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| 1 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 2 | Community analysis of ammonia-oxidizing bacteria in activated sludge of eight wastewater treatment systems显示文摘We investigated the communities of ammonia-oxidizing bacteria(AOB) in activated sludge collected from eight wastewater treatment systems using polymerase chain reaction(PCR) followed by terminal restriction fragment length polymorphism(T-RFLP),cloning,and sequencing of the α-subunit of the ammonia monooxygenase gene(amoA).The T-RFLP fingerprint analyses showed that different wastewater treatment systems harbored distinct AOB communities.However,there was no remarkable difference among the AOB TRFLP profiles from different parts of the same system.The T-RFLP fingerprints showed that a full-scale wastewater treatment plant(WWTP) contained a larger number of dominant AOB species than a pilot-scale reactor.The source of influent affected the AOB community,and the WWTPs treating domestic wastewater contained a higher AOB diversity than those receiving mixed domestic and industrial wastewater.However,the AOB community structure was little affected by the treatment process in this study.Phylogenetic analysis of the cloned amoA genes clearly indicated that all the dominant AOB in the systems was closely related to Nitrosomonas spp.not to Nitrosospira spp.Members of the Nitrosomonas oligotropha and Nitrosomonas communis clusters were found in all samples,while members of Nitrosomonas europaea cluster occurred in some systems. | Xiaohui Wang Xianghua Wen Craig Criddle George Wells Jie Zhang Yin Zhao | 2010 | Journal of Environmental Sciences2010，22，4： | 17 |
| 3 | Giant photonic spin Hall effect in momentum space in a structured metamaterial with spatially varying birefringence显示文摘The photonic spin Hall effect(SHE)in the reflection and refraction at an interface is very weak because of the weak spin-orbit interaction.Here,we report the observation of a giant photonic SHE in a dielectric-based metamaterial.The metamaterial is structured to create a coordinate-dependent,geometric Pancharatnam–Berry phase that results in an SHE with a spin-dependent splitting in momentum space.It is unlike the SHE that occurs in real space in the reflection and refraction at an interface,which results from the momentum-dependent gradient of the geometric Rytov–Vladimirskii–Berry phase.We theorize a unified description of the photonic SHE based on the two types of geometric phase gradient,and we experimentally measure the giant spin-dependent shift of the beam centroid produced by the metamaterial at a visible wavelength.Our results suggest that the structured metamaterial offers a potential method of manipulating spin-polarized photons and the orbital angular momentum of light and thus enables applications in spin-controlled nanophotonics. | Xiaohui Ling Xinxing Zhou Xunong Yi Weixing Shu Yachao Liu Shizhen Chen Hailu Luo Shuangchun Wen Dianyuan Fan | 2015 | Light(Science & Applications)2015，4，1： | 15 |
| 4 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 5 | DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells显示文摘染色质改变为人的初发的细菌房间的 epigenetic reprogramming 是重要的。然而,全面染色质状态还没为人的胎儿的细菌房间(FGC ) 被分析了。这里,我们使用 nucleosome 占有和 methylation 定序方法在人和老鼠在胎儿的细菌房间开发期间在一系列关键时间点分析染色体宽的染色质可接近性和 DNA methylome。我们在人和老鼠 FGC 发现 116 887 和 137 557 个弄空 nucleosome 的区域(NDR ) ,盖住 germline 特定、高度有活力的规章的 genomic 元素的一个大集合,例如 enhancers。而且,我们发现远侧的 NDR 在人的 FGC 为象 NANOG , SOX17 , AP2 和 OCT4 那样的 pluripotency 和细菌房间主人管理者的有约束力的主题明确地被充实,显示在pluripotency相关的基因和细菌之间的精细的规章的平衡的存在在人的 FGC 的房间特定的基因,并且为在 vivo 的细菌房间开发的这些基因的功能的意义。我们的工作为把提供一张全面、高分辨率的路线图染色质状态转变动力学在人和老鼠 FGC 的 epigenomic reprogramming 期间。 | Hongshan Guo Boqiang Hu Liying Yan Jun Yong Yan Wu Yun Gao Fan Guo Yu Hou Xiaoying Fan Ji Dong Xiaoye Wang Xiaohui Zhu Jie Yan Yuan Wei Hongyan Jin Wenxin Zhang Lu Wen FuchouTang Jie Qiao | 2017 | Cell Research2017，27，2： | 9 |
| 6 | Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG2) to arsenic trioxide-induced cell death显示文摘细胞内部的氧化还原作用动态平衡在决定肿瘤房间的敏感到导致药的 apoptosis 起一个关键作用。这里,我们调查了 thioredoxin-1 (TRX1 ) 的角色,氧化还原作用规定的一个关键部件,在砷三氧化物(作为(2 ) O (3 )) 导致的 apoptosis。在 HepG ( 2 )房间的野类型的 TRX1 的在表示上导致了抑制当( 2 ) O ( 3 )导致了细胞色素 c ( cyto c ),释放, caspase 激活和 apoptosis ,并且由 RNAi 的 TRX1 表示的绒毛规定敏化 HepG ( 2 )房间到当( 2 ) O ( 3 )导致了 apoptosis 。有趣地,到重量的单位(32/35 ) 的从 Cys (32/35 ) 的 TRX1 的活跃地点的变化从一个 apoptotic 保护者把这个分子变换成一个 apoptotic 倡导者。以理解这变换的机制,我们从老鼠肝使用了孤立的线粒体并且发现了野类型的 TRX1 能保护的那重组体从 apoptotic 的线粒体变化。相反, TRX1 的变异的形式独自得到了线粒体相关的 apoptotic 变化,包括 mitochondrial 渗透转变毛孔(mPTP ) 洞, mitochondrial 膜潜力的损失,和 cyto 从线粒体的 c 版本。这些 apoptotic 效果被 cyclosporine A (CsA ) 禁止,显示指向到 mPTP 的那变异的 TRX1。到由 2,4-dinitrochlorobenzene (DNCB ) 的氧化形式体内的从它的减少的形式的 TRX1 的改变, TRX reductase 的一个特定的禁止者,也敏化的 HepG (2 ) 房间到当(2 ) O (3 ) 导致了 apoptosis。这些数据建议 TRX1 由任何一个变化在由堵住 cyto c 版本调整 apoptosis,并且在 TRX1 的激活起一个中央作用或活跃地点半胱氨酸的氧化可以敏化肿瘤房间到当(2 ) O (3 ) 导致了 apoptosis。 | Changhai Tian Ping Gao Yanhua Zheng Wen Yue Xiaohui Wang Haijing Jin Quan Chen | 2008 | Cell Research2008，18，4： | 7 |
| 7 | New insights into hepatitis B virus biology and implications for novel antiviral strategies显示文摘Hepatitis B virus(HBV), a small DNA virus with a unique replication mode, can cause chronic hepatitis(CHB), which is characterized by the persistence of the viral covalently closed circular DNA that serves as the template for HBV replication and the production of large amounts of secreted HBV surface antigen(HBs Ag) that is present in excess of the levels of infectious virus. Despite the success of currently approved antiviral treatments for CHB patients, including interferon and nucleotide analogs, which suppress HBV replication and reduce the risk of CHB-related liver diseases, these therapies fail to eradicate the virus in most of the patients. With the development of the cell and animal models for HBV study, a beter understanding of the HBV life cycle has been achieved and a series of novel antiviral strategies that target diferent stages of HBV replication have been designed to overcome the viral factors that contribute to HBV persistence. Such basic HBV research advancements and therapeutic developments are the subject of this review. | Jieliang Chen Min Wu Kuancheng Liu Wen Zhang Yaming Li Xiaohui Zhou Lu Bai Zhenghong Yuan | 2015 | National Science Review2015，2，3： | 6 |
| 8 | Detection of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome using mismatch negativity显示文摘In this experiment,97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups(mild,moderate,severe) according to minimum oxygen saturation,and 35 healthy subjects were examined as controls.Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment.The results revealed that as the disease worsened,the mismatch negativity latency was gradually extended,and the amplitude gradually declined in patients with obstructive sleep apnea hypopnea syndrome.Importantly,mismatch negativity latency in severe patients with a persistent time of minimum oxygen saturation < 60 seconds was significantly shorter than that with a persistent time of minimum oxygen saturation > 60 seconds.Correlation analysis revealed a negative correlation between minimum oxygen saturation latency and Montreal Cognitive Assessment scores.These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montreal Cognitive Assessment scores.As indicators for detecting the cognitive functional status of obstructive sleep apnea hypopnea syndrome patients,the sensitivity of mismatch negativity is 82.93%,the specificity is 73.33%,the accuracy rate is 81.52%,the positive predictive value is 85.00%,the negative predictive value is 70.21%,the positive likelihood ratio is 3,and the negative likelihood ratio is 0.23.These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients. | Xiaohui Wen Ningyu Wang Jinfeng Liu Zhanfeng Yan Zhonghai Xin | 2012 | Neural Regeneration Research2012，7，20： | 6 |
| 9 | Photonic spin Hall effect on the surface of anisotropic two-dimensional atomic crystals显示文摘We examine the spin-orbit interaction of light and photonic spin Hall effect on the surface of anisotropic two-dimensional atomic crystals. As an example, the photonic spin Hall effect on the surface of black phosphorus is investigated. The photonic spin Hall effect manifests itself as the spin-dependent beam shifts in both transverse and in-plane directions. We demonstrate that the spin-dependent shifts are sensitive to the orientation of the optical axis, doping concentration, and interband transitions. These results can be extensively extended to other anisotropic two-dimensional atomic crystals. By incorporating the quantum weak measurement techniques, the photonic spin Hall effect holds great promise for detecting the parameters of anisotropic two-dimensional atomic crystals. | WENSHUAI ZHANG WEIJIE WU SHIZHEN CHEN JIN ZHANG XIAOHUI LING WEIXING SHU HAILU LUO SHUANGCHUN WEN | 2018 | Photonics Research2018，6，6： | 4 |
| 10 | Local inhibition of GABA affects precedence effect in the inferior colliculus显示文摘The precedence effect is a prerequisite for faithful sound localization in a complex auditory environment,and is a physiological phenomenon in which the auditory system selectively suppresses the directional information from echoes.Here we investigated how neurons in the inferior colliculus respond to the paired sounds that produce precedence-effect illusions,and whether their firing behavior can be modulated through inhibition with gamma-aminobutyric acid(GABA).We recorded extracellularly from 36 neurons in rat inferior colliculus under three conditions: no injection,injection with saline,and injection with gamma-aminobutyric acid.The paired sounds that produced precedence effects were two identical 4-ms noise bursts,which were delivered contralaterally or ipsilaterally to the recording site.The normalized neural responses were measured as a function of different inter-stimulus delays and half-maximal interstimulus delays were acquired.Neuronal responses to the lagging sounds were weak when the inter-stimulus delay was short,but increased gradually as the delay was lengthened.Saline injection produced no changes in neural responses,but after local gamma-aminobutyric acid application,responses to the lagging stimulus were suppressed.Application of gamma-aminobutyric acid affected the normalized response to lagging sounds,independently of whether they or the paired sounds were contralateral or ipsilateral to the recording site.These observations suggest that local inhibition by gamma-aminobutyric acid in the rat inferior colliculus shapes the neural responses to lagging sounds,and modulates the precedence effect. | Yanjun Wang Ningyu Wang Dan Wang Jun Jia Jinfeng Liu Yan Xie Xiaohui Wen Xiaoting Li | 2014 | Neural Regeneration Research2014，9，4： | 4 |
| 11 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 12 | Competing endogenous RNA screening based on long noncoding RNA-messenger RNA co-expression profile in Hepatitis B virus-associated hepatocarcinogenesis显示文摘OBJECTIVE: To profile the liver cancer specific long noncoding RNAs(lnc RNAs) and competing endogenous RNA(ce RNA) networks of Hepatitis B virus(HBV)-associated hepatocarcinogensis(HCG) and to examine the effect of compound K on the expression of identified ce RNA networks.METHODS: Based on lnc RNA and messenger RNA(m RNA) microarray data of HBV-associated liver cancer, the current study profiles the cancer specific lnc RNAs and ce RNA networks of HBV-associated HCG through comprehensive application of Reg RNA 2, mi RTar Base and Pearson correlation coefficient analysis. Compound K-treated liver cancer cells were harvested for analysis of transcriptional levels of both enoyl-Co A hydratase and 3-hydroxyacyl Co A dehydrogenase(EHHADH)-AS1 and ENTPD5.RESULTS: The results revealed that 11 Encyclopedia of DNA Elements annotated lnc RNAs were differentially expressed in the process of HBV-associated HCG. Among these lnc RNAs, 95 potential ce RNA networks with highly positively correlated expression profiles between the interacting lnc RNAs and m RNAs(Pearson correlation coefficient ≥ 0.7) were constructed. Of note, two HBV-associated ce RNA networks, EHHADH-AS1-hsa-mi R-4459-ectonucleoside triphosphate diphosphohydrolase 5 and LINC01018-hsa-mi RNA-574-5p-glucose-6-phosphatase catalytic subunit, with Pearson correlation coefficient ≥ 0.9, may play a critical role in hepatocellular carcinoma development, which was supported by experimental evidence. Interestingly, compound K, an intestinal bacterial metabolite of ginseng protopanaxadiol saponin, which has been proven to promote apoptosis of human hepatocellular carcinoma cells, was found to impede the down-regulation of EHHADH-AS1 in several liver cancer cell lines including Hep G3 B, Huh-7 and plc/prf/5 cells.CONCLUSION: Comprehensive application of co-expression network analysis and prediction of RNA interaction may be a feasible strategy to unravel the potential ce RNA networks involved in the process of human diseases. | Wen Quan Yang Yao Chen Xianhua Pan Xiaodong Han Qi Wang Dong Deng Youcai Li Xiaohui Yan Jun Zhou Jihong | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 3 |
| 13 | Deep Fault Diagnosis for Rotating Machinery with Scarce Labeled Samples显示文摘Early and accurately detecting faults is crucial for the modern manufacturing system.We proposed a novel Deep fault diagnosis(DFD)method for rotating machinery with scarce labeled samples.A spectrogram of the raw vibration signal is calculated by applying a Short-time Fourier transform(STFT).Several candidate Support vector machine(SVM)models are trained with different combinations of features in the feature pool with scarce labeled samples.By evaluating the pretrained SVM models on the validation set,the most discriminative features and best-performed SVM models can be selected,which are used to make predictions on the unlabeled samples.The predicted labels reserve the expert knowledge originally carried by the SVM model.They are combined together with the scarce fine labeled samples to form an Augmented training set(ATS).Finally,a novel 2D deep Convolutional neural network(CNN)model is trained on the ATS to learn more discriminative features and a better classifier.Experimental results on two fault diagnosis datasets demonstrate the effectiveness of the proposed DFD. | ZHANG Jing TIAN Jing WEN Tao YANG Xiaohui RAO Yong XU Xiaobin | 2020 | Chinese Journal of Electronics2020，29，4： | 2 |
| 14 | High-Order Extended Kalman Filter Design for a Class of Complex Dynamic Systems with Polynomial Nonlinearities显示文摘A novel High-order extended Kalman Filter(HEKF)is designed for a class of complex dynamic systems with polynomial nonlinearities.The state and measurement models are represented by multidimensional high-order polynomials,respectively.All highorder polynomials in the state model are defined as implicit variables.By combining original variables with implicit variables,the state model is equivalently formulated to be a pseudo-linear form.By modeling dynamic relationship between implicit variables and combining original variables with all implicit variables,a new linear augmented state model is established correspondingly.The measurement model can be equivalently formulated as a linear form.On the basis of the new linear state and linear measurement models,the HEKF is designed and derived in detail.Simulation results demonstrate the effectiveness of the proposed estimator. | SUN Xiaohui WEN Chenglin WEN Tao | 2021 | Chinese Journal of Electronics2021，30，3： | 2 |
| 15 | Community dynamics of ammonia oxidizing bacteria in a fullscale wastewater treatment system with nitrification stability显示文摘To determine whether the functional stability of nitrification was correlated to a stable community structure of ammonia oxidizing bacteria(AOB)in a fullscale wastewater treatment plant,the AOB community dynamics in a wastewater treatment system was monitored over one year.The community dynamics were investigated using specific PCR followed by terminal restriction fragment length polymorphism(T-RFLP)analysis of the amoA gene.The T-RFLP results indicated that during the period of nitrification stability,the AOB community structure in the full-scale wastewater treatment system was relatively stable,and the average change rate every 15 d of the system was 6.6%±5.8%.The phylogenetic analysis of the cloned amoA gene showed clearly that the dominant AOB in the system was Nitrosomonas spp.The results of this study indicated that throughout the study period,the AOB community structure was relatively stable in the full-scale wastewater treatment system with functional stability of nitrification. | Xiaohui WANG Xianghua WEN Hengjing YAN Kun DING Man HU | 2011 | Frontiers of Environmental Science & Engineering2011，5，1： | 2 |
| 16 | CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice显示文摘CD38 is the main enzyme for nicotinamide adenine dinucleotide(NAD)degradation in mammalian cells.Decreased NAD levels are closely related to metabolic syndromes and aging-related diseases.Our study showed that CD38 deficiency significantly alleviated angiotensin II(Ang ll)-induced vascular remodeling in mice,as shown by decreased blood pressures;reduced vascular media thickness,media-to-lumen ratio,and collagen deposition;and restored elastin expression.However,our bone marrow transplantation assay showed that CD38 deficiency in lymphocytes led to lack of protection against Ang ll-induced vascular remodeling,suggesting that the effects of CD38 on Ang ll-induced vascular remodeling might rely primarily on vascular smooth muscle cells(VSMCs),not lymphocytes.In addition,we observed that CD38 deficiency or NAD supplementation remarkably mitigated Ang ll-induced vascular senescence by suppressing the biogenesis,secretion,and internalization of senescence-associated small extracellular vesicles(SA-sEVs),which facilitated the senescence of neighboring non-damaged VSMCs.Furthermore,we found that the protective effects of CD38 deficiency on VSMC senescence were related to restoration of lysosome dysfunction,particularly with respect to the maintenance of sirtuin-mediated mitochondrial homeostasis and activation of the mitochondria-lysosomal axis in VSMCs.In conclusion,our findings demonstrated that CD38 and its associated intracellular NAD decline are critical for Ang ll-induced VSMC senescence and vascular remodeling. | Lu Gan Demin Liu Jing Liu Erya Chen Chan Chen Lian Liu Hang Hu Xiaohui Guan Wen Ma Yanzi Zhang Yarong He Bofu Liu Songling Tang Wei Jiang Jianxin Xue Hongbo Xin | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 2 |
| 17 | In situ atomic-scale observation of monolayer graphene growth from SiC显示文摘 | Kaihao Yu Wen Zhao Xing Wu Jianing Zhuang Xiaohui Hu Qiubo Zhang Jun Sun Tao Xu Yang Chai Feng Ding Litao Sun | 2018 | Nano Research2018，11，5： | 2 |
| 18 | A Novel Step-by-Step High-Order Extended Kalman Filter Design for a Class of Complex Systems with Multiple Basic Multipliers显示文摘A novel step-by-step linearization high-order Extended Kalman filter SH-EKF is designed for a class of nonlinear systems composed of linear functions and the product of several separable basic functions.The basic functions in the state and measurement models are defined as latent variables;the state and measurement models are equivalently formulated into pseudo-linear models based on the combination of the original variable and the latent variables;latent variables are regarded as new variables,and a dynamic linear model between each latent variable and other latent variables with original state is established;the measurement model is rewritten into the first-order linear product form between the current state and each latent variable;latent variables are solved by Kalman filter step by step,and a stepwise linearized high-order extended Kalman filter is designed.Illustration examples are presented to demonstrate the effectiveness of the new algorithm. | SUN Xiaohui WEN Chenglin WEN Tao | 2021 | Chinese Journal of Electronics2021，30，2： | 2 |
| 19 | Molecular-beam epitaxy-grown HgCdTe infrared detector:Material physics, structure design, and device fabrication显示文摘Infrared(IR) detectors have important applications in numerous civil and military sectors. Hg Cd Te is one of the most important materials for IR detector manufacture. This review systematically discusses the progress of Hg Cd Te materials grown via molecular-beam epitaxy(MBE) for IR detection in terms of material physics, structure design, and fabrication. The material physics of Hg Cd Te includes crystal information, band structure, and electrical and optical properties. The characterization methods of the As-grown Hg Cd Te materials are also summarized. Then, four design structures of Hg Cd Te for IR detectors, with multilayer, superlattice, double-layer heterojunction, and barrier properties, which significantly improve the device performance,are discussed. The third section summarizes the studies on Hg Cd Te MBE-grown on different substrates, including Cd Zn Te, Si,and Ga Sb, in recent decades. This review discusses the factors influencing the growth of the Hg Cd Te film and their relationships and optimal conditions. Finally, we present the prospects and challenges associated with the fabrication and applications of Hg Cd Te materials for IR detectors. | Xiaohui Wang Mengbo Wang Yulong Liao Huaiwu Zhang Baohui Zhang Tianlong Wen Jiabao Yi Liang Qiao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，3： | 1 |
| 20 | Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways显示文摘 | Liyun Sang Julie J. Miller Kevin C. Corbit Rachel H. Giles Matthew J. Brauer Edgar A. Otto Lisa M. Baye Xiaohui Wen Suzie J. Scales Mandy Kwong Erik G. Huntzicker Mindan K. Sfakianos Wendy Sandoval J. Fernando Bazan Priya Kulkarni Francesc R. Garcia-Gonza | 2011 | Cell2011，，4： | 1 |
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