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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila显示文摘The limited bioavailability of plant-derived natural products with anticancer activity poses major challenges to the pharmaceutical industry.An example of this is camptothecin,a monoterpene indole alkaloid with potent anticancer activity that is extracted at very low concentrations from woody plants.Recently,camptothecin biosynthesis has been shown to become biotechnologically amenable in hairy-root systems of the natural producer Ophiorrhiza pumila.Here,time-course expression and metabolite analyses were performed to identify novel transcriptional regulators of camptothecin biosynthesis in O.pumila.It is shown here that camptothecin production increased over cultivation time and that the expression pattern of the WRKY transcription factor encoding gene OpWRKY2 is closely correlated with camptothecin accumulation.Overexpression of OpWRKY2 led to a more than three-fold increase in camptothecin levels.Accordingly,silencing of OpWRKY2 correlated with decreased camptothecin levels in the plant.Further detailed molecular characterization by electrophoretic mobility shift,yeast one-hybrid and dual-luciferase assays showed that OpWRKY2 directly binds and activates the central camptothecin pathway gene OpTDC.Taken together,the results of this study demonstrate that OpWRKY2 acts as a direct positive regulator of camptothecin biosynthesis.As such,a feasible strategy for the over-accumulation of camptothecin in a biotechnologically amenable system is presented. | Xiaolong Hao Chenhong Xie Qingyan Ruan Xichen Zhang Chao Wu Bing Han Jun Qian Wei Zhou Hans-Wilhelm Nutzmann Guoyin Kai | 2021 | Horticulture Research2021，8，1： | 7 |
| 3 | Recent advances in wireless epicortical and intracortical neuronal recording systems显示文摘An implantable brain-computer interface(BCI)has proven to be effective in the field of sensory and motor function restoration and in the treatment of neurological disorders.Using a BCI recording system,we can transform current methods of human interaction with machines and the environment,especially to help those with cognitive and mobility disabilities regain mobility and reintegrate into society.However,most reported work has focused on a simple aspect of the whole system,such as electrodes,circuits,or data transmission,and only a very small percentage of systems are wireless.A miniature,lightweight,wireless,implantable microsystem is key to realizing long-term,real-time,and stable monitoring on freely moving animals or humans in their natural conditions.Here,we summarize typical wireless recording systems,from recording electrodes,processing chips and controllers,wireless data transmission,and power supply to the system-level package for either epicortical electrocorticogram(ECoG)or intracortical local field potentials(LFPs)/spike acquisition,developed in recent years.Finally,we conclude with our vision of challenges in next-generation wireless neuronal recording systems for chronic and safe applications. | Bowen JI Zekai LIANG Xichen YUAN Honglai XU Minghao WANG Erwei YIN Zhejun GUO Longchun WANG Yuhao ZHOU Huicheng FENG Honglong CHANG Jingquan LIU | 2022 | Science China(Information Sciences)2022，65，4： | 2 |
| 4 | Host adaptation and host–parasite co-evolution in Cryptosporidium : implications for taxonomy and public health显示文摘 | Lihua Xiao Irshad M Sulaiman Una M Ryan Ling Zhou Edward R Atwill Monica L Tischler Xichen Zhang Ronald Fayer Altaf A Lal | 2002 | International Journal for Parasitology2002，，14： | 1 |
| 5 | Nonlinear fusion filters based on prediction and smoothing显示文摘To attenuate white noise, nonstationary noise and impulse noise are important for signal processing. In this letter, we present nonlinear fusion filters (NFF) based on prediction and smoothing. By means of least square fitting of a polynomial, we define and give the operators of left prediction and right prediction, left smoothing and right smoothing, central smoothing and cross-validation smoothing. In simulated experiments, it is shown that the present method is an effective one. | Qiansheng Cheng Xiaobo Zhou Xichen Sun | 2000 | Chinese Science Bulletin2000，45，18： | 0 |
| 6 | INFLUENCE OF PURIFICATION ON GLASS FORMABILITY AND THERMOSTABILITY OF METALLIC GLASS Ni_(75)B_(17)Si_8显示文摘The glass formability of Ni75B17Si8 melt and the thermostability of this metallic glass formedfrom the the melt can be enhanced by eliminating the heterogeneous catalystg. The purificationwas done by cyclical superheating melt in special glasses and subsequently cyclicallysuperheating it in an electromagnetic levitation apparatus. The purified Ni75B17Si8 amorphoussample sized up to 20 I0 x 0.5 mm was prepared as four times the thickness of unpurifiedones. | XING Liqian CHEN Xichen, Institute of Physics, Academia Sinica, Beijing, ChinaYANG Gencang ZHOU Yaohe, Northwestern Polytechnic University, Xi’an, ChinaGUO Zhenqi, Northwestern University, Xi’an, China XING Liqian, Postdoctoral, Institute of Physics, Academia Sinica, Beijing 100080, China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，7： | 0 |
| 7 | Uncertainties of ENSO-related Regional Hadley Circulation Anomalies within Eight Reanalysis Datasets显示文摘El Nino-Southern Oscillation(ENSO),the leading mode of global interannual variability,usually intensifies the Hadley Circulation(HC),and meanwhile constrains its meridional extension,leading to an equatorward movement of the jet system.Previous studies have investigated the response of HC to ENSO events using different reanalysis datasets and evaluated their capability in capturing the main features of ENSO-associated HC anomalies.However,these studies mainly focused on the global HC,represented by a zonal-mean mass stream function(MSF).Comparatively fewer studies have evaluated HC responses from a regional perspective,partly due to the prerequisite of the Stokes MSF,which prevents us from integrating a regional HC.In this study,we adopt a recently developed technique to construct the three-dimensional structure of HC and evaluate the capability of eight state-of-the-art reanalyses in reproducing the regional HC response to ENSO events.Results show that all eight reanalyses reproduce the spatial structure of HC responses well,with an intensified HC around the central-eastern Pacific but weakened circulations around the Indo-Pacific warm pool and tropical Atlantic.The spatial correlation coefficient of the three-dimensional HC anomalies among the different datasets is always larger than 0.93.However,these datasets may not capture the amplitudes of the HC responses well.This uncertainty is especially large for ENSO-associated equatorially asymmetric HC anomalies,with the maximum amplitude in Climate Forecast System Reanalysis(CFSR)being about 2.7 times the minimum value in the Twentieth Century Reanalysis(20CR).One should be careful when using reanalysis data to evaluate the intensity of ENSO-associated HC anomalies. | Yadi LI Xichen LI Juan FENG Yi ZHOU Wenzhu WANG Yurong HOU | 2024 | Advances in Atmospheric Sciences2024，41，1： | 0 |
| 8 | Rationally designed/constructed MnO_x/WO_3 anode for photoelectrochemical water oxidation显示文摘Photoelectrocatalytic water splitting is an effective way to utilize the solar energy to solve the energy shortage. The valence band edge of WO_3 located at ~3V vs. normal hydrogen electrode(NHE), which can offer enough potential to kinetically oxidize water for oxygen evolution reaction. However, water oxidation reaction kinetics is sluggish when only WO_3 is used as the photoanode. It is highly desirable to use cocatalyst to promote the kinetics. Mn Oxloaded on the WO_3 photoanode through photodeposition methods improves the photoelectrochemical water oxidation performance. A maximum photocurrent density of composite photoanode is achieved with a deposition time of 3 min, which is higher than that of pristine WO_3 photoanode around 40%. Mn O2 is not only a cocatalyst for water splitting but also for improving oxidation selectivity. We tried to use two means to load Mn Oxon WO_3 photoanode material. It is observed that loading a moderate amount of Mn Oxon the WO_3 by photodeposition can promote the performance of the WO_3 photoanode. | Xiaohu Cao Xiangyu Zang Xichen Zhou Mindong Chen Yong Ding | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
| 9 | More complex interactions:Continuing progress in understanding the dynamics of regional climate change under a warming climate显示文摘Our planet experienced a number of extreme climate events in 2022,including extreme summer heat in the northern hemisphere,droughts in China and Brazil,and floods in Pakistan,South Africa,and Australia.Persistent global warming is believed to be the key factor in these extreme climate events,which were rare in past decades.Understanding the physical dynamics of regional climate change is essential if we are to reliably project such events in a warmer climate. | Ping Huang Xiao-Tong Zheng Xichen Li Kaiming Hu Zhen-Qiang Zhou | 2023 | The Innovation2023，4，2： | 0 |
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