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| 1 | Tea aroma formation显示文摘Besides water,tea is one of the most popular beverages around the world.The chemical ingredients and biological activities of tea have been summarized recently.The current review summarizes tea aroma compounds and their formation in green,black,and oolong tea.The flavor of tea can be divided into two categories:taste(non-volatile compounds)and aroma(volatile compounds).All of these aroma molecules are generated from carotenoids,lipids,glycosides,etc.precursors,and also from Maillard reaction.In the current review,we focus on the formation mechanism of main aromas during the tea manufacturing process.©2015 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Chi-Tang Ho Xin Zheng Shiming Li | 2015 | Food Science and Human Wellness2015，4，1： | 62 |
| 2 | Bioengineered miR-27b-3p and miR-328-3p modulate drug metabolism and disposition via the regulation of target ADME gene expression显示文摘Drug-metabolizing enzymes, transporters, and nuclear receptors are essential for the absorption, distribution, metabolism, and excretion(ADME) of drugs and xenobiotics. MicroRNAs participate in the regulation of ADME gene expression via imperfect complementary Watson–Crick base pairings with target transcripts. We have previously reported that Cytochrome P450 3A4(CYP3A4) and ATP-binding cassette sub-family G member 2(ABCG2) are regulated by miR-27b-3p and miR-328-3p,respectively. Here we employed our newly established RNA bioengineering technology to produce bioengineered RNA agents(BERA), namely BERA/miR-27b-3p and BERA/miR-328-3p, via fermentation. When introduced into human cells, BERA/miR-27b-3p and BERA/miR-328-3p were selectively processed to target miRNAs and thus knock down CYP3A4 and ABCG2 mRNA and their protein levels,respectively, as compared to cells treated with vehicle or control RNA. Consequently, BERA/miR-27b-3p led to a lower midazolam 10-hydroxylase activity, indicating the reduction of CYP3A4 activity. Likewise,BERA/miR-328-3p treatment elevated the intracellular accumulation of anticancer drug mitoxantrone, a classic substrate of ABCG2, hence sensitized the cells to chemotherapy. The results indicate that biologic miRNA agents made by RNA biotechnology may be applied to research on miRNA functions in the regulation of drug metabolism and disposition that could provide insights into the development of more effective therapies. | Xin Li Ye Tian Mei-Juan Tu Pui Yan Ho Neelu Batra Ai-Ming Yu | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 10 |
| 3 | Morphological variability and genetic diversity in five species of Skeletonema(Bacillariophyta)显示文摘从中国沿海的水的 Skeletonema 的 12 紧张和来自朝鲜的西方海的另一紧张用轻显微镜学(LM ) 被检验,扫描并且传播电子显微镜学(SEM, TEM ) ,并且小子单元(SSU ) rDNA 顺序分析。我们识别了 Skeletonema 的四种:S。marinoi Sarno 和 Zingone, S。subsalsum (A.Cleve ) Bethge, S。dohrnii Sarno 和 Kooistra, S。回归线嗯 Cleve,以及象 Skeletonema 一样种。这些是 S 的第一个记录。marinoi, S。dohrnii 和 S。在中国的 subsalsum。象 Skeletonema 一样种类, MMDL5067,从 Changjiang 河的河口被孤立。这种的词法、种系发生的特征不任何以前出版的 Skeletonema 种类对应于那些。闰的 fultoportula 过程(IFPP ) 有长开的试管,和闰的 rimoportula 过程(IRP ) 在 IFPP 的边界内短、定位。种系发生的分析揭示了与 S 聚类的那 MMDL5630。回归线嗯在 NJ 和 MP,树,而是它的 IRP S 的以前描述的标本不同于那些。回归线嗯。IRP 部分是开的,与在试管的底的一个伸长的洞,并且比 IFPP 长。S 的一些标本。marinoi 和 S。dohrnii 也比 IFPP 有更长管状的 IRP。比作 S 的以前描述的标本。marinoi 和 S。dohrnii,我们识别了的这二个标本有更短的 IRP。我们的结果反映 Skeletonema 分类的歧义和差异。他们为未来鉴定和 Skeletonema 在中国附近在海引起的红潮的管理也是重要的。 | Jinfeng Cheng Yang Li Junrong Liang Yahui Gao PengWang Ho Kin-Chung Xin Lin | 2008 | Progress in Natural Science:Materials International2008，18，11： | 5 |
| 4 | Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7显示文摘The voltage-gated Na^+ channel subtype Nav1.7 is important for pain and itch in rodents and humans. We previously showed that a Nav1.7-targeting monoclonal antibody(SVmab) reduces Na+ currents and pain and itch responses in mice. Here, we investigated whether recombinant SVmab(rSVmab) binds to and blocks Nav1.7 similar to SVmab. ELISA tests revealed that SVmab was capable of binding to Nav1.7-expressing HEK293 cells,mouse DRG neurons, human nerve tissue, and the voltagesensor domain Ⅱ of Nav1.7. In contrast, rSVmab showed no or weak binding to Nav1.7 in these tests. Patch-clamp recordings showed that SVmab, but not rSVmab, markedly inhibited Na+ currents in Nav1.7-expressing HEK293 cells. Notably, electrical field stimulation increased the blocking activity of SVmab and rSVmab in Nav1.7-expressing HEK293 cells. SVmab was more effective than rSVmab in inhibiting paclitaxel-induced mechanical allodynia. SVmab also bound to human DRG neurons and inhibited their Na^+ currents. Finally, potential reasons for the differential efficacy of SVmab and rSVmab and future directions are discussed. | Sangsu Bang Jiho Yoo Xingrui Gong Di Liu Qingjian Han Xin Luo Wonseok Chang Gang Chen Sang-Taek Im Yong Ho Kim Judith A.Strong Ma-Zhong Zhang Jun-Ming Zhang Seok-Yong Lee Ru-Rong Ji | 2018 | Neuroscience Bulletin2018，34，1： | 2 |
| 5 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 6 | Role of protein kinase C on the alteration of retinal endothelin-1 in streptozotocin-induced diabetic rats显示文摘 | Qi Zhu Xun Xu Xin Xia Qing Gu Patrick C.P. Ho | 2005 | Experimental Eye Research2005，，2： | 1 |
| 7 | Circulating miR-210 as a Novel Hypoxia Marker in Pancreatic Cancer显示文摘 | Allen S. Ho Xin Huang Hongbin Cao Claudia Christman-Skieller Kevin Bennewith Quynh-Thu Le Albert C. Koong | 2010 | Translational Oncology2010，，2： | 1 |
| 8 | Surface composition of a series of dimethylsiloxane-urea-urethane segmented copolymers studied by electron spectroscopy for chemical analysis显示文摘 | CHEN XIN GARDELLA JR J A HO TAI | 1995 | Macromolecules1995，28，5： | 1 |
| 9 | Trends in seaweed research显示文摘 | CHAN Cheong xin HO Chai ling PHANG Siew moi | 2006 | Trends in Plant Science2006，11，4： | 1 |
| 10 | Residual Embryonic Cells as Precursors of a Barrett’s-like Metaplasia显示文摘 | Xia Wang Hong Ouyang Yusuke Yamamoto Pooja Ashok Kumar Tay Seok Wei Rania Dagher Matthew Vincent Xin Lu Andrew M. Bellizzi Khek Yu Ho Christopher P. Crum Wa Xian Frank McKeon | 2011 | Cell2011，，7： | 1 |
| 11 | Three-arm randomised controlled phase 2 study comparing pemetrexed and erlotinib to either pemetrexed or erlotinib alone as second-line treatment for never-smokers with non-squamous non-small cell lung cancer显示文摘 | Dae Ho Lee Jung Shin Lee Sang-We Kim José Rodrigues-Pereira Baohui Han Xiang-Qun Song Jie Wang Hoon-Kyo Kim Tarini Prasad Sahoo Raghunadharao Digumarti Xin Wang Sedat Altug Mauro Orlando | 2013 | European Journal of Cancer2013，，： | 1 |
| 12 | Surface composition of a series of dimethylsiloxane urea urethane segmented copolymers studied by electron spectroscopy for chemical analysis显示文摘 | CHEN XIN GARDELLA J A HO TAI | 1995 | Macromolecules1995，28，5： | 1 |
| 13 | Portable quantitative phase microscope for material metrology and biological imaging显示文摘Quantitative phase microscopy(QPM)has emerged as an important tool for material metrology and biological imaging.For broader adoption in those applications,we have proposed and demonstrated a new portable off-axis QPM method,which works in both transmission and reflection modes to meet different sample measurement requirements.The temporal and spatial sensitivities of our system,as quantified by optical path-length difference values,are 0.65 nm and 1.04 nm,respectively.To demonstrate its applicability for a wide range of applications,we deployed our system for profiling transistor gold electrode samples,observing red blood cell membrane fluctuations,imaging living cells flowing in a microfluidic chip,etc.Our portable QPM system has a low-cost design and involves a simple and robust phase-retrieval algorithm that we envision will allow for broader deployment at different environmental settings,including in resource-limited sites and integration with other metrology or imaging modalities. | Mengxuan Niu Gang Luo Xin Shu Fuyang Qu Shuang Zhou Yi-Ping Ho Ni Zhao Renjie Zhou | 2020 | Photonics Research2020，8，7： | 1 |
| 14 | Theoretical and Experimental Studies of Schottky Diodes that Use Aligned Arrays of Single-Walled Carbon Nanotubes显示文摘We present theoretical and experimental studies of Schottky diodes that use aligned arrays of single-walled carbon nanotubes. A simple physical model, taking into account the basic physics of current rectification, can adequately describe the single-tube and array devices. We show that for as-grown array diodes, the rectification ratio, defined by the maximum-to-minimum-current-ratio, is low due to the presence of metallic-single-walled nanotube (SWNT) shunts. These tubes can be eliminated in a single voltage sweep resulting in a high rectification array device. Further analysis also shows that the channel resistance, and not the intrinsic nanotube diode properties, limits the rectification in devices with channel length up to 10 μm. | Xinning Ho Lina Ye Slava V.Rotkin Xu Xie Frank Du Simon Dunham Jana Zaumseil John A.Rogers | 2010 | Nano Research2010，3，6： | 0 |
| 15 | A dual-functional BODIPY-based molecular rotor probe reveals different viscosity of protein aggregates in live cells显示文摘Aberrant protein aggregation leads to various human diseases,but little is known about the physical chemical properties of these aggregated proteins in cells.Herein,we developed a boron-dipyrromethene(BODIPY)-based HaloTag probe,whose conjugation to HaloTag-fused proteins allows us to study protein aggregates using both fluorescence intensity and lifetime.Modulation of BODIPY fluorophore reveals key structural features to attain the dual function.The optimized probe exhibits increased fluorescence intensity and elongated fluorescence lifetime in protein aggregates.Fluorescence lifetime imaging using this probe indicates that protein aggregates afford different viscosity in the forms of soluble oligomers and insoluble aggregates in live cells.The strategy presented in this work can be extended to enable a wide class of HaloTag probes that can be used to study a variety of physical properties of protein aggregates,thus helping unravel the pathogenic mechanism and develop therapeutic strategy. | Baoxing Shen Kwan Ho Jung Songtao Ye Conner A.Hoelzel Charles H.Wolstenholme He Huang Yu Liu Xin Zhang | 2023 | Aggregate2023，4，3： | 0 |
| 16 | Facile designing a superhydrophobic anti-icing surface applied for reliable long-term deicing显示文摘While superhydrophobic coatings have shown promise as potential anti-icing coatings, the surface roughness of these coatings is prone to damage during repeated icing-deicing cycles. Herein, two kinds of superhydrophobic anti-icing coatings are prepared from organic resin and micro-nano particles using two strategies, and their excellent anti-icing properties are also investigated. However, superhydrophobic surface Ⅰ(SF1), prepared by first strategy, cannot be used for extended periods of time due to irreversible damage to the surface roughness during the icing–deicing process. Finite element simulations and experimental studies are preformed to investigate the fatal issue of such roughness damage. In contrast,the anti-icing properties of superhydrophobic surface Ⅱ(SF2), prepared by second strategy, can easily regain through a simple sandpaper abrasion treatment even the surface roughness was damaged during the icing–deicing process. These exploratory results and SF2 preparation strategy provide a facile design of anti-icing coating, and the derived restorable anti-icing coating is expected to be useful for a wide application. | Feng Liu Xin Wang Meng Wang Yao Li Zishuai Jiang Wenbo Zhang Haiyue Yang Chengyu Wang Shih-Hsin Ho | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 17 | Factors early in life associated with hepatic steatosis显示文摘BACKGROUND The rise in prevalence of non-alcoholic fatty liver disease(NAFLD)mirrors the obesity epidemic.NAFLD is insidious but may gradually progress from simple steatosis to steatohepatitis,fibrosis and cirrhosis and/or hepatocellular carcinoma.Intervention strategies to ameliorate developmental programming of NAFLD may be more efficacious during critical windows of developmental plasticity.AIM To review the early developmental factors associated with NAFLD.METHODS Databases MEDLINE via PubMed,and EMBASE and Reference Citation Analysis were searched and relevant publications up to April 30,2021 were assessed.Original research studies that included risk factors associated with early development of NAFLD in human subjects were included.These factors include:Maternal factors,intrauterine and prenatal factors,post-natal factors,genetic and ethnic predisposition,childhood and adolescence environmental factors.Studies were excluded if they were review articles or animal studies,case reports or conference abstracts,or if NAFLD was not clearly defined and assessed radiologically.RESULTS Of 1530 citations identified by electronic search,420 duplicates were removed.Of the 1110 citations screened from title and abstract,80 articles were included in the final analysis.Genetic polymorphisms such as patatin-like phospholipase domain-containing protein 3(PNPLA3)and membrane-bound O-acyltransferase domain-containing protein 7(MBOAT7)were associated with increased risk of NAFLD.Familial factors such as maternal obesogenic environment and parental history of hepatic steatosis was associated with offspring NAFLD.Longer duration of exclusive breastfeeding in infancy was associated with a lower risk of developing NAFLD later in life while metabolic dysfunction and/or obesity in adolescence was associated with increased risk of NAFLD.Studies relating to socioeconomic factors and its association with NAFLD reported confounding results.CONCLUSION Maternal metabolic dysfunction during pregnancy,being exclusively breastfed for a longer time postnatally,diet and physical activity in childhood and adolescence are potential areas of intervention to decrease risk of NAFLD. | Sabrina Xin Zi Quek Eunice Xiang-Xuan Tan Yi Ping Ren Mark Muthiah Evelyn Xiu Ling Loo Elizabeth Huiwen Tham Kewin Tien Ho Siah | 2022 | World Journal of Hepatology2022，14，6： | 0 |
| 18 | The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model显示文摘The interaction between host circadian rhythm and gut microbes through the gut-brain axis provides new clues for tea polyphenols to improve host health.Our present research showed that oolong tea polyphenols(OTP)improved the structural disorder of the intestinal flora caused by continuous darkness,thereby modulating the production of metabolites related to pyruvate metabolism,glycolysis/gluconeogenesis,and tryptophan metabolism to alleviate the steady-state imbalance.After fecal microbiota transplantation from the OTP group,the single-cell transcriptomic analysis revealed that OTP significantly increased the number of hypothalamus cell clusters,up-regulated the number of astrocytes and fibroblasts,and enhanced the expression of circadian rhythm genes Cry2,Per3,Bhlhe41,Nr1d1,Nr1d2,Dbp and Rorb in hypothalamic cells.Our results confirmed that OTP can actively improve the intestinal environmental state as well as internal/peripheral circadian rhythm disorders and cognitive impairment,with potential prebiotic functional characteristics to notably contribute to host health. | Ruonan Yan Chi-Tang Ho Yanan Liu Shengnan Zhan Zufang Wu Xin Zhang | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
| 19 | Modulatory effects in circadian-related diseases via the reciprocity of tea polyphenols and intestinal microbiota显示文摘Tea is a widespread functional plant resource.Phytochemicals such as tea polyphenols(TP)can interact with the intestinal flora and participate in regulating the expression and rhythm of biological clock genes.Circadian rhythm controls a variety of behaviors and physiological processes,and circadian misalignment has been found to be closely related to multiple metabolic diseases.Interestingly,the gut microbiota also has diurnal fluctuations,which can be affected by diet composition and feeding rhythm,and play a role in maintaining the host’s circadian rhythm.The two-way relationship between the host’s circadian rhythm and intestinal microbiota confirms the possibility that prebiotics or probiotic can be used to adjust the intestinal environment and microbiome composition to improve the host health.This article reviews the relationship between the host’s circadian rhythm and microbiota and its influence on metabolic diseases.The beneficial effects of the interaction between TP and gut microbiota on diseases related to rhythm disorders are emphasized to improve the theories of disease prevention and treatment. | Ruonan Yan Chi-Tang Ho Xin Zhang | 2022 | Food Science and Human Wellness2022，11，3： | 0 |
| 20 | Regenerated polymer optical fiber Bragg gratings with thermal treatment for high temperature measurements显示文摘We report for the first time, to the best of our knowledge, regenerated polymer optical fiber Bragg gratings(RPOFBGs) in ZEONEX-based polymer optical fibers(POFs). The regeneration temperature can be adjusted using a heat treatment process on the POF before FBG inscription, enabling a scalable improvement of the thermal stability of the RPOFBGs. Thermal sustainability of the RPOFBGs at high temperature conditions was investigated for their prolonged use in diverse environments. Furthermore, these RPOFBGs can withstand strain levels up to 2.8% while maintaining a good linearity, even at temperature of 110℃. The RPOFBGs are capable of short-term operation at elevated temperatures of up to 132℃, which is the standard temperature for steam sterilization with at least a 4 min exposure period. The distinction in the morphologies of the two grades of ZEONEX(E48R and 480R, ZEON Corp.) used to fabricate the optical fiber together with the characteristics of UV irradiated and regenerated gratings is explained using micro-Raman spectroscopy. Collectively, these findings provide new heights for long-term operation of POF Bragg gratings(POFBGs) at elevated temperature environments and would be applicable to a wide range of disciplines. | Dinusha Serandi Gunawardena Xin Cheng Jingxian Cui Geraldi Edbert Linyue Lu Yuk Ting Ho Hwa-Yaw Tam | 2022 | Photonics Research2022，10，4： | 0 |
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