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| 1 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 2 | A fully automatic registration approach based on contour and SIFT for HJ-1 images显示文摘To achieve a fully automatic registration between HJ-1 CCD images and HJ-1 infrared images is a difficult task as it must deal with the varying illuminations and resolutions of the images,different perspectives,and the local deformations within the images.In this paper,aimed at those registration issues,a fully automatic registration approach based on contour and SIFT is proposed.The registration technique performs a pre-registration process using contour feature matching algorithm that decides the overlapping region between a reference image and an input image.Once the coarse regions are obtained,it performs a fine registration process based on SIFT detector and a local adaptive matching strategy.In the fine registration process,image blocking theory is used,which not only speeds up the features extraction and matching,but also makes the matching point pairs distributed uniformly in images,and further improves the accuracy of input image rectification.Experiments with visible images and infrared images from HJ-1A/B demonstrate the efficiency and the accuracy of the proposed technique for multisource remote sensing images registration. | NI XiLiang CAO ChunXiang DING Lin JIANG Tao ZHANG Hao JIA HuiCong LI GuangHe ZHAO Jian CHEN Wei JI Wei XU Min GAO MengXu ZHENG Sheng TIAN Rong LIU Cheng LI Sha | 2012 | Science China Earth Sciences2012，55，10： | 5 |
| 3 | Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils显示文摘Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully elucidated.In this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and mice.FGF2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling pathway.FGF2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and activation.More importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected mice.Based on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting neutrophils.Thus,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection. | Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang Penghui Yang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 4 | Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin αVβ3显示文摘 | Yunling Li Li Sun Hong Xu Zhengyu Fan Wantong Yao Wei Guo Jia Rao Xiliang Zha | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 1 |
| 5 | The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation显示文摘Acetaminophen(APAP)overdose is a major cause of liver injury.Neural precursor cell expressed developmentally downregulated 4—1(NEDD4-1)is an E3 ubiquitin ligase that has been implicated in the pathogenesis of numerous liver diseases;however,its role in APAP-induced liver injury(AILI)is unclear.Thus,this study aimed to investigate the role of NEDD4-1 in the pathogenesis of AILI.We found that NEDD4-1 was dramatically downregulated in response to APAP treatment in mouse livers and isolated mouse hepatocytes.Hepatocyte-specific NEDD4-1 knockout exacerbated APAP-induced mitochondrial damage and the resultant hepatocyte necrosis and liver injury,while hepatocyte-specific NEDD4-1 overexpression mitigated these pathological events both in vivo and in vitro.Additionally,hepatocyte NEDD4-1 deficiency led to marked accumulation of voltage-dependent anion channel 1(VDAC1)and increased VDAC1 oligomerization.Furthermore,VDAC1 knockdown alleviated AILI and weakened the exacerbation of AILI caused by hepatocyte NEDD4-1 deficiency.Mechanistically,NEDD4-1 was found to interact with the PPTY motif of VDAC1 through its WW domain and regulate K48-linked ubiquitination and degradation of VDAC1.Our present study indicates that NEDD4-1 is a suppressor of AILI and functions by regulating the degradation of VDAC1. | Yiwei Zhu Lin Lei Xinghui Wang Linfang Chen Wei Li Jinxia Li Chenchen Zhao Xiliang Du Yuxiang Song Wenwen Gao Guowen Liu Xinwei Li | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 6 | Bipolar doping and band- gap anomalies in delafossite transparent conductive oxides 显示文摘 | Nie Xiliang Wei Suhuai Zhang S | 2002 | Phys Rev Lett2002，88，06： | 1 |
| 7 | Application of sentinel lymph node (SLN) biopsy in breast cancer patients显示文摘Objective: To discuss if the sentinel lymph node (SLN) biopsy is able to reflect the status of the axillary lymph node and the application of this technic in clinic. Methods: Using 99mTc-signed dextran, SLN-biopsy (SLNB) was carried out in 182 cases with breast cancer during May 1999 to September 2006. During the operation, γ-detector was used for orientation. After the SLNB, a modified radical mastectomy or breast conserving surgery were carried out to the patients, then a particular separate pathological examination of the SLN was made. Results: 178 cases of SLNB were carried out successfully, and the success rate was 97.8%, the out-checked SLN of each case ranged from 1 to 4, with an average of 2.5. All SLN was located at the first level of axilla, sensitivity of the SLNB was 93.4%, specificity was 100%, false negative rate was 6.6%, false positive rate was 0, accuracy was 97.8%, positive predictive value was 100.0%, negative predictive value was 96.7%, and Youden’s index was 0.934. Immunohistochemical examination was carried out in 59 cases of SLN, and 14 cases showed the existences of micro-metastasis, however, metastasis had not been found in non-SLN of these cases. Conclusion: SLN is able to reflect the metastasis of the axillary lymph node, and this can suggest the necessity of the axillary dissection in clinic. The SLNB using the isotope-tracer technic is simple and accurate. | Tao Zhang Baoning Zhang Hong Wang Baoping Chen Xiliang Wei Ying Fu Lin Liu HongyingYang Shengzu Ghen | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，1： | 1 |
| 8 | Rapid pattern recognition of different types of sulphur-containing species as well as serum and bacteria discrimination using Au NCs-Cu2+ complexes显示文摘Discrimination of different types of sulfur-containing species not only helps us to deeply understand how sulfur affects cellular signaling,but also contribute to the early diagnosis of diseases.However,the current investigation about sulfur-containing species discrimination is mainly concentrated in biothiols,which is relatively limited for practical application.Toward circumventing this limitation,herein,a convenient sensor array consisting of three kinds of Au NCs-Cu2+ for simultaneous and rapid identification of different types of sulfur-containing species is reported.Based on the fingerprint-like fluorescence responses generated by competitive binding between Au NCs-Cu2+ and different sulfurcontaining species,not only ten different types of sulfur-containing species separately but also their binary or ternary randomly selected mixtures can be well discriminated even in human urine and serum samples.It is worth noting that it only takes 2 min to obtain the best response signals for sulfurcontaining species discrimination.Most importantly,serums from cancer patients(such as liver cancer and breast cancer) and healthy people as well as sulfur-oxidizing bacteria(SOB) and sulfur-free bacteria can be both effectively and rapidly identified within 2 min,respectively,making it a promising approach for point-of-care disease diagnostic. | Wentao Li Xiaomei Sun Xuan Zhao Wei Wang Shenghao Xu Xiliang Luo | 2020 | Chinese Chemical Letters2020，31，9： | 1 |
| 9 | 乳腺癌前哨淋巴结微小转移的检测(英文)显示文摘Objective: To study the best examination method of micrometastases in sentinel lymph node (SLN) of breast cancer and study the related factors with micrometastases. Methods: By step serial sectioning technique and immunohisto- chemistry, 121 SLNs and 44 tumors of 59 cases were examined. Results: Micrometastases was found in 17 SLNs (14%) of 14 (24%) cases. The more sections or examination methods, the more micrometastases were found. Micrometastases was related with the tumor size and the expression of c-erbB2, MMP-2 and VEGF. Conclusion: The best examination method is making sections at two levels with 100 μm interval and combination of HE staining and muc1 immunohistochemistry. We can get the excellent detection/cost by this method. Micrometastases is a bad prognostic factor. | Tao Zhang Baoning Zhang Baoping Chen Xiliang Wei Hongtu Zhang Yuntian Sun | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，6： | 1 |
| 10 | Ru(Ⅲ)-catalyzed construction of variously substituted quinolines from 2-aminoaromatic aldehydes(ketones)and isoxazoles:Isoxazoles as cyclization reagent and cyano sources显示文摘A Ru(Ⅲ)-catalyzed annulation reaction of 2-aminoaromatic aldehydes(ketones)and isoxazoles to afford diverse 3-cyanoquinolines has been developed.Notably,isoxazole acted as a cyclization reagent and nontoxic cyano source via N-O bond cleavage and fragmentation.Variously substituted(especially 6-or 7-substituted)quinolines could be easily afforded.This procedure features wide functional group compatibility,efficiency and avoiding toxic cyano source.Meanwhile,this protocol could be successfully applied to scale-up synthesis.Further chemical transformations of 3-cyanoquinoline could give some valuable skeletons,demonstrating its potential in synthetic application. | Di Hu Chao Pi Wei Hu Xiliang Han Yangjie Wu Xiuling Cui | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 11 | Aqueous synthesis of bright near-infrared-emitting Zn-Cu-In-Se quantum dots for multiplexed detection of tumor markers显示文摘Aqueous synthesis is a green but challenging pathway to produce cadmium-free,bright,and near-infrared(NIR)emitting quantum dots(QDs).Herein,we develop a straightforward aqueous phase approach to prepare Zn-Cu-In-Se QDs with tunable emission from 630 to 800 nm through varying the molar ratio of Zn and Cu.The ultrasmall nanoparticle size remains nearly fixed(~2.6 nm)when the QD composition is varied,allowing for the effects of composition on the optical properties of QDs to be decoupled from the impact of particle size.By leveraging the off-stoichiometric effect on photoluminescence(PL),Zn-Cu-In-Se QDs with a Zn:Cu molar ratio of 1.0 show a long PL decay lifetime of 211 ns and an absolute photoluminescence quantum yield(PLQY)of 14.2%.The PLQY is further enhanced by overcoating a ZnS shell,reaching up to 25.8%.Based on the bright,biocompatible,and emission-tunable QDs,nanoprobes with targeting capability for multiple tumor markers are further constructed and employed to simultaneously ascertain targets in the cytoplasm and cell membrane.This study provides a green and effective strategy for achieving bright and biocompatible NIR quantum dots for multiplexed biodetection applications. | Hui Liu Peng Cai Kevin J.McHugh Collin F.Perkinson Laishuo Li Shuna Wang Wei Wang Mingxia Jiao Xiliang Luo Lihong Jing | 2022 | Nano Research2022，15，9： | 0 |
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