.5 cm),and positive resection margin.CONCLUSIONS: Vascular resection improved the survival rate of patients with HCCA involving the hepatic artery or portal vein. Lymph node metastasis,tumor size(>2.5 cm) and positive resection margin were poor prognostic factors in patients with HCCA. | Shu-Tong Wang Shun-Li Shen Bao-Gang Peng Yun-Peng Hua Bin Chen Ming Kuang Shao-Qiang Li Qiang He Li-Jian Liang | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，6： | 12 |
| 5 | Astragaloside Ⅳ protects RGC-5 cells against oxidative stress显示文摘Astragaloside Ⅳ is the main active compound of Astragalus membranaceus. Astragaloside Ⅳ has strong anti-oxidative activities and protective effects against progression of peripheral neuropathy. In this study, we determined whether astragaloside Ⅳ protects retinal ganglion cells(RGC) from oxidative stress injury using the rat RGC-5 cell line. Hydrogen peroxide(H_2O_2) was used to induce oxidative stress injury, with the protective effect of astragaloside Ⅳ examined. Cell Counting Kit-8 and 4′,6-diamidino-2-phenylindole staining showed that astragaloside Ⅳ increased cell survival rate and decreased apoptotic cell number. Flow cytometry showed that astragaloside Ⅳ decreased H_2O_2-induced reactive oxygen species levels. While laser confocal microscopy showed that astragaloside Ⅳ inhibited the H_2O_2-induced decrease of mitochondrial membrane potential. Western blot assay showed that astragaloside Ⅳ reduced cytochrome c release induced by H_2O_2, inhibited Bax and caspase-3 expression, and increased Bcl-2 expression. Altogether, these results indicate that astragaloside Ⅳ has potential protective effects against H_2O_2-induced oxidative stress in retinal ganglion cells. | Ming Hao Yu Liu Ping Chen Hong Jiang Hong-Yu Kuang | 2018 | Neural Regeneration Research2018，13，6： | 10 |
| 6 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 7 | Efficacy of microwave versus radiofrequency ablation for treatment of small hepatocellular carcinoma: experimental and clinical studies显示文摘 | Guo-Jun Qian Neng Wang Qiang Shen Yue Sheng Jie-Qiong Zhao Ming Kuang Guang-Jian Liu Meng-Chao Wu | 2012 | European Radiology2012，，9： | 3 |
| 8 | Numerical simulation of flow hydrodynamics of struvite pellets in a liquid–solid fluidized bed显示文摘Phosphorus recovery in the form of struvite has been aroused in recent decades for its dual advantages in eutrophication control and resource protection.The usage of the struvite products is normally determined by the size which is largely depended on the hydrodynamics.In this study,flow behavior of struvite pellets was simulated by means of Eulerian–Eulerian two-fluid model combining with kinetic theory of granular flow in a liquid–solid fluidized bed reactor(FBR).A parametric study including the mesh size,time step,discretization strategy,turbulent model and drag model was first developed,followed by the evaluations of crucial operational conditions,particle characteristics and reactor shapes.The results showed that a cold model with the mesh resolution of 16 × 240,default time step of 0.001 sec and first order discretization scheme was accurate enough to describe the fluidization.The struvite holdup profile using Syamlal–O'Brien drag model was best fitted to the experimental data as compared with other drag models and the empirical Richardson–Zaki equation.Regarding the model evaluation,it showed that liquid velocity and particle size played important roles on both solid holdups and velocities.The reactor diameter only influenced the solid velocity while the static bed height almost took no effect.These results are direct and can be applied to guide the operation and process control of the struvite fluidization.Moreover,the model parameters can also be used as the basic settings in further crystallization simulations. | Xin Ye Dongyuan Chu Yaoyin Lou Zhi-Long Ye Ming Kuang Wang Shaohua Chen | 2017 | Journal of Environmental Sciences2017，29，7： | 3 |
| 9 | Classical Communication Cost and Remote Preparation of Multi-qubit with Three-Party显示文摘We present a scheme for probabilistic remote preparation of multi-qubit with three-party from a sender toeither of two receivers.The quantum channel is composed of a partial entangled tripartite GHZ state.We obtain thesuccessful total probability of the scheme in the general case and special case,respectively.We also calculate total classicalcommunication cost required in the RSP process with three-party in the general case and special case,respectively. | DAI Hong-Yi ZHANG Ming KUANG Le-Man | 2008 | Communications in Theoretical Physics2008，50，7： | 3 |
| 10 | SARS-CoV-2 spike protein interacts with and activates TLR41显示文摘Dear Editor,Accumulating clinical data suggest the main causes of death by COVID-19 include respiratory failure and the onset of sepsis.1 Importantly,sepsis has been observed in nearly all deceased patients.2,3,4,5 It remains elusive how SARS-CoV-2 infection results in viral sepsis in humans.Toll-like receptor 4(TLR4)mediates anti-gram-negative bacterial immune responses by recognizing lipopolysaccharide(LPS)from bacteria.6 We recently found that SARS-CoV-2 infection provoked an anti-bacterial like response at the very early stage of infection via TLR4.However,the identity of the original trigger initiating these abnormal immune responses during SARS-CoV-2 infection is unknown. | Yingchi Zhao Ming Kuang Junhong Li Ling Zhu Zijing Jia Xuefei Guo Yaling Hu Jun Kong Hang Yin Xiangxi Wang Fuping You | 2021 | Cell Research2021，31，7： | 3 |
| 11 | Grain size-dependent electrical resistivity of bulk nanocrystalline Gd metals显示文摘The electrical resistivity of the as-consolidated and coarse-grained bulk gadolinium(Gd) metals was studied in the temperature range of 3-315K.The experimental results showed that with decrease in the grain size of Gd grains from micrometer to nanometer range,the room temperature electrical resistivity increased from 209.7 to 333.0 μΩcm,while the electrical resistivity at the low temperature of 3K was found to increase surprisingly from 16.5 to 126.3 μΩcm.The room temperature coefficient resistivity(TCR) values were obtained as 39.2×10-3,5.51×10-3 and 33.7×10-3K-1.The ratios of room temperature to residual resistivity [RRR=ρ(300K)/ρ(3K)] are 2.64,11.0,respectively,for the as-consolidated samples at 280℃ and 700℃ with respect to that of the coarse-grained sample.All results indicate the remarkable influence of the nanostructure on the electrical resistivity of Gd due to the finite size effect and large fraction of grain boundaries. | Hong Zeng Ying Wu Jiuxing Zhang Chunjiang Kuang Ming Yue Shaoxiong Zhou | 2013 | Progress in Natural Science:Materials International2013，23，1： | 2 |
| 12 | Enhanced frameless slotted ALOHA protocol with Markov chains analysis显示文摘In this paper, we propose a novel approach to enhance the performance of frameless slotted ALOHA(SA) protocol. We employ signature codes to help the receiver identify the packets contained in collisions, and use successive interference cancellation(SIC) for packet recovery. We model the proposed scheme as a two-state Markov model represented by a uni-partite graph. We evaluate the throughput,expected delay and average memory size of the proposed scheme, and optimize the proposed scheme to maximize the throughput. We show that the theoretical analysis matches well with simulation results.The throughput and expected delay of the proposed protocol outperform the conventional slotted ALOHA protocol significantly. | Dai JIA Zesong FEI Ming XIAO Congzhe CAO Jingming KUANG | 2018 | Science China(Information Sciences)2018，61，10： | 2 |
| 13 | Chinese clinical practice guidelines for ultrasound-guided irreversible electroporation of liver cancer(version 2022)显示文摘Introduction Liver cancer remains a global health challenge,and its incidence is increasing worldwide.It is estimated that by 2025,more than one million individuals will be affected by liver cancer annually[1,2].In recent years,ablation has become a widely accepted treatment option for patients with primary and secondary liver malignancies[3].The commonly used ablation method for liver cancer is thermal ablation,including radiofrequency ablation. | Min Xu Li-Ting Xie Yue-Yong Xiao Ping Liang Qi-Yu Zhao Zhong-Min Wang Wei-Lu Chai Ying-Tian Wei Lin-Feng Xu Xiao-Kun Hu Ming Kuang Li-Zhi Niu Chen-Guo Yao Hai-Ying Kong Guo Tian Xiao-Yan Xie Xin-Wu Cui Dong Xu Jun Zhao Tian-An Jiang The Interventional Diagnosis and Treatment Group of the Ultrasonic Medicine Branch of Chinese Medical Association,The Nanoknife Tumor Ablation Society of the Interventional Minimally Invasive Therapy Special Committee of China Medicine Education Association | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，5： | 2 |
| 14 | Notch1 Drives the Formation and Proliferation of Intrahepatic Cholangiocarcinoma显示文摘The molecular mechanisms underlying the development of intrahepatic cholangiocarcinoma(ICC)are not clear yet.In this study,we investigated the involvement of Notch1 in the development of ICC.The cDNA microarray analysis showed that Notch1 expression was higher in ICC tissues than in normal biliary epithelial cells.Stable transfection of Notchl receptor intracellular domain(NICD1)by hydrodynamic tail vein injection induced ICC formation in mice.Western blotting confirmed that Notchl signaling was activated in human ICC cell lines and mouse ICC tissues.Silencing Notchl with specific short interfering RNA(siRNA)inhibited the proliferation of ICC cells.Flow cytometry and Western blotting indicated that apoptosis was induced in Notchl-silenced ICC cells compared with controls.Additionally,Notchl silencing was associated with the inhibition of hairy and enhancer of split-1(Hes1)and activation of the phosphatase and tensin homolog(PTEN)/p53 pathway.Taken together,these data suggest that Notchl drives ICC formation and proliferation;downregulation of Notchl induces apoptosis in ICC cells;Notchl signaling may serve as a novel therapeutic target for the treatment of ICC. | Jun GUO Wen FU Ming XIANG Yu ZHANG Ke ZHOU Chuan-rui XU Lei LI Dong KUANG Feng YE | 2019 | Current Medical Science2019，39，6： | 2 |
| 15 | Hepatitis C virus core protein-induced miR-93-5p upregulation inhibits interferon signaling pathway by targeting IFNAR1显示文摘AIM To investigate the mechanism by which hepatitis C virus(HCV) core protein-induced mi R-93-5 p up-regulation regulates the interferon(IFN) signaling pathway.METHODS HCV-1 b core protein was exogenously expressed in Huh7 cells using pc DNA3.1(+) vector. The expression of mi R-93-5 p and interferon receptor 1(IFNAR1) was measured using quantitative reverse transcriptionpolymerase chain reaction and Western blot. The protein expression and phosphorylation level of STAT1 were evaluated by Western blot. The overexpression and silencing of mi R-93-5 p and IFNAR1 were performed using mi R-93-5 p agomir and antagomir, and pc DNA3.1-IFNAR1 and IFNAR1 si RNA, respectively. Luciferase assay was used to identify whether IFNAR1 is a target of mi R-93-5 p. Cellular experiments were also conducted.RESULTS Serum mi R-93-5 p level was increased in patients with HCV-1 b infection and decreased to normal level after HCV-1 b clearance, but persistently increased in those with pegylated interferon-α resistance, compared with healthy subjects. Serum mi R-93-5 p expression had an AUC value of 0.8359 in distinguishing patients with pegylated interferon-α resistance from those with pegylated interferon-α sensitivity. HCV-1 b core protein increased mi R-93-5 p expression and induced inactivation of the IFN signaling pathway in Huh7 cells. Furthermore, IFNAR1 was identified as a direct target of mi R-93-5 p, and IFNAR1 restore could rescue mi R-93-5 p-reduced STAT1 phosphorylation, suggesting that the mi R-93-5 p-IFNAR1 axis regulates the IFN signaling pathway.CONCLUSION HCV-1 b core protein-induced mi R-93-5 p up-regulation inhibits the IFN signaling pathway by directly targeting IFNAR1, and the mi R-93-5 p-IFNAR1 axis regulates STAT1 phosphorylation. This axis may be a potential therapeutic target for HCV-1 b infection. | Chang-Long He Ming Liu Zhao-Xia Tan Ya-Jun Hu Qiao-Yue Zhang Xue-Mei Kuang Wei-Long Kong Qing Mao | 2018 | World Journal of Gastroenterology2018，24，2： | 2 |
| 16 | Differential diagnosis between benign and malignant gallbladder diseases with real-time contrast-enhanced ultrasound显示文摘 | Xiao-Hua Xie Hui-Xiong Xu Xiao-Yan Xie Ming-De Lu Ming Kuang Zuo-Feng Xu Guang-Jian Liu Zhu Wang Jin-Yu Liang Li-Da Chen Man-Xia Lin | 2010 | European Radiology2010，，1： | 2 |
| 17 | Influence of screw length and diameter on tibial strain energy density distribution after anterior cruciate ligament reconstruction显示文摘Postoperative tunnel enlargement has been frequently reported after anterior cruciate ligament(ACL)reconstruction.Interference screw,as a surgical implant in ACL reconstruction,may influence natural loading transmission and contribute to tunnel enlargement.The aims of this study are(1)to quantify the alteration of strain energy density(SED)distribution after the anatomic single-bundle ACL reconstruction;and(2)to characterize the influence of screw length and diameter on the degree of the SED alteration.A validated finite element model of human knee joint was used.The screw length ranging from 20 to 30 mm with screw diameter ranging from 7 to 9 mm were investigated.In the post-operative knee,the SED increased steeply at the extra-articular tunnel aperture under compressive and complex loadings,whereas the SED decreased beneath the screw shaft and nearby the intra-articular tunnel aperture.Increasing the screw length could lower the SED deprivation in the proximal part of the bone tunnel;whereas increasing either screw length or diameter could aggravate the SED deprivation in the distal part of the bone tunnel.Decreasing the elastic modulus of the screw could lower the bone SED deprivation around the screw.In consideration of both graft stability and SED alteration,a biodegradable interference screw with a long length is recommended,which could provide a beneficial mechanical environment at the distal part of the tunnel,and meanwhile decrease the bone-graft motion and synovial fluid propagation at the proximal part of the tunnel.These findings together with the clinical and histological factors could help to improve surgical outcome,and serve as a preliminary knowledge for the following study of biodegradable interference screw. | Jie Yao Guan-Ming Kuang Duo Wai-Chi Wong Wen-Xin Niu Ming Zhang Yu-Bo Fan | 2014 | Acta Mechanica Sinica2014，30，2： | 2 |
| 18 | Treatment response evaluation with three-dimensional contrast-enhanced ultrasound for liver cancer after local therapies显示文摘 | Hui-Xiong Xu Ming-De Lu Xiao-Hua Xie Xiao-Yan Xie Ming Kuang Zuo-Feng Xu Guang-Jian Liu Zhu Wang Li-Da Chen Man-Xia Lin | 2009 | European Journal of Radiology2009，，1： | 1 |
| 19 | Optimization of Dry Machining Parameters for High-purity Graphite in End Milling Process via Design of Experiments Methods显示文摘 | Yung Kuang Yang Ming Tsan Chuang Show Shyan Lin | 2009 | Journal of Materials Processing Technology2009，209，9： | 1 |
| 20 | Clinical presentations of patients from different age cohorts with biliary tract stone diseases显示文摘 | Kuang‐Chun Hu Horng‐Yuan Wang Wen‐Hsiung Chang Cheng‐Hsin Chu Shee‐Chan Lin Chun‐Jen Liu Ming‐Shiang Wu Shou‐Chuan Shih | 2014 | J Gastroenterol Hepatol2014，，8： | 1 |
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