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| 1 | The Power of Inbreeding: NGS-Based GWAS of Rice Reveals Convergent Evolution during Rice Domestication显示文摘低范围的整个染色体的定序是为在人的染色体宽的协会研究的有效策略,由于为遗传型归罪的大参考面板的可获得性。然而,没有引用面板,这策略是否能在另外的种类被利用,是不清楚的。用模拟,我们有效地证明这条途径在象米饭(Oryza sativa L.) 那样的生来的种类是甚至更相关的,它是打电话的 haploid,允许的容易的 haplotype 构造和基于归罪的遗传型,甚至没有大参考面板的可获得性。我们在 1.5 桔牯捡獯潣祰的平均深度从农业米饭微型核心收集的美国部门与描绘得好的显型定序 203 个米饭变化吗?? | Hongru Wang Xun Xu Filipe Garrett Vieira Yunhua Xiao Zhikang Li Jun Wang Rasmus Nielsen Chengcai Chu | 2016 | Molecular Plant2016，9，7： | 17 |
| 2 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 3 | The Dabie Orogen as the early Jurassic sedimentary provenance: Constraints from the detrital zircon SHRIMP U-Pb dating显示文摘The SHRIMP U-Pb ages of detrital zircon from the oldest Mesozoic strata, the Fanghushan Fomation, in the Hefei Basin range from 200 Ma to ca. 2500 Ma, which indicates that the Dabie Orogen as the early Jurassic sedimentary provenance was complex. The composition of the Dabie Orogen includes: the Triassic high pressure-ultrahigh pressure metamorphic rocks, of which the detrital zircon ages are from 234 Ma to 200 Ma; the rocks possibly related to the Qinling and Erlangping Groups representing the southern margin of the Sino-Korean craton in the Qinling and Dabie area, of which the detrital zircon has an age of 481-378 Ma; the Neoproterozoic rocks originated from the Yangtze croton, of which the detrital zircon ages are 799-721 Ma old; and the rocks with the detrital zircon ages of ca. 2000 Ma and ca. 2500 Ma, which could be the old basement of the Yangtze craton. | LI Renwei, WAN Yusheng, CHENG Zhenyu, ZHOU Jianxiong, XU Yunhua, LI Zhong & JIANG Maosheng Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037, China | 2005 | Science China Earth Sciences2005，48，2： | 9 |
| 4 | Evaluation of maize inbred lines currently used in Chinese breeding programs for resistance to six foliar diseases显示文摘Foliar diseases are common in most maize-producing regions and have caused serious yield reduction in China. To evaluate genetic resistance of parental lines actively used in maize breeding programs to major foliar diseases, 152 maize inbred lines were tested against northern corn leaf blight(NCLB), southern corn leaf blight(SCLB), Curvularia leaf spot(CLS),gray leaf spot(GLS), common rust, and southern rust from 2003 to 2005. A small number of lines exhibited highly resistant reactions to common rust and southern rust, but none were highly resistant to NCLB, SCLB, CLS, and GLS. Although 53.3%, 40.8%, and 80.7% of lines were resistant to NCLB, SCLB, and common rust, the resistance in most lines was moderate.Resistance to CLS, GLS, and southern rust was rare in this collection of maize lines. Five lines,313, Chang 7-2, Qi 319, Qi 318, and Shen 137, were resistant to five diseases tested. Lines belonging to heterotic subgroup PB exhibited better resistance to the foliar diseases than lines from other heterotic subgroups, such as BSSS, PA, Lancaster, LRC, and PA. The results will be of benefit to breeders for selecting lines in disease resistance breeding programs. | Xiaoming Wang Yunhua Zhang Xiude Xu Hongjie Li Xiaofei Wu Shihuang Zhang Xinhai Li | 2014 | The Crop Journal2014，2，4： | 8 |
| 5 | Xenograft tumors derived from malignant pleural effusion of the patients with non-small-cell lung cancer as models to explore drug resistance显示文摘Background:Non-small cell lung cancer(NSCLC)patients with epidermal growth factor receptor(EGFR)mutations or anaplastic lymphoma kinase(ALK)fusions show dramatic responses to specific tyrosine kinase inhibitors(TKIs);however,after 10-12 months,secondary mutations arise that confer resistance.We generated a murine xenograft model using patient-derived NSCLC cells isolated from the pleural fluid of two patients with NSCLC to investigate the mechanisms of resistance against the ALK-and EGFR-targeted TKIs crizotinib and osimertinib,respectively.Methods:Genotypes of patient biopsies and xenograft tumors were determined by whole exome sequencing(WES),and patients and xenograft-bearing mice received targeted treatment(crizotinib or osimertinib)accordingly.Xenograft mice were also treated for prolonged periods to identify whether the development of drug resistance and/or treatment responses were associated with tumor size.Finally,the pathology of patients biopsies and xenograft tumors were compared histologically.Results:The histological characteristics and chemotherapy responses of xenograft tumors were similar to the actual patients.WES showed that the genotypes of the xenograft and patient tumors were similar(an echinoderm microtu-bule-associated protein-like 4-ALK(EML4-ALK)gene fusion(patient/xenograft:CTC15035EML4-ALK)and EGFR L858R and T790M mutations(patient/xenograft:CTC15063EGFR L858R,T790M)).After continuous crizotinib or osimertinib treatment,WES data suggested that acquired ALK E1210K mutation conferred crizotinib resistance in the CTC15035EML4-ALK xenograft,while decreased frequencies of EGFR L858R and T790M mutations plus the appearance of v-RAF murine sarcoma viral oncogene homolog B(BRAF)G7V mutations and phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha(PIK3C2A)A86fs frame shift mutations led to osimertinib resistance in the CTC15063EGFR L858R,T790M xenografts.Conclusions:We successfully developed a new method of generating drug resistance xenograft models from liquid biopsies using microfluidic technology,which might be a useful tool to investigate the mechanisms of drug resist-ance in NSCLC. | Yunhua Xu Feifei Zhang Xiaoqing Pan Guan Wang Lei Zhu Jie Zhang Danyi Wen Shun Lu | 2018 | Cancer Communications2018，38，1： | 7 |
| 6 | Big Grain3, encoding a purine permease, regulates grain size via modulating cytokinin transport in rice显示文摘Grain size is an important agronomic trait affecting grain yield,but the underlying molecular mechanisms remain to be elucidated.Here,we isolated a dominant mutant,big grainy(bg3-D),which exhibits a remarkable increase of grain size caused by activation of the PURINE PERMEASE gene,OsPUP4.BC3/OSPUP4 is predominantly expressed in vascular tissues and is specifically suppressed by exogenous cytokinin application.Hormone profiling revealed that the distribution of different cytokinin forms,in roots and shoots of the bg3-D mutant,is altered.Quantitative reverse transcription-PCR(qRT-PCR)analysis indicated that expression of rice cytokinin type-A RESPONSE REGULATOR(OsRR)genes is enhanced in the roots of the bgj-D mutant.These results suggest that OSPUP4 might contribute to the long-distance transport of cytokinin,by reinforcing cytokinin loading into vascular bundle cells.Furthermore,plants overexpressing OsPUP7,the closest homolog of OsPUP4,also exhibited a similar phenotype to the bg3-D mutant.Interestingly,subcellular localization demonstrated that OSPUP4 was localized on the plasma membrane,whereas OSPUP7 was localized to the endoplasmic reticulum.Based on these findings,we propose that OSPUP4 and OSPUP7 function in a linear pathway to direct cytokinin cell-to-cell transport,affecting both its long-distance movement and local allocation. | Yunhua Xiao Dapu Liu Guoxia Zhang Shaopei Gao Linchuan Liu Fan Xu Ronghui Che Yiqin Wang Hongning Tong Chengcai Chu | 2019 | Journal of Integrative Plant Biology2019，61，5： | 7 |
| 7 | Functional nanogenerators as vibration sensors enhanced by piezotronic effects显示文摘 | Zheng Zhangt Qingliang Liao Xiaoqin Yan Zhong Lin Wang Wenduo Wang Xu Sun Pei Lin Yunhua Huang Yue Zhang | 2014 | Nano Research2014，7，2： | 6 |
| 8 | Oxalate-assisted morphological effect of NaYF4:Yb3+,Er3+on photoelectrochemical performance for dye-sensitized solar cells显示文摘In this study. we have employed a facile oxalate-assisted hydrothermal approach to tailor the morphology of β-NaYF_4:Er^(3+),Yb^(3+)(NYFEY) powders through the variation of the molar ratio of oxalate ions(Oxa^(2-)) and rare earth ions(RE^(3+)) in the range of 0.5:1.1:1.2:1, 5:1. and 10:1. The obtained results show that the crystallinity, particle size and upconversion luminescence intensity of the as-synthesized NYFEY particles are gradually decreased as the Oxa^(2-):RE^(3+) molar ratio increases from 0.5:1 to 10:1. For the purpose of photoelectrochemical performance evaluation,the as-synthesized NYFEY particles with different morphologies are incorporated into the nanocrystalline TiO2 films to form the multifunctional nano-and sub-micro meter composite photoanodes of dye-sensitized solar cells(DSSCs). A short-circuit current density(Jsc) of 14.26 mA/cm^2 and power conversion efficiency(PCE) of 7.31% are obtained for DSSCs prepared with hexagonal rod-like NYFEY crystals,evidencing an increase of 29.8% compared with DSSCs prepared with only TiO_2 nanoparticles. The demonstrated synthesis approach for tailoring the morphology and size of NYFEY particles and enhancing the performance of DSSCs can also be applied for other types of solar cells. | Juan Wang Zhenqiang Du Mirabbos Hojamberdiev Siqi Zheng Yunhua Xu | 2018 | Journal of Rare Earths2018，36，4： | 4 |
| 9 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 10 | δ^(15)N-stable isotope analysis of NH_(x): An overview on analytical measurements, source sampling and its source apportionment显示文摘Agricultural sources and non-agricultural emissions contribute to gaseous ammonia(NH_(3))that plays a vital role in severe haze formation.Qualitative and quantitative contributions of these sources to ambient PM_(2.5)(particulate matter with an aerodynamic equivalent diameter below 2.5µm)concentrations remains uncertain.Stable nitrogen isotopic composition(δ^(15)N)of NH_(3)and NH_(4)+(δ^(15)N(NH_(3))andδ^(15)N(NH_(4)+),respectively)can yield valuable information about its sources and associated processes.This review provides an overview of the recent progress in analytical techniques forδ^(15)N(NH_(3))andδ^(15)N(NH_(4)+)measurement,sampling of atmospheric NH_(3)and NH_(4)+in the ambient air and their sources signature(e.g.,agricultural vs.fossil fuel),and isotope-based source apportionment of NH_(3)in urban atmosphere.This study highlights that collecting sample that are fully representative of emission sources remains a challenge in fingerprintingδ^(15)N(NH_(3))values of NH_(3)emission sources.Furthermore,isotopic fractionation during NH_(3)gas-to-particle conversion under varying ambient field conditions(e.g.,relative humidity,particle pH,temperature)remains unclear,which indicates more field and laboratory studies to validate theoretically predicted isotopic fractionation are required.Thus,this study concludes that lack of refinedδ^(15)N(NH_(3))fingerprints and full understanding of isotopic fractionation during aerosol formation in a laboratory and field conditions is a limitation for isotope-based source apportionment of NH_(3).More experimental work(in chamber studies)and theoretical estimations in combinations of field verification are necessary in characterizing isotopic fractionation under various environmental and atmospheric neutralization conditions,which would help to better interpret isotopic data and our understanding on NH_(x)(NH_(3)+NH_(4)+)dynamics in the atmosphere. | Noshan Bhattarai Shuxiao Wang Yuepeng Pan Qingcheng Xu Yanlin Zhang Yunhua Chang Yunting Fang | 2021 | Frontiers of Environmental Science & Engineering2021，15，6： | 3 |
| 11 | Effects of heat treatment on mechanical properties and microstructure of tungsten fiber reinforced grey cast iron matrix composites显示文摘In this study,grey cast iron matrix composites reinforced by different volume fractions of tungsten fibers(Vr=0.95%,1.90%,2.85%,3.80%)were investigated in as-cast and under the heat treatment temperatures of 1,000℃and 1,100℃.The microstructure and mechanical properties of the composites were analyzed and tested by means of SEM,micro-hardness tester and three-point bend testing.The results show that with increasing of the volume fraction of tungsten fibers,the composites reinforced by the tungsten fiber have higher flexural strength and modulus than that of cast iron without reinforcement,and the flexural strength increases with the increasing of heat treatment temperatures.Due to diffusion reaction between matrix and reinforcing phases,the process of heat treatment,the number of graphite flakes in the matrix seemingly becomes lower;and some hard carbide particles are formed around the residual tungsten fibers.Not only does the hardness of both matrix and reinforcement change tremendously,but also the region of reinforcement is also extended from the original 0.11 mm to 0.19 mm in radius. | Niu Libin Xu Yunhua Peng jianHong Wu Hong | 2009 | China Foundry2009，6，4： | 3 |
| 12 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 13 | Synthesis and electrochemical properties of Li_2MnSiO_4/C nanoparticles via polyol process显示文摘Carbon-coated lithium manganese silicate(Li2MnSiO4/C) nanoparticles were synthesized by polyol process.X-ray diffraction(XRD) patterns of the obtained materials exhibit a good fit with that of the Li2MnSiO4 phase.Field emission scanning electron microscopy(FESEM) images of the obtained samples show that the particle size is only tens of nanometers.The high resolution transmission electron microscopy(HRTEM) analysis shows that the Li2MnSiO4 nanoparticles are surrounded by a very thin film of amorphous carbon.The composite prepared through polyol process shows good performance as cathode materials in lithium cells at room temperature.The charge capacity of the Li2MnSiO4/C samples is 219 mAh/g(about 1.3 Li+ per unit formula extracted),and the discharge capacity is 132 mAh/g(about 0.8 Li+ per unit formula inserted) in the first cycle in the voltage range of 1.5-4.8 V.A good capacity cycling maintenance of 81.8% after 10 cycles was obtained. | LIU Wengang XU Yunhua YANG Rong | 2010 | Rare Metals2010，29，5： | 3 |
| 14 | A redox-active conjugated microporous polymer cathode for highperformance lithium/potassium-organic batteries显示文摘Organic redox-active materials have emerged as a class of electrode materials for rechargeable batteries due to their high redox activity,low cost,structure diversity and flexibility.However,the high solubility of organic small molecules in organic electrolytes commonly leads to the fast capacity decay with cycling.Herein,we report a redox-active conjugated microporous polymer of poly(pyrene-co-anthraquinone)(Py Aq)cathode material consisting of pyrene and anthraquinone units.Benefiting from the highly cross-linked polymer structure with insoluble nature in organic electrolytes,the high surface area and the plentiful redox-active carbonyl groups,the Py Aq cathode demonstrates outstanding electrochemical performances for both lithium-ion batteries(LIBs)and potassium-ion batteries(KIBs).Specifically,the Py Aq cathode for LIBs delivers a high reversible capacity of 169 m Ah g^-1 at the current density of 20 m A g^-1,a high rate capability(142 m Ah g^-1 at 1000 m A g^-1)and an excellent cycling stability for 4000 cycles.Additionally,the Py Aq cathode for KIBs also exhibits a high reversible capacity of143 m Ah g^-1 with a long cycling life over 800 cycles.The excellent electrochemical performance demonstrates that the newly developed Py Aq could be an attractive cathode material for the advanced energy storage technologies. | Lian-Wei Luo Chong Zhang Peixun Xiong Yongbo Zhao Wenyan Ma Yu Chen Jing Hui Zeng Yunhua Xu Jia-Xing Jiang | 2021 | Science China Chemistry2021，64，1： | 3 |
| 15 | Study on in-situ WC particles/tungsten wire reinforced iron matrix composites under electromagnetic field显示文摘By applying electromagnetic field to a system consisting of tungsten wires and grey cast iron melt,the grey cast iron matrix composite reinforced by either in-situ WC particles or the combination ofin-situ WC particles and the residual tungsten wire was obtained.By means of differential thermal analysis(DTA),the pouring temperature ofiron melt was determined at 1,573 K.The microstructures of the composites were analyzed by using of X-ray diffraction(XRD),scanning electron microscopy(SEM) equipped with an energy dispersive spectrum(EDS) and pin-on-disc abrasive wear test.The obtained results indicated that,with the enhancing frequency of electromagnetic field,the amount ofin-situ WC particles gradually increases,leading to continuous decrease of the residual tungsten wires.When the electromagnetic field frequency was up to 4 kHz,tungsten wires reacted completely with carbon atoms in grey cast iron melt,forming WC particals.The electromagnetic field appeared to accelerate the elemental diffusion in the melt,to help relatively quick formation of a series of small FeW-C ternary zones and to improve the kinetic condition ofin-situ WC fabrication.As compared with the composite prepared without the electromagnetic field,the composite fabricated at 4 kHz presented good wear resistance. | Niu Libin Xu Yunhua Wu Hong | 2010 | China Foundry2010，7，2： | 2 |
| 16 | A cell wall-localized NLR confers resistance to Soybean mosaic virus by recognizing viral-encoded cylindrical inclusion protein.显示文摘Soybean mosaic virus (SMV) causes severe yield losses and seed quality reduction in soybean (Glycine max) production worldwide. Rsc4 from cultivar Dabaima is a dominant genetic locus for SMV resistance, and its mapping interval contains three Nucleotide-binding domain Leucine-rich Repeat containing (NLR) candidates (Rsc4-1, Rsc4-2, and Rsc4-3). The NLR-type resistant proteins were considered as important intracellular pathogen sensors in the previous studies. In this research, based on transient expression assay in Nicotiana benthamiana leaves, we found that the longest transcript of Rsc4-3 is sufficient to induce resistance response to SMV;and CRISPR/Cas9-mediated Rsc4-3 knockout in resistant cultivar Dabaima compromised the resistance. These indicate that Rsc4-3 confers resistance to SMV. Interestingly, Rsc4-3 encodes a cell wall localized NLR-type resistant protein (Rsc4-3). The internal polypeptide region responsible for apoplastic targeting of Rsc4-3 and the putative palmitoylation sites on the N-terminus are essential for the resistance response. Furthermore, we showed that viral-encoded cylindrical inclusion (CI) protein partially localizes to the cell wall and can interact with Rsc4-3. Virus-driven or transient expression of CI protein of avirulent SMV strains is enough to induce resistance response in the presence of Rsc4-3, suggesting that CI is the avirulent gene for Rsc4-3 mediated resistance. Our work exhibited a case of NLR recognizing virus in the apoplast and provided a simple and effective method for identifying resistant genes against SMV infection. | Jinlong Yin Liqun Wang Tongtong Jin Yang Nie Hui Liu Yanglin Qiu Yunhua Yang Bowen Li Jiaojiao Zhang Dagang Wang Kai Li Kai Xu Haijian Zhi | 2021 | Molecular Plant2021，14，11： | 2 |
| 17 | EVchain: An Anonymous Blockchain-Based System for Charging–Connected Electric Vehicles显示文摘Purchases of electric vehicles have been increasing in recent years. These vehicles differ from traditional fossil-fuel-based vehicles especially in the time consumed to keep them running. Electric-Vehicle-charging Service Providers(EVSPs) must arrange reasonable charging times for users in advance. Most EVSP services are based on third-party platforms, but reliance on third-party platforms creates a lack of security, leaving users vulnerable to attacks and user-privacy leakages. In this paper, we propose an anonymous blockchain-based system for charging-connected electric vehicles that eliminates third-party platforms through blockchain technology and the establishment of a multi-party security system between electric vehicles and EVSPs. In our proposed system, digital certificates are obtained by completing distributed Public Key Infrastructure(distributed-PKI) identity registration,with the user registration kept separate from the verification process, which eliminates dependence on the EVSP for information security. In the verification process, we adopt smart contracts to solve problems associated with centralized verification and opaque services. Furthermore, we utilize zero-knowledge proof and ring-signature superposition to realize completely anonymous verification, which ensures undeniability and unforgeability with no detriment to anonymity. The evaluation results show that the user anonymity, information authenticity, and system security of our system fulfill the necessary requirements. | Shiyuan Xu Xue Chen Yunhua He | 2021 | Tsinghua Science and Technology2021，26，6： | 2 |
| 18 | Simple non-fullerene electron acceptors with unfused core for organic solar cells显示文摘Two simple electron acceptors based on unfused bithiophene core and 1,1-dicyanomethylene-3-indanone end group were easily prepared via three synthetic steps. These acceptors exhibited broad absorption in the range of 300 nm to 800 nm, aligned energy levels and high crystallinity. When combined with a wide band gap donor polymer in non-fullerene solar cells, an initial power conversion efficiency of 2.4% was achieved. The relatively low efficiencies were due to the large phase separation in blended thin films, which is originated from their high aggregation tendency in thin films. Our results suggest that these electron acceptors with unfused core are promising candidates for commercial application of solar cells due to the low cost starting materials and facile synthesis. | Yao Li Yunhua Xu Fan Yang Xudong Jiang Cheng Li Shengyong You Weiwei Li | 2019 | Chinese Chemical Letters2019，30，1： | 2 |
| 19 | Characterization and processing of talc-magnesite from the Zinelbulak deposit显示文摘The characteristics of talc-magnesite from the Zinelbulak deposit(Uzbekistan) were investigated via X-ray diffraction, differential thermal analysis,infrared spectroscopy and optical microscopy.The mineralogical composition of the Zinelbulak talc-magnesite consists of 52 wt.%talc,43 wt.%carbonates and 5 wt.%of the iron-containing minerals magnetite,siderite and chlorite.Petrographic analysis confirmed the presence of carbonates in two forms:magnesite and breunnerite.Grindability tests revealed that talc and magnesite particles are completely separated after a grinding process carried out for 10~12 min.The distribution of the yield of talc and magnesite,as a function of the particle size,shows an irregular feature in that a comparatively coarser sample(>0.1 mm) is richer in magnesite and poor in talc while a comparatively finer sample(<0.1 mm) has a composition poorer in magnesite.The dressability of the Zinelbulak talc-magnesite was tested using conventional gravity concentration,flotation and electromagnetic separation.Gravity concentration was found to be the most economic initial process for the complete separation of magnesium carbonate and talc.Subsequent flotation and magnetic separation techniques could further increase the yield of high quality magnesite and talc.Refractory samples prepared by heating the separated magnesite at 1600℃for 2 h met the State Standards for refractory materials. | HOJAMBERDIEV Mirabbos ARIFOV Pulat TADJIEV Kamil XU Yunhua | 2010 | Mining Science and Technology2010，20，3： | 2 |
| 20 | Highly sensitive,sub-microsecond polymer photodetectors for blood oxygen saturation testing显示文摘Bottom surface of active layers and interface of indium tin oxide(ITO)electrodes and active layers play a crucial role in determining the performance of polymer photodetectors with photomultiplication(PM-PPDs).The interfacial trapped electron distribution closing to ITO electrodes will determine spectral response range and external quantum efficiency(EQE)of PMPPDs.The bottom interface is more sensitive than top interface when light is coming from the ITO side,and the larger density of generated charge on the bottom interfaces will induce interfacial band more bending for efficient charge tunneling injection.Highly sensitive and sub-microsecond PM-PPDs are achieved with PMBBDT:Y6(100:7,w/w)as active layers under forward bias,yielding EQE of 18,700%at 320 nm,21,700%at 600 nm and 16,400%at 810 nm under a bias of 7 V,respectively,as well as fast response time of 79μs.The high EQE of the PM-PPDs is attributed to efficient hole tunneling injection from ITO electrode under forward bias.The electron traps closing to ITO electrode will be quickly filled up when light is coming from ITO side,leading to interfacial band more bending for hole tunneling injection.Importantly,the PM-PPDs is performed to measure heart rate(HR)and blood oxygen saturation(SpO_(2)),and the measured data by the PM-PPDs are very similar with those obtained by commercial photodetectors. | Zijin Zhao Baiqiao Liu Changlin Xie Yao Ma Jian Wang Ming Liu Kaixuan Yang Yunhua Xu Jian Zhang Weiwei Li Liang Shen Fujun Zhang | 2021 | Science China Chemistry2021，64，8： | 2 |
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