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| 1 | Cenozoic sedimentary records and geochronological constraints of differential uplift of the Qinghai-Tibet Plateau显示文摘Geological mapping data (1:250000) in the Qinghai-Tibet Plateau and its adjacent regions reveal the sediment sequences, distribution and tectonic evolution of the 92 Tertiary remnant basins. Southern Tibet and the Yecheng area in Xinjiang, located at southern and northwestern margins of the Qinghai-Tibet Plateau, respectively, were parts of the Neo-Tethys remnant sea in the Paleogene. In southern Tibet, both the subabyssal and abyssal sequences occur at the Gyangze, Saga, Guoyala, and Sangmai areas. The deep-water facies successions outcrop in the west, whereas the shallow-water facies sequences in the east, indicating the east to the west retreat of the Neo-Tethys Ocean. The retreat of the Neo-Tethys Ocean in the east was contributed to the earlier tectonic uplift of the eastern Qinghai-Tibet Plateau. The uplift process of the Plateau from the Late Cretaceous to Pliocene is described as follows: During the Late Cretaceous, tectonic uplift of the Qinghai-Tibet Plateau occurred in the northeastern part and the configuration of the Qinghai-Tibet Plateau was characterized by rise in the northeast and depression in the west. In the Paleocene-Eocene interval, the Tengchong-Baingoin and Kuyake-Golmud areas experienced local tectonic uplifting, the West Kunlun uplift zone broadened easterly, the Qilian uplift zone broadened southerly, and the Songpan-Garzê uplift zone shrank easterly. The Oligocene configuration of the Qinghai-Tibet Plateau was characterized by mountain chains rising along its margins and sedimentary basins in the central part because of tectonic uplifts of the Gangdisê and the Himalaya blocks. Meanwhile, the Kunlun-Altyn-Qilian uplift zones have also broadened southerly and northerly. In contrast, the great uplift zones of the Gangdisê, the Himalaya, the Karakorum, and the Kunlun blocks characterize the paleogeographic contours of the Qinghai-Tibet Plateau during the Miocene-Pliocene. Additionally, the thermochronological data on tectonic uplift events in southern Tibet, West Kunlun Mountains, Altyn Tagh, eastern Tibet, and western Sichuan all suggest that the most intense deformation occurred at 13-8 Ma and since 5 Ma, respectively, corresponding to two great uplift periods in Neogene. As a result, turnover of paleogeographic configuration of the Qinghai-Tibet Plateau occurred during the Neogene, experiencing a change from high contours in the east in the pre-Oligocene to high contours in the west at the end-Pliocene. The uplift of the Qinghai-Tibet Plateau during the Cenozoic was episodic, and the uplifts of various blocks within the Plateau were spatially and chronologically different. | ZHANG KeXin WANG GuoCan CAO Kai LIU Chao XIANG ShuYuan HONG HanLie KOU XiaoHu XU YaDong CHEN FenNing MENG YanNing CHEN RuiMing | 2008 | Science China Earth Sciences2008，51，11： | 31 |
| 2 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 3 | Role and effect of vein-transplanted human umbilical cord mesenchymal stem cells in the repair of diabetic foot ulcers in rats显示文摘Diabetic foot ulcer(DFU)is one of diabetic complications,which is frequently present and tormented in diabetes mellitus.Most multipotent mesenchymal stromal cells(MSCs)are capable of immune evasion,providing an allogeneic,ready-to-use,cell product option for therapeutic applications.The beneficial effect of MSCs for the treatment of a variety of traumatic injuries,such as open wounds,has been extensively explored.In this study,a rat DFU model was used to simulate the pathophysiology of clinical patients and to investigate the localization of human umbilical cord mesenchymal stem cells(hUC-MSCs)after intravenous transplantation and its role in DFU healing,so as to evaluate the potential of hUC-MSCs in the treatment of DFU.The diabetic rat model was established by streptozotocin injection,which was used to create full-thickness foot dorsal skin wounds to mimic DFU by a 6-mm skin biopsy punch and a Westcott scissor.The hUC-MSCs were transplanted through femoral vein,and the ulcer cicatrization situation and the fate of hUC-MSCs were evaluated.Our data suggest that intravenously transplantated hUC-MSCs have the ability to migrate and locate to the wound tissue and are helpful to wound healing in DFU rats,partly by regulating inflammation,trans-differentiation and providing growth factors that promote angiogenesis,cell proliferation and collagen deposition.Herein,we demonstrate that hUC-MSC transplantation is able to accelerate DFU healing in rats and transplantation of exogenous stem cells may be a potential strategy for clinical application in DFUs. | Rongfeng Shi Weishuai Lian Yinpeng Jin Chuanwu Cao Shilong Han Xiaohu Yang Suming Zhao Maoquan Li Hui Zhao | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 13 |
| 4 | The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy显示文摘Cytokines exert powerful immunomodulatory effects that are critical to physiology and pathology in humans.The application of natural cytokines in clinical studies has not been clearly established,and there are often problems associated with toxicity or lack of efficacy.The key reasons can be attributed to the pleiotropy of cytokine receptors and undesired activation of off-target cells.With a deeper understanding of the structural principles and functional signals of cytokine-receptor interactions,artificial modification of cytokine signaling through protein engineering and synthetic immunology has become an increasingly feasible and powerful approach.Engineered cytokines are designed to selectively target cells.Herein,the theoretical and experimental evidence of cytokine engineering is reviewed,and the“supercytokines”resulting from structural enhancement and the“immunocytokines”generated by antibody fusion are described.Finally,the“engager cytokines”formed by the crosslinking of cytokines and bispecific immune engagers and other synthetic cytokines formed by nonnatural analogs are also discussed. | Xiaohu Zheng Yaqi Wu Jiacheng Bi Yingying Huang Ying Cheng Yangyang Li Yuwei Wu Guoshuai Cao Zhigang Tian | 2022 | Cellular & Molecular Immunology2022，19，2： | 4 |
| 5 | Full-spectrum cell-free RAN for 6G systems:system design and experimental results显示文摘With distributed transceivers and scalable cooperative transmission,cell-free massive multipleinput multiple-output(CF-mMIMO)technology eliminates the“cells”of traditional mobile communications,thereby significantly improving the performance of wireless networks.CF-mMIMO is considered as a major technical tool for achieving the key performance indicators of sixth generation(6G)mobile communication systems.In this paper,a scalable implementation architecture for CF-mMIMO is proposed,based on which potential key technologies such as channel information acquisition,transceiver design,dynamic user and access point association,and novel duplexing are introduced.Finally,based on low-cost commercial access points,a CF-mMIMO testbed with 64 transmit and receive antennas is developed,and the performance of the distributed receiver design is evaluated. | Dongming WANG Xiaohu YOU Yongming HUANG Wei XU Jiamin LI Pengcheng ZHU Yanxiang JIANG Yang CAO Xinjiang XIA Ziyang ZHANG Qingji JIANG Pan WANG Dongjie LIU Kang ZHENG Mengting LOU Jing JIN Qixing WANG Jiangzhou WANG | 2023 | Science China(Information Sciences)2023，66，3： | 3 |
| 6 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://bencao.bmicc.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 7 | Molybdenum improves antioxidant and osmotic-adjustment ability against salt stress in Chinese cabbage (Brassica campestris L. ssp. Pekinensis)显示文摘 | Mu Zhang Chengxiao Hu Xiaohu Zhao Qiling Tan Xuecheng Sun Anyong Cao Min Cui Ying Zhang | 2012 | Plant and Soil2012，，1： | 1 |
| 8 | Results of Treating Vertebral Metastases by Percutaneous Vertebroplasty Combined with Interventional Chemotherapy显示文摘 | Hongyi Cai Xiaohu Wang Huiping Cao Xiaoqi Wang Xiaodong Liu Zhiyong Zhang Xinchun Dong | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 1 |
| 9 | Recent development of nanomaterials for carbon dioxide electroreduction显示文摘Electrochemical CO_(2) reduction reaction(CO_(2)RR)to produce value‐added products has received tremendous research attention in recent years.With research efforts across the globe,remarkable advancement has been achieved,including the improvement of selectivity for the reduction products,the realization of efficient reduction beyond two electrons,and the delivery of industrially relevant current densities.In this review,we introduce the recent development of nanomaterials for CO_(2)RR,including the zero‐dimensional graphene quantum dots,two‐dimensional materials such as metal chalcogenides and metal/covalent organic framework,singleatom catalysts,and nanostructured metal catalysts.The engineering of materials into three‐dimensional structure will also be discussed.Finally,we will provide a summary of the catalytic performance and perspectives on future development. | Jianjun Su Yong Liu Yun Song Libei Huang Weihua Guo Xiaohu Cao Yubing Dou Le Cheng Geng Li Qiushi Hu Ruquan Ye | 2022 | SmartMat2022，3，1： | 1 |
| 10 | Molybdenum improves antioxidant and osmotic-adjustment ability against salt stress in Chinese cabbage (Brassica campestris L. ssp. Pekinensis)显示文摘 | Mu Zhang Chengxiao Hu Xiaohu Zhao Qiling Tan Xuecheng Sun Anyong Cao Min Cui Ying Zhang | 2012 | Plant and Soil2012，，1： | 1 |
| 11 | Energy efficiency modeling and analyzing based on multi-cell and multi-antenna cellular networks显示文摘 | Ge Xiaohu Cao Chengqian Jo Minho | 2010 | Ksii Transactions on Internet and Information Systems2010，4，4： | 1 |
| 12 | Breaking the activity limitation of iridium single-atom catalyst in hydrogenation of quinoline with synergistic nanoparticles catalysis显示文摘Single-atom catalysts(SACs)with the advantages of homogeneous and heterogeneous catalysts have become a hot-spot in catalysis field.However,for lack of metal–metal bond in SACs,H_(2)has to go through heterolytic dissociation pathway,which has higher barrier than homolytic dissociation pathway,and thus limits the hydrogenation activity of SACs.Herein,we propose and demonstrate through constructing synergistic iridium single atoms and nanoparticles co-existed catalyst(denoted as Ir_(1+NPs)/CMK)to boost the catalytic activity of quinoline hydrogenation.Both experimental and density functional theory calculation results confirm that Ir_(1)single sites activate quinoline,while Ir nanoparticles boost hydrogen dissociation.H atoms generated at Ir nanoparticles migrate to the quinoline bounded Ir_(1)single sites to complete hydrogenation.The Ir_(1+NPs)/CMK catalyst exhibits much higher reactivity with turnover frequency of 7,800 h^(−1)than those counterpart Ir_(1)/CMK and IrNPs/CMK catalysts,and is 20,000 times higher activity of commercial Ir/C benchmark catalyst for hydrogenation of quinoline under the same reaction conditions.This synergistic catalysis strategy between single atoms and nanoparticles provides a solution to further improve the performance of SACs for hydrogenation. | Qikai Shen Hongqiang Jin Peipei Li Xiaohu Yu Lirong Zheng Weiguo Song Changyan Cao | 2022 | Nano Research2022，15，6： | 0 |
| 13 | Structural and Kinetics Understanding of Support Effects in Pd-Catalyzed Semi-Hydrogenation of Acetylene显示文摘In this study,the support effects on the Pd-catalyzed semi-hydrogenation of acetylene have been investigated from the structural and kinetic perspectives.According to the results of kinetic analysis and X-ray photoelectron spectroscopy,hydrogen temperature-programmed reduction,temperature-programmed hydride decomposition,and in situ X-ray diffraction measurements,using carbon nanotubes as support for Pd nanocatalysts with various sizes instead of a-Al_(2)O_(3) decreases the Pd^(0)3d binding energy and suppresses the formation of undesirable palladium hydride species,thus increasing the ethylene yield.Furthermore,X-ray absorption spectroscopy,high-resolution transmission electron microscopy,and C_(2)H_(4) temperature-programmed desorption studies combined with density-functional theory calculations reveal the existence of a unique Pd local environment,containing subsurface carbon atoms,that produces positive geometric effects on the acetylene conversion reaction.Therefore,tailoring the Pd local environment and electronic properties represents an effective strategy for the fabrication and design of highly active and selective Pd semi-hydrogenation catalysts. | Yueqiang Cao Xiaohu Ge Yurou Li Rui Si Zhijun Sui Jinghong Zhou Xuezhi Duan Xinggui Zhou | 2021 | Engineering2021，7，1： | 0 |
| 14 | In-situ doping nickel single atoms in two-dimensional MXenes analogue support for room temperature NO_(2) sensing显示文摘MXenes are promising supports for anchoring metal single atoms due to their versatile composition,well-defined nanostructures,and suitable conductivity.However,metal single atoms are usually coordinated with surface terminal groups(-O,-OH,-Cl,etc.)of MXenes via conventional wet-impregnation,resulting in limited electronic structure modification.Through a NiCl2 molten salt etching method,we observed that Ni single atoms could be in-situ doped in the lattice of MXenes analogue TiC_(0.5)N_(0.5) support(denoted as Ni1/TiC0.5N0.5),resulting in much larger charge transfer from Ni atoms to adjacent Ti atoms,and thus increasing the electronic density of these Ti atoms.When used for NO_(2) sensing,Ni_(1)/TiC_(0.5)N_(0.5) exhibited excellent response sensitivity(ultra-low limit of detection~10 ppb),selectivity,and good stability at room temperature.This study provides an effective strategy for producing MXenes analogue supported metal single atoms for potential application in gas sensing. | Weiming Chen Peipei Li Jia Yu Peixin Cui Xiaohu Yu Weiguo Song Changyan Cao | 2022 | Nano Research2022，15，10： | 0 |
| 15 | Histomorphological observation in arterial remodeling following New Zealand rabbit auto-extremity artery transplantation显示文摘Objective:To investigate the histomorphological change in auto-extremity artery following transplantation.Methods:50 New Zealand rabbits were randomly divided into 5 groups(postoperative 1 d,3 d,7 d,14 d,56 d,n = 10).Femoral artery was harvested and end-to-side anastomosed with carotid in order to build the auto-extremity arterial graft animal model.On the postoperative 1st,3rd,7th,14th and 56th days,grafts for morphometric analysis under the Image analysis system were obtained;and electron microscope was scanned to observe endothelial cells.In addition,Immunostaining of sections were performed with the mouse monoclonal antibody of the α-smooth muscle isoform of actin and proliferating cell nuclear antigen antibody.Results:Overall patency rate for all conduits was 86%.The intimal hyperplasia was first observed in the 7th day group,and continued to increase in the 56th day group(183.21±111.74)μm,P < 0.01.Additionally,the luminal narrowed(32.43±18.28)% in the 56th day group.Smooth muscle cells were the mainly hyperplastic components.The most active proliferation of cells was detected in the 14th day group,where the extracellular matrix gradually deposited in the intima.Conclusion:Moderate intimal hyperplasia occurred in arterial conduits and vascular structure experienced constrictive remodeling after auto-transplantation. | Yangyang Zhang Wen Ge Biao Yuan Xiaohu Zhang Kejiang Cao | 2007 | Journal of Nanjing Medical University2007，21，6： | 0 |
| 16 | Corrigendum to“Structural and Kinetics Understanding of Support Effects in Pd-Catalyzed Semi-Hydrogenation of Acetylene”[Engineering 7(2021)103–110]显示文摘 | Yueqiang Cao Xiaohu Ge Yurou Li Rui Si Zhijun Sui Jinghong Zhou Xuezhi Duan | 2021 | Engineering2021，7，5： | 0 |
| 17 | Rationally designed/constructed MnO_x/WO_3 anode for photoelectrochemical water oxidation显示文摘Photoelectrocatalytic water splitting is an effective way to utilize the solar energy to solve the energy shortage. The valence band edge of WO_3 located at ~3V vs. normal hydrogen electrode(NHE), which can offer enough potential to kinetically oxidize water for oxygen evolution reaction. However, water oxidation reaction kinetics is sluggish when only WO_3 is used as the photoanode. It is highly desirable to use cocatalyst to promote the kinetics. Mn Oxloaded on the WO_3 photoanode through photodeposition methods improves the photoelectrochemical water oxidation performance. A maximum photocurrent density of composite photoanode is achieved with a deposition time of 3 min, which is higher than that of pristine WO_3 photoanode around 40%. Mn O2 is not only a cocatalyst for water splitting but also for improving oxidation selectivity. We tried to use two means to load Mn Oxon WO_3 photoanode material. It is observed that loading a moderate amount of Mn Oxon the WO_3 by photodeposition can promote the performance of the WO_3 photoanode. | Xiaohu Cao Xiangyu Zang Xichen Zhou Mindong Chen Yong Ding | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
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