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| 1 | Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy显示文摘The prevalence of skin cancer is rising along with the rapid population aging in recent years.Traditional therapies,such as surgical treatment,radiotherapy,chemotherapy,photodynamic therapy,and immunotherapy,may accompany serious side effects,limiting their clinical benefits.According to the biological characteristics of skin cancer,we have already established two kinds of synergetic systems of photothermal therapy(microneedle)and chemotherapy,containing gold nanorods(GNR).Although the microneedle system exhibited great potential for skin cancer treatment,the system could be still improved further.So,we designed a near-infrared lightresponsive 5-fluorouracil(5-Fu)and indocyanine green(ICG)loaded monomethoxy-poly(ethylene glycol)-polycaprolactone(MPEG-PCL)nanoparticle(5-Fu-ICG-MPEG-PCL),and then 5-Fu-ICG-MPEG-PCL was integrated with a hyaluronic acid dissolvable microneedle system(HA MN)to get 5-Fu-ICG-MPEG-PCL loaded HA MN for treating skin cancers,including human epidermoid cancer and melanoma.In this system,hyaluronic acid,the microneedle carrier,possesses good skin penetration ability and is approved by FDA as a pharmaceutical adjuvant;5-Fu is recommended by FDA for skin cancer treatment;ICG,a photothermal agent,possesses a strong photothermal ability and is approved by FDA for its use in the human body.We hypothesized that 5-Fu-ICG-MPEG-PCL could be delivered by the dissolvable microneedle through the skin,and the release behavior of the drug in the nanoparticle could be controlled by near-infrared light for achieving a single-dose cure of skin cancer,improving the cure rate of skin cancer and providing a new idea and possibility for the clinical treatment of skin cancer. | Ying Hao YuWen Chen XinLong He Fan Yang RuXia Han ChengLi Yang Wei Li ZhiYong Qian | 2020 | Bioactive Materials2020，5，3： | 17 |
| 2 | Adhesion Characteristics of a Novel Synthetic Polydimethylsiloxane for Bionic Adhesive Pads显示文摘 | Qingsong He Min Yu Yang Li Xinlong Chen Hao Zhang Ling Gong Zhendong Dai | 2014 | Journal of Bionic Engineering2014，11，3： | 6 |
| 3 | Multistage analysis method for detection of effective herb prescription from clinical data显示文摘为特定的疾病条件或特别的耐心的组决定有效繁体中文药(TCM ) 治疗是因为复杂个性化的表明,在真实世界的病人和在临床的背景规定的个性化的联合治疗要求调查的一个困难的问题。在这研究,集成倾向大小写匹配的一个多级式的分析方法,复杂网络分析,和植物给了丰富分析被建议为特别疾病识别有效植物药方(例如,失眠) 。首先,匹配的倾向大小写被使用匹配临床的盒子。然后,核心网络抽取和植物集合丰富被联合检测核心有效植物药方。基于有效性的相互的信息被用来检测强壮的 herbsymptom 关系。这个方法在一个 TCM 临床的数据集合上被使用, 955 个病人从设计得好的观察研究收集了。结果与更高的有效性率揭示了那组植物药方(76.9% 对 42.8% 为匹配的样品;94.2% 对 84.9% 为所有样品) 与原版相比,药方被发现。有症状表明的特别的耐心的组也被识别帮助调查有效植物药方的指示。 | Kuo Yang Runshun Zhang Liyun He Yubing Li Wenwen Liu Changhe Yu Yanhong Zhang Xinlong Li Yan Liu Weiming Xu Xuezhong Zhou Baoyan Liu | 2018 | Frontiers of Medicine2018，12，2： | 5 |
| 4 | Third-order nonlinear optical properties of WTe2 films synthesized by pulsed laser deposition显示文摘The prominent third-order nonlinear optical properties of WTe2 films are studied through the Z-scan technique using a femtosecond pulsed laser at 1030 nm.Open-aperture(OA)and closed-aperture(CA)Z-scan measurements are performed at different intensities to investigate the nonlinear absorption and refraction properties of WTe2 films.OA Z-scan results show that WTe2 films always hold a saturable absorption characteristic without transition to reverse saturable absorption.Further,a large nonlinear absorption coefficientβis determined to be-3.37×10^3 cm∕GW by fitting the OA Z-scan curve at the peak intensity of 15.603 GW∕cm^2.In addition,through the slow saturation absorption model,the ground state absorption cross section,excited state absorption cross section,and absorber's density were found to be 1.4938×10^-16 cm^2,1.2536×10^-16 cm^2,and 6.2396×10^20 cm^-3,respectively.CA Z-scan results exhibit a classic peak–valley shape of the CA Z-scan signal,which reveals a self-defocusing optical effect of WTe2 films under the measured environment.Furthermore,a considerable nonlinear refractive index value n2 can be obtained at-1.629×10^-2 cm^2∕GW.Ultimately,the values of the real and imaginary parts of the third-order nonlinear susceptibility of WTe2 are roughly estimated to be-5.93×10^-9 and-1.01×10^-8 esu with the help of first-principles calculations.WTe2 possesses sizeable thirdorder nonlinear coefficients compared with other materials,which suggests that it has great potential to improve performance in nonlinear optical devices. | MI HE YEQUAN CHEN LIPENG ZHU HUAN WANG XUEFENG WANG XINLONG XU ZHANYU REN | 2019 | Photonics Research2019，7，12： | 1 |
| 5 | The construction of a lymphoma cell-based, DC-targeted vaccine, and its application in lymphoma prevention and cure显示文摘In recent years,Non-Hodgkin lymphoma(NHL)has been one of the most fast-growing malignant tumor diseases.NHL poses severe damages to physical health and a heavy burden to patients.Traditional therapies(chemotherapy or radiotherapy)bring some benefit to patients,but have severe adverse effects and do not prevent relapse.The relevance of emerging immunotherapy options(immune-checkpoint blockers or adoptive cellular methods)for NHL remains uncertain,and more intensive evaluations are needed.In this work,inspired by the idea of vaccination to promote an immune response to destroy tumors,we used a biomaterial-based strategy to improve a tumor cell-based vaccine and constructed a novel vaccine named Man-EG7/CH@CpG with antitumor properties.In this vaccine,natural tumor cells are used as a vector to load CpG-ODN,and following lethal irradiation,the formulations were decorated with mannose.The study of the characterization of the doubleimproved vaccine evidenced the enhanced ability of DCs targeting and improved immunocompetence,which displayed an antitumor function.In the lymphoma prevention model,the Man-EG7/CH@CpG vaccine restrained tumor formation with high efficiency.Furthermore,unlike the non-improved vaccine,the double-improved vaccine elicited an enhanced antitumor effect in the lymphoma treatment model.Next,to improve the moderate therapeutic effect of the mono-treatment method,we incorporated a chemotherapeutic drug(doxorubicin,DOX)into the process of vaccination and devised a combination regimen.Fortunately,a tumor inhibition rate of~85%was achieved via the combination therapy,which could not be achieved by mono-chemotherapy or mono-immunotherapy.In summary,the strategy presented here may provide a novel direction in the establishment of a tumor vaccine and is the basis for a prioritization scheme of immuno-chemotherapy in enhancing the therapeutic effect on NHL. | Tianlin Zhou Jinrong Penga Ying Hao Kun Shi Kai Zhou Yun Yang Chengli Yang Xinlong He Xinmian Chen Zhiyong Qian | 2021 | Bioactive Materials2021，6，3： | 1 |
| 6 | Effects of probiotic fermentation on the enhancement of biological and pharmacological activities of Codo- nopsis lanceolata extracted by high pressure treat- ment显示文摘 | Xinlong He Yunyun Zou Won-Byong Yoon | 2011 | Journal of Bioscience and Bioengineering2011，112，2： | 1 |
| 7 | Patterned Thermoresponsive Microgel Surfaces to Control Cell Detachment显示文摘 | Xia Yongqing Tang Ying He Xinlong | 2016 | Biomacromolecules2016，17，2： | 1 |
| 8 | A new method to deduce high-order compact difference schemes for two-dimensional Poisson equation显示文摘 | Zhai Shuying Feng Xinlong He Yinnian | 2014 | Applied Mathematics and Computation2014，230，： | 1 |
| 9 | Convergence and stability of two-level penalty mixed finite element method for stationary Navier-Stokes equations显示文摘 | Pengzhan HUANG Yinnian HE Xinlong FENG | 2013 | Frontiers of Mathematics in China2013，8，4： | 1 |
| 10 | Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy显示文摘Breast cancer has become the most commonly diagnosed cancer type in the world.A combination of chemotherapy and photothermal therapy(PTT) has emerged as a promising strategy for breast cancer therapy.However,the intricacy of precise delivery and the ability to initiate drug release in specific tumor sites remains a challenging puzzle.Therefore,to ensure that the therapeutic agents are synchronously delivered to the tumor site for their synergistic effect,a multifunctional nanoparticle system(PCRHNs) is developed,which is grafted onto the prussian blue nanoparticles(PB NPs) by reductionresponsive camptothecin(CPT) prodrug copolymer,and then modified with tumor-targeting peptide cyclo(Asp-D-Phe-Lys-Arg-Gly)(cRGD) and hyaluronic acid(HA).PCRHNs exhibited nano-sized structure with good monodispersity,high load efficiency of CPT,triggered CPT release in response to reduction environment,and excellent photothermal conversion under laser irradiation.Furthermore,PCRHNs can act as a photoacoustic imaging contrast agent-guided PTT.In vivo studies indicate that PCRHNs exhibited excellent bio compatibility,prolonged blood circulation,enhanced tumor accumulation,allow tumor-specific che mo-photo thermal therapy to achieve synergistic antitumor effects with reduced systemic toxicity.Moreover,hyperthermia-induced upregulation of heat shock protein 70 in the tumor cells could be inhibited by CPT.Collectively,PCRHNs may be a promising therapeutic way for breast cancer therapy. | Yun Yang Danrong Hu Yi Lu Bingyang Chu Xinlong He Yu Chen Yao Xiao Chengli Yang Kai Zhou Liping Yuan Zhiyong Qian | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 1 |
| 11 | Single-Cell Microwell Platform Reveals Circulating Neural Cells as a Clinical Indicator for Patients with Blood-Brain Barrier Breakdown显示文摘Central nervous system diseases commonly occur with the destruction of the blood-brain barrier.As a primary cause of morbidity and mortality,stroke remains unpredictable and lacks cellular biomarkers that accurately quantify its occurrence and development.Here,we identify NeuN^(+)/CD45^(−)/DAPI^(+)phenotype nonblood cells in the peripheral blood of mice subjected to middle cerebral artery occlusion(MCAO)and stroke patients.Since NeuN is a specific marker of neural cells,we term these newly identified cells as circulating neural cells(CNCs).We find that the enumeration of CNCs in the blood is significantly associated with the severity of brain damage in MCAO mice(p<0:05).Meanwhile,the number of CNCs is significantly higher in stroke patients than in negative subjects(p<0:0001).These findings suggest that the amount of CNCs in circulation may serve as a clinical indicator for the real-time prognosis and progression monitor of the occurrence and development of ischemic stroke and other nervous system disease. | Yu Zhang Antony R.Warden Khan Zara Ahmad Yanlei Liu Xijun He Minqiao Zheng Xinlong Huo Xiao Zhi Yuqing Ke Hongxia Li Sijia Yan Wenqiong Su Deng Cai Xianting Ding | 2021 | Research2021，，1： | 0 |
| 12 | Macrophage Membrane-Camouflaged shRNA and Doxorubicin:A pH-Dependent Release System for Melanoma Chemo-Immunotherapy显示文摘mproving the eficacy of melanoma treatment remains an important global challenge.Here,we combined chemotherapy with protein tyrosine phosphatase nonreceptor type 2(Ptpn2)based immunotherapy in an effort to address this challenge.Shorthairpin RNA(shRNA)targeting Ptpn2 was coencapsulated with doxorubicin(DOX)in the cell membrane of MI macrophages(MIHD@RPR).The prepared nanoparticles(NPs)were effectively phagocytosed by B16F10 cells and MI macrophages,but not by MOmacrophages.Hence,NPevasion from the reticuloendothelial system(RES)was improved and NPenrichment in tumor sites increased.MIHD@RPR can directly kill tumor cells and stimulate immunogenic cell death(ICD)by DOX and downregulate Ptpn2.It can promote Ml macrophage polarization and dendritic cell maturation and increase the proportion of CD8+T cells.MIHD@RPR killed and inhibited the growth of primary melanoma and lung metastatic tumor celis without harming the surrounding tssue.These findings establish MIHD@RPR as a safe multifunctional nanoparticle capable of effectively combining chemotherapy and gene immunotherapies against melanoma. | Chengli Yang Yang Ming Kai Zhou Ying Hao Danrong Hu Bingyang Chu Xinlong He Yun Yang Zhiyong Qian | 2022 | Research2022，，2： | 0 |
| 13 | Erratum to “Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy” [Bioact. Mater. 5 (2020) 542–552]显示文摘This is an erratum to our published paper,the scale bar in Fig.6A was wrong[1].In the paper mentioned above,the scale bar in Fig.6A was wrong[1].We missed a decimal point of the scale bar.The correct scale bar of 5-Fu-ICG-MPEG-PCL@HA MN should be 1.00 mm instead of 100 mm.We have corrected the scale bar in Fig.6 as follows. | Ying Hao YuWen Chen XinLong He Fan Yang RuXia Han ChengLi Yang Wei Li ZhiYong Qian | 2021 | Bioactive Materials2021，6，1： | 0 |
| 14 | 6-11 Status of the Electro-polishing System at IMP显示文摘Institution of Modern Physics (IMP) has designed, fabricated and installed the first SRF cavity electropolishing system of China. It’s sized for 1.3 GHz SRF cavities, and also can works for multiple cell cavities with further upgrade of structure. | Li Lu He Yuan You Zhiming Guo Hao Xiong Pingran Zhu Xinlong Li Yongming Zhang Shenghu Zhang Bin Shi Zhixiong | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 15 | S-doped porous carbon fibers with superior electrode behaviors in lithium ion batteries and fuel cells显示文摘The orientation construction of S-doped porous carbon fibers(SPCFs)is realized by the facile template-directed methodology using asphalt powder as carbon source.The unique fiber-like morphology without destruction can be well duplicated from the template by the developed methodology.MgSO4 fibers serve as both templates and S dopant,realizing the in-situ S doping into carbon frameworks.The effects of different reaction temperatures on the yield and S doping level of SPCFs are investigated.The S doping can not only significantly enhance the electrical conductivity,but also introduce more defects or disorders.As anode material for lithium ion batteries(LIBs),SPCFs electrode delivers better rate capability than undoped PCFs.And the capacity of SPCFs electrode retains around 90%after 300 cycles at 2 A g1,exhibiting good cycling stability.As the electrocatalysts for fuel cells,the onset potentials of SPCFs obtained at 800 and 900C are concentrated at 0.863 V,and the higher kinetic current densities at 0.4 V of them are larger than that of PCFs,demonstrating the superior electrocatalytic performance.Due to the synergistic effect of abundant pore channels and S doping,SPCFs electrode exhibits superior electrochemical performances as anode for LIBs and elecctrocatalyst for fuel cells,respectively.Additionally,the oriented conversion of asphalt powder into high-performance electrode material in this work provides a new way for the high value application of asphalt. | Peng Jin Long Li Xiaohu Gu Yanshao Hu Xiaojing Zhang Xiongchao Lin Xinlong Ma Xing He | 2022 | Materials Reports(Energy)2022，2，4： | 0 |
| 16 | A Review of the Application of Artificial Intelligence in Orthopedic Diseases显示文摘In recent years,Artificial Intelligence(AI)has revolutionized people’s lives.AI has long made breakthrough progress in the field of surgery.However,the research on the application of AI in orthopedics is still in the exploratory stage.The paper first introduces the background of AI and orthopedic diseases,addresses the shortcomings of traditional methods in the detection of fractures and orthopedic diseases,draws out the advantages of deep learning and machine learning in image detection,and reviews the latest results of deep learning and machine learning applied to orthopedic image detection in recent years,describing the contributions,strengths and weaknesses,and the direction of the future improvements that can be made in each study.Next,the paper also introduces the difficulties of traditional orthopedic surgery and the roles played by AI in preoperative,intraoperative,and postoperative orthopedic surgery,scientifically discussing the advantages and prospects of AI in orthopedic surgery.Finally,the article discusses the limitations of current research and technology in clinical applications,proposes solutions to the problems,and summarizes and outlines possible future research directions.The main objective of this review is to inform future research and development of AI in orthopedics. | Xinlong Diao Xiao Wang Junkang Qin Qinmu Wu Zhiqin He Xinghong Fan | 2024 | Computers, Materials & Continua2024，78，2： | 0 |
| 17 | 6-9 Status of the Electropolishing System at IMPCAS显示文摘IMP(Institution of Modern Physics)has designed,fabricated and installed the first SRF cavity electropolishing system of China.It’s sized for 1.3 GHz SRF cavities,and can work for multiple cell cavities with further upgrade of structure as well.Producing high field and Q-values in superconducting RF cavities of niobium has required the removal of a substantial layer of the inner cavity surface,typically of the order of 100 microns in depth.Two methods have commonly been used:EP(electropolishing)or BCP(buffered chemical polish).EP of niobium cavities is proving to yield consistently better performance than BCP.To take advantage of high performance levels obtainable with EP technique,a completed EP system was installed and operated at IMP. | Li Lu He Yuan You Zhiming Guo Hao Xiong Pingran Zhu Xinlong Li Yongming Zhang Shenghu Zhang Bin | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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