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| 1 | Inflammatory response and neuronal necrosis in rats with cerebral ischemia显示文摘In the middle cerebral artery occlusion model of ischemic injury, inflammation primarily occurs in the infarct and peripheral zones. In the ischemic zone, neurons undergo necrosis and apoptosis, and a large number of reactive microglia are present. In the present study, we investigated the pathological changes in a rat model of middle cerebral artery occlusion. Neuronal necrosis appeared 12 hours after middle cerebral artery occlusion, and the peak of neuronal apoptosis appeared 4 to 6 days after middle cerebral artery occlusion. Inflammatory cytokines and microglia play a role in damage and repair after middle cerebral artery occlusion. Serum intercellular cell adhesion molecule-1 levels were positively correlated with the permeability of the blood-brain barrier. These findings indicate that intercellular cell adhesion molecule-1 may be involved in blood-brain barrier injury, microglial activation, and neuronal apoptosis. Inhibiting blood-brain barrier leakage may alleviate neuronal injury following ischemia. | Lingfeng Wu Kunnan Zhang Guozhu Hu Haiyu Yang Chen Xie Xiaomu Wu | 2014 | Neural Regeneration Research2014，9，19： | 19 |
| 2 | Interlayer interactions in anisotropic atomically thin rhenium diselenide显示文摘在这个工作,我们学习夹层声子颤动模式, layer-numberdependent 原子地薄的金来 diselenide 的光 bandgap,和各向异性的光致发光(PL ) 系列(ReSe 2) 第一次。在 ReSe 2 的 ultralow 频率夹层拉曼系列和解决极化的高频率拉曼系列允许它的层数字和水晶取向的鉴定。而且, PL 大小显示出材料的各向异性的光排放紧张,它的 bandgap 在单层在体积从 1.26 eV 增加到 1.32 eV。拉曼模式和 PL 系列的层数字依赖的学习揭示相对弱的货车 der Waals 相互作用并且二维(2D ) 在原子地薄的 ReSe 2 的量监禁。在单层和多层的 ReSe 2 的吸引人的各向异性的夹层相互作用和悦耳的光转变的试验性的观察在在在红外线附近的光谱工作的各向异性的 optoelectronic 设备的发展为这材料的进一步的探索建立基础,它为在光通讯并且红外线的察觉到的许多应用是重要的。 | Huan Zhao Jiangbin Wu Hongxia Zhong Qiushi Guo Xiaomu Wang Fengnian Xia Li Yang Pingheng Tan Han Wang | 2015 | Nano Research2015，8，11： | 14 |
| 3 | Novel Wx alleles generated by base editing for improvement of rice grain quality显示文摘Amylose content(AC),which is regulated by the Waxy(Wx)gene,is a major indicator of eating and cooking quality(ECQ)in rice(Oryza sativa).Thus far,only a limited number of mutations in the N-terminal domain of Wx were found to have a major impact on the AC of rice grains and no mutations with such effects were reported for other regions of the Wx protein.Here,nucleotide substitutions in the middle region of Wx were generated by adenine and cytosine base editors.The nucleotide substitutions led to changes in 15 amino acid residues of Wx,and a series of novel Wx alleles with ACs of 0.3%-29.43%(wild type with AC of 19.87%)were obtained.Importantly,the waxy~(abe2)allele showed a'soft rice'AC,improved ECQ,favorable appearance,and no undesirable agronomic traits.The transgenes were removed from the waxy~(abe2)progeny,generating a promising breeding material for improving rice grain quality. | Xiaorui Huang Fei Su Sheng Huang Fating Mei Xiaomu Niu Changle Ma Hui Zhang Xiaoguo Zhu Jian-Kang Zhu Jinshan Zhang | 2021 | Journal of Integrative Plant Biology2021，63，9： | 4 |
| 4 | Creation of aromatic maize by CRISPR/Cas显示文摘Aroma is an important quality parameter for breeding in rice(Oryza sativa).For example,the aromatic rice varieties basmati and jasmine rice,with a popcorn-like scent,are popular worldwide and routinely command a price premium.2-acetyl-1-pyrroline(2AP)is a key flavor compound among over 200 volatiles identified in fragrant rice.A naturally fragrant germplasm exists in multiple plant species besides rice,which all exhibit lower activity of BETAINE ALDEHYDE DEHYDROGENASE 2(BADH2).However,no equivalent aromatic germplasm has been described in maize(Zea mays).Here,we characterized the two maize BADH2 homologs,ZmBADH2a and ZmBADH2b.We generated zmbadh2a and zmbadh2b single mutants and the zmbadh2a-zmbadh2b double mutant by CRISPR/Cas in four inbred lines.A popcorn-like scent was only noticeable in seeds from the double mutant,but not from either single mutant or in wild type.In agreement,we only detected 2AP in fresh kernels and dried mature seeds from the double mutant,which accumulated between 0.028 and 0.723 mg/kg 2AP.These results suggest that ZmBADH2a and ZmBADH2b redundantly participate in 2AP biosynthesis in maize,and represent the creation of the world's first aromatic maize by simultaneous genome editing of the two BADH2 genes. | Yanxiao Wang Xiaoqin Liu Xiuxiu Zheng Wenxia Wang Xunqing Yin Haifeng Liu Changle Ma Xiaomu Niu Jian-Kang Zhu Fei Wang | 2021 | Journal of Integrative Plant Biology2021，63，9： | 3 |
| 5 | Kidney injury molecule-1 is a potential receptor for SARS-CoV-2显示文摘COVID-19 patients present high incidence of kidney abnormalities,which are associated with poor prognosis and mortality.The identification of SARS-CoV-2 in the kidney of COVID-19 patients suggests renal tropism of SARS-CoV-2.However,whether there is a specific target of SARS-CoV-2 in the kidney remains unclear.Herein,by using in silico simulation,coimmunoprecipitation,fluorescence resonance energy transfer,fluorescein isothiocyanate labeling,and rational design of antagonist peptides,we demonstrate that kidney injury molecule-1(KIM1),a molecule dramatically upregulated upon kidney injury,binds with the receptor-binding domain(RBD)of SARS-CoV-2 and facilitates its attachment to cell membrane,with the immunoglobulin variable Ig-like(Ig V)domain of KIM1 playing a key role in this recognition.The interaction between SARS-CoV-2 RBD and KIM1 is potently blockaded by a rationally designed KIM1-derived polypeptide AP2.In addition,our results also suggest interactions between KIM1 Ig V domain and the RBDs of SARS-CoV and MERS-CoV,pathogens of two severe infectious respiratory diseases.Together,these findings suggest KIM1 as a novel receptor for SARS-CoV-2 and other coronaviruses.We propose that KIM1 may thus mediate and exacerbate the renal infection of SARS-CoV-2 in a‘vicious cycle’,and KIM1 could be further explored as a therapeutic target. | Chen Yang Yu Zhang Xia Zeng Huijing Chen Dong Yang Yuchen Chen Ziwei Shen Xiaomu Wang Xinran Liu Mingrui Xiong Hong Chen Kun Huang | 2021 | Journal of Molecular Cell Biology2021，13，3： | 2 |
| 6 | OsCBL1 Modulates Lateral Root Elongation in Rice via Affecting Endogenous Indole-3-Acetic Acid Biosynthesis显示文摘Root growth is important for plants to efficiently acquire water and mineral nutrients from soil.Root system architecture(RSA),which is determined mainly by root branching through lateral root formation and root angles,has a significant influence on root growth.Generally,the growth and development of roots are regulated by numerous plant hormones,which respond to external environmental stimulation through com- | Jing Yang Xiaomu Zhang Yunqing Huang Yuqi Feng Yangsheng Li | 2015 | Journal of Genetics and Genomics2015，42，6： | 2 |
| 7 | The role of Interleukin-6 in pulmonary inflammation and injury induced by exposure to environmental air pollutants显示文摘 | Mang Y Xiaomu Z Hanspeter W | 2002 | Toxicol Sci2002，68，2： | 1 |
| 8 | The role of Interleukin-6 in pulmonary inflammation and injury induced by exposure to environmental air pollutants显示文摘 | Mang Y Xiaomu Z Hanspeter W | 2002 | Toxicol Sci2002，68，2： | 1 |
| 9 | Cellulose synthesis in maize: isolation and expression analysis of the cellulose synthase (CesA) gene family显示文摘 | Laura Appenzeller Monika Doblin Roberto Barreiro Haiyin Wang Xiaomu Niu Krishna Kollipara Lori Carrigan Dwight Tomes Mike Chapman Kanwarpal S. Dhugga | 2004 | Cellulose (-)2004，，3： | 1 |
| 10 | The role of Interleukin- 6 in pulmonary in flammation and injury induced by exposure to environmental air pollutants 显示文摘 | Mang Y Xiaomu Z Hanspeter W | 2002 | Toxiccol Sci2002，68，2： | 1 |
| 11 | Characterization of novel microsatellite loci in rare minnow (Gobiocypris rarus) and amplification in closely related species in Gobioninae显示文摘 | Xiaolin Liao Dan Wang Xiaomu Yu Weitao Li Lei Cheng Jianwei Wang Jingou Tong | 2007 | Conservation Genetics2007，，4： | 1 |
| 12 | S100P enhances the chemosensitivity of human gastric cancer celllines显示文摘 | Xiaomu Zhao Zhigang Bai Ping Wu Zhongtao Zhang | 2013 | Cancer Biomarkers2013，，1： | 1 |
| 13 | Intensive versus conventional glucose control in critically ill patients:a meta - analysis of ran- domized controlled trials 显示文摘 | Ling Yan Li Xiaomu Gao Xin | 2012 | European Journal of Internal Med- icine2012，23，6： | 1 |
| 14 | The role of interleukin-6 in pulmonary inflammation and injury induced by egposse to environmental air pollutants显示文摘 | Mang Yu Xiaomu Zheng Hanspeter Witsehi | 2002 | Toxieol Sci2002，68，2： | 1 |
| 15 | p53 inhibition provides a pivotal protective effect against ischemia-reperfusion injury in vitro via mTOR signaling显示文摘 | Xiaomu Li Shixin Gu Yan Ling Chao Shen Xiaoyun Cao Rong Xie | 2015 | Brain Research2015，，： | 1 |
| 16 | Quality Management and Manufacturing Strategies in China显示文摘 | Choong Y Lee Xiaomu Zhou | 2000 | International Journal of Quality and Reliability Management2000，17，8： | 1 |
| 17 | RNA-Seq analysis and development of SSR and KASP markers in lentil(Lens culinaris Medikus subsp. culinaris)显示文摘Lentil(Lens culinaris Medikus subsp.culinaris,2 n=14)is a cool-season legume with high production potential for multiple uses.However,limited molecular research has been conducted in this species owing to its large genome,which impedes the generation of genome sequences and the development of molecular markers.In this study,more than 1.37 billion filtered clean reads were collected by RNA-Seq of six diverse lentil accessions and217,836 transcripts and 161,095 unigenes were de novo assembled,yielding respectively 257.1 and 240.6 million nucleotides.The mean transcript length was 1180 bp and the N50 and N90 lengths were respectively 2075 and 479 bp.The mean length of the unigenes was 1494 bp and their N50 and N90 values were respectively 2203 and 714 bp.The unigenes were annotated against seven databases.The FLOWERING LOCUS T(FT)gene homolog in lentil showed high protein sequence similarity to the FT gene homologs of pea and alfalfa.On the basis of the RNA-Seq analysis,26,449 EST-SSR markers were designed in silico,and 276 preliminarily screened markers were selected to evaluate polymorphism in 94 diverse lentil accessions.In total,125(45.29%)of 276 EST-SSR markers were found to be polymorphic.A total of 130,073 SNP loci were detected and 78(61.41%)of 127 SNPs were successfully converted to KASP markers.Population genetic analyses of the lentil accessions with EST-SSR and KASP markers revealed similar genetic structures,suggesting that the RNA-Seq-generated resources and the developed markers are reliable for use in molecular marker-assisted breeding of lentil. | Dong Wang Tao Yang Rong Liu Nana Li Xiaomu Wang Ashutosh Sarker Xiaodong Zhang Runfang Li Yanyan Pu Guan Li Yuning Huang Yishan Ji Zhaojun Li Qian Tian Xuxiao Zong Hanfeng Ding | 2020 | The Crop Journal2020，8，6： | 1 |
| 18 | Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibi- tion and tissue growth control显示文摘 | Bin Zhao Xiaomu Wei Weiquan Li | 2007 | Genes and Development2007，21，： | 1 |
| 19 | Control of cell proliferation and apoptosis by Mob as Tumor Suppressor显示文摘 | Zhi - Chun Lai Xiaomu Wei Takeshi Shimizu et aI | 2005 | Mats Cell2005，120，： | 1 |
| 20 | METAL INERT GAS WELDING OF 2519-T87 HIGH STRENGTH ALUMINUM ALLOY显示文摘20 公里 2519-T87 的厚盘子高力量铝合金被焊接了。填料电线,热输入和在焊接关节的机械性质和微观结构上防护气体的作文的作文的效果被调查了。Theresults 显示那更好的微观结构,更好机械的性质和 HAZ 的坚硬的更高的价值能被使用更低的热输入获得。Ar/He 的使用混合了防护气体比防护气体的纯 Ar 有几个优点。随比例的增加他在混合防护气体,焊接金属的谷物尺寸以及孔危险性减少。什么时候体积比率他到达 7 到 Ar:3,孔和焊接金属的谷物尺寸到达最小,和孔能被充满一些 CO_2 进一步减少。 | XU Lianghong TIAN Zhiling ZHANG Xiaomu PENG Yun | 2007 | Chinese Journal of Mechanical Engineering2007，20，4： | 1 |
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