|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 1-MeV electron irradiation effects on InGaAsP/InGaAs double-junction solar cell and its component subcells显示文摘Solar cells(SCs)are used as the primary source of power in satellites and other space missions,and operate in a harsh radiation environment in orbit.The demand for power has been increasing in various space tasks.Space applications require high radiation hardness and power-to-mass ratio for SCs.In the past decade,high efficiency(30%at AM0,1 sun),lattice-matched,Ga In P/Ga | Xiaofan ZHAO Maliya HEINI Momin SAILAI Abuduwayiti AIERKEN Qi GUO Yudong LI Shulong LU Pan DAI Yuanyuan WU Ming TAN | 2017 | Science China(Information Sciences)2017，60，12： | 2 |
| 2 | Progress and prospect of research on forest landscape model显示文摘森林风景模型(FLM ) 是森林生态系统结构和功能的确定的表示的一个效率工具。根据识别 FLM ,根据开发的阶段,这篇论文总结模型的发展特征,它包括数学模型,的理论基础看台规模的 FLM ,空间风景模型,的主要开发生态系统过程模型的快速的开发作为优先级,并且开发多因素驾驶的结构和过程的时期。根据不同 FLM 的特征,这篇论文以机制,性质和应用程序分类存在 FLM,并且详细描述模型的不同类型的鉴定,优点和劣势。它从是空间模式和生态的过程的变化的二个方面总结并且评估存在模型的主要应用程序领域。最后,这份报纸以后论述 FLM 挑战和开发的方向,包括:(1 ) 森林管理目的实际策略上的更突出的服务;(2 ) 多模块和多插件到的建设处于各种各样的条件满足风景研究需求;(3 ) 高分辨率的采纳空间时间的数据;(4 ) 多版本的结构的建设模块;(5 ) 改进模型申请的空间适用性。 | DAI Erfu WU Zhuo WANG Xiaofan FU Hua XI Weimin PAN Tao | 2015 | Journal of Geographical Sciences2015，25，1： | 2 |
| 3 | Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19显示文摘COVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection.It is currently unknown as to the correlation between the magnitude of neutralizing antibody(NAb)responses and the disease severity in COVID-19 patients.In a cohort of 59 recovered patients with disease severity including severe,moderate,mild,and asymptomatic,we observed the positive correlation between serum neutralizing capacity and disease severity,in particular,the highest NAb capacity in sera from the patients with severe disease,while a lack of ability of asymptomatic patients to mount competent NAbs.Furthermore,the compositions of NAb subtypes were also different between recovered patients with severe symptoms and with mild-tomoderate symptoms.These results reveal the tremendous heterogeneity of SARS-CoV-2-specific NAb responses and their correlations to disease severity,highlighting the needs of future vaccination in COVID-19 patients recovered from asymptomatic or mild illness. | Xiangyu Chen Zhiwei Pan Shuai Yue Fei Yu Junsong Zhang Yang Yang Ren Li Bingfeng Liu Xiaofan Yang Leiqiong Gao Zhirong Li Yao Lin Qizhao Huang Lifan Xu Jianfang Tang Li Hu Jing Zhao Pinghuang Liu Guozhong Zhang Yaokai Chen Kai Deng Lilin Ye | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 4 | A complete assembly of the rice Nipponbare reference genome显示文摘Dear Editor,In 2005,the current commonly used rice reference genome(Oryza sativa ssp.japonica cv.Nipponbare)was initially released by the International Rice Genome Sequencing Project(International Rice Genome Sequencing Project,2005).Thereafter,the reference genome was further updated in 2013 with improved genome assembly(IRGSP-1.0)and gene annotations(MSU7,RAP-DB)(Kawahara et al.,2013;Sakai et al.,2013).In the past 10 years,this reference has been serving as one of the most important genetic resources for subsequent rice functional genomics efforts.As several rice genomes had been assembled into gapless chromosomes with only 2–5 telomeres absent(Li et al.,2021;Song et al.,2021;Zhang et al.,2022),the IRGSP1.0 and its annotations still performed as the most widely used reference.However,limitations of sequencing technology and intricate genomic organization led to an under-representation of complex regions in this reference,leaving a total of 72 major gaps(including 19 telomeres),167 minor gaps,and 779 unknown bases(Kawahara et al.,2013),with an estimated length of3%of the genome unsolved. | Lianguang Shang Wenchuang He Tianyi Wang Yingxue Yang Qiang Xu Xianjia Zhao Longbo Yang Hong Zhang Xiaoxia Li Yang Lv Wu Chen Shuo Cao Xianmeng Wang Bin Zhang Xiangpei Liu Xiaoman Yu Huiying He Hua Wei Yue Leng Chuanlin Shi Mingliang Guo Zhipeng Zhang Bintao Zhang Qiaoling Yuan Hongge Qian Xinglan Cao Yan Cui Qianqian Zhang Xiaofan Dai Congcong Liu Longbiao Guo Yongfeng Zhou Xiaoming Zheng Jue Ruan Zhukuan Cheng Weihua Pan Qian Qian | 2023 | Molecular Plant2023，16，8： | 1 |
| 5 | Generalized local-world models for weighted networks 显示文摘 | Zaofeng Pan Xiang Li and Xiaofan Wang | 2006 | Physical Review E2006，73，5： | 1 |
| 6 | A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global pandemic of novel coronavirus disease(COVID-19).The neutralizing monoclonal antibodies(mAbs)targeting the receptor-binding domain(RBD)of SARS-CoV-2 are among the most promising strategies to prevent and treat COVID-19.However,SARS-CoV-2 variants of concern(VOCs)profoundly reduced the efficacies of most of mAbs and vaccines approved for clinical use.Herein,we demonstrated mAb 35B5 efficiently neutralizes both wild-type(WT)SARS-CoV-2 and VOCs. | Xiaofei Wang Ao Hu Xiangyu Chen Yixin Zhang Fei Yu Shuai Yue Arong Li Junsong Zhang Zhiwei Pan Yang Yang Yao Lin Leiqiong Gao Jing Zhou Jing Zhao Fang Li Yaling Shi Feng Huang Xiaofan Yang Yi Peng Luoyang Tu Huan Zhang Huanying Zheng Jun He Hui Zhang Lifan Xu Qizhao Huang Yongqun Zhu Kai Deng Lilin Ye | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 1 |
| 7 | Mailuoning suppresses H_2O_2-induced cortical neuronal injury and correlates with increased catalase activity and inhibited oxidative stress function显示文摘BACKGROUND:Mailuoning,a Chinese herb,has been widely used in China to treat acute ischemic stroke,and the major component exhibits anti-oxidative effects.However,the precise anti-oxidation pathway remains uncertain.OBJECTIVE:To validate the protective effects of Mailuoning on H2O2-induced primary cortical neuron injury in embryonic mice.DESIGN,TIME AND SETTING:Comparative observation and in vitro experiments were performed at the Jiangsu Key Laboratory for Molecular Medicine from January 2008 to September 2009.MATERIALS:Mailuoning(Nanjing Jinling Medical Company,China),reactive oxygen species(ROS) kit(Beyotime Biotechnology,China),superoxide dismutase(SOD),Cu/Zn SOD kit,malondialdehyde(MDA) kits(Nanjing Jiancheng,China),mitochondrial membrane potential(GMS10013.1,GENMED,USA) and catalase activity assay kit(Beyotime Biotechnology,China) were utilized for the present study.METHODS:Mouse embryonic cortical neurons were isolated and cultured with culture medium containing H2O2(80 μmol/L) and/or Mailuoning(1.25 μg/mL) for 24 hours.MAIN OUTCOME MEASURES:Neuronal viability and death were detected by methyl thiazolyl tetrazdium and flow cytometry;ROS production was determined by flow cytometry;mitochondrial membrane potential was detected using fluorescent staining;SOD activity was detected using a modified nitroblue tetrazolium method;Cu/Zn SOD and catalase activity was detected by spectrophotometry;and MDA was determined using the lipid peroxidation method.RESULTS:H2O2 increased ROS production and MDA concentration(P < 0.05),and decreased mitochondrial membrane potential,SOD,Cu/Zn SOD and catalase activity(P < 0.05);the number of surviving neurons(P < 0.05) was also reduced.Mailuoning reversed these changes.CONCLUSION:Mailuoning protects H2O2-induced injury in cortical cells by inhibiting ROS and MDA,increasing depolarization of mitochondrial membrane,and enhancing SOD and catalase activity. | Xiaofan Pan Siyuan Huang Lingling Li Yun Xu | 2010 | Neural Regeneration Research2010，5，8： | 1 |
| 8 | Aberrant single-subject morphological brain networks in first-episode,treatment-naive adolescents with major depressive disorder显示文摘Background:Neuroimaging-based connectome studies have indicated that major depressive disorder(MDD)is associated with dis-rupted topological organization of large-scale brain networks.However,the disruptions and their clinical and cognitive relevance are not well established for morphological brain networks in adolescent MDD.Objective:To investigate the topological alterations of single-subject morphological brain networks in adolescent MDD.Methods:Twenty-five first-episode,treatment-naive adolescents with MDD and 19 healthy controls(HCs)underwent T1-weighted magnetic resonance imaging and a battery of neuropsychological tests.Single-subject morphological brain networks were constructed separately based on cortical thickness,fractal dimension,gyrification index,and sulcus depth,and topologically characterized by graph-based approaches.Between-group differences were inferred by permutation testing.For significant alterations,partial correla-tions were used to examine their associations with clinical and neuropsychological variables in the patients.Finally,a support vector machine was used to classify the patients from controls.Results:Compared with the HCs,the patients exhibited topological alterations only in cortical thickness-based networks character-ized by higher nodal centralities in parietal(left primary sensory cortex)but lower nodal centralities in temporal(left parabelt complex,right perirhinal ectorhinal cortex,right area PHT and right ventral visual complex)regions.Moreover,decreased nodal centralities of some temporal regions were correlated with cognitive dysfunction and clinical characteristics of the patients.These results were largely reproducible for binary and weighted network analyses.Finally,topological properties of the cortical thickness-based net-works were able to distinguish the MDD adolescents from HCs with 87.6%accuracy.Conclusion:Adolescent MDD is associated with disrupted topological organization of morphological brain networks,and the disrup-tions provide potential biomarkers for diagnosing and monitoring the disease. | Xiaofan Qiu Junle Li Fen Pan Yuping Yang Weihua Zhou Jinkai Chen Ning Wei Shaojia Lu Xuchu Weng Manli Huang Jinhui Wang | 2023 | Psychoradiology2023，3，1： | 0 |
| 9 | GRB 220408B:A Three-episode Burst from a Precessing Jet显示文摘Jet precession has previously been proposed to explain the apparently repeating features in the light curves of a few gamma-ray bursts(GRBs).In this paper,we further apply the precession model to a bright GRB 220408B by examining both its temporal and spectral consistency with the predictions of the model.As one of the recently confirmed GRBs observed by our GRID CubeSat mission,GRB 220408B is noteworthy as it exhibits three apparently similar emission episodes.Furthermore,the similarities are reinforced by their strong temporal correlations and similar features in terms of spectral evolution and spectral lags.Our analysis demonstrates that these features can be well explained by the modulated emission of a Fast-Rise-Exponential-Decay(FRED)shape light curve intrinsically produced by a precessing jet with a precession period of 18.4_(-0.2)~(+0.2)s,a nutation period of11.1_(-0.2)~(+0.2)s and viewed off-axis.This study provides a straightforward explanation for the complex yet similar multiepisode GRB light curves. | Zijian Zhang Yi-Han Iris Yin Chenyu Wang Xiangyu Ivy Wang Jun Yang Yan-Zhi Meng Zi-Ke Liu Guo-Yin Chen Xiaoping Fu Huaizhong Gao Sihao Li Yihui Liu Xiangyun Long Yong-Chang Ma Xiaofan Pan Yuanze Sun Wei Wu Zirui Yang Zhizhen Ye Xiaoyu Yu Shuheng Zhao Xutao Zheng Tao Zhou Qing-Wen Tang Qiurong Yan Rong Zhou Zhonghai Wang Hua Feng Ming Zeng Bin-Bin Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，11： | 0 |
| 10 | Single-Atomic Site Catalyst Enhanced Lateral Flow Immunoassay for Point-of-Care Detection of Herbicide显示文摘Point-of-care(POC)detection of herbicides is of great importance due to their impact on the environment and potential risks to human health.Here,we design a single-atomic site catalyst(SASC)with excellent peroxidase-like(POD-like)catalytic activity,which enhances the detection performance of corresponding lateral flow immunoassay(LFIA).The iron single-atomic site catalyst(Fe-SASC)is synthesized from hemin-doped ZIF-8,creating active sites that mimic the Fe active center coordination environment of natural enzyme and their functions.Due to its atomically dispersed iron active sites that result in maximum utilization of active metal atoms,the Fe-SASC exhibits superior POD-like activity,which has great potential to replace its natural counterparts.Also,the catalytic mechanism of Fe-SASC is systematically investigated.Utilizing its outstanding catalytic activity,the Fe-SASC is used as label to construct LFIA(Fe-SASC-LFIA)for herbicide detection.The 2,4-dichlorophenoxyacetic acid(2,4-D)is selected as a target here,since it is a commonly used herbicide as well as a biomarker for herbicide exposure evaluation.A linear detection range of 1-250 ng/mL with a low limit of detection(LOD)of 0.82 ng/mL has been achieved.Meanwhile,excellent specificity and selectivity towards 2,4-D have been obtained.The outstanding detection performance of the Fe-SASC-LFIA has also been demonstrated in the detection of human urine samples,indicating the practicability of this POC detection platform for analyzing the 2,4-D exposure level of a person.We believe this proposed Fe-SASC-LFIA has potential as a portable,rapid,and high-sensitive POC detection strategy for pesticide exposure evaluation. | Zhaoyuan Lyu Shichao Ding Peter Tieu Lingzhe Fang Xin Li Tao Li Xiaoqing Pan Mark H.Engelhard Xiaofan Ruan Dan Du Suiqiong Li Yuehe Lin | 2023 | Research2023，，1： | 0 |
| 11 | The Endosperm-Specific Expression of YUCCA Genes Enhances Rice Grain Filling显示文摘Grain filling is a crucial process that affects yield in rice(Oryza sativa L.).Auxin biosynthesis and signaling are closely related to rice yield;therefore,it is important to understand the effects of auxin biosynthesis on rice grain filling to improve crop yield.In this study,we used physiological and molecular strategies to identify the roles of auxin in rice grain filling.Exogenous application of auxin(IAA)or auxin analogues(2,4-D)to young spikelets and flag leaves improved the seed-setting rate and yield per spike.Furthermore,real-time quantitative PCR assays confirmed that nine members of the OsYUCCA family of auxin biosynthetic genes were upregulated during grain filling,implication that auxin biosynthesis plays a major role in grain development.The specific expression of either Arabidopsis AtYUCCA1 or OsYUCCA2 in the endosperm or leaves resulted in increased expression of OsIAA genes and auxin content of seeds,as well as increased grain filling and seed-setting rate.This result establishes that the auxin content in grains and leaves is important for grain development.Our findings further highlight the potential applications for improving rice yield by elevating targeted gene expression in specific tissues. | Huijun Jiang Kaien Zhai Xiaofan Ye Tianwei Hu Jieming Jiang Xiaoqiu Dong Weihuai Pan Jianwei Pan Jianxin Shou | 2022 | Phyton-International Journal of Experimental Botany2022，91，12： | 0 |
| 12 | Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor显示文摘The adoptive transfer of chimeric antigen receptor-T(CAR-T)cells has shown remarkable clinical responses in hematologic malignancies.However,unsatisfactory curative results and side effects for tumor treatment are still unsolved problems.Herein we develop a click CAR-T cell engineering strategy via cell glycometabolic labeling for robustly boosting their antitumor effects and safety in vivo.Briefly,paired chemical groups(N3/BCN)are separately incorporated into CAR-T cell and tumor via nondestructive intrinsic glycometabolism of exogenous Ac4GalNAz and Ac4ManNBCN,serving as an artificial ligand-receptor.Functional groups anchored on cell surface strengthen the interaction of CAR-T cell and tumor via bioorthogonal click chemistry,further enhancing specific recognition,migration and selective antitumor effects of CAR-T cells.In vivo,click CAR-T cell completely removes lymphoma cells and minimizes off-target toxicity via selective and efficient bioorthogonal targeting in blood cancer.Surprisingly,compared to unlabeled cells,artificial bioorthogonal targeting significantly promotes the accumulation,deep penetration and homing of CAR-T cells into tumor tissues,ultimately improving its curative effect for solid tumor.Click CAR-T cell engineering robustly boosts selective recognition and antitumor capabilities of CAR T cells in vitro and in vivo,thereby holding a great potential for effective clinical cell immunotherapy with avoiding adverse events in patients. | Hong Pan Wenjun Li Ze Chen Yingmei Luo Wei He Mengmeng Wang Xiaofan Tang Huamei He Lanlan Liu Mingbin Zheng Xin Jiang Ting Yin Ruijing Liang Yifan Ma Lintao Cai | 2021 | Bioactive Materials2021，6，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员