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| 1 | CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization显示文摘Despite the diverse etiologies of drug-induced liver injury(DILI),innate immunity activation is a common feature involved in DILI progression.However,the involvement of innate immunity regulation in inflammation resolution and liver regeneration in DILI remains obscure.Herein,we identified the chemokine CCL5 as a central mediator of innate immunity regulation in the pathogenesis of DILI.First,we showed that serum and hepatic CCL5 levels are elevated in both DILI patients and an APAP-induced liver injury(AILI)mouse model.Interestingly,both nonparenchymal cells and stressed hepatocytes are cell sources of CCL5 induction in response to liver injury.Functional experiments showed that CCL5 deficiency has no effect on the early phase of AILI but promotes liver repair in the late phase mainly by promoting inflammation resolution and liver regeneration,which are associated with an increased number of hepatic M2 macrophages.Mechanistically,CCL5 can directly activate M1 polarization and impede M2 polarization through the CCR1-and CCR5-mediated activation of the MAPK and NF-κB pathways.We then showed that CCL5 inhibition mediated by either a CCL5-neutralizing antibody or the antagonist Met-CCL5 can greatly alleviate liver injury and improve survival in an AILI mouse model.Our data demonstrate CCL5 induction during DILI,identify CCL5 as a novel innate immunity regulator in macrophage polarization,and suggest that CCL5 blockage is a promising therapeutic strategy for the treatment of DILI. | Meng Li Xuehua Sun Jie Zhao Lei Xia Jichang Li Min Xu Bingrui Wang Han Guo Chang Yu Yueqiu Gao Hailong Wu Xiaoni Kong Qiang Xia | 2020 | Cellular & Molecular Immunology2020，17，7： | 13 |
| 2 | Development strategies for the sea cucumber industry in China显示文摘The sea cucumber, Apostichopus japonicus, is an important marine aquaculture species in China. After nearly thirty years of development, the production of A. japonicus has become commercially lucrative and successful. In this report, current advances in sea cucumber industry are addressed in terms of the basic biology, culturing methods, and health care bene?ts. Next, the challenges restricting development of the sea cucumber industry are discussed, including weaknesses in the basic biological research, the problem of germplasm degradation, environmental stress caused by global climate change, and food safety problems. Finally, several strategies are presented that might contribute to sustainable development of the sea cucumber industry. These strategies include advances in genome studies, behavioral studies, selective breeding, ecological culture technologies, reforms in food safety management, and the development of health care functions based on contemporary medical practices. Thus, our work provides new insights into how to explore the sustainable development of the sea cucumber industry in the future. | RU Xiaoshang ZHANG Libin LI Xiaoni LIU Shilin YANG Hongsheng | 2019 | Journal of Oceanology and Limnology2019，37，1： | 10 |
| 3 | In vitro inhibitory and pro-apoptotic effect of Stellera Chamaejasme LExtract on human lung cancer cell line NCI-H157显示文摘OBJECTIVE:To investigate the inhibitory and pro-apoptotic effect of Stellera Chamaejasme L extract(ESC) in vitro.METHODS:ESC was first extracted with ethanol,and then washed using a polyamide column with 60% ethanol.ESC was then decompressively recycled and vacuum dried at room temperature to obtain active fractions.Subsequently,the cytotoxic and apoptotic effects of ESC on NCI-H157 human lung cancer cells were determined.RESULTS:The results showed that ESC was rich in isomers of Chamaejasminor,neochamaejasmine and Sikokianin.ESC had significant cytotoxicity against NCI-H157 cells,with an IC 50 of approximately 18.50 μg.mL-1.ESC caused significant increase in total apoptotic rate,the activity of caspase 3 and 8,and Fas protein expression(P<0.05).CONCLUSION:The inhibitory effect of ESC on NCI-H157 tumor cells might partly be attributed to its apoptotic induction through activation of the Fas death receptor pathway. | Xiaoni Liu Yujie Li Qing Yang Ying Chen Xiaogang Weng Yiwei Wang Ning Li Xiaoxin Zhu | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 8 |
| 4 | Linear Complexity of Some Binary Sequences Derived from Fermat Quotients显示文摘We determined the linear complexity of a family of p2-periodic binary threshold sequences and a family of p2-periodic binary sequences constructed using the Legendre symbol,both of which are derived from Fermat quotients modulo an odd prime p.If 2 is a primitive element modulo p2,the linear complexity equals to p2-p or p2-1,which is very close to the period and it is large enough for cryptographic purpose. | Chen Zhixiong Hu Lei, Du Xiaoni | 2012 | China Communications2012，9，2： | 7 |
| 5 | TRANSFER MATRIX METHOD FOR ANALYZING VIBRATION AND DAMPING CHARACTERISTICS OF ROTATIONAL SHELL WITH PASSIVE CONSTRAINED LAYER DAMPING TREATMENT显示文摘The first order differential matrix equations of the host shell and constrained layer for a sandwich rotational shell are derived based on the thin shell theory.Employing the layer wise principle and first order shear deformation theory, only considering the shearing deformation of the viscoelastic layer, the integrated first order differential matrix equation of a passive constrained layer damping rotational shell is established by combining with the normal equilibrium equation of the viscoelastic layer.A highly precise transfer matrix method is developed by extended homogeneous capacity precision integration technology.The numerical results show that present method is accurate and effective. | Jing Lu Yu Xiang Yuying Huang Xiaoni Li Qiao Ni | 2010 | Acta Mechanica Solida Sinica2010，23，4： | 5 |
| 6 | Park7 interacts with p47phox to direct NADPH oxidase- dependent ROS production and protect against sepsis显示文摘 | Wenjun Liu Hailong Wu Lili Chen Yankai Wen Xiaoni Kong Wei-Qiang Gao | 2015 | Cell Research2015，25，6： | 5 |
| 7 | On the Linear Complexity of New Generalized Cyclotomic Binary Sequences of Order Two and Period pqr显示文摘Periodic sequences over finite fields, constructed by classical cyclotomic classes and generalized cyclotomic classes, have good pseudorandom properties. The linear complexity of a period sequence plays a fundamental role in the randomness of sequences. Let p, q, and r be distinct odd primes with gcd(p–1, q–1)=gcd(p–1, r –1)=gcd(q–1, r –1)=2. In this paper, a new class of generalized cyclotomic sequence with respect to pqr over GF(2) is constructed by finding a special characteristic set. In addition, we determine its linear complexity using cyclotomic theory. Our results show that these sequences have high linear complexity, which means they can resist linear attacks. | Longfei Liu Xiaoyuan Yang Xiaoni Du Bin Wei | 2016 | Tsinghua Science and Technology2016，21，3： | 4 |
| 8 | Trace Representations of Generalized Cyclotomic Sequences of Length pq with Arbitrary Order显示文摘 | DU Xiaoni CHEN Zhixiong | 2009 | Chinese Journal of Electronics2009，18，3： | 4 |
| 9 | Diversification of Sisorid catfishes(Teleostei: Siluriformes)in relation to the orogeny of the Himalayan Plateau显示文摘Sisorid catfishes are primarily limited in distribution to rivers of the Himalayan region and Tibetan Plateau. These species have external morphologies that are adapted for extremely fast-flowing riverine systems. Given the diversity of the group and the above qualities of these catfishes, this lineage serves as an ideal group for inferring the geological history of this region based on their phylogenetic relationships reflecting evolutionary history. We sequenced the complete mitochondrial genome and four nuclear genes of representative sisorids distributed across river systems in China. Phylogenetic analyses strongly support the monophyly of the Sisoridae and the glyptosternoids. An analysis of the reconstructed ancestral states derived from inferred genealogical relationships suggests that the evolution of this lineage was accompanied by convergent evolution in morphological traits that were presumably in response to environmental pressure involving the rapid flowing river system that were generated during the uplift of the Tibetan Plateau(UTP).Molecular dating indicates that the Chinese sisorids and the glyptosternoids originated at the later Miocene(*10.9–9.8Mya), and with further biogeographic analyses indicates that the species of Sisoridae likely originated from a widely distributed ancestor. Moreover, the divergence of the Sisoridae in China can be divided into two phases consistent with the UTP. All of these results indicate that the diversification and dispersal events in this lineage occurred as a result of drainage systems formed during and after the UTP in the late Miocene and Quaternary periods. | Chuanjiang Zhou Xuzhen Wang Xiaoni Gan Yaping Zhang David M.Irwin Richard L.Mayden Shunping He | 2016 | Science Bulletin2016，61，13： | 4 |
| 10 | Cyprininae phylogeny revealed independent origins of the Tibetan Plateau endemic polyploid cyprinids and their diversifications related to the Neogene uplift of the plateau显示文摘Origin and diversification of the Tibetan polyploid cyprinids(schizothoracins) may help us to explore relationships between diversification of the cyprinids and the Tibetan Plateau uplift. Cyprininae phylogeny was analyzed using mitochondrial and nuclear DNA sequences to trace origins of polyploidy and diversifications of schizothoracins. Ancestral states reconstruction for ploidy levels indicated that the Cyprininae was diploid origin and the schizothoracin clades tetraploid origins. There were two diversification rate shifts along with diversification of the cyprinine fishes in response to the Tibetan uplift. The unusual diversification shifts were located to branches subtending the clades of Tibetan polyploid cyprinids. Our analyses suggested that(i) phylogeny of Cyprininae recovered two independent origins of the Tibetan polyploidy schizothoracins;(ii) diversifications of the schizothoracins were closely related to the Neogene uplift of the Tibetan plateau in the following ways: the relatively ancient Late Oligocene-Middle Miocene adaptive radiation may be associated with the uplift of the southern Tibet and Himalaya; the Middle Miocene-Early Pleistocene lineage-specific diversification broadly coincident with major phase of the Neogene Tibetan uplift; and the most recent Pleistocene diversification shift in Schizothorax closely coincident with the successive Kunlun-Huanghe and Gonghe movements of the Tibetan uplift and the glaciation-induced climate oscillations on the plateau. | Xuzhen Wang Xiaoni Gan Junbing Li Yiyu Chen Shunping He | 2016 | Science China(Life Sciences)2016，59，11： | 4 |
| 11 | Mesenchymal stem cells therapy for acute liver failure: Recent advances and future perspectives显示文摘Acute liver failure(ALF)is a life-threatening disease characterized by the rapid development of hepatocyte death and a systemic inflammatory response,which leads to high mortality.Despite the prevention of ALF complications,therapeutic effectiveness remains limited because of the rapid disease progression.Thus,there is a need to explore various therapeutic approaches.Currently,the only effective treatment is liver transplantation;However,the lack of donors,surgical complications,immunosuppression,and high medical costs limit its clinical application.Recently,mesenchymal stem cells(MSCs)have been found to exert hepatoprotective effects in ALF through suppression of inflammation,immunoregulation,promotion of mitosis,anti-apoptosis effects,and alleviation of the metabolic and oxidative stress imbalance.In this review,we summarize the advantages and disadvantages of MSCs from different sources and their molecular mechanisms in ALF treatment,along with future perspectives that may provide guidance to improve the current status of MSCs therapy for ALF. | Yuling Luan Xiaoni Kong Yu Feng | 2021 | Liver Research2021，5，2： | 3 |
| 12 | Effects of mepiquat chloride on yield and main properties of cottonseed under different plant densities显示文摘Background:Cottonseed oil and protein content as well as germination traits are major indicators of seed quality.However,the responses of these indicators to plant density and mepiquat chloride(MC)are still uncertain.To investigate plant density and MC effects on cotto nseed yield and main quality parameters,we con ducted a twoyear field experiment including four plant densities(1.35,2.55,3.75 and 4.95 plants·m^-2)and two closes of MC(0 and 135g·hm^-2)in Dafeng,Jiangsu Province,in 2013 and 2014.Results:The application of MC reduced plant height,fruit branch length and fruiting branch number under different plant densities,resulting in a lower and more compact plant canopy.Cottonseed yield showed a nonlinear increase as plant density increasing and achieved the highest value at 3.75 plants·m^-2,regardless of MC application.No significant interactio ns were found between plant density and MC for cotton seed yield and quality parameters.The 100-seed weight,cottonseed oil content and vigor index significantly decreased as plant density increased,while these parameters significantly increased with MC applying under different plant densities.Seed vigor index was positively correlated with 100-seed weight and seed oil con tent across different plant densities and MC treatments.Conclusions:Thus,application of MC could realize a win-win situation between cottonseed yield and main quality parameters under various densities;and plant density of 3.75 plants·m^-2 combined with 135 g·hm^-2 of MC applying is optimal for high cottonseed yield and quality in this cotton production area. | ZHAO Wenqing YAN Qiang YANG Hongkun YANG Xiaoni WANG Leran CHEN Binglin MENG Yali ZHOU Zhiguo | 2019 | Journal of Cotton Research2019，2，2： | 3 |
| 13 | Comparison of pigment composition and melanin content among white,light-green,dark-green,and purple morphs of sea cucumber,Apostichopus japonicus显示文摘Sea cucumber, Apostichopus japonicus(Selenka), is a commercially important marine species in China. Among the differently colored varieties sold in China, white and purple sea cucumbers have the greatest appeal to consumers. Identification of the pigments that may contribute to the formation of different color morphs of sea cucumbers will provide a scientific basis for improving the cultivability of desirable color morphs. In this study,sea cucumbers were divided into four categories according to their body color: white, light green, dark green, and purple. The pigment composition and contents in the four groups were analyzed by high performance liquid chromatography(HPLC). The results show that the pigment contents differed significantly among the white, lightgreen, dark-green, and purple sea cucumbers, and there were fewer types of pigments in white sea cucumber than in the other color morphs. The only pigments detected in white sea cucumbers were guanine and pteroic acid.Guanine and pteroic acid are structural colors, and they were also detected in light-green, dark-green, and purple sea cucumbers. Every pigment detected, except for pteroic acid, was present at a higher concentration in purple morphs than in the other color morphs. The biological color pigments melanin, astaxanthin, β-carotene, and lutein were detected in light-green, dark-green, and purple sea cucumbers. While progesterone and lycopene,which are also biological color pigments, were not detected in any of the color morphs. Melanin was the major pigment contributing to body color, and its concentration increased with deepening color of the sea cucumber body. Transmission electron microscopy analyses revealed that white sea cucumbers had the fewest epidermal melanocytes in the body wall, and their melanocytes contained fewer melanosomes as well as non-pigmented pre-melanosomes. Sea cucumbers with deeper body colors contained more melanin granules. In the body wall of dark-green and purple sea cucumbers, melanin granules were secreted out of the cell. The results of this study provide evidence for the main factors responsible for differences in coloration among white, light-green, darkgreen, and purple sea cucumbers, and also provide the foundation for further research on the formation of body color in sea cucumber, A. japonicus. | XING Lili SUN Lina LIU Shilin LI Xiaoni MIAO Ting ZHANG Libin YANG Hongsheng | 2017 | Acta Oceanologica Sinica2017，36，12： | 3 |
| 14 | Linear complexity problems of level sequences of Euler quotients and their related binary sequences显示文摘The Euler quotient modulo an odd-prime power p^r(r > 1) can be uniquely decomposed as a p-adic number of the form(u^(p-1)p^(r-1)- 1)/p^r≡ a_0(u) + a_1(u)p + ··· + a_r-1(u)p^(r-1)(mod pr), gcd(u, p) = 1, where0≤a_j(u) < p for 0≤j≤r- 1 and we set all a_j(u) = 0 if gcd(u, p) > 1. We firstly study certain arithmetic properties of the level sequences(aj(u))u≥0over Fp via introducing a new quotient. Then we determine the exact values of linear complexity of(a_j(u))u≥0 and values of k-error linear complexity for binary sequences defined by(a_j(u))u≥0. | Zhihua NIU Zhixiong CHEN Xiaoni DU | 2016 | Science China(Information Sciences)2016，59，3： | 3 |
| 15 | The transport of chemical components in homogeneous snowpacks on Urumqi Glacier No.1, eastern Tianshan Mountains, Central Asia显示文摘Chemical records from alpine ice cores provide an invaluable source of paleoclimatic and environmental information. Not only the atmospheric chemical composition but also depositional and post-depositional processes are recorded within snow/firn strata. To interpret the environmental and climatic significance of ice core records, we studied the variability of glacier snowpack chemistry by investigating homogeneous snowpacks from October 2003 to September 2006 on Urumqi Glacier No. 1 in eastern Tianshan Mountains, Central Asia. Principle Component Analysis of ionic species in dry and wet seasons revealed the impact of meltwater in redistributing ions in the snowpacks. The 1st, 2nd and 3rd principle components for dry seasons differ significantly, reflecting complex associations between depositional or/and post-depositional processes. The variability trend of ionic concentrations during the wet seasons was found to fit a Gauss Function with significant parameters. The elution factor revealed that more than half of ions are leached out during the wet seasons. Differences with respect to ion snowpack mobility were found. Of the ions studied SO42– was the most mobile and Mg2+ the least mobile. A threshold relationship between air temperatures and the elution process was investigated over the study period. The results indicate that the strong melt /ablation processes and iconic redistribution occur at a threshold air temperature of 0°C. The study found that surface melt on the snowpacks is the main factor causing the alteration of the snowpack chemistry. Rainfall also has an impact on the chemistry but plays a less significant role than the surface melt. | YOU Xiaoni LI Zhongqin Ross EDWARDS WANG Lixia | 2015 | Journal of Arid Land2015，7，5： | 3 |
| 16 | The c-myc coding DNA sequences of cyprinids (Teleostei:Cypriniformes):Implications for phylogeny显示文摘The family Cyprinidae is one of the largest fish families in the world,which is widely distributed in East Asian,with obvious difference in characteristic size among species. The phylogenetic analysis of cy-prinid taxa based on the functionally important genes can help to understand the speciation and functional divergence of the Cyprinidae. The c-myc gene is an important gene regulating individual growth. In the present study,the sequence variations of the cyprinid c-myc gene and their phylogenetic significance were analyzed. The 41 complete sequences of the c-myc gene were obtained from cyprinids and outgroups through PCR amplification and clone. The coding DNA sequences of the c-myc gene were used to infer molecular phylogenetic relationships within the Cyprinidae. Myxocyprinus asiaticus (Catostomidae),Misgurnus anguillicaudatus (Cobitidae) and Hemimyzon sinensis (Homalopteridae) were assigned to the outgroup taxa. Phylogenetic analyses using maximum parsimony (MP). maximum likelihood (ML),and Bayesian retrieved similar topology. Within the Cyprinidae,Leuciscini and Barbini formed the monophyletic lineage respectively with high nodal supports. Leuciscini comprises Xeno-cyprinae,Cultrinae,East Asian species of Leuciscinae and Danioninae,Gobioninae and Acheilog-nathinae,and Barbini contains Schizothoracinae,Barbinae,Cyprininae and Labeoninae. Danio rerio,D. myersi and Rasbora trilineata were supposed to separate from Leuciscinae and Barbini and to form another lineage. The positions of some Danioninae species were still unresolved. Analyses of both amino acid variation with parsimony information and two high variation regions indicated that there is no correlation between variations of single amino acid or high variation regions and characteristic size of cyprinids. In addition,the species with smaller size were usually found to be basal within clades in the tree,which might be the results of the adaptation to the primitive ecology and survival pressure. | KONG XiangHui WANG XuZhen GAN XiaoNi HE ShunPing | 2007 | Chinese Science Bulletin2007，52，11： | 3 |
| 17 | Methodology for fish biodiversity monitoring with environmental DNA metabarcoding:The primers,databases and bioinformatic pipelines显示文摘Environmental DNA(eDNA)originates from cellular material shed by organisms into aquatic or terrestrial environments and can be sampled and monitored using metabarcoding technology,which is revolutionizing fish biodiversity monitoring.Several reviews concerning fish eDNA have focused on standard sampling methods and its applications,though a systematic review focused on marker genes,databases,and bioinformatic pipelines has not yet been published.Here,we present a comprehensive literature review of studies applying metabarcoding technology to fish eDNA for the purpose of fish biodiversity monitoring.We systematically provide the available universal primers used to amplify barcoding sequences from fish eDNA,and then discuss reference barcoding databases,relevant bioinformatic analyses,as well as developed pipelines.The performances of universal primers and their relevant reference databases are summarized.Combined use of multiple primer pairs targeted for more than one gene marker(e.g.,12S,16S,Cytb,COI),and use of both local and public databases are recommended as approaches to improve the sensitivity and reliability of fish eDNA analyses.We also compare the effectiveness of eDNA metabarcoding to traditional approaches for monitoring fish biodiversity and highlight challenges and future perspectives associated with this new tool.Ultimately,we advocate for greater incorporation of eDNA analysis into fish biodiversity assessments to assist environmental managers. | Fan Xiong Lu Shu Honghui Zeng Xiaoni Gan Shunping He Zuogang Peng | 2022 | Water Biology and Security2022，1，1： | 3 |
| 18 | Cyprinid phylogeny based on Bayesian and maximum likelihood analyses of partitioned data:implications for Cyprinidae systematics显示文摘Cyprinidae is the biggest family of freshwater fish, but the phylogenetic relationships among its higher-level taxa are not yet fully resolved. In this study, we used the nuclear recombination activating gene 2 and the mitochondrial 16S ribosomal RNA and cytochrome b genes to reconstruct cyprinid phylogeny. Our aims were to (i) demonstrate the effects of partitioned phylogenetic analyses on phylogeny reconstruction of cyprinid fishes; (ii) provide new insights into the phylogeny of cyprinids. Our study indicated that unpartitioned strategy was optimal for our analyses; partitioned analyses did not provide better-resolved or-supported estimates of cyprinid phylogeny. Bayesian analyses support the following relationships among the major monophyletic groups within Cyprinidae: (Cyprininae, Labeoninae), ((Acheilognathinae, ((Leuciscinae, Tincinae), Gobioninae)), Xenocyprininae). The placement of Danioninae was poorly resolved. Estimates of divergence dates within the family showed that radiation of the major cyprinid groups occurred during the Late Oligocene through the Late Miocene. Our phylogenetic analyses improved our understanding of the evolutionary history of this important fish family. | WANG XuZhen GAN XiaoNi LI JunBing MAYDEN Richard L. HE ShunPing | 2012 | Science China(Life Sciences)2012，55，9： | 2 |
| 19 | 不同近地层大气稳定度条件下洱海湖-气界面潜热和感热通量的控制因子显示文摘本文利用由涡动相关法观测得到的2015年高原开放淡水湖泊(洱海)的湍流通量资料,分析了湖面近地层大气稳定度特征以及不同稳定度条件下潜热和感热通量的主要控制因子。湖面近地层大气稳定度具有显著的日变化和季节变化特征。不同大气变量对潜热和感热通量的相对影响程度受到大气稳定度的调控。在稳定和不稳定范围内,潜热通量与湖-气间的水汽压差密切相关,而在弱不稳定到弱稳定范围内,潜热通量主要受风速控制。在稳定条件下,风速和湖-气温差对感热通量具有显著影响,而在不稳定条件下对感热通量的影响不显著。 | MENG Xiaoni LIU Huizhi DU Qun LIU Yang XU Lujun | 2020 | Atmospheric and Oceanic Science Letters2020，13，5： | 2 |
| 20 | Pollutant emissions,energy consumption and economic development in China:Evidence from dynamic panel data显示文摘This study investigates the relationship among pollutant emissions,energy consumption and economic development in China during the period 1982-2007 by using a one-step GMM-system model under a multivariable panel VAR framework,controlling for capital stock and labor force.Regarding the data for all 28 provinces as a whole,we find that there is a unidirectional positive relationship running from pollutant emission to economic development and a unidirectional negative relationship between pollutant emission and energy consumption.Based on traditional economic planning,the panel data of28 provinces are divided into two cross-province groups.It is discovered that in the eastern coastal region of China,there is only a unidirectional positive causal relationship leading from economic development to pollutant emission;while in the central and western regions,there are the unidirectional Granger causal relationships between pollutant emission and energy consumption,as well as between pollutant emission and economic development.There is also a unique unidirectional causal relationship running from economic development to energy consumption,which does not appear in the eastem coastal region or in China as a whole. | Baoshan Zhang Xiaoni Zhang Xiaoling Yuan | 2013 | Chinese Journal of Population,Resources and Environment2013，11，2： | 2 |
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