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| 1 | Comparative expression analysis of three genes from the Arabidopsis vacuolar Na^+/H^+ antiporter (AtNHX) family in relation to abiotic stresses显示文摘Na^+/H^+ antiporters (NHX) are ubiquitous transmembrane proteins that play a key role in salt tolerance of plants. In this study, the sequence of 3 Arabidopsis NHX gene (AtNHX2―4) were compared with other AtNHX members. Putative cis-elements analysis identified elements that have been associated with stress responses. The activities of the promoters AtNHX2―4 were studied in transgenic plants carrying corresponding promoter-β-glucuronidase (GUS) fusions. The AtNHX2 promoter-GUS analysis indicated that AtNHX2 was expressed in constitutive pattern with high GUS activity in roots and leaves. AtNHX2 promoter activity was not up-regulated by NaCl or abscisic acid (ABA), in contrast to the AtNHX1 promoter which was previously studied. The AtNHX3 and AtNHX4 promoters showed tissue-specific activities. Strong GUS activity was detected in roots and vascular bundles of the stele in plants carry-ing an AtNHX4 promoter-GUS fusion, and GUS activity increased under salt stress suggesting a func-tion related to salt tolerance. Transgenic plants carrying the AtNHX3 promoter-GUS fusion showed strong GUS activity in petals, stamens and tops of siliques, suggesting a possible role of AtNHX3 in flower and seed development. Results of histochemical analysis suggested that AtNHX2―4 are involved in divergent functions and are differentially regulated under abiotic stress. The structure of AtNHX4 was predicted to include 12 transmembrane regions and a NHX domain. Overexpression of AtNHX4 in Arabidopsis transgenic lines confers greater salt tolerance than in wild type plants. These results suggest that AtNHX4 may encode a putative vacuolar NHX that plays an important role in salt tolerance. | WANG WeiQuan LI Yin ZHANG YiYue YANG CuiPing ZHENG NuoYan XIE Qi | 2007 | Chinese Science Bulletin2007，52，13： | 5 |
| 2 | Reappearance of Risk of Schistosomiasis Transmission and the Response After 27 Years of Interrupted Transmission—Guangdong Province,China,2019显示文摘Summary What is already known about this topic?No live specimens of the snail Oncomelania hupensis(O.hupensis)and indigenous infected cases of schistosomiasis japonicum have been found in Guangdong Province since 1993,but live O.hupensis was found again in 2019.This study conducted O.hupensis identification and elimination.What is added by this report?In 2019,live O.hupensis specimens were detected by routine surveillance in areas in Qujiang of Shaoguan City and Yingde of Qingyuan City,and an emergency response was launched immediately. | Shaoyu Huang Qiang Mao Qili Zhong Xiuhong Fan Weiquan Li Yonghua Rao Fuquan Pei Shizhu Li Zhuohui Deng | 2021 | China CDC weekly2021，3，51： | 4 |
| 3 | Barcelona Clinic Liver Cancer outperforms Hong Kong Liver Cancer staging of hepatocellular carcinoma in multiethnic Asians: Real-world perspective显示文摘AIM To compare the Barcelona Clinic Liver Cancer(BCLC) and Hong Kong Liver Cancer(HKLC) classification systems when applied to HCC patients from the largest tertiary-level centre in Singapore.METHODS One thousand two hundred and seventy hepatocellular carcinoma(HCC) patients prospectively enrolled in a tertiary-level centre registry in Singapore since 1988 were studied. Patients were grouped into their respective BCLC and HKLC stages. Data such as demography, aetiology of HCC and type of treatment were collected. Survival data was based on census with the National Registry of Births and Deaths on 31 st October 2015. Statistical analyses were done using SPSS version 21(Chicago, IL, United States). Survival analyses were done by the Kaplan-Meier method. Differences in survival rates were compared using the log-rank test.RESULTS The median age at presentation was 63 years(range 13-94); male 82.4%; Chinese 89.4%, Malay 7.1%, Indian, 2.8%. Hepatitis B was the predominant aetiology(75.0%; Hepatitis C 7.2%, Hepatitis B and C co-infection 3.8%, non-viral 14.0%). Both BCLC and HKLC staging systems showed good separation with overall log rank test confirming significant survival differences between stages in our cohort(P < 0.001). 206 out of the 240 patients(85.8%) assigned for curative treatment by the BCLC treatment algorithm received curative therapy for HCC [Stage 0 93.2%(68/73); Stage A 82.6%(138/167)]. In contrast, only 341/558(61.1%) patients received curative treatment despite being assigned for curative treatment by the HKLC treatment algorithm [Stage Ⅰ 72.7%(264/363); Stage Ⅱ 40.2%(66/164); Stage Va 35.5%(11/31)]. Patients who were assigned to curative treatment by HKLC but did not receive curative treatment had significantly poorer ECOG(P < 0.001), higher ChildPugh status(P < 0.001) and were older(median age 66 vs 61, P < 0.001) than those who received curative therapy. Median overall survival in patients assigned to curative treatment groups by BCLC and HKLC were 6.1 and 2.6 years respectively(P < 0.001). When only patients receiving curative treatment were analyzed, BCLC still predicted overall median survival better than HKLC(7.1 years vs 5.5 years, P = 0.037). CONCLUSION BCLC performs better than HKLC in our multiethnic Asian population in allocating patients to curative treatment in a real-life situation as well as in predicting survival. | James Weiquan Li Boon-Bee George Goh Pik-Eu Chang Chee-Kiat Tan | 2017 | World Journal of Gastroenterology2017，23，22： | 4 |
| 4 | Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the AKT/GSK3β/STAT3 signaling axis显示文摘Marsdenia tenacissima injection,a standard Marsdenia tenacissima extract(MTE),has been approved as an adjuvant therapeutic agent for various cancers.Our previous study showed that MTE inhibited the proliferation and metastasis of prostate cancer(PCa)cells.However,the underlying mechanisms and active ingredients of MTE against PCa were not completely understood.This study revealed that MTE induced significant decreases in cell viability and clonal growth in PCa cells.In addition,MTE induced the apoptosis of DU145 cells by reducing the mitochondrial membrane potential and increasing the expression of Cleaved Caspase 3/7,Cyt c,and Bax.In vivo,DU145 xenografted NOD-SCID mice treated with MTE showed significantly decreased tumor size.TUNEL staining and Western blot confirmed the pro-apoptotic effects of MTE.Network pharmacology analysis collected 196 ingredients of MTE linked to 655 potential targets,and 709 PCa-associated targets were retrieved,from which 149 overlapped targets were screened out.Pathway enrichment analysis showed that the HIF-1,PI3K-AKT,and ErbB signaling pathways were closely related to tumor apoptosis.Western blot results confirmed that MTE increased the expression of p-AKT^(Ser473) and p-GSK3β^(Ser9),and decreased the expression of p-STAT3^(Tyr705) in vitro and in vivo.A total of 13 compounds in MTE were identified by HPLC-CAD-QTOF-MS/MS and UPLCQTOF-MS/MS.Molecular docking analysis indicated that six compounds may interact with AKT,GSK3β,and STAT3.In conclusion,MTE induces the endogenous mitochondrial apoptosis of PCa by regulating the AKT/GSK3β/STAT3 signaling axis,resulting in inhibition of PCa growth in vitro and in vivo. | LI Xiaolan HE Songhua LIANG Wei ZHANG Weiquan CHEN Xin LI Qiaofeng YANG Xin LIU Yanying ZHU Dan LI Li LIU Buming SU Zhiheng CHEN Jie GUO Hongwei | 2023 | Chinese Journal of Natural Medicines2023，21，2： | 2 |
| 5 | Apelin inhibits motor neuron apoptosis in the anterior horn following acute spinal cord and sciatic nerve injuries显示文摘Rat models of acute spinal cord injury and sciatic nerve injury were established.Apelin expression in spinal cord tissue was determined.In normal rat spinal cords,apelin expression was visible;however,2 hours post spinal cord injury,apelin expression peaked.Apelin expression increased 1 day post ligation of the sciatic nerve compared with normal rat spinal cords,and peaked at 3 days.Apelin expression was greater in the posterior horn compared with the anterior horn at each time point when compared with the normal group.The onset of neuronal apoptosis was significantly delayed following injection of apelin protein at the stump of the sciatic nerve,and the number of apoptotic cells after injury was reduced when compared with normal spinal cords.Our results indicate that apelin is expressed in the normal spinal cord and central nervous system after peripheral nerve injury.Apelin protein can reduce motor neuron apoptosis in the spinal cord anterior horn and delay the onset of apoptosis. | Zhiyue Li Weiguo Wang Qun Zhao Weiquan Ning Bin Yang Suling Zhang Siyin Feng | 2011 | Neural Regeneration Research2011，6，20： | 2 |
| 6 | Azeotropic distillation-assisted preparation of macro-mesostructurecl γ-Al2 O3 nanofibres of crumpled sheet-like morphology 显示文摘 | Cai Weiquan Li Huiquan Zhang Yi | 2006 | Mater Chem Phys2006，，96： | 1 |
| 7 | A large insert Thellungiella halophila BIBAC library for genomics and identification of stress tolerance genes显示文摘 | Weiquan Wang Yaorong Wu Yin Li Jiaying Xie Zhonghui Zhang Zhiyong Deng Yiyue Zhang Cuiping Yang Jianbin Lai Huawei Zhang Hongyan Bao Sanyuan Tang Chengwei Yang Peng Gao Guixian Xia Huishan Guo Qi Xie | 2010 | Plant Molecular Biology (-)2010，，1： | 1 |
| 8 | Biological activity of the essential oil from the leaves of Piper sarmentosum Roxb. (Piperaceae) and its chemical constituents on Brontispa longissima (Gestro) (Coleoptera: Hispidae)显示文摘 | Weiquan Qin Shanchun Huang Chaoxu Li Siting Chen Zhengqiang Peng | 2009 | Pesticide Biochemistry and Physiology2009，，3： | 1 |
| 9 | Laser Cooling and Deceleration of Neutral Atoms by Red-Shifted Diffuse Light显示文摘We report a cooling and deceleration experiment of a thermal beam by using a nearly resonant red-shifted diffuse light in an optical integral sphere cavity.By using of this red-shifted diffuse light,the velocity of a part of thermal sodium atoms is cooled to 380m/s and the velocity width of cooled atoms is about 18m/s.The mechanism of this kind of laser cooling and the experimental results are discussed. | CHEN Hongxin CAI Weiquan LIU Liang SHU Wei LI Fosheng WANG Yuzhu | 1994 | Chinese Physics Letters1994，11，9： | 1 |
| 10 | Reliability analysis for vertical integration of protection,measurement,merge unit,and intelligent terminal device显示文摘The reliability analysis of vertically integrated protection devices is crucial for designing International Electrotechnical Commission(IEC)61850-based substations.This paper presents the hardware architecture of a four-inone vertically integrated device and the information transmission path of each function based on the functional information transmission chain of protection devices,measurement and control devices,merging units,and intelligent terminals.Additionally,a reliability analysis model of the protection device and its protection system is constructed using the fault tree analysis method while considering the characteristics of each module of the vertically integrated device.The stability probability of the protection system in each state is analyzed by combining the state-transfer equations of line and busbar protection with a Markov chain.Finally,the failure rate and availability of the protection device and its protection system are calculated under different ambient temperatures using a 110 kV intelligent substation as an example.The sensitivity of each device module is analyzed. | Ying Li Weiquan Wang Liang Zhang Zhujian Liang Zhenli Xu Yuansheng Liang | 2023 | Global Energy Interconnection2023，6，6： | 1 |
| 11 | FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene显示文摘 | Tao Zuo Lizhong Wang Carl Morrison Xing Chang Huiming Zhang Weiquan Li Yan Liu Yin Wang Xingluo Liu Michael W.Y. Chan Jin-Qing Liu Richard Love Chang-gong Liu Virginia Godfrey Rulong Shen Tim H.-M. Huang Tianyu Yang Bae Keun Park Cun-Yu Wang Pan Zheng Yan | 2007 | Cell2007，，7： | 1 |
| 12 | FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene显示文摘 | Tao Zuo Lizhong Wang Carl Morrison Xing Chang Huiming Zhang Weiquan Li Yan Liu Yin Wang Xingluo Liu Michael W.Y. Chan Jin-Qing Liu Richard Love Chang-gong Liu Virginia Godfrey Rulong Shen Tim H.-M. Huang Tianyu Yang Bae Keun Park Cun-Yu Wang Pan Zheng Yan | 2007 | Cell2007，，7： | 1 |
| 13 | Effect of temperature on the population growth of Rhynchophorusferrugineus ( Coleoptera: Cur- culionidae) on sugarcane 显示文摘 | Lei Li weiquan Qin zilong Ma | 2010 | Environmental Entomology2010，39，3： | 1 |
| 14 | Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibi- tion and tissue growth control显示文摘 | Bin Zhao Xiaomu Wei Weiquan Li | 2007 | Genes and Development2007，21，： | 1 |
| 15 | Biological activity of the essential oil from the leaves of Piper sarmentosum Roxb (Piperaceae) and its chemical constituents on Brontispa longissima (Gestro) (Coleoptera: Hispidae)显示文摘 | QIN WEIQUAN HUANG SHANCHUN LI CHAOXU | 2010 | Pesticide Biochemistry and Physiology2010，96，3： | 1 |
| 16 | Colonoscopy and artificial intelligence:Bridging the gap or a gap needing to be bridged?显示文摘Research in artificial intelligence(AI)in gastroenterology has increased over the last decade.Colonoscopy represents the most widely published field with regards to its use in gastroenterology.Most studies to date center on polyp detection and characterization,as well as real-time evaluation of adequacy of mucosal exposure for inspection.This review article discusses how advances in AI has bridged certain gaps in colonoscopy.In addition,the gaps formed with the development of AI that currently prevent its routine use in colonoscopy will be explored. | James Weiquan Li Tiing Leong Ang | 2021 | Artificial Intelligence in Gastrointestinal Endoscopy2021，2，2： | 1 |
| 17 | Omnidirectional Antenna Diversity System for High-Speed Onboard Communication显示文摘In this article,an omnidirectional dual-polarized antenna with synergetic electromagnetic and aerodynamic properties is propounded for high-speed diversity systems.The propounded antenna comprises a probe-fed cavity for horizontally polarized radiation and a microstrip-fed slot for vertical polarization.Double-layer metasurfaces are properly designed as artificial magnetic conductor boundaries with direct metal-mountable onboard installation and compact sizes.An attached wedge-shaped block is utilized for windage reduction in hydrodynamics.The propounded antenna is fabricated for design verification,and the experimental results agree well with the simulated ones.For vertical polarization,the operating bandwidth is in the range of 2.37–2.55 GHz,and the realized gain variation in the azimuthal radiation pattern is 3.67 decibels(dB).While an impedance bandwidth in the range of 2.45–2.47 GHz and a gain variation of 3.71 dB are also achieved for horizontal polarization.A port isolation more than 33 dB is obtained in a compact volume of 0.247λ_(0)×0.345λ_(0)×0.074λ_(0),whereλ_(0)represents the wavelength in vacuum at the center frequency,wherein the wedge-shaped block is included.The propounded diversity antenna has electromagnetic and aerodynamic merits,and exhibits an excellent potential for high-speed onboard communication. | Yongjian Zhang Yue Li Weiquan Zhang Zhijun Zhang Zhenghe Feng | 2022 | Engineering2022，8，4： | 0 |
| 18 | Effects of clinorotation on COL-1A1-EGFP gene expression显示文摘 | DAI Zhongquan LI Yinghui DING Bai ZHANG Yuguo LIU Weiquan LIU Pengpeng | 2005 | 中国生物学文摘2005，19，7： | 0 |
| 19 | Role of artificial intelligence in early detection and screening for pancreatic adenocarcinoma显示文摘Pancreatic adenocarcinoma remains to be one of the deadliest malignancies in the world despite treatment advancement over the past few decades.Its low survival rates and poor prognosis can be attributed to ambiguity in recommendations for screening and late symptom onset,contributing to its late presentation.In the recent years,artificial intelligence(AI)as emerged as a field to aid in the process of clinical decision making.Considerable efforts have been made in the realm of AI to screen for and predict future development of pancreatic ductal adenocarcinoma.This review discusses the use of AI in early detection and screening for pancreatic adenocarcinoma,and factors which may limit its use in a clinical setting. | Kenneth Weicong Lin Tiing Leong Ang James Weiquan Li | 2022 | Artificial Intelligence in Medical Imaging2022，3，2： | 0 |
| 20 | Velocity Selection of Atomic Beam by Laser显示文摘It is possible to deflect a group of atoms with a certain velocity from an effusive atomic beam if we use a properly detuned laser beam with a small angle off orthogonal to the atomic beam.Theoretical and initial experimental results of this simple method for velocity selection are given. | CAI Weiquan CHEN Hongxin LI Fusheng SHU Wei SUN Shundi WANG Yuzhu | 1995 | Chinese Physics Letters1995，12，5： | 0 |
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